College London Research Articles

Risk factors, mechanisms, and clinical outcomes of stroke in young adults presenting to a North Central London stroke service: UCL Young Stroke Systematic Evaluation Study (ULYSSES).

Stroke incidence in younger adults is increasing worldwide yet few comprehensive studies exist from a UK population. We investigated the risk factors, mechanisms, functional outcome and stroke recurrence rate in a cohort of young adults with stroke. We included consecutive patients (<55 years) with ischaemic stroke or intracerebral haemorrhage (ICH) admitted to the University College London Hospitals Hyperacute Stroke Unit between 2017 and 2020. Ischaemic stroke was classified using Trial of Org 10172 in Acute Stroke Treatment (TOAST) criteria and ICH using modified CLAS-ICH criteria. Multivariable logistic regression was performed to identify predictors of unfavourable functional outcome (modified Rankin Scale [mRS] > 1) at 6 months. Five hundred fifty-two patients were included (median age 47, IQR 41-51; 33% female; 76% ischaemic stroke). Common risk factors included dyslipidaemia (57%), hypertension (40%), and cigarette smoking (34%). Ischaemic stroke was mostly due to cardioembolism (22%). Probable cerebral small vessel disease was the most frequent ICH aetiology (53%). Unfavourable functional outcome was prevalent in 50% at 6 months and was associated with ICH (OR 2.02, 95%CI 1.14-3.58, p = 0.017), female sex (OR 1.62, 95%CI 1.03-2.55, p = 0.037), admission stroke severity (per point increase, OR 1.11, 95%CI 1.07-1.16, p < 0.001) and pre-morbid mRS 2-5 (OR 3.16; 95%CI 1.11-9.03, p = 0.032). 4.4% had a recurrent stroke within 6 months. Traditional cardiovascular risk factors are common in young adults with stroke. Unfavourable functional outcome is associated with female sex, ICH, severe stroke and pre-morbid disability. These findings can inform national stroke prevention and rehabilitation strategies.

RETRACTION: Investigating the Effectiveness of Forensic Genetics and Population Genetic Diversity Using a Multi-InDel System in Chinese Hezhou and Southern Shaanxi Han Populations.

Wang, X., Q. Lan, Y. Lin, etal. "Investigating the Effectiveness of Forensic Genetics and Population Genetic Diversity Using a Multi-InDel System in Chinese Hezhou and Southern Shaanxi Han Populations," Annals of Human Genetics (Early View): https://doi.org/10.1111/ahg.12553. The above article, published online on 20 May 2024, in Wiley Online Library (http://onlinelibrary.wiley.com/), has been retracted by an agreement between the authors; the journal's Editor in Chief, Dr. Rosemary Ekong; University College London; and John Wiley & Sons, Ltd. The authors reported that a number of errors had been included in the published article, which would require corrections to the abstract, results, and conclusions, as well as Figure 5. The editors confirmed these errors. The retraction has been agreed to because the corrections required to amend these major errors would require substantial changes to the results and conclusions in the article. The authors have agreed to submit the revised version of this article for evaluation by the journal.

Reproducibility of fetal ultrasound doppler parameters used for growth assessment.

To produce standards of references for quality control and assess the reproducibility of fetal ultrasound Doppler measurements commonly used for blood flow assessment in fetal growth. Women with singleton normal pregnancies were prospectively recruited at University College London Hospital, UK, between 24 and 41weeks. Umbilical artery (UA), middle cerebral artery (MCA), and their pulsatility indices (PI), resistance indices (RI) and ratios such as cerebro-placental (CPR) and umbilical cerebral ratio (UCR) were obtained twice by two sonographers in training or after completion of training, blind to each other's measurements. Bland-Altman plots were generated, the mean differences and 95% limits of agreement (LOA) were calculated to assess intra- and interobserver reproducibility. Values were expressed as absolute values or as z-score. One hundred ten women were recruited. Overall reproducibility was variable for absolute values and highly variable for z-scores, independently from vessel sampled, index or ratio used, intra- or interobserver reproducibility. The widest absolute values of 95% LOA were 0.3 for UA PI, 0.7 for MCA PI, 0.9 for CPR and 0.3 for UCR, respectively. Regarding z-score, the widest 95% LOA were 1.9 for UA PI, 2.1 for CPR and 1 for UCR. Reproducibility was slightly better for intra- compared with interobserver variability. There was significant difference in z-score reproducibility between MCA peak systolic velocity and CPR vs UCR. Reference standards of reproducibility of fetal Doppler parameters are produced for standardization and quality-control purposes. Overall, the reproducibility for fetal Doppler parameters was variable independently from vessel sampled, Doppler index (PI or RI) or ratio used, intra- and interobserver comparison. UCR was the most reproducible parameter which should be recommended, together with UA PI, for clinical use and in research studies on fetal growth.

