Long-distance Races Research Articles

Predictive Performance Models in Long-Distance Runners: A Narrative Review.

Physiological variables such as maximal oxygen uptake (VO2max), velocity at maximal oxygen uptake (vVO2max), running economy (RE) and changes in lactate levels are considered the main factors determining performance in long-distance races. The aim of this review was to present the mathematical models available in the literature to estimate performance in the 5000 m, 10,000 m, half-marathon and marathon events. Eighty-eight articles were identified, selections were made based on the inclusion criteria and the full text of the articles were obtained. The articles were reviewed and categorized according to demographic, anthropometric, exercise physiology and field test variables were also included by athletic specialty. A total of 58 studies were included, from 1983 to the present, distributed in the following categories: 12 in the 5000 m, 13 in the 10,000 m, 12 in the half-marathon and 21 in the marathon. A total of 136 independent variables associated with performance in long-distance races were considered, 43.4% of which pertained to variables derived from the evaluation of aerobic metabolism, 26.5% to variables associated with training load and 20.6% to anthropometric variables, body composition and somatotype components. The most closely associated variables in the prediction models for the half and full marathon specialties were the variables obtained from the laboratory tests (VO2max, vVO2max), training variables (training pace, training load) and anthropometric variables (fat mass, skinfolds). A large gap exists in predicting time in long-distance races, based on field tests. Physiological effort assessments are almost exclusive to shorter specialties (5000 m and 10,000 m). The predictor variables of the half-marathon are mainly anthropometric, but with moderate coefficients of determination. The variables of note in the marathon category are fundamentally those associated with training and those derived from physiological evaluation and anthropometric parameters.

RETRACTED: Physical education image analysis based on virtual crowd simulation and FPGA

Physical Culture and Sports research are coordinated with the game (rational, educators, game director, and game theory from a specific or a general point) medicine sociology. They revolve around representatives, value theory, and modern games near parts. This journal is dedicated to humanists, social researchers, students, and practitioners, social analysts, research institutions, and professionals. To practice city models, company directors need to incorporate a large number of personnel for the legs, automobiles, and other powerful elements. Analysts use the same design of registration, i.e. more than 100 million long-distance race. To reproduce and become a member, they continue to be referring many inferences using the fluffy ground on the Graphical Process Unit (GPU). This is an element of PC Vision that is often used to extract the perspective of one of the computing where the histogram is used. Using this calculation requires a large amount of isolated bright spots in the image calculation. One approach, Adaptive speed from the games, for example to support calculations, a Field-Programmable GateArray (FPGA) is equal to the front door. First, an overview of the position and inclination calculation apparatus histogram is given. To implement the full classification, it only uses the equations of decision boundaries. This is to simplify the FPGA implementation through simple expressions, rather than the whole classification. At this point, will see how field-programmable front position has been used in the last decade, i.e. the slope of the histogram. The remainder of the beam is information including resolution, a large number of the task of the receptacle and the direction, progress, and standardized way of calculation. The third cluster is a first program which is a common computing device program, including the position angle dependence modemed histogram and highlights its execution apparatus implemented. The goal uses different pixel per clock cycle analysis and the asset uses the so-called fast measurement purposes. Finally, the speed and accuracy are calculated and present a summary indicator of the value of using the planned use of assets, and the ability to locate the image to the overall performance.

Correr, sufrir, disfrutar. El cuerpo como instrumento de investigación

El running constituye un estilo de vida de notoria masividad en la Argentina contemporánea que excede la decisión puntual de salir a correr con frecuencia de manera solitaria o en grupos de entrenamiento. En este caso, la decisión de realizar una etnografía del fenómeno obliga al investigador a compartir las rutinas y exigencias habituales de actores que se imponen desafíos variados para completar, en el mejor tiempo posible, carreras de larga distancia. Así es que un etnógrafo, como un nativo marginal, necesita mantener un estado atlético que le permita sostener algunas de esas exigencias que además constituyen instancias fundamentales del trabajo de campo. Por ende, en este artículo se analiza al cuerpo del etnógrafo como un instrumento clave de investigación, apelando a diversas herramientas teóricas, principalmente fenomenológicas. Aunque no se plantea que este grado de involucramiento corporal sea excluyente, sí implica un recurso relevante para comprender un estilo de vida caracterizado por el desarrollo de firmes preceptos morales y estéticos. Esta fenomenología del etnógrafo-corredor permite entonces describir, a través de la conciencia encarnada, un amplio conjunto de emociones y "técnicas corporales" que son definitorias de la pasión por correr como un estilo de vida. Todo ello está orientado a desarrollar principios metodológicos que hacen a la producción del conocimiento social y que trascienden a este tipo de prácticas deportivas.

