Long-term Cosmetic Results Research Articles

Cosmetic outcomes of simple facial laceration suturing in the pediatric emergency department

Purpose: The long-term cosmetic outcomes of simple facial lacerations have not been well addressed, specifically regarding those of suturing by pediatric emergency physicians (PEPs) and plastic surgery (PS) residents. Methods: A retrospective study was performed at the pediatric emergency department of Shaare Zedek Medical Center in Jerusalem, Israel. Cosmetic outcomes of simple facial lacerations sutured within 1 year of the study were reviewed using digital photographs taken by legal guardians of children sutured in the department. The photographs were reviewed and rated blindly using the Stony Brook scar score as measures of cosmetic outcomes by 2 plastic surgeons and 1 PEP, as well as the general numeric score (GNS) rated by the guardians and the 3 doctors. The scores were compared between children sutured by PEPs (PEP group) and those sutured by PS residents (PS group). A sample size of 50 children in each study group was calculated to have enough power to show a difference. Results: Among a total of 108 children who participated in the study (median age, 4.0 years [interquartile range, 3.0-7.0]), 57 and 51 were sutured by PEPs and PS residents, respectively. Guardian-rated median GNS showed no difference between the 2 groups (PEP, 90.0 [70.0-95.0] vs. PS, 90.0 [60.0-90.0]; P = 0.310). In contrast, doctor-rated median GNS was higher in the PEP group (PEP, 75.0 [63.3-86.7] vs. PS, 70.0 [53.3-83.3]); P = 0.046). A Stony Brook scar score of 3 or higher was similarly frequent in both groups (PEP, 87.7% vs. PS, 74.5%; P = 0.173) with a low interrater agreement (Kappa = 0.36). Conclusion: Cosmetic outcomes of simple facial lacerations in the pediatric emergency department were favorable regardless of the specialty or expertise of doctors. The guardians were more satisfied with the outcomes, compared to the doctors.

The oncological safety and long-term cosmetic effect of free dermal fat graft with epidermis removal for breast defect repair in breast conserving surgery

BackgroundFree dermal fat grafts (FDFG) are used for immediate breast defect repair in breast-conserving surgery (BCS), and have achieved satisfactory immediate postoperative cosmetic effects (Sawai et al., 2004) [1]. However, the oncologic safety and long-term cosmetic outcomes of these surgical procedures remain unknown. Therefore, t，in this study, we aim to investigate the oncological safety and long-term cosmetic outcomes of FDFG in patients with breast cancer. MethodsThis matched retrospective case-control study included patients with non-special types of breast cancer who underwent FDFG for breast defect repair after BCS or BCS alone at two breast cancer research centers in Guangxi Province, China, from January 2016 to December 2019. The patients were divided into either the FDFG or BCS group. Control cases were screened using propensity score matching, and survival analysis and cosmetic evaluations were performed. ResultsA total of 442 patients with breast cancer were included in the study. After 1:4 propensity score matching, 53 and 212 patients were included in the FDFG and BCS groups, respectively. The median follow-up time was 49.9 (9.0–76.0) months. The rate of local recurrence in the FDFG group (9.4 %) was significantly higher than that in the BCS group (1.9 %; p < 0.05). The total cosmetic evaluation score was significantly higher in the BCS group 18 months after surgery than in the FDFG group (p < 0.05). ConclusionsIn this retrospective study, FDFG was significantly associated with an increased risk of local recurrence. Further prospective studies are required to confirm these results. No significant difference in long-term cosmetic effects were observed for FDFG than for BCS alone for immediate breast defect repair.

Long-term Cosmetic and Functional Outcomes of Feminizing Genital Surgery

Long-term Cosmetic and Functional Outcomes of Feminizing Genital Surgery

Long-term cosmetic outcomes of the slit-slide procedure for umbilical hernia repair in children.

To assess the long-term cosmetic outcomes of the "slit-slide procedure", designed to provide a more natural appearance for umbilical hernia repair, as perceived by the patients and their parents. A total of 149 patients with umbilical hernia underwent the slit-slide procedure at our hospital. The slit-slide procedure allows for the creation of an umbilicus with a more natural and integrated appearance. The patient satisfaction survey questionnaire was mailed to the families (n = 139), and there were 74 (53.2%) respondents. A questionnaire survey on postoperative appearance was also distributed to pediatric surgeons. The median age at the time of operation was 2.5years (range, 2months to 14years) and the average median age at the time of answering the questionnaire was 6.25years old (range, 2.5-14.8years). The average median period of observation was 3.2years (range, 4months to 8.97years). Most patients (89.2%) and parents (93.2%) were satisfied with the appearance of the umbilicus. Twenty-seven patients reported improved satisfaction after surgery (36.2%). Surgeons tended to score the elongated-oval shape highly; however, there was no difference in satisfaction among the shapes. The slit-slide procedure is not only effective and safe, but it achieves a satisfactory aesthetic outcome.

