Long-range Temporal Correlations Research Articles

Multiscale fractality in partial phase synchronisation on simplicial complexes around brain hubs

Brain hubs are best connected central nodes in the human connectome that play a critical role in integrated brain dynamics. How the hubs perform their function vs different dynamical processes and the role of their higher-order connections involving different brain regions remains elusive. Here we simulate the phase synchronisation processes on the human connectome core network consisting of the eight brain hubs and all attached simplexes of different sizes. The leading pairwise interactions among neighbouring nodes are assumed, taking into account the natural weights of edges. Our results reveal that increasing the positive pairwise couplings promotes a continuous synchronisation while a weak partial synchronisation occurs for a wide range of negative couplings. The weights of edges stabilise the synchronisation process supporting the absence of hysteresis. Furthermore, the time evolution of the order parameter shows cyclic fluctuations induced by the concurrent evolution of phases associated with different groups of nodes. We show that these oscillations exhibit long-range temporal correlations and multifractality. The asymmetrical singularity spectra are determined, which vary with the time scale and depend on the weights of edges. These findings suggest a possible way that the brain functional geometry maintains a desirable low-level synchrony through complex patterns of phase fluctuations.

Bumetanide Effects on Resting-State EEG in Tuberous Sclerosis Complex in Relation to Clinical Outcome: An Open-Label Study.

Neuronal excitation-inhibition (E/I) imbalances are considered an important pathophysiological mechanism in neurodevelopmental disorders. Preclinical studies on tuberous sclerosis complex (TSC), suggest that altered chloride homeostasis may impair GABAergic inhibition and thereby E/I-balance regulation. Correction of chloride homeostasis may thus constitute a treatment target to alleviate behavioral symptoms. Recently, we showed that bumetanide—a chloride-regulating agent—improved behavioral symptoms in the open-label study Bumetanide to Ameliorate Tuberous Sclerosis Complex Hyperexcitable Behaviors trial (BATSCH trial; Eudra-CT: 2016-002408-13). Here, we present resting-state EEG as secondary analysis of BATSCH to investigate associations between EEG measures sensitive to network-level changes in E/I balance and clinical response to bumetanide. EEGs of 10 participants with TSC (aged 8–21 years) were available. Spectral power, long-range temporal correlations (LRTC), and functional E/I ratio (fE/I) in the alpha-frequency band were compared before and after 91 days of treatment. Pre-treatment measures were compared against 29 typically developing children (TDC). EEG measures were correlated with the Aberrant Behavioral Checklist-Irritability subscale (ABC-I), the Social Responsiveness Scale-2 (SRS-2), and the Repetitive Behavior Scale-Revised (RBS-R). At baseline, TSC showed lower alpha-band absolute power and fE/I than TDC. Absolute power increased through bumetanide treatment, which showed a moderate, albeit non-significant, correlation with improvement in RBS-R. Interestingly, correlations between baseline EEG measures and clinical outcomes suggest that most responsiveness might be expected in children with network characteristics around the E/I balance point. In sum, E/I imbalances pointing toward an inhibition-dominated network are present in TSC. We established neurophysiological effects of bumetanide although with an inconclusive relationship with clinical improvement. Nonetheless, our results further indicate that baseline network characteristics might influence treatment response. These findings highlight the possible utility of E/I-sensitive EEG measures to accompany new treatment interventions for TSC.Clinical Trial RegistrationEU Clinical Trial Register, EudraCT 2016-002408-13 (www.clinicaltrialsregister.eu/ctr-search/trial/2016-002408-13/NL). Registered 25 July 2016.

Comparative multifractal analysis of methane gas concentration time series in India and regions within India

In the present study GOSAT CH4 has been used to analyze the methane gas concentration in India over the eight years from 2010 to 2017. The data have been analyzed using the multifractal detrended fluctuation analysis technique. Two different geographical regions within India have been selected and CH4 data for those regions are also analyzed. The generalized Hurst exponents for India and the two regions are 1.27, 0.74 and 0.91, which are significantly high from their shuffled data counterparts i.e. 0.50, 0.51 and 0.51 respectively. This finding reveals that methane gas concentration over time show multifractal nature which in turn establishes the presence of long-range temporal correlations in the data. The width of the Multifractal spectrum for India and the two regions are found to be 0.76, 1.38 and 1.01 respectively. This result shows that strength of correlation is different for the two regions selected, which we suggest may be due to the different methane emission process of the considered regions. Comparison of the results with that of shuffled data signify that the correlation is purely due to the methane production dynamics and not a result of mere statistics.

