Local Women Research Articles

Overall survival differences between women and men with leiomyosarcomas.

e17562 Background: Leiomyosarcomas (LMS) are one of the most frequently occurring subtypes of soft tissue sarcomas and are associated with poor prognosis and high risk of recurrence even in the early stages of the disease. Primary management involves surgical excision followed by chemotherapy for all stages. We sought to determine the prognostic factors on associated with leiomyosarcoma survival. Methods: The National Cancer Database from 2004-2016 was utilized to obtain demographics, tumor characteristics and treatment factors of LMS. LMS was divided into three groups for analysis- women with uterine LMS, women with ex-uterine LMS and men with LMS. Univariate and backward stepwise multivariate logistic regression models were used to determine prognostic factors associated with long-term survival in each group. Kaplan-Meier method with log rank test was used to compare overall survival (OS) rates among the three groups. Results: A total of 23194 patients were identified. Only 18.7% of men with LMS utilized chemotherapy as compared to 47.4% women with uterine and 25.0% with ex-uterine LMS. Both men and women had comparable palliative care use- 3.9% in women with uterine LMS, 3.5% in women with ex-uterine LMS and 3.0% in men with LMS. There were statistically significant differences (P=0.000) between overall survival among the three groups. Median OS was highest among men with LMS (72m) followed by women with ex-uterine LMS (57.2m) and women with uterine LMS (36.7 m). On multivariate analysis, in women with uterine LMS, increasing age (OR =0.95, P=0.018), presence of lymphovascular invasion (OR=0.25, P=0.000) were associated with decrease in the likelihood of survival. In women with ex-uterine LMS, increasing age (OR=0.97, P=0.000), increasing stage (I-IV) (OR=0.56, P=0.000), presence of tumor (OR=0.39, P=0.001), those with residual tumor and surgical margins (OR=0.87, P=0.009), and patients who received systemic therapy and surgery (OR= 0.85, P=.0016) had a reduced likelihood of survival. In men with LMS, factors such as increasing age (OR=0.96, P=0.000), increasing number of regional lymph nodes (OR=0.91, P=0.027), having had a surgical diagnostic or staging procedure (OR= 0.69, P=0.004), increasing stage (OR = 0.64, P=0.005), and residual tumor or margins (OR=-0.76, P=0.013) were associated with reduced likelihood of survival. Results also suggest that increasing year of diagnosis was associated with an increased likelihood of survival (OR=1.51; P=0.000). Conclusions: Women were found to comprise almost two third of the patient population with LMS. Men were found to have longer survival than women with LMS, despite low utilization of chemotherapy. It may be due to poor prognosis of LMS in the female reproductive organs while LMS in the extremities has better prognosis. Future prospective trials should stratify based on sex and in women location.

Mom Expo: Bridging the Gap Between Local Women and Perinatal Resources

The purpose of this project was to describe the implementation of a perinatal health fair intended to connect local women to holistic resources. Researchers used participatory strategies to develop the health fair with local women and perinatal educators. Researchers evaluated the health fair using pragmatic measures based on the (Reach, Effectiveness, Adoption, Implementation, Maintenance) framework. Forty-two attendees were reached and 23 educators hosted booths and educational sessions. Feedback indicated strong enthusiasm for future similar events. Nearly three quarters of the time spent implementing the health fair was devoted to building relationships within the community. Overall, this project provides practical and empirical information to inform the planning, implementation, and evaluation of perinatal health fairs that establish meaningful connection between local women, perinatal educators, and health researchers.

An intrauterine genomic classifier reliably delineates the location of nonviable pregnancies