A Population-Based Assessment of Long-Term Sexual Well-Being and Patient Satisfaction after Breast Reconstruction and Post-Mastectomy Radiation

In 2016, more than 40% of women who underwent mastectomy for breast cancer went on to have breast reconstruction, but there is little data regarding long-term cosmetic outcomes past 5 years after post-mastectomy radiation (PMRT) and reconstruction. This study aims to evaluate the difference in patient breast satisfaction and sexual well-being over time by receipt of reconstruction and PMRT. The iCanCare study is a population-based, longitudinal study of women diagnosed with breast cancer in 2014-15 identified in the Los Angeles and Georgia SEER registries. Women were surveyed during initial treatment and again approximately 6 years later in survivorship (2021-2022). Participants were asked about their "Sexual well-being after mastectomy" and "Satisfaction with breasts" using the Breast-Q, which was dichotomized into "high" and "low" scores (using the median), with a high score indicating increased satisfaction. We then evaluated whether satisfaction differed by treatment characteristics, using unadjusted odds ratios (OR) for categorical variables, calculated using the Chi-square test, or the Kruskal-Wallis test for continuous variables. Adjusted odds ratios were found using multivariable logistic regression models adjusting for treatment characteristics, diagnosis, age, BMI, education, and breast cancer stage. In this preliminary sample of 1191 respondents, 445 underwent mastectomy, of which 272 (61.12%) had reconstruction, and 65 (14.61%) had PMRT. Having breast reconstruction was associated with higher long-term sexual well-being (median score 36.30 vs. 22.20, OR 1.69, 95% confidence interval [CI] 1.09 - 2.64) and breast satisfaction scores (OR 1.53, 95% CI 1.01 - 2.33) compared to not having reconstruction. However, this improvement in sexual well-being was attenuated in women who additionally had PMRT (OR 0.83, CI 0.271 - 2.51). In women who did not have reconstruction after mastectomy, there was no statistically significant difference in sexual well-being scores regardless of the use of PMRT (OR 0.68, CI 0.39 - 1.22). Among respondents in adjusted models who did not receive PMRT, those with reconstruction had higher sexual well-being scores than those with without reconstruction (aOR 2.47, CI 1.34 - 4.56), though there was no statistically significant difference in breast satisfaction scores (p = 0.16) among the groups. Sexual well-being and breast satisfaction are improved with reconstruction 6 years after mastectomy for breast cancer. However, these improvements were attenuated for women who received PMRT. To our knowledge, this is the first study to look at long term outcomes of sexual well-being and treatment satisfaction after breast reconstruction for patients who underwent mastectomy for breast cancer. These data suggest that continued work should be done to optimize patient outcomes when combining PMRT and breast reconstruction.

Natural history of mild trigonocephalic deformities.

Ridging along the metopic suture line can be a common cause of concern for parents and has been theorized to represent a mild form of trigonocephaly, a cranial deformity associated with risks of negative cosmetic outcomes, if not surgically corrected. Yet the literature contains sparse reports of long-term cosmetic results or expectations for infants with isolated metopic ridging compared with those with severe trigonocephaly, or even what objective metrics discriminate isolated metopic ridging from severe trigonocephaly. Therefore, the authors' goals for this study were to 1) quantify the degree of frontal deformity among patients with metopic ridge, metopic craniosynostosis, and normocephalic head shapes; and 2) document the natural history of frontal deformities in isolated metopic ridge patients in the 1st year of life. This was a retrospective cohort study of patients with normocephalic head shapes, metopic ridges, and metopic craniosynostoses who presented at < 1 year of age to the Connecticut Children's neurosurgery clinic from January 2019 to December 2021. Data were collected regarding demographics and photograph-based craniometrics. A total of 212 normocephalic, 34 metopic ridge, and 29 metopic craniosynostosis patients were included. Both the normocephalic and metopic ridge groups had a significantly higher anterior arc angle (AAA) value compared with the metopic craniosynostosis group (p < 0.0001). The AAA did not differ significantly among normocephalic patients and those with ridging. Over the course of 1 year of follow-up, patients with metopic ridging demonstrated a slight decrease in AAA values, but overall remained within the same range as normocephalic patients. Photograph-based craniometrics suggest that metopic ridge patients with frontal bone angulations > 2.2 radians have a mild degree of frontal constriction that does not significantly worsen over the 1st year of life.