Impact of deep or ovarian endometriosis on pelvic pain and quality of life: prospective cross-sectional ultrasound study.

To assess whether premenopausal women diagnosed with deep or ovarian endometriosis on transvaginal sonography (TVS) were more likely to suffer from dyspareunia and pelvic pain symptoms, and have a lower quality of life, compared to women without sonographically diagnosed deep or ovarian endometriosis. This was a prospective, cross-sectional study carried out between February 2019 and October 2020 at the general gynecology clinic at University College London Hospital, London, UK. All premenopausal women aged 18-50 years, who were examined consecutively by a single experienced examiner and underwent a detailed TVS scan, were eligible for inclusion. Pregnant women and those who had received a previous diagnosis of endometriosis or who had experienced a hysterectomy or unilateral/bilateral oophorectomy were excluded. Sonographic findings consistent with deep or ovarian endometriosis were noted. All women completed the British Society of Gynaecological Endoscopy pelvic pain questionnaire. The primary outcome was to determine whether women with sonographic evidence of endometriosis were more likely to experience moderate-to-severe levels of dyspareunia (score of ≥ 4 on an 11-point numerical rating scale (NRS)). Secondary outcomes included assessing moderate-to-severe levels of other pelvic pain symptoms (NRS score of ≥ 4), bowel symptoms (score of ≥ 2 on a 5-point Likert scale) and quality of life, which was measured using the EuroQol-5D-3L (EQ-5D) questionnaire. The number of women with pain scores ≥ 4 and bowel scores ≥ 2, as well as the mean EQ-5D scores, were compared between the group with and that without sonographic evidence of endometriosis using logistic regression analysis, and multivariable analysis was used to adjust for demographic and clinical variables. A total of 514 women were included in the final study population, of whom 146 (28.4%) were diagnosed with deep or ovarian endometriosis on TVS. On multivariable analysis, the presence of moderate-to-severe dyspareunia was not found to be associated with endometriosis. Moderate-to-severe dyspareunia was significantly associated with lower age (odds ratio (OR), 0.70 (95% CI, 0.56-0.89); P = 0.003) and a history of migraine (OR, 3.52 (95% CI, 1.42-8.77); P = 0.007), and it occurred significantly less frequently in women with non-endometriotic ovarian cysts (OR, 0.47 (95% CI, 0.28-0.78); P = 0.003). There was also a trend towards a positive association between anxiety/depression and moderate-to-severe dyspareunia (OR, 1.94 (95% CI, 0.93-4.03); P = 0.08). Following multivariable analysis, the only symptoms that were significantly more common in women with endometriosis compared to those without were menstrual dyschezia (OR, 2.44 (95% CI, 1.59-3.78); P < 0.001) and difficulty emptying the bladder (OR, 2.56 (95% CI, 1.52-4.31); P < 0.001). Although not reaching statistical significance on multivariable analysis, dysmenorrhea (OR, 1.72 (95% CI, 0.92-3.20); P = 0.09) and lower EQ-5D score (mean ± SD, 0.67 ± 0.33 vs 0.72 ± 0.28; P = 0.06) also occurred more frequently in women with sonographic evidence of endometriosis. The majority of pelvic pain symptoms did not differ significantly between women with and those without sonographic evidence of endometriosis, indicating that endometriosis may not always be the source of pelvic pain, even if present. This highlights the need to rule out other causes of pain in symptomatic endometriosis patients before considering surgical procedures, and to provide appropriate patient counseling. © 2024 The Author(s). Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.

R21 in Matrix-M adjuvant in UK malaria-naive adult men and non-pregnant women aged 18-45years: anopen-label, partially blinded, phase 1-2a controlled human malaria infection study.