Using Accelerometry for Evaluating Energy Consumption and Running Intensity Distribution Throughout a Marathon According to Sex.

The proportion of females participating in long-distance races has been increasing in the last years. Although it is well-known that there are differences in how females and males face a marathon, higher research may be done to fully understand the intrinsic and extrinsic factors affecting sex differences in endurance performance. In this work, we used triaxial accelerometer devices to monitor 74 males and 14 females, aged 30 to 45 years, who finished the Valencia Marathon in 2016. Moreover, marathon split times were provided by organizers. Several physiological traits and training habits were collected from each participant. Then, we evaluated several accelerometry- and pace-estimated parameters (pacing, average change of speed, energy consumption, oxygen uptake, running intensity distribution and running economy) in female and male amateur runners. In general, our results showed that females maintained a more stable pacing and ran at less demanding intensity throughout the marathon, limiting the decay of running pace in the last part of the race. In fact, females ran at 4.5% faster pace than males in the last kilometers. Besides, their running economy was higher than males (consumed nearly 19% less relative energy per distance) in the last section of the marathon. Our results may reflect well-known sex differences in physiology (i.e., muscle strength, fat metabolism, VO2max), and in running strategy approach (i.e., females run at a more conservative intensity level in the first part of the marathon compared to males). The use of accelerometer devices allows coaches and scientific community to constantly monitor a runner throughout the marathon, as well as during training sessions.

Winning by hiding behind others: An analysis of speed skating data.

In some athletic races, such as cycling and types of speed skating races, athletes have to complete a relatively long distance at a high speed in the presence of direct opponents. To win such a race, athletes are motivated to hide behind others to suppress energy consumption before a final moment of the race. This situation seems to produce a social dilemma: players want to hide behind others, whereas if a group of players attempts to do so, they may all lose to other players that overtake them. To support that speed skaters are involved in such a social dilemma, we analyzed video footage data for 14 mass start skating races to find that skaters that hid behind others to avoid air resistance for a long time before the final lap tended to win. Furthermore, the finish rank of the skaters in mass start races was independent of the record of the same skaters in time-trial races measured in the absence of direct opponents. The results suggest that how to strategically cope with a skater’s dilemma may be a key determinant for winning long-distance and high-speed races with direct opponents.

Life-threatening and major cardiac events during long-distance races: updates from the prospective RACE PARIS registry with a systematic review and meta-analysis.

Limited data exist regarding the incidence and aetiology of life-threatening events such as major cardiac events or exertional heat stroke during long-distance races. We aimed to provide an updated incidence, etiology and prognosis of life-threatening events during long-distance races. The prospective RACE PARIS registry recorded all life-threatening events/fatal events occurring during 46 marathons, half-marathons and other long-distance races in the Paris area between 2006 and 2016, comprising 1,073,722 runners. Event characteristics were determined by review of medical records and interviews with survivors. The incidence of life-threatening events, exertional heat stroke and major cardiac events was 3.35 per 100,000, 1.02 per 100,000 and 2.33 per 100,000, respectively, including 18 sudden cardiac arrests (1.67 per 100,000). The main aetiology of sudden cardiac arrest was myocardial ischaemia (11/18), due to acute coronary thrombosis (6/11), stable atherosclerotic coronary artery disease (2/11), coronary dissection (1/11), anomalous connection (1/11) or myocardial bridging (1/11). A third of participants with ischaemia-related major cardiac events presented with pre-race clinical symptoms. Major cardiac events were more frequent in the case of a high pollution index (6.78 per 100,000 vs. 2.07 per 100,000, odds ratio 3.27, 95% confidence interval 1.12-9.54). Case fatality was low (0.19 per 100,000). Similarly, we report in a meta-analysis of eight long-distance race registries comprising 16,223,866 runners a low incidence of long-distance race-related sudden cardiac arrest (0.82 per 100,000) and fatality (0.39 per 100,000). Death following sudden cardiac arrest was strongly associated with initial asystole or pulseless rhythm. Long-distance race-related life-threatening events remain rare although serious events. Better information for runners on the risk of pre-race clinical symptoms, outside air pollution and temperature may reduce their incidence.