O080 Evaluation of patient post-operative outcomes after deep inferior epigastric perforator (DIEP) flap surgery

Abstract Introduction The Deep Inferior Epigastric Perforator (DIEP) flap is considered the gold standard procedure for breast reconstruction. The long-term cosmetic outcomes of the reconstructed breast are unmatched by alternative reconstructive methods, however the donor site morbidity, including pain, scarring and extended recovery periods, require patients to consider their preferred option. Methods There is a paucity of data regarding return to pre-surgical activity timelines, and effect of reconstruction on psychosocial, sexual, and physical wellbeing. After obtaining audit approval, we utilized the Breast-QTM questionnaire to conduct a prospective cohort study. DIEP breast reconstruction patients in a tertiary referral, high-volume centre (N=26) were assessed prior to surgery and at 3 months post-operatively. Results An average of 20.3 days were lost to hospital admissions, follow-up, and post-operative recovery. Of employed patients, 68% had not yet returned to work. For those that did, an average of 6 weeks was required to feel well enough. Additionally, patients reported needing 4.8 weeks to drive again, 4.4 weeks to resume chores, 3.7 weeks to recommence childcare duties and 4.3 weeks to resume exercise. Comparing pre-operative and post-operative Rasch Transformed Scores, patients’ sexual wellbeing score decreased (58.3 to 52.2, p=0.09), while their psychosocial wellbeing score increased (62.1 to 66.7, p=0.16). Qualitatively, patients reported significant challenges impacting return to baseline, particularly involving abdominal scar site, size, and associated healing delays. Conclusion Ultimately, results of our work indicate the need for additional patient supports to improve outcomes, decrease the burden of recovery and time required to return to baseline.

Perimammary uniportal vats fissureless right anterior segmentectomy for lung metastasectomy: a case report

: Secondary lung cancer is frequently witnessed in practice. Surgical resection is considered an essential approach in managing pulmonary metastases, with open or video-assisted thoracoscopic surgery (VATS) lobectomy typically preferred for centrally located metastasis. On the other hand, uniportal VATS anatomical segmentectomy provides an excellent lung parenchyma sparing technique to prevent the lobectomy, but it is challenging and demands strong skills in VATS. Therefore, we present a novel approach for uniportal VATS segmentectomy based on a vertical and curved utility incision performed in the perimammary fold of a 58-year-old female with a known case of colorectal cancer presented with a solitary lung metastasis located in the right anterior segment. The patient underwent, for the first time, a successful right perimammary uniportal VATS fissureless anterior segmentectomy. She experienced low postoperative pain, being the average postoperative pain (EVA scale) ± SD (0.466±0.9), and was discharged on the second postoperative day. Free margin was achieved and no recurrence has been observed within the last 20 months of follow-up. The patient is highly satisfied with the long-term cosmetic result due to a less-visible scar. In conclusion, the perimammary uniportal approach provides, low pain, short length hospital stay and an excellent cosmetic outcome. Further studies are required to prove the benefits of the perimammary approach.

Modern aspects of photodynamic therapy of basal cell skin cancer

Photodynamic therapy (PDT) is one of the most effective treatments for basal cell skin cancer (BCC). As the incidence rate of BCC is increasing worldwide, interest in developing new methods for diagnosing and treating this disease, taking into account long-term cosmetic results, is growing. The review article presents the results of domestic and foreign studies on the treatment of BCC with PDT. The presented results of studies from various domestic and foreign clinics indicate the high efficiency of independent PDT and a combination of PDT with other treatment methods. PDT is proposed to be used in combination with surgical methods and radiation therapy, immunomodulating and chemotherapeutic agents, and inhibitors of molecules involved in the carcinogenic process. These new strategies open the way to increasing the effectiveness of treatment and prevention of BCC. Moreover, in all studies, the safety of this non-invasive treatment, a low level of adverse reactions during therapy, good tolerance for the patient and excellent cosmetic treatment results are noted. The guidelines currently being developed in Europe and the United States provide consistent expert advice that reflects current published evidence of treatment outcomes for BCC using PDT. Moreover, the recommendations emphasize that the treatment plan for patients with “difficult to treat” BCC should be discussed at an interdisciplinary oncological council.

