Appropriate environment management requires an understanding of how mining activity alters environmental characteristics and how those changes affect an area. Therefore, to reduce the adverse effects of mining activity on the land, it becomes crucial to have relevant information about responses to environmental degradation. This study aims to assess the impact of semi-mechanised and artisanal mining activities on the land cover using remote sensing data and photogrammetric analysis, in the Mbale locality, Northern Cameroon. For this purpose, the maximum likelihood classification algorithm of the supervised classification method combined with field surveys was used to map environmental changes, based on Sentinel-2 images of 2019, 2021, and 2023. Normalized Difference Vegetation Index (NDVI), Normalised Difference Water Index (NDWI), Brithness index (BI), and Soil crust index (SCI), were calculated to assess changes in vegetation, bare soil, water body, and exploited area. The orthophoto obtained from photogrammetric processing was performed to outline river network change through visual interpretation techniques and to calculate the volume of pits created by mining. The result of classified images indicated that vegetation cover decreased by 11.74% over the studied years. However, bare soil and exploited areas increased by 9.2% and 5.4% respectively. The calculated spectral indices show that between 2019 and 2023 the locality of Mbale considerably lost its vegetation cover, in favor of bare soil. The color of the soil and the granulometric size of the topsoil have also changed. The photogrammetry analysis highlighted the deviation of the main river and estimated the volume of pits created by mining activity to 22188.7 m3. The mining activities caused a loss of the vegetation cover, generated big pits, and multiple deviations of the Lom River from its natural course, which have a substantial negative influence on the ecosystem. Such data can be used for long-term environmental management, reclamation and rehabilitation monitoring, and mining area restoration.