R21 is a novel malaria vaccine, composed of a fusion protein of the malaria circumsporozoite protein and hepatitis Bsurface antigen. Following favourable safety and immunogenicity in a phase 1study, we aimed to assess the efficacy of R21 administered with Matrix-M (R21/MM) against clinical malaria in adults from the UK who were malaria naive in a controlled human malaria infection study. In this open-label, partially blinded, phase 1-2A controlled human malaria infection study undertaken inOxford, Southampton, and London, UK, we tested five novel vaccination regimens of R21/MM. Astandard three-dose regimen (groups 1and 6) was compared with a reduced (fractional) third dose (groups 2and 5) of R21/MM, concomitant administration with viral vectors ChAd63-MVA expressing ME-TRAP (group 3), and a two-dose R21/MM regimen (group 7). Controlled Human Malaria Infection (CHMI) was delivered by mosquito bite at Imperial College London, London, UK, 3-4 weeks after final vaccination (or 18months after final vaccination for group 6) alongside unvaccinated controls (groups 4A and 4B). The primary outcome measures were to assess safety of the vaccines in healthy malaria-naive volunteers and the efficacy (occurrence of blood-stage malaria infection) of the different vaccine regimens compared with non-vaccinated controls after CHMI. The trial was registered with ClinicalTrials.gov (NCT02905019). 66volunteers were enrolled with 59undergoing subsequent CHMI. All vaccination schedules were well tolerated. The highest level of protection against CHMI was observed in participants receiving the standard three-dose regimen of R21/MM (group 1, nine of 11volunteers protected) with protection maintained in three of five volunteers re-challenged by CHMI 7·5months later. Protection against malaria was also seen in group 2, group 3, and group 5compared with unvaccinated control participants. Total IgG antibody responses to the NANP repeat region of circumsporozoite protein peaked after the third dose of R21/MM in all volunteers and were well maintained to 90days after challenge. Reducing the third dose did not affect protection or antibody concentrations. Our study shows that R21/MM elicits high-level efficacy against clinical malaria in a controlled human infection model of malaria in adults who are malaria naive. These data supported the evaluation of R21/MM in field efficacy trials in the target population of young children in malaria-endemic areas. EU Horizon 2020, the UK Medical Research Council, the European Commission, the UK National Institute of Health Research, the Imperial NIHR Clinical Research Facility, the Oxford NIHR Biomedical Research Centre, and the Wellcome Trust.

Integration of a specialist pharmacist-led multidisciplinary team in primary care: preventing strokes in people with atrial fibrillation across North East London

Public Health England outlines a national ambition of anticoagulating 90% of eligible patients with atrial fibrillation (AF) by 2029. In 2019/2020, two out of three boroughs reviewed in this study...

An early, transient Interferon-associated innate immune response associates with protection from SARS-CoV-2 infection

A proportion of individuals exposed to respiratory viruses avoid contracting detectable infection. We tested the hypothesis that early innate immune responses associate with resistance to detectable infection in close contacts of COVID-19 cases. 48 recently-exposed household contacts of symptomatic COVID-19 cases were recruited in London, UK between May 2020 and March 2021 through a prospective, longitudinal observational study. Blood and nose and throat swabs were collected during the acute period of index case viral shedding and longitudinally thereafter. Magnitude of SARS-CoV-2 exposure was quantified, and serial PCR and serological assays used to determine infection status of contacts. Whole-blood RNA-seq was performed and analysed to identify transcriptomic signatures of early infection and resistance to infection. 24 highly-exposed household contacts became PCR-positive and seropositive whilst 24 remained persistently PCR-negative and seronegative. A 96-gene transcriptomic signature of early SARS-CoV-2 infection was identified using RNA-seq of longitudinal blood samples from PCR-positive contacts. This signature was dominated by interferon-associated genes and expression correlated positively with viral load. Elevated expression of this 96-gene signature was also observed during exposure in 25% (6/24) of persistently PCR-negative, seronegative contacts. PCR-negative contacts with elevated signature expression had higher-magnitude SARS-CoV-2 exposure compared to those with low signature expression. We validated this signature in SARS-CoV-2-infected individuals in two independent cohorts. In naturally-exposed healthcare workers (HCWs) we found that 7/58 (12%) PCR-negative HCWs exhibited elevated signature expression. Comparing gene-signature expression in SARS-CoV-2 Controlled Human Infection Model (CHIM) volunteers pre- and post-inoculation, we observed that 14 signature genes were transiently upregulated as soon as 6hr post-inoculation in PCR-negative volunteers, while in PCR-positive volunteers gene-signature upregulation did not occur until 3 days later. Our interferon-associated signature of early SARS-CoV-2 infection characterises a subgroup of exposed, uninfected contacts in three independent cohorts who may have successfully aborted infection prior to induction of adaptive immunity. The earlier transient upregulation of signature genes in PCR-negative compared to PCR-positive CHIM volunteers suggests that ultra-early interferon-associated innate immune responses correlate with, and may contribute to, protection against SARS-CoV-2 infection. This work was supported by the NIHR Health Protection Research Unit in Respiratory Infections, United Kingdom, NIHR Imperial College London, United Kingdom (Grant number: NIHR200927; AL) in partnership with the UK Health Security Agency and the NIHR Medical Research Council (MRC), United Kingdom (Grant number: MR/X004058/1). Support for sequencing was provided by the Imperial BRC Genomics Facility which is funded by the NIHR, United Kingdom. The development of the hybrid DABA assay used for quantification of SARS-CoV-2 anti-Spike RBD antibodies was supported by the MRC (MC_PC_19078).