Cardiac adaptation to endurance exercise training: Differential impact of swimming and running

Objectives: High-intensity training has been associated with bi-ventricular and bi-atrial remodelling and a potentially increased risk of arrhythmias. Most of the evidence is based on endurance disciplines mainly involving the lower part of the body, while few data is available on upper body disciplines. The purpose of this study was to compare chronic cardiac remodelling induced by running and swimming as well as the acute response of ventricular and atrial performance after an upper-body and a lower-body endurance race. Methods: Standard and speckle tracking echocardiographic assessment of left ventricle, right ventricle and both atria was performed at baseline and immediately after a 9.5 km open-water swimming race in 26 healthy men and before and after a 35 km-trail-running race in 21 male runners. Results: No significant differences were observed in baseline ventricular dimensions. However, both right ventricular and atrial systolic deformation were greater in runners. This group also showed slightly larger atrial volumes as compared to swimmers. After the race, right ventricular dilatation was observed in both groups, but only runners showed a decrease in right ventricular deformation and a decrease in atrial volumes and deformation. Significant increases in atrial deformation without reduction in atrial volumes were observed only in swimmers after the race. Conclusions: Right ventricular and atrial remodelling is different depending on the endurance training discipline. Long-distance running races induce a greater impairment in right ventricular performance and atrial function compared to endurance swimming competitions.

Effect of Ibuprofen on Muscle, Hematological and Renal Function, Hydric Balance, Pain, and Performance During Intense Long-Distance Running.

de Souza, RF, de Matos, DG, Ferreira, ARP, Chilibeck, P, Barros, NdA, de Oliveira, AS, Cercato, LM, da Silva, DS, and Aidar, FJ. Effect of ibuprofen on muscle, hematological and renal function, hydric balance, pain, and performance during intense long-distance running. J Strength Cond Res 34(7): 2076-2083, 2020-The aim of this study was to investigate the effect of prophylactic use of nonsteroidal anti-inflammatory drugs (i.e., ibuprofen) on physical performance, vertical jump, muscle biomarkers, liver, kidney, acute pain, and hydration status of participants in the 42-km Trail Running Challenge, a long-distance race integrated over mountain routes. The sample consisted of 20 men randomly divided into 2 groups: a control group (CG) and an experimental group (EG), with 12 completing the race (41.1 ± 8.8 years; 75.7 ± 12.1 kg) and included in the final analysis. The EG were administered an ibuprofen capsule (400 mg) 15 minutes before the beginning of the race and again after 5 hours of racing if the route was not yet completed. There were significant time main effects for creatine kinase (p = 0.001; f Cohen = 0.25), lactate dehydrogenase (p < 0.001; f Cohen = 2.05), aspartate aminotransferase (p = 0.002; f Cohen = 1.53), creatinine (p = 0.002; f Cohen = 2.24), urea (p = 0.001; f Cohen = 2.25), heart rate (p < 0.001; f Cohen = 4.88), and pain scores (p < 0.001; f Cohen = 1.93) all of which increased during the race. There was a group × time interaction for squat jump, which significantly decreased only in the CG (p = 0.045; f Cohen = 2.17). This may have been related to increased frequency of pain reported after the race in the gastrocnemius of the CG compared with the EG (p ≤ 0.05). It was concluded that ibuprofen intake did not reduce muscle damage during the competition but maintained leg muscular power performance (i.e., vertical jump), possibly by reducing gastrocnemius muscle pain.