To compare the intrauterine gene expression signatures of women with surgically confirmed ectopic pregnancy (ECT) and those of women with miscarriage to inform the development of a genomic classifier for the reliable delineation of pregnancy location in women with clinically nonviable pregnancies of unknown location (NV-PULs). Discovery-based prospective cohort study. Academic medical center. Women with clinically nonviable early pregnancy to include abnormal intrauterine pregnancy (AIUP), ECT, or NV-PUL. Endometrial (EM) pipelle sampling of the uterus was conducted at the time of scheduled surgery for clinically nonviable early pregnancy (dilation and curettage, manual vacuum aspiration, or laparoscopy). All pregnancy locations were surgically and/or histologically confirmed as intrauterine or ectopic. Gene expression profiles as determined by array hybridization, quantitative real-time polymerase chain reaction, and nCounter technology. Intrauterine samples were obtained by EM pipelle from 27 women undergoing surgery for a clinically nonviable early pregnancy. Comparison of array-based global gene expression signatures from women with histologically confirmed ECT versus AIUP revealed 61 differentially expressed genes from which the 5 most informative were included in the pregnancy location classifier. All 5 genes (C20orf85, LRRC46, RSPH4A, WDR49, and ZBBX) were cilia-associated and showed increased expression in pipelle samples from women with ECT relative to expression in samples from women with AIUP. The 5-gene classifier demonstrated an average area under the receiver operator characteristic curve of 0.97 for the detection of ECT. In an external test set composed of publicly available EM pipelle-based gene expression data from a study with similar ECT and AIUP cohorts (n = 19), the classifier revealed an average area under the receiver operator characteristic curve of 0.84. Consistently increased expression of cilia-associated genes in the uterine cavity of women with ECT provides a reliable molecular signal for the delineation of pregnancy location in women with clinically assessed NV-PUL. A classifier consisting of the 5 most informative cilia-associated genes demonstrated 91% (42/46) accuracy in predicting the pregnancy location.

Inequalities in Cervical Cancer Screening Uptake Between Chinese Migrant Women and Local Women: A Cross-Sectional Study

Inequalities in Cervical Cancer Screening Uptake Between Chinese Migrant Women and Local Women: A Cross-Sectional Study

Examining Care and Opposition in the Narratives of U.S. Local Women of Color Activists

Despite a long history of critical engagement in local justice movements, the efforts of U.S. Women of Color activists remain understudied. In the present study we examine the manifestations of opposition and care that Women of Color utilize in exercising and sustaining their activism as they work to build justice-oriented change in their communities. We specifically explore how oppositional consciousness and ethics of care shape the perspectives and actions of local Women of Color activists. Qualitative data were collected via oral history interviews with eight local Women of Color activists in Cincinnati, Ohio. Using thematic narrative analysis, we identified three overarching thematic phases: building awareness of inequity, conscious interdependence, and putting awareness into action. These three phases aid in understanding how the women developed their commitment to social justice activism both as individuals and in consideration of their relationships with others in the community. Furthermore, we consider theories of oppositional consciousness and ethics of care and how they manifest in each phase. We then discuss how these findings contribute to understanding the experiences and efforts of local Women of Color activists. Findings from our research suggest timely incentives for broader inclusion of underrepresented voices to better inform decision-making bodies.

Inequalities in Cervical Cancer Screening Uptake Between Chinese Migrant Women and Local Women: A Cross-Sectional Study.

Introduction:Uptake of cervical cancer screening services in Chinese migrant workers is unknown and may be lower than non-migrant workers in China.Methods:We conducted a cross-sectional study among migrant and non-migrant women aged 21-65 at 7 provinces across China and administered a questionnaire investigating knowledge and attitudes regarding cervical cancer, human papillomavirus (HPV), and HPV vaccine. We used multivariable logistic regression to evaluate odds of previous cervical cancer screening in migrant workers.Results:737 women participated in the study. Mean age was 41.9 ± 7.2 years. 50.2% of the participants were migrant workers. 27.6% of the migrant workers reported previous cervical cancer screening compared to 33.2% of local participants. 36.6% migrant workers reported awareness of HPV compared to 40.2% of local participants. In adjusted analysis migrant status was not associated with increased odds of previous cervical cancer screening (aOR = 1.11 95%CI: 0.76-1.60). High school or higher education compared to less than high school education and employer-sponsored insurance compared to uninsured were associated with increased odds of previous cervical cancer screening (aOR = 2.15 95%CI: 1.41-3.27 and aOR = 1.67 95% CI: 1.14-2.45, respectively). Having heard of HPV compared to no awareness of HPV was associated with increased odds of cervical cancer screening (aOR = 2.02 95%CI: 1.41-2.91). Awareness of HPV among migrant workers was associated with increased odds of cervical cancer screening compared to migrant and local participants without awareness (aOR = 2.82 95% CI: 1.70-4.69 and 2.97 95%CI: 1.51-5.83, respectively).Conclusions:Efforts to increase education opportunities, provide insurance, and promote HPV awareness could increase cervical cancer screening uptake in migrant women in China.