Using Soft-Preserved Body Donors to Improve the Anatomy Learning Experience for Orthopedic Residents

Working with deceased human bodies to advance anatomical knowledge as part of orthopedic residency programs is critical to improving clinical skills. Formalin-preserved donors are routinely used but don't retain similar features to patients. This study compares Imperial College London- soft preserved (ICL-SP) donors to standard formalin-preserved donors in teaching anatomy to orthopedic residents. Orthopedic Residents were invited to fill out a dissection survey after they had completed different dissections over a 6-week period. At the end of the study, residents and observers then comprehensively analyzed the experience between the donors. The surveys used a Likert scale format from 1 to 5. These survey questions include assessments of tendons, muscles, ligaments, nerves, vessel quality, fascia, ease of dissection, similarity to in vivo tissue, finding specific structures, and more. Descriptive statistics were used to describe the resident opinion/experience differences between the 2 types of donors. A total of 24 residents participated in the dissector surveys, and 30 residents completed the observer surveys. In completing the Likert scale questionnaires, 88.3% of residents in the dissections and 86% of residents in the observer surveys stated that they favored learning from ICL-SP donors. When residents were asked to evaluate the differences in the donor preservations, residents favored ICL-SP donors. Orthopedic Residents ultimately agreed that dissecting and identifying structures is more effective when working with ICL-SP. The results suggest that orthopedic residency programs should consider preservation techniques when teaching their students anatomy from human donors. ICL-SP donors can encourage residents to transfer the skills learned to their clinical experiences and improve patient care.

Effects of UK hostile environment policies on maternity care for refugees, asylum seekers, and undocumented migrants in Camden: Examining the experiences of healthcare professionals and community organisations.

The London borough of Camden has long been home for many refugees, asylum seekers, and undocumented migrants (RASUs). Over time, it has witnessed an increase in the population of these migrant groups, accompanied by notable changes in the obstacles they encounter when seeking health services, particularly maternity care. We explore how the 'hostile environment' policies affect access to and delivery of quality maternity services for RASUs. This study was conducted over eight months (November 2021-July 2022) both remotely and face-to-face, in various locations in Camden and in the Maternity Department at University College London Hospital, UK. Healthcare professionals (HCPs) and community organisations (COs) were identified as two major stakeholders involved in the care provision for RASUs. 33 semi-structured interviews were conducted (with 22 HCPs and 11 COs) to understand their experiences of delivering care to this population. There was consensus among HCPs and COs that the current immigration policies undermined their duty of care, personal morals, and the principles of the NHS. These policies have created a restrictive environment, making it increasingly difficult for migrants to navigate the healthcare system and creating an atmosphere of distrust, propagating fears of being charged. This has led to HCPs and COs going beyond their remits to ensure that RASUs are accessing and engaging with maternity care, regardless of an individual's status and despite any potential repercussions for themselves. In the face of an intensifying hostile environment under the UK government, supporting RASUs cannot be solely reliant on political measures. We need to advocate for healthcare navigator roles, health justice partnerships, specialist teams, and comprehensive training for service providers. HCPs and COs should be adequately supported in their endeavours to ensure RASUs have access to standardised, high-quality maternity care.