A Simple Equation to Estimate Half-Marathon Race Time From the Cooper Test

Half-marathon races have become increasingly more popular with many recreational athletes all around the world. New and recreational runners are likely to have the greatest need for training advice to set running paces during long-distance races. To develop a simple equation to estimate half-marathon time from the Cooper test and verify its validity. One hundred ninety-eight recreational runners (177 men and 21 women, 40 [6.8] years and 33.7 [8] years, respectively) participated in this study. All runners completed the Cooper test 7 to 10 days prior to races. A stepwise multiple regression analysis was performed to select the main predictors of half-marathon time. Simple correlation analysis showed that Cooper test performance (distance) was a good construct to estimate half-marathon time (r = -.906; 95% confidence interval, -0.927 to -0.877; P < .0001). The authors also derived an equation with a high predictive validity (R2 = .82; standard error of estimation = 5.19min) and low systematic bias (mean differences between the predicted value and the criterion of 0.48 [5.2]min). Finally, the concordance coefficient of correlation (.9038) and proportional bias analysis (Kendall τ = -.0799; 95% confidence interval, -0.184 to 0.00453; P = .09) confirmed a good concurrent validity. In this study, the authors derived an equation from the Cooper test data with a high predictive and concurrent validity and low bias.

Challenging the selection for consistency in the rank of endurance competitions

BackgroundControl of the environmental variability by genetic selection offers possibilities for new selection objectives for productive traits. This methodology aims at reducing heterogeneity in productive traits and has been applied to several traits and species for which animal homogeneity is profitable. In horse breeding programmes, rank in competitions is a common selection objective but has been challenging to model. In this study, the parameters of environmental variability for the rank of a horse were computed to analyse the capability of a horse to maintain the best ranking across competitions that consist of long-distance races in which the adapted physical condition of the horse is essential. The genetic component of the environmental variance for the rank in endurance competitions was evaluated, which resulted in proposing a new transformation of horse scores in competitions.ResultsHomogeneous and heterogeneous variance models were compared by assaying three random effects that affect both the rank and its variability, using endurance ride data consisting of 2863 records. The pedigree relationship matrix contained 5931 animals. The rank trait was transformed into a normalized variable to prevent false estimates of the genetic correlation by inappropriate artificial skewness. The models included the number of participants in the race, sex, and age as systematic effects. The rider, the rider-horse interaction, or an environmental permanent effect were tested as random effects, in addition to additive genetic and residual effects. The models were analysed using the GSEVM program. Estimates of heritability for rank ranged from 0.12 to 0.15. The heterogeneous variance model that fitted the rider was assessed as the best model based on the deviance information criterion. Estimates of genetic variance for rank variability ranged from 0.12 to 0.13. The genetic correlation between the rank and its environmental variability was low and did not differ from 0.ConclusionsThese results offer an opportunity to select animals for canalization by reducing the variability of race results and achieving the best positions, which could be a new selection objective by weighting estimated breeding values for rank and its variability in a selection index.

Double poling kinematic changes during the course of a long-distance race: effect of performance level

ABSTRACTWe aimed to evaluate the changes in double poling (DP) kinematics due to a long-distance cross-country skiing race in athletes with different performance levels. A total of 100 cross-country skiers, belonging to 10 different performance groups, were filmed on flat terrain 7 and 55 km after the start line, during a 58-km classical race. Cycle velocity, frequency and length decreased from the best to the lower-ranked group, while duty cycle increased (all P <.001). Between track sections, cycle velocity and length decreased, duty cycles increased (all P <.001) while frequency was unaltered (P =.782). Group*section interactions resulted for cycle velocity (P =.005). Considering all the participants together, % change in cycle velocity between sections correlated with % change in length and duty cycle (all P <.001). Thus i) skiers in better groups showed longer and more frequent cycles as well as shorter duty cycles than skiers in slower groups; ii) throughout the race all the groups maintained the same cycle frequency while decreasing cycle velocity and length; iii) better groups showed a lower reduction in cycle velocity. Individually, a low reduction in cycle velocity during the race related to the capacity to maintain long cycles and short duty cycles.