Association of Dosimetric Parameters and Boost Volume with Quantitative Cosmetic Outcomes in a Randomized Trial of Conventionally Fractionated vs. Hypofractionated Whole Breast Irradiation

<h3>Purpose/Objective(s)</h3> Whole breast irradiation (WBI) is the most common treatment in radiation oncology, yet there is a relative paucity of evidence delineating the relationship between dosimetric parameters and long-term outcomes. We conducted a prospective randomized trial with longitudinal follow up to compare two different WBI dosing schedules and sought to evaluate the association of dosimetric parameters and boost volume with long term cosmetic outcomes using novel, previously validated, quantitative metrics of breast cosmesis derived from 2-dimensional photographs. <h3>Materials/Methods</h3> A prospective randomized trial of patients with early breast cancer who were randomly assigned to conventionally fractionated or hypofractionated WBI plus boost was conducted from 2011-14. Anteroposterior photographs from the low-neck to umbilicus were obtained at baseline, 6 months, and yearly through 5 years. Fiducial points marking each nipple and inframammary fold were delineated on each photograph and used to calculate a measure of nipple symmetry (M1) and breast vertical symmetry (M2), as previously described (PMID 28333010). These values range from 0 to 1 with values closer to 1 indicating better symmetry. Multivariable logistic regression longitudinal models with M1 and M2 as outcomes, dichotomized at the median, evaluated associations of dosimetric parameters and boost volume with M1 and M2 adjusting for relevant clinical, demographic and treatment variables. Candidate dosimetric variables included volume of tissue encompassed by the 90% isodose line (PTV), tumor bed volume, volume encompassed by the 105% isodose line, maximum point dose in the breast (Dmax), central axis separation, percent dose delivered with 18 MV photons, boost energy, boost position, boost modality, and cross-sectional area of the boost field. <h3>Results</h3> Of the 287 patients included in this trial, 149 patients received CF-WBI and 138 received HF-WBI, with median follow up 48 months. Median age was 60 years. Median PTV was 1340cc (IQR 904-1760), median tumor bed volume was 23cc (IQR 13-43), and median boost field size was 64cm² (IQR 54-80). 50% of patients had a Dmax of ≥107% of the prescription dose. A total of 1600 photographs were annotated to calculate M1 and M2. In multivariable analysis, highest quartile of PTV (OR 0.40, P=0.002) and boost field size (OR 0.50, P=0.02) were associated with worse M1 outcome compared to the lowest quartile. Highest quartile of tumor bed volume was associated with worse M2 compared to the lowest quartile (OR 0.52, P=0.03). <h3>Conclusion</h3> Utilizing previously validated quantitative measures of cosmetic outcome derived from 2D photographs, we found that boost fields with cross-sectional area <54 cm² and PTV <1760cc were associated with better nipple symmetry, and tumor bed volume >43cc was associated with worse vertical breast symmetry. Understanding how dosimetric parameters and boost volume affect long-term cosmetic outcomes can facilitate optimization of breast radiation treatment plans.

Thermal Boost Combined with Interstitial Brachytherapy in Early Breast Cancer Conserving Therapy-Initial Group Long-Term Clinical Results and Late Toxicity.