Historicising the agency of India’s reproductive subjects

ABSTRACT Research on female foeticide in India frames India’s reproductive subjects as incapable of exercising mastery over their bodies. This framing often questions Indian women’s exercise of reproductive agency within Indian patriarchy and views women as preferring sons. Such framing is problematic as it pays very little attention to India’s population control measures, which are steeped in India’s colonial history, and sets women up for tutelage, instead. In response, this essay using Foucault historicises influential theoretical approaches to population control based on three texts, originating in different historical and geographical locations, written by Thomas Malthus, Margaret Sanger and Amartya Sen. This analysis demonstrates how colonial contexts and history framed research in the past and continues doing so in the present. This study addresses the epistemological conditions of knowing female foeticide. Drawing on Butler’s notion of framing this essay argues that Indian women’s autonomy is framed both as passive − a masculinist position − and as ‘other’ − an Orientalist position. This essay also argues that this causal location of women then deflects attention from state policies which may be exacerbating such a practice and is not helping the Indian reproductive subject.

#BlackBreastsMatter: Process Evaluation of Recruitment and Engagement of Pregnant African American Women for a Social Media Intervention Study to Increase Breastfeeding.

BackgroundIn the United States, there are lower rates of breastfeeding among African American mothers, particularly those who are younger women. Recent epidemiological studies have shown a strong association of more aggressive types of breast cancer (estrogen receptor negative) among African American women, with a higher risk in African American women who did not breastfeed their children.ObjectiveThis study aims to describe the process evaluation of recruitment and educational strategies to engage pregnant African American participants for a pilot study designed to determine whether social media messaging about breast cancer risk reduction through breastfeeding may positively influence breastfeeding rates.MethodsThis pilot study is conducted in collaboration with a local Women, Infants, and Children (WIC) organization and hospital and prenatal clinics of a local health care network. To engage African American women to enroll in the study, several methods and monitoring processes were explored, including WIC electronic text-based messages sent out to all phones of current WIC recipients (referred to as e-blasts); keyword responses to texts from flyers and posters in local community-based organizations, hospitals, and prenatal clinics; keyword responses using electronic links posted in established Facebook groups; and snowball recruitment of other pregnant women by current participants through Facebook. Once enrolled, participants were randomized to 2 study conditions: (1) an intervention group receiving messages about breast cancer risk reduction and breastfeeding or (2) a control group receiving breastfeeding-only messages. Data were obtained through electronic monitoring, SurveyMonkey, qualitative responses on Facebook, focus groups, and interviews.ResultsMore than 3000 text messages were sent and received through WIC e-blasts and keyword responses from flyers. A total of 472 women were recruited through WIC e-blast, and 161 responded to flyers and contacts through the local health care network, community-based organizations, Facebook, and friend referrals. A total of 633 women were assessed for eligibility to participate in the study. A total of 288 pregnant African American women were enrolled, consented, and completed presurvey assessments (102.8% of the goal), and 22 participants attended focus groups or interviews reporting on their experiences with Facebook and the educational messages.ConclusionsThis process evaluation suggests that using electronic, smartphone apps with social media holds promise for both recruitment and conduct of health education intervention studies for pregnant African American women. Providing messaging and resources through social media to reinforce and educate women about breastfeeding and potentially provide lactation support is intriguing. Convenience (for researchers and participants) is an attribute of social media for this demographic of women and worthy of further research as an educational tool.Trial RegistrationClinicalTrials.gov NCT03680235; https://clinicaltrials.gov/ct2/show/NCT03680235

A Comparative Research on Space of Women in Prayer Place Interiors of Celestial Religions: Cases from Istanbul

Cross-cultural comparison has been used in architecture mostly to discuss the components of culture, knowledge, and value systems, yet to date there is not a specific comparative study on gendered architecture in prayer places of celestial religions, namely Judaism, Christianity, and Islam. Hence, this study aims to reveal how attendance of women in prayer places with different national, historic, religious, and cultural characteristics shaped architectural space organization and to assess potential similarities and differences of women’s section in prayer spaces of celestial religions by examining literature survey, archival and historic research, including field observations. In addition to general observations in building scale, some exemplary historic synagogues, churches, and mosques in Istanbul still in use have been chosen as case studies, and their plan typologies, as well as types and locations of women’s galleries/sections have been discussed. Cross-cultural comparison parameters were; development of women’s section in prayer places as a structured architectural space and basic architectural terminologies used to define women’s section. The major conclusion of the study is that originally women had right to worship in prayer spaces without any physical separation in all three religions, yet in time the place of women had a more defined/divided/structured character especially in Islam and Judaism. The study also indicates that while at present day, gendered architecture is still the predominant approach in Islam and in Orthodox Judaism; mix congregation in a single-unsegregated space for both sexes is more common in contemporary society of Christianity.

