The methodology of inventory management in the transport and logistics chain was developed based on the justification of organizational decisions, the characteristics of the inventory management system in the intermediate link of the logistics chain (regional transport and distribution center), which interacts with manufacturers, consumers and carriers of goods. The proposed method of determining the size of the insurance stock in the transport and logistics chain is an alternative to traditional methods that depend only on the time of late delivery due to the fault of the carrier. This allows not only to calculate the required size of the insurance stock in the system, but also to draw conclusions about the reliability of enterprises that supply and transport goods. Analysis of the necessary level reliability of the transport and logistics chain determines the quality of logistics service and allows taking into account the well-founded characteristics of the operation of the transport and logistics chain.The results of the study are proposed to be used in the process of optimizing the functioning of the enterprise in the market of goods sales.