(1) In breast-conserving therapy (BCT), adjuvant radiation, including tumor bed boost, is mandatory. Safely delivered thermal boost (TB) based on radio-sensitizing interstitial microwave hyperthermia (MWHT) preceding standard high-dose-rate (HDR) brachytherapy (BT) boost has the potential for local control (LC) improvement. The study is to report the long-term results regarding LC, disease-free survival (DFS), overall survival (OS), toxicity, and cosmetic outcome (CO) of HDR-BT boost ± MWHT for early breast cancer (BC) patients treated with BCT. (2) In the years 2006 and 2007, 57 diverse stages and risk (IA-IIIA) BC patients were treated with BCT ± adjuvant chemotherapy followed by 42.5–50.0 Gy whole breast irradiation (WBI) and 10 Gy HDR-BT boost. Overall, 25 patients (group A; 43.9%) had a BT boost, and 32 (group B; 56.1%) had an additional pre-BT single session of interstitial MWHT on a tumor bed. Long-term LC, DFS, OS, CO, and late toxicity were evaluated. (3) Median follow-up was 94.8 months (range 1.1–185.5). LC was 55/57, or 96.5% (1 LR in each group). DFS was 48/57, or 84.2% (4 failures in group A, 5 in B). OS was 46/57, or 80.7% (6 deaths in group A, 5 in B). CO was excellent in 60%, good in 36%, and satisfactory in 4% (A), and in 53.1%, 34.4%, and 9.4% (B), respectively. One poor outcome was noted (B). Late toxicity as tumor bed hardening occurred in 19/57, or 33.3% of patients (9 in A, 10 in B). In one patient, grade 2 telangiectasia occurred (group A). All differences were statistically insignificant. (4) HDR-BT boost ± TB was feasible, well-tolerated, and highly locally effective. LC, DFS, and OS were equally distributed between the groups. Pre-BT MWHT did not increase rare late toxicity.

Simple oncoplastic breast defect closure improves long-term cosmetic outcome of breast conserving surgery for breast cancer: A randomised controlled trial

IntroductionBreast conserving surgery (BCS) is associated with unsatisfactory cosmetic outcomes in up to 30% of patients, carrying psychological and quality-of-life implications. This study compares long-term cosmetic outcomes after BCS for breast cancer with v without simple oncoplastic defect closure. MethodsA randomised controlled trial was performed, recruiting patients who underwent BCS over four years and randomising to the “reshaping” group (closure of excision defect with mobilised breast tissue; n = 124) and to the “control” group (no attempt at defect closure; n = 109). The estimated excision volume (EEV) was <20% of breast volume (BV) in both groups. Photography and breast retraction assessment (BRA) were recorded preoperatively. Cosmetic outcomes were blindly assessed annually for five years by BRA, panel assessment of patients, and body image questionnaire (BIQ). ResultsThere were no significant differences between the reshaping and control groups in mean age (52.4 v 53.0; p = 0.63), body mass index (27.8 v 27.7; p = 0.80), margin re-excision (9 v 9; p = 0.78), mean BV (562.5 v 590.3 cc; p = 0.56), mean EEV (54.6 v 60.1 cc; p = 0.14), mean EEV/BV ratio (11.2 v 11.0; p = 0.84), or mean specimen weight (52.1 v 57.7 g; p = 0.24). Reshaping group patients had significantly better outcomes compared to control group patients in terms of mean BRA (0.9 v 2.8; p < 0.0001), achieving a score of “good” or “excellent” by panel assessment at 5 years (75.8% v 48%, p < 0.0001), body image questionnaire top score at 5 years (66.9% v 35.8%; p = 0.0001). ConclusionsSimple oncoplastic closure of defects after breast-conserving surgery improves long-term objective and subjective cosmetic outcomes.

Single Center Oncoplastic Experience and Patient Satisfaction Reported via Patient Reported Outcomes.

Background:Oncoplastic breast surgery (OPS) is gaining in popularity compared with traditional breast conserving surgery due to wider resections and better satisfaction with cosmetic outcomes. This study analyzed OPS versus traditional breast conserving surgery outcomes: wound complications, reoperations for margins or fat necrosis, and ipsilateral recurrence.Methods:This retrospective review compared 191 OPS and traditional breast conserving surgery patients on patient-related factors, primary outcomes, and patient reported outcome measures results. A propensity score method analysis using 1:1 to nearest neighbor was also performed.Results:OPS patients were younger, less likely to be smokers, more likely to be ER+ and PR+, and had larger specimen volumes than did traditional breast conserving surgery patients (P < 0.05). There were also differences in distribution of invasive ductal carcinoma and noninvasive disease (P < 0.05). After the propensity score method, the differences observed between the cohorts disappeared. No differences were observed between groups for wound complication, reoperation for positive margins or fat necrosis, or ipsilateral recurrence. Results of patient reported outcome measures showed greater satisfaction with breast surgery in OPS patients (P < 0.01).Conclusions:We showed that OPS is a noninferior technique that should be discussed with appropriate patients. Operative planning should involve patient preferences in optimizing long-term cosmetic outcomes.