Benefits, challenges, and recommendations of cultural instruction in second language learning

In the fast-growing globalized and culturally diverse society today, multiculturalism, i.e. knowledge of variegated culture, is considered to be an essential individual resource. This study examines the views of international postgraduate students on the benefits and challenges of incorporating cultural instruction into second language learning within an English-speaking higher education context in the UK. The objectives are to identify the advantages of cultural instruction, the barriers to its implementation in academic settings, and strategies to overcome these barriers. To achieve this, surveys and face-to-face discussions were conducted with a group of multiracial postgraduate language learners at Westminster University in London. The findings reveal that cultural instruction enhances learners’ understanding and engagement by providing contextually relevant information. The findings also show that there is a significant lack of institutional curricula and standards for integrating cultural materials into language learning, along with limited awareness among students and educators. The study recommends that academic stakeholders—including students, educators, and institutions—collaborate to incorporate cultural education into second language programs to enhance learning outcomes.

Assessing Results of University Research Activities: Indicators of Openness in Rankings

Open access to scientific results and research data becomes an engine for the successful development of modern science. The article examines popular rankings of world universities: the CWTS Leiden Ranking, the Times Higher Education World University Rankings (THE Rankings), the QS World University Rankings (QS), the SCImago Institutions Rankings (SIR) and the Academic Ranking of World Universities (ARWU). The objective of the research was to study the ranking methodologies in the ratings under consideration and to determine the place of the openness criteria in them. A comparative analysis of world’s and Russia’s top universities in rankings is provided. The author has made an assessment of the significance of openness indicators in the world rankings, on the basis of which it has been concluded that only two world rankings pay due attention to these ranking criteria. Of those considered, only the evaluation methodologies of the CWTS Leiden Ranking and the SCImago Institutions Rankings take into account a quantitative analysis of open access publications and altmetric impact indicators. The rest of the considered rankings focus mainly on standard bibliometric indicators from different blocks related to the assessment of education, research, academic impact and international cooperation. Thus, in 2019–2022, the University College London (UK) was the top university in the CWTS Leiden Ranking in terms of the share of open access publications (90.8%) and Moscow Institute of Physics and Technology was ranked the first among Russian universities (66.6%).

Empowering professionals: a multidisciplinary approach to supporting people seeking asylum and refugees.

People seeking asylum and refugees living in initial accommodation in the UK can experience significant barriers to accessing care. They often have complex health and social needs and may experience fragmentation in the delivery of services. The Respond Integrated Refugee Health Service, hosted by University College London Hospital and operating across North Central London, has been created to address some of these challenges. In addition to offering in-person holistic health and well-being assessments, infection screening and onward care planning, Respond has developed an online multidisciplinary team (MDT) forum to support professionals working with the most complex of cases. Key professional groups from across the network are invited to contribute to multidisciplinary care planning, providing an efficient and streamlined multiagency model of care, improved access to interdisciplinary pathways and opportunities for interprofessional learning. Here, we describe the creation of the Respond Complex Refugee Health Advice and Guidance MDT and discuss the perceived benefits and limitations of the MDT approach in improving the care of people seeking asylum and refugees.

The Effects of Social Identity Incompatibility on Student Mental Health

Background: Students from ethnic minority backgrounds have been shown to be more vulnerable to developing mental health disorders compared to White British students. They have also been shown to experience greater social identity incompatibility; however, it is not yet clear if this may explain some of the disparities in mental health. The aim of the current study was to investigate the relationship between social identity incompatibility and non-clinical generalised anxiety, depression and academic distress in students from ethnic minority backgrounds compared to White students. Methods: A total of 526 students from City St George’s, University of London, completed the Counselling Centre Assessment of Psychological Symptoms (CCAPS-62) and the student identity scale. Results: Results showed correlations between the measures of mental health and incompatibility across all students. Even though there were no significant group differences in the level of anxiety and depression, we found that the interaction between ethnic group and practical incompatibility predicted academic distress. Conclusions: The results may be specific to the multi-ethnic and cultural nature of this inner London city university, but they highlight the importance of practical incompatibility, in particular, in understanding student mental health across different ethnicities.

