Location Of Men Research Articles

Anatomic Distribution of Cutaneous Melanomas and Painful Sunburns in Adults

Background: Data show that intermittent painful sunburns are an important causative factor for cutaneous malignant melanoma. Objective: This study was undertaken to determine whether the differences in the anatomic distribution of melanomas in men, compared to women, could be accounted for by the distribution of sunburns and whether the high incidence of melanomas on the lower extremities of women is associated with the distribution of sunburns. Methods: One hundred and fifty nonmelanoma patients, men and women aged 20 to 60 years, recalled having painful sunburns within the previous 6 months. The locations of the sunburns were indicated on body surface diagrams. The locations of 1168 melanomas as recorded in the NYU-Melanoma Cooperative Group data base were plotted on anatomic diagrams. The anatomic distribution of melanomas and of sunburns for men and women were compared. Results: There was no statistically significant difference in the distribution of sunburns on any anatomic location in men as compared to women. However, there was a disproportionately high number of melanomas on the backs of men and on the legs of women. In both men and women, there was a significant difference between the anatomic distribution of painful sunburns and melanomas. Conclusion: Since the anatomic distribution of painful sunburns is similar in men and women, whereas the anatomic distribution of melanomas differ, it would appear that factors in addition to sunburns in adults account for the differences in the anatomic distribution of melanomas in men and women.

Comments on Gallie

Duncan Gallie's paper returns to a subject which has been at the centre of David Lockwood's work: the extent to which there has occurred convergence in class position between lower white-collar workers and manual workers. After a briefreview of work on the impact of (rigid) automation on the work and class situation of workers during the 1950s and 60s, Gallie systematically addresses the claims of both the proletarianization and embourgeoisement theses in the context of a radically changed technological environment. Gallie employs the Goldthorpe class schema and follows Lockwood's theoretical approach, developed in the Btacksoated Worker study, of conceiving class position in terms of market and work situation. To measure the two, he develops indicators of market and work situation which follow Lockwood quite closely. Gallie uses data from a recent large-scale suivey on the association of aspects of work and market situation with new technology to test some of the central claims of both the proletarianization and the proletarianization thesis. The paper analyses the work situation of both types of workers by assessing the following aspects: trends in skill development; control over the work task; and relations with superiors. Assessment of market situation covers the components of income, payment systems, promotion chances and job security. Apart from the theoretical concerns shared with David Lockwood, Gallie's approach differs from that of Lockwood in a number of respects. In substantive terms, the inteivening thirty-eight years have demanded a stronger focus on technology as a decisive influence on both market and work situation, as well as a consideration of the different location of men and women with respect to many aspects of their work and market situation. The difference in research method is equally marked. Lockwood's qualitative study consulted a wide range of secondary sources and was able to study both the content and the context of clerical work in great depth, giving due weight to the considerable diversity between different groups of clerical workers. Whereas for Lockwood technology was only one variable among others, in Gallie's work it becomes the central variable, and environmental influences like degree of bureaucratization, size of work group and competitive position of employing organizations remain unconsidered. Even the notion of management policy, which is crucial to Gallie's definition of the effect of new technology and which has been found to be a

Morphologic and clinical study of the retinal circulation in the miniature pig. A: Morphology of the retinal microvasculature

The microvasculature of the retina was studied in 20 miniature pigs by means of vascular corrosion casts and semithin histological sections. These techniques provided information useful for a better understanding of retinal fluoangiography. Various characteristics of the porcine retinal vessels, which are similar in the human retinal vasculature, were demonstrated in this study: the holangiotic retina, the trilaminar organization of the retinal capillaries and the presence of particular avascular zones, radial peridiscal capillaries and initial annular constrictions of certain arteriolar side-branches. The intrinsic retinal vasculature also shows some dissimilarities between both species. The major retinal blood vessels of the pig lie very superficially in the nerve fibre layer, in contrast to their deeper location in man. The streak-shaped macular area of the pig contains no major vessels but, unlike the central fovea in the human eye, it is not completely avascular. Another interesting finding is the presence of a large anterior border venule in the porcine retina.