Preservation, reconstruction, and rehabilitation of the facial nerve

Der Umgang mit dem N. facialis ist bei der Operation eines Parotiskarzinoms wichtig für die Langzeitlebensqualität des Patienten. In etwa 2 Drittel der Fälle ist der N. facialis nicht vom Tumor befallen. In diesen Fällen sind neben vollständiger Tumorentfernung die Identifizierung und der Erhalt des Nervs für eine erfolgreiche Operation wesentlich. Ist der Nerv vom Tumor infiltriert, muss der betroffene Teil des Nervs im Rahmen einer radikalen Parotidektomie reseziert werden. Die primäre Nervenrekonstruktion, sofern möglich, führt zu den besten funktionellen und kosmetischen Langzeitergebnissen. Das individuell optimale Therapiekonzept basiert zum einen auf der klinischen Prüfung der Gesichtsbeweglichkeit, zum anderen auf der präoperativen Bildgebung, um die Lagebeziehung zwischen Tumor und Nerv zu verstehen, und schließlich auf einer elektrophysiologischen Untersuchung zur Funktion des Nervs. Intraoperativ hilft ein standardisiertes Vorgehen, um den Nerv zu identifizieren und zu erhalten. Wenn eine radikale Parotidektomie indiziert ist, kann bereits die präoperative Diagnostik helfen, neben der einzeitigen Rekonstruktion auch die adjuvante postoperative Therapie zu planen. Das Ziel der Rehabilitation ist die Wiederherstellung von Tonus, Symmetrie und Bewegung des gelähmten Gesichts. Die Wiederherstellung des Augenschlusses hat hohe Priorität. Bei der chirurgischen Therapie von Gesichtslähmungen gab es in den letzten Jahren viele Verbesserungen. Die vorliegende Arbeit gibt einen Überblick über die jüngsten Fortschritte in der Diagnostik, den Operationstechniken und weiteren Möglichkeiten zur Protektion des gesunden N. facialis. Anderseits wird die Rehabilitation des tumorinfiltrierten N. facialis im Kontext der Behandlung von Speicheldrüsenmalignomen beschrieben.

Cosmetic Change of the Apparent Color of the Eye: A Review on Surgical Alternatives, Outcomes and Complications.

An increasing number of people are seeking elective cosmetic change of eye color. We review the surgical techniques, outcomes and complications arising from the various existing surgical alternatives, including cosmetic iris implants—which based on the available evidence should be considered malpractice—as well as laser iris depigmentation and cosmetic keratopigmentation. Laser iris depigmentation has been used clinically for aesthetic purposes without receiving official approval or licensing. The technique can be performed in an outpatient clinic thanks to the use of neodymium: yttrium–aluminum–garnet (Nd:YAG) lasers, but scientific literature data about this treatment is very limited. Cosmetic iris implants are neither CE-marked nor Food and Drug Administration (FDA)-approved, and lead to severe complications arising from their placement including uveitis, hyphema, glaucoma, cataract, corneal endothelial damage and severe vision loss. Management of complications resulting from iris implants might require several surgical procedures, and the follow-up is difficult among these poorly informed patients. Keratopigmentation is the most extensively studied technique and had long been investigated before being introduced into clinical practice: already introduced centuries ago, it was recently developed, reporting adequate levels of safety and efficacy. The medium- and long-term cosmetic outcomes of keratopigmentation and patient satisfaction have been the subject of recent reports. The available level of evidence suggests that cosmetic keratopigmentation is the best evidence-supported surgical choice for patients seeking a permanent cosmetic eye color change. Still, additional investigation is needed to optimize the outcomes, minimize postoperative complications and further develop this and other new surgical alternatives such as laser procedures.

Buried penis surgical treatment in children: Dorsal dartos flap VS. Fascia fixation. A retrospective cohort study

Several surgical techniques for buried penis (BP) treatment have been described, although there is not a reference pattern for it. In our institution, we have traditionally performed penis fixation to Buck's fascia at 3 points. In 2014 we introduced a dorsal dartos flap technique, fixed at both sides of the penis base. To compare both techniques and their long-term outcomes. A retrospective cohort study was conducted on consecutive patients with BP who underwent surgery between 2010 and 2018. They were divided according to surgical technique performed: group A (fascia fixation) and B (dorsal dartos flap). Demographic variables, surgical time and postoperative complications were analyzed. Long-term cosmetic outcomes were evaluated through a telephone survey to patients parents. Thirty-five patients were included (16 group A; 19 group B). Median age at intervention was 9.7 years in group A, with no statistical differences with group B (7.3 years; p=0.071). No statistically significant differences were observed in mean surgical time or postoperative complications between both groups. Cosmetic outcomes (Table 2) were significantly better in group B, which presented higher percentages of satisfaction with the outcomes (95% vs. 64%; p=0.02) and age at intervention (89% vs. 59%; p=0.032), higher perception of the procedure as "minimally invasive" (100% vs. 71%; p=0.013) and higher recommendation rate of the intervention (95% vs. 57%; p=0.029). Dorsal dartos flap is a reproducible, minimally invasive technique with minimal adverse effects and satisfactory long-term results. It has fewer postoperative complications and more satisfactory cosmetic results compared to fascia fixation.