IoT Based Smart Security and Safety System for Women and Children

Now a days, women and children are facing various issues like sexual assaults. Such violence will definitely have huge impact on the lives of victim. It also affects their health and their psychological balance. These kinds of violence keep on increasing day by day. Even school children are kidnapped and sexually abused. We are living in a society where a nine months old girl child doesn’t have security, the child was kidnapped, raped and then murdered. On witnessing those violations against women, its impulses us to do something for women and children safety. So, in this project we have planned to propose a device which will act as a tool to provide security and ensures the safety of the women and the children. Microcontroller, GSM and GPS module are used to send notifications and current location of women to various mobile numbers in their contact. In addition, this project will also act as a safety measure which will stun the opposition for few seconds. This project will help us to rescue many women and children from those fiendish in the society.

Crafting Authenticity: Reality, Storytelling, and Female Self-Representation through Instapoetry

This article focuses on the phenomenon of instapoetry, considering the ways that this literary genre exists as a subset of other digital poetic fields. In examining this genre, I use the work of a number of instapoets, considering how this cohort create an aesthetic that is specifically built for this medium of dissemination. In a digital age, questions of identity and the ways in which we disseminate become more and more complex. In this article, I examine how instapoetry tackles issues of authenticity, particularly in light of the highly contentious nature of influencer culture and Instagram as a site that has a tendency to distort our vision of the world. In this exploration, I interrogate the tensions between these perceptions and an era of poetic expression that has been charged with favoring authenticity above poetic craft (Watts). This article examines the stories told by instapoets as well as the depiction of the self that is curated via the site. Finally, in light of all of this, I explore the potential of Instagram and instapoetry as a location for women's self-expression and self-representation in the digital age, and examine how this genre has allowed for a greater range of identities and self-expressions to be reflected.

Taiwan's Intersectional Cosmopolitanism: Local Women in Their Communities

Author(s): Brown, Melissa J. | Abstract: Women’s shifting positions in common public space have contributed significantly to the historical ebb and flow of Taiwan’s cosmopolitanism. The importance of Austronesian and Bendi 本地 contributions to Taiwan’s history are widely accepted, but women’s roles in these contributions are still largely overlooked. Austronesian women facilitated the sociality across diversity that made Taiwan cosmopolitan under seventeenth-century Dutch colonialism. But cosmopolitanism is a fragile social niche, and it waned under Qing settler colonialism. Taiwan’s post-1860 forced reentry into global trade—with a woman-processed product, tea, as its top export—again expanded cosmopolitanism under late Qing and early Japanese rule, also expanding Bendi women’s quotidian public engagements. Recovery from a long, war-related, mid-twentieth-century nadir occurred via economic development that was driven by global trade and relied particularly on Bendi women’s labor. Historical intersectionality has repeatedly enabled social linkages for burgeoning cosmopolitanism in Taiwan. Keywords: Taiwan, cosmopolitanism, gender, indigeneity, public sphere, Austronesian, Bendi, ethnic intermarriage, global trade, historical contingency

Abstract 15: Public Access Defibrillators: Sex-Based Inequities in Access and Application

Introduction: It is unclear if the benefits of public access defibrillator (PAD) programs are similar between men and women. We investigated the location of out-of-hospital cardiac arrests (OHCA) stratified by sex to determine what proportion was eligible for PAD application. Second, we sought to determine if patient sex was associated with PAD utilization. Methods: We analyzed prospectively collected data from the North American Resuscitation Outcomes Consortium (ROC) Epistry dataset (2011 - 2015), excluding emergency medical services (EMS)-witnessed cases, those not treated by EMS, and children aged less than 10. We compared sex-based differences in public vs private location, and location type (street or highway, public building, place of recreation, industrial place, home residence, farm or ranch, healthcare facility, residential institution, other public property, or other private location). Among public location OHCAs with bystander interventions, we fit an adjusted logistic regression model to estimate the association between sex and PAD application. Results: Among the 61,473 cases, 20,933 (34%) were female, 30,353 had resuscitation attempted by bystander, and 13,597 had initial shockable rhythms. The OHCA incidence in a public location for women and men was 8.8% and 18%, respectively (95% CI for difference 8.7 - 9.7). Women had a significantly lower proportion of OHCAs on the street/highway, in public buildings, places of recreation, and farms, but a significantly higher proportion in the home, healthcare facilities, and residential institutions. Among public location OHCAs with bystander interventions, female sex was associated with a lower odds of bystander PAD application (adjusted OR 0.83, 95% CI 0.70-0.99). Conclusion: Women had fewer OHCAs in public locations eligible for PAD application. Further, among public OHCAs with bystander interventions, women were less likely to have PADs applied.

