Coated crosstie products and counter mold components are created in 3-D model using Inventor software, preparing for CAE analysis. By using Moldflow software , to determine products gate location, filling, packing, cooling, push-out processing, as well as the injection process conditions optimization of simulation analysis to find possible defects, modify and optimize the design, determine the best processing parameters and conditions. Binding using Ansys11.0 software to analyze rail sleeper mold cavity deformation, structure stress, get distribution of property of von Mises stress and displacement vector sum, in the mold cavity on the contact surface. By changing the cavity wall thickness, and other factors to improve the force which it is subjected, providing references to structure optimization of injection mold design. It has been proven that in collaborative application of these three softwares, the design of the injection mold is a very efficient and easy.