Burn Care in the Era of Rapid Enzymatic Debridement: Challenging the Dogma that Healing Beyond 21 Days Results in Hypertrophic Scarring

Deep burns are characterized by the presence of a necrotic eschar that delays healing and results in a local and systemic inflammatory response and following healing by secondary intention: heavy scarring. Early surgical debridement followed by grafting was a major advance in deep burn care and is now the standard of care, reducing mortality and hypertrophic scarring. Eschars have alternatively been managed by non-surgical, autolytic debridement, which often results in infection-inflammation, slow epithelialization, granulation tissue formation and subsequent scarring. Studies based on these traditional approaches have demonstrated an association between delayed wound closure (beyond 21 days) and scarring. Early enzymatic debridement with NexoBrid (NXB) followed by appropriate wound care is a novel minimally invasive modality that challenges the well-accepted dictum of a high risk of hypertrophic scarring associated with wound closure that extends beyond 21 days. This is not surprising since early and selective removal of only the necrotic eschar often leaves enough viable dermis and skin appendages to allow healing by epithelialization over the dermis. In the absence of necrotic tissue, healing is similar to epithelialization of clean dermal wounds (like many donor sites) and not healing by the secondary intention that is based on granulation tissue formation and subsequent scarring. If and when granulation islands start to appear on the epithelializing dermis, they and the inflammatory response generally can be controlled by short courses (1-3 days) of topically applied low strength corticosteroid ointments minimizing the risk of hypertrophic scarring, albeit with wound closure delayed beyond the magic number of 21 days. Results from multiple studies and field experience confirm that while deep burns managed with early enzymatic debridement often require more than 21 days to reepithelialize, long-term cosmetic results are at least as good as with excision and grafting.

Vancouver Scar Scale for Assessing the Long-term Cosmetic results of surgical treatment of children with deep neck burns

BACKGROUND: Deep neck burns always result in cicatricial changes in the skin. Scars in this area can lead not only to functional disorders but also affect the psychoemotional status of the patient and family. Current studies have reported on the results of the treatment of deep neck burns in both adults and children. However, among foreign and Russian publications available, no studies have assessed the cosmetic results of treatment using validated scales.&#x0D; AIM: This study aimed to analyze the long-term cosmetic results of surgical treatment of deep neck burns in children using the Vancouver Scar Scale.&#x0D; MATERIALS AND METHODS: A non-interventional case control study was conducted. The article analyzes the long-term cosmetic results of treatment of 64 children with deep neck burns. All patients were divided into the main group 1 35 (29%) children who received early surgical treatment] and control group 2 29 (45%) children after staged treatment]. The main group was further divided into subgroups 1a, 1b, and 1c. Subgroup 1a included 13 (20%) children who underwent tangential necrectomy with simultaneous autodermoplasty, subgroup 1b included 12 (19%) children who underwent radical necrectomy with simultaneous autodermoplasty, and subgroup 1c included 10 (16%) children who underwent necrectomy with delayed autodermoplasty. The Vancouver Scar Scale was used to assess the vascularization, pigmentation, elasticity, and size of the scar mass. For statistical analysis, the results of different options for early surgical treatment were compared with a staged method.&#x0D; RESULTS: The best indicators for vascularization, elasticity, size of the formed cicatricial mass, and overall score were obtained in children who received surgical treatment of deep neck burns by early necrectomy (tangential or radical) with simultaneous autodermoplasty in comparison with staged surgical treatment. When analyzing the pigmentation indicator, the scores of patients who underwent all types of early surgical treatment were comparable with those in patients who received staged surgery.&#x0D; CONCLUSIONS: According to the analysis of the Vancouver Scar Scale, the best cosmetic results in children with deep neck burns can be achieved by performing tangential or radical necrectomy with simultaneous autodermoplasty.