THE EFFECT AND POWER OF DISCOURSE: A CASE STUDY OF A METAPHOR IN HOSEA

At the core of this article are two questions. Where do metaphors come from? What do metaphors do? As the article will demonstrate these are not idle questions, but questions that matter. The article presents a literary and sociological analysis of women in Hosea, with particular reference to Hosea 1-3. The first section examines the marriage-harlotry metaphor in two parts. The first part of this examination focuses on three analyses of the marriage-harlotry metaphor by feminist biblical scholars. The second part of the examination concentrates on the nature of metaphor. This discussion leads into the second section in which I explore the relationship between language and life, particularly the life of women in Israel. The third and concluding section reflects on the relationship between language and the sociological location of women in the biblical text and our own South African context. The power of metaphor in the biblical text and our context challenges us to discourse carefully and critically concerning all metaphors, but particularly those metaphors in which women are not only the vehicles but also the victims.

Adherence to the World Cancer Research Fund/American Institute for Cancer Research 2018 Recommendations for Cancer Prevention and Risk of Colorectal Cancer.

The World Cancer Research Fund/American Institute for Cancer Research (WCRF/AICR) 2018 diet, nutrition, and physical activity recommendations aim to reduce cancer risk. We examined adherence to the WCRF/AICR recommendations and colorectal cancer risk in two prospective cohorts. We followed 68,977 women in the Nurses' Health Study and 45,442 men in the Health Professionals Follow-up Study from 1986 until 2012. We created cumulatively averaged WCRF/AICR scores using updated diet, adiposity, and physical activity data from questionnaires, and used Cox regression to estimate sex-specific HRs and 95% confidence intervals (CI) for incident colorectal cancer. We documented 2,449 colorectal cancer cases. Men in the highest quintile of the WCRF/AICR lifestyle score had a lower risk of colorectal cancer compared with those in the lowest quintile (HRQ5vsQ1 = 0.64; 95% CI, 0.52-0.77). The result was weaker in women (HRQ5vsQ1 = 0.86; 95% CI, 0.72-1.02; P heterogeneity by sex = 0.006). When analyzing the diet recommendations alone, we similarly observed stronger inverse associations in men (HRQ5vsQ1 = 0.74; 95% CI, 0.61-0.90) compared with women (HRQ5vsQ1 = 0.93; 95% CI, 0.77-1.12; P heterogeneity by sex = 0.06). In men, the lifestyle score was more strongly inversely associated with risk of distal colon cancer compared with proximal colon or rectal cancer (P common effects = 0.03); we did not observe significant differences between anatomic locations in women. The 2018 WCRF/AICR cancer prevention recommendations are associated with lower colorectal cancer risk in men, with weaker results in women. Consideration of adiposity and physical activity in conjunction with diet is important for colorectal cancer prevention.

“Being a Good Daughter of the Party”?

Like other socialist institutions surviving in China’s market reforms, the All-China Women’s Federation (ACWF or WF when referring to its local branches), as the only state-sponsored organisation representing women’s interests, has been constantly refashioning itself to meet new existential challenges. In July 2015, the central leadership of the Chinese Communist Party commanded a new wave of mass organisational reforms, in which the Women’s Federation’s alienation from the grassroots and a weakening representation of women’s interests were questioned. After three years of intensive reform, are the local structures of the ACWF being substantially improved to reconnect to its mass base? Drawing from extensive fieldwork in three provinces and a neo-institutional analysis, this article argues that in the short term, although the reform serves principally as a consolidation of Party authority, local Women’s Federations are creatively using the reform to expand their popular base and broaden their representativeness. In the long term, however, local WFs are facing unreformed institutional problems such as political marginalisation, bureaucratisation, and ineffective implementation, which stagnate further development of China’s state feminism.