Artificial intelligence in anesthesiology: a bibliometric analysis

AbstractThe application of artificial intelligence (AI) in anesthesiology has become increasingly widespread. However, no previous study has analyzed this field from the bibliometric analysis dimension. The objective of this paper was to assess the global research trends in AI in anesthesiology using bibliometric software. Literatures relevant to AI and anesthesiology were retrieved from the Web of Science until 10 April 2024 and were visualized and analyzed using Excel, CiteSpace, and VOSviewer. After screening, 491 studies were included in the final bibliometric analysis. The growth rate of publications, countries, institutions, authors, journals, literature co-citations, and keyword co-occurrences was computed. The number of publications increased annually since 2018, with the most significant contributions from the USA, China, and England. The top 3 institutions were Yuan Ze University, National Taiwan University, and Brunel University London. The top three journals were Anesthesia &amp; Analgesia, BMC Anesthesiology, and the British Journal of Anaesthesia. The researches on the application of AI in predicting hypotension have been extensive and represented a hotspot and frontier. In terms of keyword co-occurrence cluster analysis, keywords were categorized into four clusters: ultrasound-guided regional anesthesia, postoperative pain and airway management, prediction, depth of anesthesia (DoA), and intraoperative drug infusion. This analysis provides a systematic analysis on the literature regarding the AI-related research in the field of anesthesiology, which may help researchers and anesthesiologists better understand the research trend of anesthesia-related AI.

Study protocol for Adaptive ChemoTherapy for Ovarian cancer (ACTOv): a multicentre phase II randomised controlled trial to evaluate the efficacy of adaptive therapy (AT) with carboplatin, based on changes in CA125, in patients with relapsed platinum-sensitive high-grade serous or high-grade endometrioid ovarian cancer

IntroductionAdaptive ChemoTherapy for Ovarian cancer (ACTOv) is a phase II, multicentre, randomised controlled trial, evaluating an adaptive therapy (AT) regimen with carboplatin in women with relapsed, platinum-sensitive high-grade serous or...

Meta-epidemiology and reporting characteristics of mapping reviews: a scoping review.

To investigate the meta-epidemiology and reporting characteristics of mapping reviews. We conducted a scoping review of a sample of recent mapping reviews (2022-2023) by searching nine electronic databases and eleven institutional websites up to January 2024. A 28-item reporting checklist, developed by our team and based on existing guidance and methodological studies of mapping reviews, was employed to assess reporting characteristics. The median (interquartile range, IQR) was calculated based on the number of studies that reported each specified reporting item. A total of 451 mapping reviews were included, with 197 published in 2022 and 254 in 2023. The USA published the most studies (80, 17.74%) and the University of London being the most active institution (23, 5.10%). Barbosa JLV from Universidade do Vale do Rio dos Sinos authored the highest number of studies, with significant collaborations primarily between Chinese and Canadian teams. The studies spanned 11 fields within health and social sciences, Environmental Evidence and Campbell Systematic Reviews published the most studies. A random sample of 200 studies was further assessed for reporting characteristics, where items such as title, author, abstract, background, conclusions, acknowledgements, contributions of authors, declarations of interest, and sources of support were reported by over 50% of the studies. Median number of studies reporting items related to methods, results, and discussion was 89.5 (IQR: 45.5, 165.25), 94.0 (IQR: 61.5, 183.5), and 164 (IQR: 124.0, 179.25) respectively. Items such as the definition of stakeholders, registration information, deviations from protocol, strategy for adequacy and priority setting, and plans for map updates were reported by less than 20% of the studies. Mapping reviews receive contributions from authors across various countries and institutions. However, collaboration between teams is limited, and the reporting of included studies, especially in the methods and results sections, needs improvement to better emphasize their unique attributes and functions compared to other methods.

Artificial intelligence applications in ophthalmic optical coherence tomography: a 12-year bibliometric analysis.

To explore the current application and research frontiers of global ophthalmic optical coherence tomography (OCT) imaging artificial intelligence (AI) research. The citation data were downloaded from the Web of Science Core Collection database (WoSCC) to evaluate the articles in application of AI in ophthalmic OCT published from January 1, 2012 to December 31, 2023. This information was analyzed using CiteSpace 6.2.R2 Advanced software, and high-impact articles were analyzed. In general, 877 articles from 65 countries were studied and analyzed, of which 261 were published by the United States and 252 by China. The centrality of the United States is 0.33, the H index is 38, and the H index of two institutions in England reaches 20. Ophthalmology, computer science, and AI are the main disciplines involved. Hot keywords after 2018 include deep learning (DL), AI, macular degeneration, and automatic segmentation. The annual number of articles on AI applications in ophthalmic OCT has grown rapidly. The United States holds a prominent position. Institutions like the University of California System and the University of London are spearheading advancements. Initial researches centered on the automatic recognition and diagnosis of ocular diseases leveraging traditional machine learning (ML) technology and OCT images. Nowadays, the imaging process algorithm selection has shifted its focus towards DL. Concurrently, optical coherence tomography angiography (OCTA) and computer-aided diagnosis (CAD) have emerged as key areas of contemporary research.