Optimizing Preventive Adjuvant LINAC (OPAL) Radiation: A Phase II Trial of Daily Partial Breast Irradiation

<h3>Purpose/Objective(s)</h3> Twice daily accelerated partial breast irradiation (APBI) may confer worse long-term cosmetic outcome than daily whole breast irradiation (WBI). We hypothesized that daily partial breast irradiation would yield improved cosmetic outcomes without compromising tumor control. To test this hypothesis, we conducted a phase II trial to evaluate a ten-fraction regimen of daily PBI (OPAL regimen). <h3>Materials/Methods</h3> From 2017-2018, 149 women aged ≥ 50 with DCIS or early invasive, ER+ breast cancer were enrolled into a multi-institutional phase II trial that treated the partial breast to 35 Gy in 10 daily fractions. Patients with close margins (< 2 mm) also received a boost of 9 Gy in 3 daily fractions. Toxicities were evaluated using CTCAE v4.0 and physician-reported cosmesis was assessed using the RTOG scale. The Breast Cancer Treatment Outcomes Scale (BCTOS) assessed patient-reported cosmesis, breast pain, and functional status. Outcomes were assessed at baseline, 6 months, 1 year, and annually thereafter. The primary outcome was incidence of grade ≥ 2 toxicity within 6 months of PBI initiation. To facilitate a comparison of the OPAL regimen to WBI, we identified 176 patients with similar clinical-pathologic features from our prior trial of WBI+boost in which toxicities were also prospectively collected. Differences in cross-sectional outcomes between the OPAL trial and historical WBI+boost cohort were tested using chi-square test. Mixed effect growth curve models evaluated outcomes over time adjusting for relevant covariates. <h3>Results</h3> Median age was 64 years and median follow-up was 2 years. All 149 patients received 35 Gy in 10 daily fractions and 26 received a boost. One patient developed an in-field DCIS recurrence. For the primary outcome, grade ≥ 2 toxicity within 6 months of PBI initiation was 14.1% with OPAL compared to 71% in the WBI+boost cohort (<i>P</i> < 0.001). At two years post-radiation, fatigue (8% vs 16%), hyperpigmentation (18% vs 30%), breast edema (0% vs 9%), superficial fibrosis (18% vs 31%), deep fibrosis (6% vs 13%), nipple areolar changes (6% vs 17%), and breast atrophy (19% vs 35%) were less prevalent in patients treated with OPAL (all <i>P</i> < 0.05). At two years, 93% of patients treated with OPAL had excellent/good cosmetic outcome compared to 77% of patients treated with WBI+boost (<i>P</i> < 0.001). In multivariable longitudinal analysis, treatment with OPAL was associated with improved patient-reported cosmetic outcome (<i>P</i> < 0.001), functional status (<i>P</i> = 0.02), breast pain (<i>P</i> = 0.003) and physician-reported cosmetic outcome (<i>P</i> < 0.001). <h3>Conclusion</h3> Treatment with this novel daily PBI regimen of 35 Gy in 10 daily fractions with selective boost yielded better cosmetic and functional outcomes and less breast pain and toxicity than WBI+boost with median follow up of 2 years. Daily external beam partial breast irradiation with 10 or fewer fractions merits further prospective evaluation.

МЕДИКАМЕНТОЗНАЯ КОРРЕКЦИЯ ПОСЛЕОПЕРАЦИОННОГО ПЕРИОДА У ДЕТЕЙ ПОСЛЕ АНТИСТРАБИЧЕСКИХ ХИРУРГИЧЕСКИХ ВМЕШАТЕЛЬСТВ

Изучалась эффективность использования глазных капель Eye-t 2%, содержащих Эктоин, на течение воспалительной реакции и косметические исходы послеоперационного периода у детей, получавших хирургическое лечение по поводу косоглазия. Под наблюдением находилось 234 ребенка в возрасте от 2-х до 18-ти лет. В послеоперационном периоде к стандартной терапии у пациентов основной группы применялись капли Eye-t 2% с частотой 3 раза в день.Статистически достоверно было показано, что использование капель Eye-t 2% в послеоперационной схеме лечения детей с косоглазием позволяет сократить время реабилитации, ускорить стихание воспалительных явлений и значительно улучшить отдаленные косметические результаты. Препарат легко переносится детьми и не имеет побочных эффектов.