The association between ultrasound-based ‘soft markers’ and endometriosis type/location: A prospective observational study

ObjectiveEvaluate whether symptoms and/or transvaginal ultrasound (TVS) ‘soft markers’ (ovarian immobility and/or site-specific tenderness (SST)) are associated with endometriosis type/location. Study designMulticenter prospective observational study (January 2009 to February 2013) in tertiary centers for women with chronic pelvic pain who underwent detailed history, specialized TVS, and laparoscopy. Chart findings were collated into a study database. Outcome measures included correlation between symptoms, ovarian immobility or SST on TVS and endometriosis type and/or location. The performance of ovarian immobility to predict ipsilateral SE was evaluated in terms of accuracy, sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV). ResultsA total of 189 participants were included. Ovarian immobility on TVS was significantly associated with: ipsilateral pelvic pain, uterosacral ligament (USL) and pelvic sidewall superficial endometriosis (SE), endometrioma, posterior compartment deep endometriosis (DE), pouch of Douglas (POD) obliteration, and need for bowel surgery (all p < 0.05). For women with isolated SE (i.e.no endometrioma, DE, or POD obliteration), left ovarian immobility was significantly associated with left USL SE (p = 0.01) and left adnexal SST corresponded to left pelvic sidewall SE (p = 0.03). The accuracy, sensitivity, specificity, PPV and NPV for ovarian immobility at TVS and the presence of ipsilateral pelvic sidewall SE for the left ovary was: 71%, 16%, 87%, 27% and 78%, respectively; and for the right ovary was: 82%, 7.0%, 94%, 14% and 87%, respectively. ConclusionOvarian immobility on TVS was significantly associated with ipsilateral pelvic pain, USL/pelvic sidewall SE, endometrioma, posterior compartment DE, and POD obliteration. The diagnostic accuracy of ovarian immobility for disease location in women with isolated SE showed a high specificity and NPV, but poor sensitivity and PPV, suggesting that ipsilateral pelvic sidewall SE is less likely to be present in women with a mobile ovary (in the absence of endometrioma or DE). Larger studies are required to further evaluate the usefulness of soft markers for the localization of isolated SE.

OC19.05: Evaluating cut‐off values for progesterone, single hCG and hCG ratio to define pregnancy viability and location in women with a pregnancy of unknown location (PUL)

OC19.05: Evaluating cut‐off values for progesterone, single hCG and hCG ratio to define pregnancy viability and location in women with a pregnancy of unknown location (PUL)

Women, Who Are Wise among You? Criteria to Identify and Describe Women as Sages in the New Testament and Early Christianity

ABSTRACTThe concepts of woman and sage seem to constitute an oxymoron. In classical antiquity women acted as prophetesses, oracles, seers, mediums, rulers etc., but wisdom or being wise was not readily associated with the mortal female. This mainly has to do with the way wisdom is perceived and the location of women in ancient society. There are very few examples of wise women in biblical literature. What is meant by “the wise,” or, to put it another way, who might qualify as a wise woman? There are passing references to the wise in the Old Testament, but little description is given of the wise and their actions or lives. Wisdom is not an exclusively religious function, of course, but religious figures are often referred to as wise. The wise in some form or another appear among all people at all times. Their function might differ from society to society and from culture to culture. But the question is: How are the wise defined? How do they differ from “ordinary” people? Is it intelligence, experience, intuition; training, education; their social role; or meanings and values associated with them; or something else; or a combination of many things? Do the wise belong to a certain group of people or are they individuals? The aim of this study is to identify the characteristics of the wise in biblical literature and to formulate some criteria to identify and describe women as sages in the New Testament and early Christianity.

Circadian nutritional behaviours and cancer risk: New insights from the NutriNet-santé prospective cohort study: Disclaimers.

Circadian disruption has been classified as probably carcinogenic to humans by the World Health Organization's International Agency for Research on Cancer. The circadian clock is subject to environmental factors, particularly light exposure and food intake rhythms. However, the association between nutritional circadian behaviours and cancer is not well understood. We investigated the longitudinal associations between number of eating episodes, night-time fasting duration, time of first and last eating episodes, as well as nutritional quality of last eating episode, respectively, with breast and prostate cancer risks, the two main cancer locations in women and men respectively. This prospective study included 41,389 day-working adults in the French NutriNet-Santé cohort (2009-2016) who completed at least three 24 h dietary records during the first 2years of follow-up. Multivariable Cox models were computed. 1,732 first primary incident cancer cases were diagnosed during the follow-up, among which 428 breast and 179 prostate cancers. After adjustment for covariates including sleep duration, late eaters (last eating episode after 9:30 pm) had an increased risk of breast (Hazard ratio [HR]=1.48 [1.02-2.17], p=0.03) and prostate (HR=2.20 [1.28-3.78], p=0.004) cancers. However, no association was observed between cancer risk and number of eating episodes, night-time fasting duration, time of first eating episode or macronutrient composition of the last eating episode. This large cohort study suggests that circadian perturbations resulting from late time of last food intake may be involved in carcinogenesis at different locations. Beyond nutritional quality of food intake, nutritional circadian regulation should be further investigated in the context of cancer prevention.