Horse Racing at the Ottoman Court, 1524–1728

This study explores horse races in and around the Ottoman capital city, their occasions, locations or participants before the nineteenth century. The competitions we know to have been organized during the sixteenth and seventeenth century imperial festivals were long-distance endurance races run outside the city walls. Courses corresponding to approximately two, three, four or six hours of racing were set out for specially trained horses, and prizes of cash or fine textiles were awarded to winners. In the course of the early 1700 s, cross-country horse racing evolved into more of a private partying ritual for the sultan and his immediate entourage, coming to be routinely observed at the end of the religious festivities, though the layout then excluded attendance by large crowds. The spatial organization of horse racing evolved from temporary installations to a permanent architecture. All the machinery and pageantry of horse racing, from paddocks through parade rings to the theatrics of the race day, a new stage came to be constructed at the Kağıdhane valley, at the far end of the Golden Horn.

Estimation of energy consumed by middle-aged recreational marathoners during a marathon using accelerometry-based devices

As long-distance races have substantially increased in popularity over the last few years, the improvement of training programs has become a matter of concern to runners, coaches and health professionals. Triaxial accelerometers have been proposed as a one of the most accurate tools to evaluate physical activity during free-living conditions. In this study, eighty-eight recreational marathon runners, aged 30–45 years, completed a marathon wearing a GENEActiv accelerometer on their non-dominant wrist. Energy consumed by each runner during the marathon was estimated based on both running speed and accelerometer output data, by applying the previously established GENEActiv cut-points for discriminating the six relative-intensity activity levels. Since accelerometry allowed to perform an individualized estimation of energy consumption, higher interpersonal differences in the number of calories consumed by a runner were observed after applying the accelerometry-based approach as compared to the speed-based method. Therefore, pacing analyses should include information of effort intensity distribution in order to adjust race pacing appropriately to achieve the marathon goal time. Several biomechanical and physiological parameters (maximum oxygen uptake, energy cost of running and running economy) were also inferred from accelerometer output data, which is of great value for coaches and doctors.

Delayed Clinical Manifestation of Parkinson's Disease Among Physically Active: Do Participants in a Long-Distance Ski Race Have a Motor Reserve?

Background:Physical activity is associated with reduced risk of Parkinson’s disease (PD). The explanations for this association are not completely elucidated. We use long-term PD-incidence data from long-distance skiers to study the relationship between exercise and PD.Objective:We aimed to investigate if physical activity is associated with long-term lower risk of PD and if this association could be explained by physically active people being able to sustain more PD neuropathology before clinical symptoms, a motor reserve.Methods:Using a prospective observational design, we studied whether long-distance skiers of the Swedish Vasaloppet (n = 197,685), exhibited reduced incidence of PD compared to matched individuals from the general population (n = 197,684) during 21 years of follow-up (median 10, interquartile range (IQR) 5–15 years).Results:Vasaloppet skiers (median age 36.0 years [IQR 29.0–46.0], 38% women) had lower incidence of PD (HR: 0.71; 95 % CI 0.56–0.90) compared to non-skiers. When reducing risk for reverse causation by excluding PD cases within the first five years from race participation, there was still a trend for lower risk of PD (HR: 0.80; 95 % CI 0.62–1.03). Further, the PD prevalence converged between skiers and non-skiers after 15 years of follow-up, which is more consistent with a motor reserve in the physically active rather than neuroprotection.Conclusions:A physical active lifestyle is associated with reduced risk for PD. This association weakens with time and might be explained by a motor reserve among the physically active.