The people behind the papers - Roberta Azzarelli and Anna Philpott.

ASCL1 is a pioneer factor that can reprogram somatic cells to produce neurons. Preventing ASCL1 from being phosphorylated appears to enhance its reprogramming abilities, but the reason for this is unclear. A new paper in Development explores how ASCL1 activity is affected by different cellular contexts and reveals that the basis of the reprogramming efficiency of ASCL1 is more complicated than it first appears. To learn more about the story behind the paper, we caught up with first author Roberta Azzarelli, who is now a Lecturer in Pharmacology at University College London, UK, and corresponding author Anna Philpott, Professor of Cancer and Developmental Biology at the University of Cambridge, UK.

Cognitive rehabilitation in schizophrenia research: a bibliometric and visualization analysis.

Cognitive impairment is notably prevalent among schizophrenic individuals and is acknowledged as one of the core features of the disorder. Despite the proliferation of literature on cognitive rehabilitation treatments for schizophrenia in recent years, there remains a dearth of systematic reviews and selections of research in this area. From a bibliometric perspective, this study aims to analyze and discuss the current state, developmental trends, and potential research hotspots of cognitive rehabilitation in schizophrenia over the past two decades. The Core database of Web of Science was utilized to retrieve articles on cognitive rehabilitation in Schizophrenia that were published from 2004 to 2024. Bibliometrics was applied to perform both quantitative and qualitative analyses of authors, institutions, countries, journals, references, and keywords, leveraging tools such as CiteSpace, VOSviewer, and the R software package Bibliometrix. A total of 2,413 articles were encompassed in this study, comprising 1,774 regular articles and 373 review articles. The United States emerged as the country with the highest productivity and citation counts, engaging in academic collaborations with over 40 nations. This was followed by the United Kingdom and Spain. King's College London stood out as the leading institution in the field. However, the article with the highest average citation rate was authored by Susan R. McGurk from the Dartmouth Centre for Psychiatric Research in the United States. Schizophrenia Research proved to be the most influential journal in this domain, with its articles being cited over 10,000 times. This study provides a comprehensive review of research achievements in cognitive rehabilitation for schizophrenia spanning from 2004 to 2024, and outlines global research hotspots and trends with future projections. Currently, methods for cognitive rehabilitation in schizophrenia and neural plasticity in the brain represent the cutting-edge of research. Thesafety, efficacy, and standardization of virtual reality are poised to emerge as potential future hotspots and trends in research. Additionally, the neurobiological foundations of cognitive remediation therapy constitute an unexplored territory ripe for further investigation.

Bioactive glasses for bone tissue engineering: a bibliometric study of the top 100-most cited papers.

Using bioactive glasses (BGs) for bone reconstruction is a promising and expanding field of investigation in regenerative medicine. Therefore, the aim of this study was to assess the key features of the 100 most cited papers on BG in bone tissue engineering through bibliometric measures. A search was conducted in the Web of Science citation indexing database until October 2023. Three researchers performed study selection and data extraction. Data extraction included publication title and year, authors, number of citations and mean number of citations, institution, country and continent, study design, journal, keywords, and bioactive glasses. Citation counts were also collected in Google Scholar and Scopus databases. Graphical bibliometric networks were created using VOSviewer software. The number of citations of the 100 most cited articles ranged from 118 to 1836, with ten papers cited more than 400 times. Articles were mostly published between 2011 and 2012. Most papers, comprising 72 in vitro studies, originated from the United States (n = 22) and were published in Biomaterials (27%). Aldo Boccaccini was the most cited author (n = 17; 6332 citations). The most prolific institution was Imperial College London (n = 19; 7073 citations), followed by Missouri University (USA; n = 7; 2494 citations). "Bioactive glass" was the most frequent keyword, with 46 occurrences. Laboratory-based studies, primarily conducted in the United States, evaluating the physicochemical, osteogenic properties, and antibacterial activity of silica-based bioactive glasses such as 45S5 have been the most cited thus far.