Assignment of human tryptophan hydroxylase locus to chromosome 11: gene duplication and translocation in evolution of aromatic amino acid hydroxylases.

A cDNA clone for rabbit tryptophan hydroxylase was used as a probe to identify human tryptophan hydroxylase gene fragments in a panel of hamster-human somatic cell hybrids and determine its chromosomal location in man. A single locus was identified for tryptophan hydroxylase on chromosome 11. Tryptophan hydroxylase is a member of the superfamily of pterin-dependent aromatic amino acid hydroxylases which includes tyrosine hydroxylase, located at 11p15.5-p15, and phenylalanine hydroxylase, located at 12q22-q24.1 in human. The locations of these genes and the evolutionary distance between their sequences suggest that at least three distinct genetic events have occurred during the evolution of the aromatic amino acid hydroxylase superfamily: two sequential gene duplications giving rise to the three distinct hydroxylase loci, and a translocation which separated the tryptophan and tyrosine hydroxylase loci on chromosome 11 from the phenylalanine hydroxylase locus on chromosome 12.

A study of intermediate lobe differentiation in the human pituitary gland.

The immunohistochemical demonstration of neurofilament (NF) polypeptide was used to identify nerves in a series of 17 pituitary adenomas. NF-positive fibres were present in two out of five corticotroph adenomas sited deep in the anterior lobe, in one out of five sited in the intermediate zone and in two out of seven non-corticotroph adenomas. Such nerve fibres were often seen in relation to blood vessels. The distribution of alpha-MSH immunoreactive cells was examined in 25 normal pituitaries and in 23 cases of Cushing's disease. Such cells were scattered throughout the normal gland and there was no increase in numbers in pregnancy. alpha-MSH was demonstrated in 18 corticotroph adenomas in Cushing's disease. There was no correlation with the site of the tumour or the presence of nerve fibres. alpha-MSH cells were distributed normally in the para-adenomatous gland. Crooke's hyaline change and alpha-MSH coexisted in some corticotrophs. These findings support the concept that 'intermediate lobe' function, as found in animals, has no discrete anatomical location in man.

Mapping of human X-linked hypophosphataemic rickets by multilocus linkage analysis.

Eleven families with X-linked dominant hypophosphataemic rickets (HPDR) have been typed for a series of X chromosome markers. Linkage with probe 99.6 (DXS41) was demonstrated with a peak lod score of 4.82 at 10% recombination. Multilocus linkage analysis showed that HPDR maps distal to 99.6; this probe has previously been located at Xp22.31-p21.3 by in situ hybridisation. In the mouse hypophosphataemia (Hyp) maps to the distal part of the X chromosome; our location in man is consistent with a scheme which relates the mouse and human X chromosomes by two rearrangements. No marker has yet been found which shows no recombination with HPDR.

The location of descending fibres to sympathetic neurons supplying the eye and sudomotor neurons supplying the head and neck.

Evidence is given of the location in man of the fibres going to the sympathetic neurons of the lateral horn that supply the intrinsic and extrinsic muscles of the eye and the sweat glands of the head and neck. For the region of the pons and medulla, the evidence is abstracted from the literature. For the cervical spinal cord, the evidence is from our cases of anterolateral cordotomy. In the medulla, thrombosis of the artery of the fossette latérale destroys the fibres; this locates the fibres in the posterolateral retro-olivary area. But not all fibres to the sudomotor neurons lie there: some run elsewhere, though they probably remain ipsilateral. In the cervical cord, the fibres supplying the sympathetic neurons of the intrinsic and extrinsic muscles of the eye run near the posterior angle of the anterior horn. Most of the fibres supplying the sudomotor neurons lie in the same region, though some lie outside this area but on the same side of the cord.