Average heart rate recovery in marathon runners: An observational study

INTRODUCTION: Marathon is a long-distance race which causes enormous physical challenges to the body. The fitness status of the runner should be checked to overcome these challenges. However, it can be assessed using an easy diagnostic method of heart rate recovery (HRR) as it is inexpensive and readily accessible. Regular monitoring and documentation of the HRR can guide a runner in his training and health status. AIM: This study was done to check the average HRR postimmediately and after 2 min of race using radial palpatory method. METHODOLOGY: The present study was a cross-sectional, observational study conducted in Belagavi city. The participants of all genders aged 18 years and above were enrolled in the study. The sample size was open ended. Heart rate was assessed using radial palpatory method before and after the marathon running. RESULTS: At the end of marathon running, the pulse rate had rapidly increased with a mean of 129.40 ± 9.79. After 2 min of postrunning, there was a significant drop in the pulse rate of mean 106.32 ± 11.53. A drop of 23.08 ± 8.63 beats was seen when compared to postimmediate and after 2-min pulse rate. When the heart rate was compared between the prepulse and after 2 min, there was a mean difference of 33.66 beats. CONCLUSIONS: The study concluded that HRR after 2 min of the run was about 23.08 ± 8.63, but it was observed that the heart rate did not go to its pretest value.

Predictors of long-distance race performance in master runners.

To determine predictors of temperature-converted VDOT in master runners training for a long-distance race (10-26.2 mi). Twenty-three master runners (age 57±9 years; eight females) performed treadmill marathon-intensity-effort (MIE) and V .O2peak tests within four weeks of their goal race. The MIE occurred at 88% of predicted maximum heart rate, which corresponds to estimated marathon intensity. Participants completed online training-history surveys. Forward stepwise multiple linear regression was used to find key predictors of VDOT. The alpha level for significance was .05. Converted VDOT was significantly associated with three-year peak weekly training distance (3YP) (r = 0.454, p = .039), V .O2peak (r = 0.845, p = .000), alloV .O2 (r = 0.623, p = .005), and EC (r = -0.528, p = .018). The best-fitting model included V .O2peak and 3YP (r = 0.898). Physiological and training factors are related to race performance in master runners. The best predictors of VDOT are V .O2peak and 3YP. Training to enhance these variables may improve distance-running performance in masters.

Delayed Clinical Manifestation of Parkinson's Disease Among Physically Active: Do Participants in a Long-Distance Ski Race Have a Motor Reserve?

Background: Physical activity is associated with reduced risk of Parkinson's disease (PD). The explanations for this association are not completely elucidated. We use long-term PD-incidence data from long-distance skiers to study the relationship between exercise and PD. Objective: We aimed to investigate if physical activity is associated with long-term lower risk of PD and if this association could be explained by physically active people being able to sustain more PD neuropathology before clinical symptoms, a motor reserve. Methods: Using a prospective observational design, we studied whether long-distance skiers of the Swedish Vasaloppet (n = 197,685), exhibited reduced incidence of PD compared to matched individuals from the general population (n = 197,684) during 21 years of follow-up (median 10, interquartile range (IQR) 5-15 years). Results: Vasaloppet skiers (median age 36.0 years [IQR 29.0-46.0], 38% women) had lower incidence of PD (HR: 0.71; 95 % CI 0.56-0.90) compared to non-skiers. When reducing risk for reverse causation by excluding PD cases within the first five years from race participation, there was still a trend for lower risk of PD (HR: 0.80; 95 % CI 0.62-1.03). Further, the PD prevalence converged between skiers and non-skiers after 15 years of follow-up, which is more consistent with a motor reserve in the physically active rather than neuroprotection. Conclusions: A physical active lifestyle is associated with reduced risk for PD. This association weakens with time and might be explained by a motor reserve among the physically active. (Less)

Physical Activity Reduces Epilepsy Incidence: a Retrospective Cohort Study in Swedish Cross-Country Skiers and an Experimental Study in Seizure-Prone Synapsin II Knockout Mice