Beyond randomness: Evaluating measures of information entropy in binary series.

The enormous amount of currently available data demands efforts to extract meaningful information. For this purpose, different measurements are applied, including Shannon's entropy, permutation entropy, and the Lempel-Ziv complexity. These methods have been used in many applications, such as pattern recognition, series classification, and several other areas (e.g., physical, financial, and biomedical). Data in these applications are often presented in binary series with temporal correlations. Herein, we compare the measures of information entropy in binary series conveying short- and long-range temporal correlations characterized by the Hurst exponent H. Combining numerical and analytical approaches, we scrutinize different methods that were not efficient in detecting temporal correlations. To surpass this limitation, we propose a measure called the binary permutation index (BPI). We will demonstrate that BPI efficiently discriminates patterns embedded in the series, offering advantages over previous methods. Subsequently, we collect stock market time series and rain precipitation data as well as perform in vivo electrophysiological recordings in the hippocampus of an experimental animal model of temporal lobe epilepsy, in which the BPI application in both public open source and experimental data is demonstrated. An index is proposed to evaluate information entropy, allowing the ability to discriminate randomness and extract meaningful information in binary time series.

An EEG-Based Neuromarketing Approach for Analyzing the Preference of an Electric Car

This study evaluates consumer preference from the perspective of neuroscience when a choice is made among a number of cars, one of which is an electric car. Consumer neuroscience contributes to a systematic understanding of the underlying information processing and cognitions involved in choosing or preferring a product. This study aims to evaluate whether neural measures, which were implicitly extracted from brain activities, can be reliable or consistent with self-reported measures such as preference or liking. In an EEG-based experiment, the participants viewed images of automobiles and their specifications. Emotional and attentional stimuli and the participants' responses, in the form of decisions made, were meticulously distinguished and analyzed via signal processing techniques, statistical tests, and brain mapping tools. Long-range temporal correlations (LRTCs) were also calculated to investigate whether the preference of a product could affect the dynamic of neuronal fluctuations. Statistically significant spatiotemporal dynamical differences were then evaluated between those who select an electric car (which seemingly demands specific memory and long-term attention) and participants who choose other cars. The results showed increased PSD and central-parietal and central-frontal coherences at the alpha frequency band for those who selected the electric car. In addition, the findings showed the emergence of LRTCs or the ability of this group to integrate information over extended periods. Furthermore, the result of clustering subjects into two groups, using statistically significant discriminative EEG measures, was associated with the self-report data. The obtained results highlighted the promising role of intrinsically extracted measures on consumers' buying behavior.

The subjectivity of self and its ontology: From the world–brain relation to the point of view in the world

The search for the subjective nature of our self is intensely debated in philosophy and neuroscience. However, despite all progress, the subjectivity of self and how it fits into the seemingly objective world remains elusive. Drawing on recent empirical data, we show how the self is shaped by the brain’s scale-free activity, that is, long-range temporal correlation (LRTC) and the world’s ecological context. We assume that the scale-free LRTC of the world–brain relation provides the ontological basis for the point of view as the foundation of subjectivity within the world. We conclude that the temporal, that is, scale-free based point of view through the world–brain relation provides the ontologically necessary a posteriori condition for the subjectivity of self on a deeper neuro-ecological level. This extends phenomenological concepts like subjectivity and world beyond both Heidegger’s fundamental ontology and Sartre’s phenomenological ontology: it complements their subjectivity-based ontologies with a truly world-based ontology.

Brain-like critical dynamics and long-range temporal correlations in percolating networks of silver nanoparticles and functionality preservation after integration of insulating matrix.

Random networks of nanoparticle-based memristive switches enable pathways for emulating highly complex and self-organized synaptic connectivity together with their emergent functional behavior known from biological neuronal networks. They therefore embody a distinct class of neuromorphic hardware architectures and provide an alternative to highly regular arrays of memristors. Especially, networks of memristive nanoparticles (NPs) poised at the percolation threshold are promising due to their capabilities of showing brain-like activity such as critical dynamics or long-range temporal correlation (LRTC), which are closely connected to the computational capabilities in biological neuronal networks. Here, we adapt this concept to networks of Ag-NPs poised at the electrical percolation threshold, where the memristive properties are governed by electro-chemical metallization. We show that critical dynamics and LRTC are preserved although the nature of individual memristive gaps throughout the network is fundamentally changed by filling the gaps with an insulating matrix. The results in this work generate important contributions towards the practical applicability of critical dynamics and LRTC in percolating NP networks by elucidating the consequences of NP network encapsulation, which is considered as an important step towards device integration.

