Long-term Management Of Obesity Research Articles

THE DEXFENFLURAMINE CONTROVERSY: NO EASY ANSWERS.

Earlier this year, primary care physicians in the United States found themselves besieged by inquiries from patients about dexfenfluramine, the first FDA-approved drug for the long-term management of obesity. But this first year of the drug's availability in the U.S. was not without controversy. In a recent case-control study that included 95 cases of primary pulmonary hypertension (PPH) from four European countries, the risk for PPH was significantly increased among users of appetite suppressants -- mostly dexfenfluramine and fenfluramine -- during the previous year (odds ratio, 10.1). The odds ratio climbed to 23.1 when these drugs were used for more than three months (N Engl J Med 1996; 335:609). Interestingly, an association between PPH and appetite suppressant drugs was first suspected several decades ago. Moreover, although the recent data were formally published after dexfenfluramine hit the U.S. market, they were well known to the manufacturer and the FDA prior to the drug's approval in …

Book Reviews: IMPROVING THE LONG‐TERM MANAGEMENT OF OBESITY. Michael G. Perri, Arthur M. Nezu, and Barbara J. Viegener, John Wiley and Sons, New York, 1992. Improving the Long‐Term Management of Obesity

Journal of Parenteral and Enteral NutritionVolume 18, Issue 1 p. 88-88 Review Book Reviews: IMPROVING THE LONG-TERM MANAGEMENT OF OBESITY. Michael G. Perri, Arthur M. Nezu, and Barbara J. Viegener, John Wiley and Sons, New York, 1992. Improving the Long-Term Management of Obesity David B. Allison, David B. Allison St Luke's/Roosevelt Hospital Columbia University New York, NYSearch for more papers by this authorCarla Wolper, Carla Wolper St Luke's/Roosevelt Hospital Columbia University New York, NYSearch for more papers by this authorSteven B. Heymsfield, Steven B. Heymsfield St Luke's/Roosevelt Hospital Columbia University New York, NYSearch for more papers by this author David B. Allison, David B. Allison St Luke's/Roosevelt Hospital Columbia University New York, NYSearch for more papers by this authorCarla Wolper, Carla Wolper St Luke's/Roosevelt Hospital Columbia University New York, NYSearch for more papers by this authorSteven B. Heymsfield, Steven B. Heymsfield St Luke's/Roosevelt Hospital Columbia University New York, NYSearch for more papers by this author First published: 01 January 1994 https://doi.org/10.1177/014860719401800123AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume18, Issue1January 1994Pages 88-88 RelatedInformation

Long-term outcome of a self-help very-low-calorie-diet weight-loss program

This paper presents 90-wk data on five seriously overweight subjects originally brought together for 1-2 wk in simple residential accommodation to share the experience of beginning a program of very-low-calorie dieting. All subjects have remained well below their starting weight; four of the five subjects have continued to lose weight (weight losses 33.7-66.8 kg), now weighing less than at the end of the first 26 wk previously reported (1). It is proposed that this self-help group model, incorporating a very-low-calorie diet, is valuable for the long-term management of obesity.

Effects of four maintenance programs on the long-term management of obesity.

This study evaluated the effectiveness of four posttreatment programs designed to enhance the long-term maintenance of weight loss. Mildly and moderately obese adults (N = 123) were randomly assigned to one of the following five conditions: (a) behavior therapy only; (b) behavior therapy plus a posttreatment therapist-contact maintenance program; (c) behavior therapy plus posttreatment therapist contact plus a social influence maintenance program; (d) behavior therapy plus posttreatment therapist contact plus an aerobic exercise maintenance program; or (e) behavior therapy plus posttreatment therapist contact plus both the aerobic exercise and social influence maintenance programs. All posttreatment programs were conducted in 26 biweekly sessions during the year following behavioral treatment for obesity. At an 18-month follow-up evaluation, all four conditions that combined behavior therapy with a posttreatment maintenance program yielded significantly greater long-term weight losses than behavior therapy alone.