BackgroundEpilepsy patients commonly exercise less than the general population. Animal studies indicate beneficial effects of physical activity in established epilepsy, while its effect on the development is currently less known.MethodsHere, we investigated the incidence of epilepsy during 20 years in a cohort of participants from the long-distance Swedish cross-country ski race Vasaloppet (n = 197,685) and compared it to the incidence of non-participating-matched controls included in the Swedish population register (n = 197,684). Individuals diagnosed with diseases such as stroke and epilepsy before entering the race were excluded from both groups. Experimentally, we also determined how physical activity could affect the development of epilepsy in epilepsy-prone synapsin II knockout mice (SynIIKO), with and without free access to a running wheel.ResultsWe identified up to 40–50% lower incidence of epilepsy in the Vasaloppet participants of all ages before retirement. A lower incidence of epilepsy in Vasaloppet participants was seen regardless of gender, education and occupation level compared to controls. The participants included both elite and recreational skiers, and in a previous survey, they have reported a higher exercise rate than the general Swedish population. Sub-analyses revealed a significantly lower incidence of epilepsy in participants with a faster compared to slower finishing time. Dividing participants according to specified epilepsy diagnoses revealed 40–50% decrease in focal and unspecified epilepsy, respectively, but no differences in generalized epilepsy. Voluntary exercise in seizure-prone SynIIKO mice for 1 month before predicted epilepsy development decreased seizure manifestation from > 70 to 40%. Brain tissue analyses following 1 month of exercise showed increased hippocampal neurogenesis (DCX-positive cells), while microglial (Iba1) and astrocytic activation (GFAP), neuronal Map2, brain-derived neurotrophic factor and its receptor tyrosine receptor kinase B intensity were unaltered. Continued exercise for additionally 2 months after predicted seizure onset in SynIIKO mice resulted in a 5-fold reduction in seizure manifestation (from 90 to 20%), while 2 months of exercise initiated at the time of predicted seizure development gave no seizure relief, suggesting exercise-induced anti-epileptogenic rather than anti-convulsive effect.ConclusionThe clinical study and the experimental findings in mice indicate that physical activity may prevent or delay the development of epilepsy.

NSE & S100B protein blood level assessment during a long-distance trail race.

Blood samples were collected from 4 athletes before, during and at the end of one of two races: Grand Raid de la Réunion 2017 (GRR: 165 km, elevation gain: 9529 m, 2 runners) and Trail de la Bourbon 2017 (TB: 111 km, elevation gain: 6433 m, 2 runners). Serum S100B and NSE levels were measured for each runner before, during and after the race. Serum S100B levels (normal range: < 0.15 μg/L) increased early during the race and remained high up to the end of the race in all 4 runners (range: 0.17-0.59 μg/L). NSE level (normal range: < 15 μg/L) increased in 3 of the 4 runners (range: 16.8-39.2 μg/L). This preliminary study shows the potential interest of S100B and NSE serum assessment during long-distance races. Further studies are needed to confirm these results and to investigate the origins and significance of this increase in brain injury markers.

Prevalence of exercise-induced pulmonary hemorrhage in competing endurance horses.

To assess the prevalence of exercise-induced pulmonary hemorrhage (EIPH) among elite endurance horses after competition in a long-distance race. 20 endurance horses and 12 nonexercised or minimally exercised age-, breed-, and trainer-matched horses from the same environment (control horses). Bronchoalveolar lavage fluid samples collected from endurance horses at 3 to 8 days (sample A) and 36 to 38 days (sample B) after the race (100 km in 1 day [n = 3], 70 km/d for 2 days [12], or 100 km/d for 2 days [5]) were cytologically examined for the presence of hemosiderophages. Samples from control horses were collected at the same time as sample B was obtained from respective matched endurance horses and similarly examined. Horses with bronchoalveolar lavage fluid samples in which > 1% of identified cells were hemosiderophages were considered to have evidence of EIPH. Of 20 endurance horses, 9 (45%; 95% confidence interval, 25% to 66%) and 10 (50%; 95% confidence interval, 29% to 71%) had cytologic evidence of EIPH in samples A and B, respectively. Evidence of EIPH was present in 6 of 20 (30%) horses at both sample collection times, 3 (15%) at the first sample time only, and 4 (20%) at the second sample time only. In contrast, 1 of 12 control horses had cytologic evidence of EIPH. The prevalence of EIPH in these elite endurance horses (45% to 50%) was higher than previously reported estimates for poor-performing endurance horses; however, differences in criteria for identification of EIPH should be considered when comparing findings between studies.