STXBP1 Syndrome Is Characterized by Inhibition-Dominated Dynamics of Resting-State EEG.

STXBP1 syndrome is a rare neurodevelopmental disorder caused by heterozygous variants in the STXBP1 gene and is characterized by psychomotor delay, early-onset developmental delay, and epileptic encephalopathy. Pathogenic STXBP1 variants are thought to alter excitation-inhibition (E/I) balance at the synaptic level, which could impact neuronal network dynamics; however, this has not been investigated yet. Here, we present the first EEG study of patients with STXBP1 syndrome to quantify the impact of the synaptic E/I dysregulation on ongoing brain activity. We used high-frequency-resolution analyses of classical and recently developed methods known to be sensitive to E/I balance. EEG was recorded during eyes-open rest in children with STXBP1 syndrome (n = 14) and age-matched typically developing children (n = 50). Brain-wide abnormalities were observed in each of the four resting-state measures assessed here: (i) slowing of activity and increased low-frequency power in the range 1.75–4.63 Hz, (ii) increased long-range temporal correlations in the 11–18 Hz range, (iii) a decrease of our recently introduced measure of functional E/I ratio in a similar frequency range (12–24 Hz), and (iv) a larger exponent of the 1/f-like aperiodic component of the power spectrum. Overall, these findings indicate that large-scale brain activity in STXBP1 syndrome exhibits inhibition-dominated dynamics, which may be compensatory to counteract local circuitry imbalances expected to shift E/I balance toward excitation, as observed in preclinical models. We argue that quantitative EEG investigations in STXBP1 and other neurodevelopmental disorders are a crucial step to understand large-scale functional consequences of synaptic E/I perturbations.

Altered Temporal Structure of Neural Phase Synchrony in Patients With Autism Spectrum Disorder.

Functional connectivity, quantified by phase synchrony, between brain regions is known to be aberrant in patients with autism spectrum disorder (ASD). Here, we evaluated the long-range temporal correlations of time-varying phase synchrony (TV-PS) of electrocortical oscillations in patients with ASD as well as typically developing people using detrended fluctuation analysis (DFA) after validating the scale-invariance of the TV-PS time series. By comparing the DFA exponents between the two groups, we found that those of the TV-PS time series of high-gamma oscillations were significantly attenuated in patients with ASD. Furthermore, the regions involved in aberrant TV-PS time series were mainly within the social ability and cognition-related cortical networks. These results support the notion that abnormal social functions observed in patients with ASD may be caused by the highly volatile phase synchrony states of electrocortical oscillations.

Multivariate patterns and long-range temporal correlations of alpha oscillations are associated with flexible manipulation of visual working memory representations.

The ability to flexibly manipulate memory representations is embedded in visual working memory (VWM) and can be tested using paradigms with retrospective cues. Although valid retrospective cues often facilitate memory recall, invalid ones may or may not result in performance costs. We investigated individual differences in utilising retrospective cues and evaluated how these individual differences are associated with brain oscillatory activity at rest. At the behavioural level, we operationalised flexibility as the ability to make effective use of retrospective cues or disregard them if required. At the neural level, we tested whether individual differences in such flexibility were associated with properties of resting-state alpha oscillatory activity (8-12 Hz). To capture distinct aspects of these brain oscillations, we evaluated their power spectral density and temporal dynamics using long-range temporal correlations (LRTCs). In addition, we performed multivariate patterns analysis (MVPA) to classify individuals' level of behavioural flexibility based on these neural measures. We observed that alpha power alone (magnitude) at rest was not associated with flexibility. However, we found that the participants' ability to manipulate VWM representations was correlated with alpha LRTC and could be decoded using MVPA on patterns of alpha power. Our findings suggest that alpha LRTC and multivariate patterns of alpha power at rest may underlie some of the individual differences in using retrospective cues in working memory tasks.

