This study investigates strategic approaches to mitigating risks in transportation and logistics within global supply chains, focusing on the integration of advanced technologies, flexibility, collaboration, and sustainability. By employing the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the study systematically reviews 37 key articles to provide a comprehensive understanding of modern risk management practices. The findings reveal the increasing reliance on technologies such as predictive analytics, the Internet of Things (IoT), and blockchain for enhancing visibility, monitoring, and decision-making. Flexibility in logistics networks, including alternative sourcing and diversified transportation routes, emerged as crucial for mitigating disruptions, while collaboration among supply chain partners, particularly through real-time information sharing, significantly reduces risk exposure. Additionally, the study highlights the growing integration of sustainability into risk management, addressing climate change and environmental risks. This research underscores the need for proactive, adaptable, and sustainable risk management strategies to maintain supply chain resilience in the face of evolving global challenges.