Self-Organised Critical Dynamics as a Key to Fundamental Features of Complexity in Physical, Biological, and Social Networks

Studies of many complex systems have revealed new collective behaviours that emerge through the mechanisms of self-organised critical fluctuations. Subject to the external and endogenous driving forces, these collective states with long-range spatial and temporal correlations often arise from the intrinsic dynamics with the threshold nonlinearity and geometry-conditioned interactions. The self-similarity of critical fluctuations enables us to describe the system using fewer parameters and universal functions that, on the other hand, can simplify the computational and information complexity. Currently, the cutting-edge research on self-organised critical systems across the scales strives to formulate a unifying mathematical framework, utilise the critical universal properties in information theory, and decipher the role of hidden geometry. As a prominent example, we study the field-driven spin dynamics on the hysteresis loop in a network with higher-order structures described by simplicial complexes, which provides a geometric-frustration environment. While providing motivational illustrations from physical, biological, and social systems, along with their networks, we also demonstrate how the self-organised criticality occurs at the interplay of the complex topology and driving mode. This study opens up new promising routes with powerful tools to address a long-standing challenge in the theory and applications of complexity science ingrained in the efficient analysis of self-organised critical states under the competing higher-order interactions embedded in complex geometries.

Relationship between regional white matter hyperintensities and alpha oscillations in older adults

Aging is associated with increased white matter hyperintensities (WMHs) and with alterations of alpha oscillations (7–13 Hz). However, a crucial question remains, whether changes in alpha oscillations relate to aging per se or whether this relationship is mediated by age-related neuropathology like WMHs. Using a large cohort of cognitively healthy older adults (N = 907, 60–80 years), we assessed relative alpha power, alpha peak frequency, and long-range temporal correlations from resting-state EEG. We further associated these parameters with voxel-wise WMHs from 3T MRI. We found that a higher prevalence of WMHs in the superior and posterior corona radiata as well as in the thalamic radiation was related to elevated alpha power, with the strongest association in the bilateral occipital cortex. In contrast, we observed no significant relation of the WMHs probability with alpha peak frequency and long-range temporal correlations. Finally, higher age was associated with elevated alpha power via total WMH volume. We suggest that an elevated alpha power is a consequence of WMHs affecting a spatial organization of alpha sources.

Prediction of Behavioral Improvement Through Resting-State Electroencephalography and Clinical Severity in a Randomized Controlled Trial Testing Bumetanide in Autism Spectrum Disorder

BackgroundMechanism-based treatments such as bumetanide are being repurposed for autism spectrum disorder. We recently reported beneficial effects on repetitive behavioral symptoms that might be related to regulating excitation-inhibition (E/I) balance in the brain. Here, we tested the neurophysiological effects of bumetanide and the relationship to clinical outcome variability and investigated the potential for machine learning–based predictions of meaningful clinical improvement. MethodsUsing modified linear mixed models applied to intention-to-treat population, we analyzed E/I-sensitive electroencephalography (EEG) measures before and after 91 days of treatment in the double-blind, randomized, placebo-controlled Bumetanide in Autism Medication and Biomarker study. Resting-state EEG of 82 subjects out of 92 participants (7–15 years) were available. Alpha frequency band absolute and relative power, central frequency, long-range temporal correlations, and functional E/I ratio treatment effects were related to the Repetitive Behavior Scale-Revised (RBS-R) and the Social Responsiveness Scale 2 as clinical outcomes. ResultsWe observed superior bumetanide effects on EEG, reflected in increased absolute and relative alpha power and functional E/I ratio and in decreased central frequency. Associations between EEG and clinical outcome change were restricted to subgroups with medium to high RBS-R improvement. Using machine learning, medium and high RBS-R improvement could be predicted by baseline RBS-R score and EEG measures with 80% and 92% accuracy, respectively. ConclusionsBumetanide exerts neurophysiological effects related to clinical changes in more responsive subsets, in whom prediction of improvement was feasible through EEG and clinical measures.

Detrended multifractal characterization of Indian rainfall records

Long term rainfall records in seven distinct temperature homogeneous regions of India have been analyzed using two different multifractal analysis techniques, namely the multifractal detrended fluctuation analysis (MFDFA) and multifractal detrended moving average (MFDMA) techniques. In all the series studied a multifractal pattern has been obtained from both the methods, though the degree of multifractality observed for any given series largely depends on the analysis methods. Emphasis is given on the calculation of the generalized Hurst exponent spectra and the singularity spectra for all the series studied. In order to explore the possible source(s) of the multifractality in the data, we also study a set of ten shuffled series corresponding to each original series. We find that the origin of multifractality as obtained from both the methods, is mainly due to the fat-tailed probability distribution of the records in the series, though the contribution of the long-range temporal correlation cannot be ignored in the rainfall records.

Wired to Punish? Electroencephalographic Study of the Resting-state Neuronal Oscillations Underlying Third-party Punishment

For over a decade, neuroimaging and brain stimulation studies have investigated neural mechanisms of third-party punishment, a key instrument for social norms enforcement. However, the neural dynamics underlying these mechanisms are still unclear. Previous electroencephalographic studies on third-party punishment have shown that inter-brain connectivity is linked to punishment behavior. However, no clear evidence was provided regarding whether the effect of inter-brain connectivity on third-party punishment is mediated by local neuronal states. In this study, we further investigate whether resting-state neuronal activity in the alpha frequency range can predict individual differences in third-party punishment. More specifically, we show that the global resting-state connectivity between the right dorsolateral prefrontal and right temporo-parietal regions is negatively correlated with the level of third-party punishment. Additionally, individuals with stronger local resting-state long-range temporal correlations in the right temporo-parietal cortices demonstrated a lower level of third-party punishment. Thus, our results further support the idea that global and local neuronal dynamics can contribute to individual differences in third-party punishment.

Kinetic roughening and nontrivial scaling in the Kardar–Parisi–Zhang growth with long-range temporal correlations

Long-range spatiotemporal correlations may play important roles in non-equilibrium surface growth processes. In order to explore the effects of long-range temporal correlation on dynamic scaling of growing surfaces, we carry out extensive numerical simulations of the (1 + 1)- and (2 + 1)-dimensional Kardar–Parisi–Zhang (KPZ) growth system in the presence of temporally correlated noise, and compare our results with previous theoretical predictions and numerical simulations. We find that surface morphologies are obviously affected with long-range temporal correlations, and as the temporal correlation exponent increases, the KPZ surfaces develop gradually faceted patterns in the saturated growth regimes. Our results show that the temporal correlated KPZ system displays evidently nontrivial dynamic properties when 0 < θ < 0.5, the characteristic roughness exponents satisfy α < α s, and α loc exhibits non-universal scaling within local window sizes, which differs with the existing dynamic scaling hypotheses, both in the (1 + 1)- and (2 + 1)-dimensions.

Computational characteristics of interictal EEG as objective markers of epileptic spasms

ObjectiveFavorable neurodevelopmental outcomes in epileptic spasms (ES) are tied to early diagnosis and prompt treatment, but uncertainty in the identification of the disease can delay this process. Therefore, we investigated five categories of computational electroencephalographic (EEG) measures as markers of ES. MethodsWe measured 1) amplitude, 2) power spectra, 3) Shannon entropy and permutation entropy, 4) long-range temporal correlations, via detrended fluctuation analysis (DFA) and 5) functional connectivity using cross-correlation and phase lag index (PLI). EEG data were analyzed from ES patients (n = 40 patients) and healthy controls (n = 20 subjects), with multiple blinded measurements during wakefulness and sleep for each patient. ResultsIn ES patients, EEG amplitude was significantly higher in all electrodes when compared to controls. Shannon and permutation entropy were lower in ES patients than control subjects. The DFA intercept values in ES patients were significantly higher than control subjects, while DFA exponent values were not significantly different between the groups. EEG functional connectivity networks in ES patients were significantly stronger than controls when based on both cross-correlation and PLI. Significance for all statistical tests was p < 0.05, adjusted for multiple comparisons using the Benjamini-Hochberg procedure as appropriate. Finally, using logistic regression, a multi-attribute classifier was derived that accurately distinguished cases from controls (area under curve of 0.96). ConclusionsComputational EEG features successfully distinguish ES patients from controls in a large, blinded study. SignificanceThese objective EEG markers, in combination with other clinical factors, may speed the diagnosis and treatment of the disease, thereby improving long-term outcomes.

Dynamics of Long-Range Temporal Correlations in Broadband EEG During Different Motor Execution and Imagery Tasks.

Brain activity is composed of oscillatory and broadband arrhythmic components; however, there is more focus on oscillatory sensorimotor rhythms to study movement, but temporal dynamics of broadband arrhythmic electroencephalography (EEG) remain unexplored. We have previously demonstrated that broadband arrhythmic EEG contains both short- and long-range temporal correlations that change significantly during movement. In this study, we build upon our previous work to gain a deeper understanding of these changes in the long-range temporal correlation (LRTC) in broadband EEG and contrast them with the well-known LRTC in alpha oscillation amplitude typically found in the literature. We investigate and validate changes in LRTCs during five different types of movements and motor imagery tasks using two independent EEG datasets recorded with two different paradigms—our finger tapping dataset with single self-initiated asynchronous finger taps and publicly available EEG dataset containing cued continuous movement and motor imagery of fists and feet. We quantified instantaneous changes in broadband LRTCs by detrended fluctuation analysis on single trial 2 s EEG sliding windows. The broadband LRTC increased significantly (p < 0.05) during all motor tasks as compared to the resting state. In contrast, the alpha oscillation LRTC, which had to be computed on longer stitched EEG segments, decreased significantly (p < 0.05) consistently with the literature. This suggests the complementarity of underlying fast and slow neuronal scale-free dynamics during movement and motor imagery. The single trial broadband LRTC gave high average binary classification accuracy in the range of 70.54±10.03% to 76.07±6.40% for all motor execution and imagery tasks and hence can be used in brain–computer interface (BCI). Thus, we demonstrate generalizability, robustness, and reproducibility of novel motor neural correlate, the single trial broadband LRTC, during different motor execution and imagery tasks in single asynchronous and cued continuous motor-BCI paradigms and its contrasting behavior with LRTC in alpha oscillation amplitude.

Long-range temporal correlations in the broadband resting state activity of the human brain revealed by neuronal avalanches

Resting-state brain activity is characterized by the presence of neuronal avalanches showing absence of characteristic size. Such evidence has been interpreted in the context of criticality and associated with the normal functioning of the brain. A distinctive attribute of systems at criticality is the presence of long-range correlations. Thus, to verify the hypothesis that the brain operates close to a critical point and consequently assess deviations from criticality for diagnostic purposes, it is of primary importance to robustly and reliably characterize correlations in resting-state brain activity. Recent works focused on the analysis of narrow-band electroencephalography (EEG) and magnetoencephalography (MEG) signal amplitude envelope, showing evidence of long-range temporal correlations (LRTC) in neural oscillations. However, brain activity is a broadband phenomenon, and a significant piece of information useful to precisely discriminate between normal (critical) and pathological behavior (non-critical), may be encoded in the broadband spatio-temporal cortical dynamics. Here we propose to characterize the temporal correlations in the broadband brain activity through the lens of neuronal avalanches. To this end, we consider resting-state EEG and long-term MEG recordings, extract the corresponding neuronal avalanche sequences, and study their temporal correlations. We demonstrate that the broadband resting-state brain activity consistently exhibits long-range power-law correlations in both EEG and MEG recordings, with similar values of the scaling exponents. Importantly, although we observe that the avalanche size distribution depends on scale parameters, scaling exponents characterizing long-range correlations are quite robust. In particular, they are independent of the temporal binning (scale of analysis), indicating that our analysis captures intrinsic characteristics of the underlying dynamics. Because neuronal avalanches constitute a fundamental feature of neural systems with universal characteristics, the proposed approach may serve as a general, systems- and experiment-independent procedure to infer the existence of underlying long-range correlations in extended neural systems, and identify pathological behaviors in the complex spatio-temporal interplay of cortical rhythms.

Temporal structure of brain oscillations predicts learned nocebo responses to pain

This study aimed to identify electrophysiological correlates of nocebo-augmented pain. Nocebo hyperalgesia (i.e., increases in perceived pain resulting from negative expectations) has been found to impact how healthy and patient populations experience pain and is a phenomenon that could be better understood in terms of its neurophysiological underpinnings. In this study, nocebo hyperalgesia was induced in 36 healthy participants through classical conditioning and negative suggestions. Electroencephalography was recorded during rest (pre- and post-acquisition) and during pain stimulation (baseline, acquisition, evocation) First, participants received baseline high thermal pain stimulations. During nocebo acquisition, participants learned to associate an inert gel applied to their forearm with administered high pain stimuli, relative to moderate intensity control stimuli administered without gel. During evocation, all stimuli were accompanied by moderate pain, to measure nocebo responses to the inert gel. Pre- to post-acquisition beta-band alterations in long-range temporal correlations (LRTC) were negatively associated with nocebo magnitudes. Individuals with strong resting LRTC showed larger nocebo responses than those with weaker LRTC. Nocebo acquisition trials showed reduced alpha power. Alpha power was higher while LRTC were lower during nocebo-augmented pain, compared to baseline. These findings support nocebo learning theories and highlight a role of nocebo-induced cognitive processing.