Localized Necking Research Articles

Cutaneous ultrasound of the nuchal-type fibroma: diagnostic clues and surgery planning.

Nuchal-type fibroma is a rare, benign tumour, arising from the connective tissue and characterized by their usual location in the posterior neck, although extra-nuchal locations may also occur. The excision of nuchal-type fibroma is curative, although it presents as a large poorly circumscribed lesion in the dermal and subcutaneous fat layer, with adipose tissue and muscle fascicles entrapment, what can lead to partial excisions and relapses. Due to its rarity, little is known about the sonographic appearances of nuchal-type fibroma. An early identification and correct extension evaluation is essential to facilitate adequate treatment. Through two clinical cases, we illustrate in this article the utility of cutaneous ultrasound in the early diagnosis of these tumours, highlighting its role in the diagnosis but also in the pre-surgical evaluation improving margins assessment and delimitation.

Tumor-Infiltrating Mast Cells in Angiosarcoma Correlate With Immuno-Oncology Pathways and Adverse Clinical Outcomes

Recent studies have described several molecular subtypes and deregulation of immuno-oncologic signaling pathways in angiosarcoma. Interestingly, mast cells were enriched in subsets of angiosarcoma, although their significance remains unknown. In this study, we aim to verify this observation using immunohistochemistry (H scores) and NanoString transcriptomic profiling and explore the association between mast cells with clinical and biological features. In the study cohort (N = 60), H scores showed a significant moderate correlation with NanoString mast cell scores (r = 0.525; P < .001). Both H score and NanoString mast cell scores showed a significant positive correlation (P < .05) with head and neck location, nonepithelioid morphology, and lower tumor grade. Mast cell enrichment significantly correlated with higher NanoString regulatory T-cell scores (H score, r = 0.32; P = .01; NanoString mast cell score, r = 0.27; P = .04). NanoString mast cell scores positively correlated with signaling pathways relating to antigen presentation (r = 0.264; P = .0414) and negatively correlated with apoptosis (r = −0.366; P = .0040), DNA damage repair (r = −0.348; P = .0064), and cell proliferation (r = −0.542; P < .001). Interestingly, in the metastatic setting, patients with mast cell–enriched angiosarcoma showed poorer progression-free survival (median, 0.2 vs 0.4 years; hazard ratio = 3.05; P = .0489) along with a trend toward worse overall survival (median, 0.2 vs 0.6 years; hazard ratio, 2.86; P = .0574) compared with patients with mast cell–poor angiosarcoma. In conclusion, we demonstrated the presence of mast cells in human angiosarcoma and provided initial evidence of their potential clinical and biological significance. Future research will be required to elucidate their specific roles and mechanisms, which may uncover novel avenues for therapeutic intervention.

Evaluation of the knowledges skin cancers amongst patients attending the dental unit of a tertiary hospital in Cameroon

Head and neck locations are the site of predilection for skin cancers. This is mainly due to the photoexposition of these areas and is made more important in our equatorial setting with high sunlight exposure, rising trend of skin bleaching and higher percentages of albinism. Hence, we sought to evaluate the knowledges of patients visiting at the dental service of a tertiary hospital on these skin cancers.We conducted a descriptive cross-sectional at the dental unit of the Garoua Regional Hospital over a period of one month. We included in our study all patients attending the dental unit willing to voluntarily take part in this survey and those not willing to voluntarily take part in this survey were excluded from our study. We carried out a consecutive sampling.We retained 69 participants with a mean age of 30 [24.0–38.0] years and a sex ratio of 0.71.52.3 % of our participants had heard about skin cancer before, with 4.6 % having seen a patient with skin cancer, all of whom were family members.Regarding sunlight exposure, 56.9 % of our participants thought UV exposure can increase the risk of skin cancer, 29.2 % thought body areas exposed to sunlight were more at risk of having skin cancer.Even though 90.8 % thought these cancers were dangerous,50.8 % thought it could be treated only 1.5 % knew any means of treatment.Our findings show that compared to other population-based studies the knowledge level on skin cancers is lower.

B-ultrasound or CT-guided 3D-printing individualized non-coplanar template brachytherapy for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.

It is worth to explore a more effective treatment method to minimize the damage for patients during the treatment process. To explore the method, feasibility and efficacy of B-ultrasound or computed tomography (CT)-guided 3D printing individualized non-coplanar template brachytherapy in the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma. Ten patients with locally uncontrolled recurrent head and neck squamous cell carcinoma who were treated in our department from August 2021 to February 2023 were collected and treated by 3D printing individualized non-coplanar template brachytherapy under the guidance of B-ultrasound or CT, using the 192Ir high-dose rate afterloading treatment machine of NUCLETRON Technologies GmbH. The radiation source was 192Ir, with a diameter of 0.5 mm, a length of 3.5 mm, a total dose of 10-24 Gy, 5-8 Gy/time, once a week. According to the efficacy evaluation criteria, CT scan was performed after 1-6 months, followed up for 24 months, including CR 40% (4/10), PR 50% (5/10), NC 10% (5/10), PD 0 (0). The total effective rate of CR + PR was 90% (9/10), the 6-month local control rate was 90%, the 12-month local control rate was 80%, the 18-month local control rate was 70%, and the 24-month local control rate was 70%. The overall survival rate at 24 months was 100%. Safe and effective interpolation is used to guide the 3D printing of a single non-coplanar template with B-ultrasound or CT in the radiotherapy of local and uncontrolled recurrent head and neck squamous cell carcinoma. According to the guidance of B-ultrasound or CT, the 3D printing individualized non-coplanar template has an obvious healing effect especially in the brachytherapy, and can also protect the functional organs well, with less side effects and fewer complications. Therefore, this method is the most effective for the treatment of locally uncontrolled recurrent head and neck squamous cell carcinoma.

Stress distribution evaluation at localized necking area using the virtual fields method with digital image correlation

Stress distribution evaluation at localized necking area using the virtual fields method with digital image correlation

A novel mechanical attachment for biaxial tensile test: Application to formability evaluation for DP590 at different temperatures

A novel mechanical attachment for conducting in-plane biaxial tensile test is provided in this paper. In this attachment, the conversion of force from an external actuator into two pairs of orthogonal forces is achieved by specially designed trapezoidal blocks. By using trapezoidal blocks with different inclination angles, biaxial tensile tests of six different tensile ratios can be performed. A heating device is designed for the attachment to conduct thermal biaxial tensile tests. The heating device adopts a combination of the induction heating technology and the conduction heating method. With the developed mechanical attachment and the heating device, the forming limit curves (FLC) of DP590 sheets at ambient temperature, 300 °C, 400 °C and 500 °C are determined using biaxial tensile tests. A classical Nakazima test procedure at ambient temperature is carried out to establish a reference FLC for the material, and the reference FLC is further used to evaluate the results from biaxial tensile tests. Furthermore, an anisotropic GTN model based on Yld2000-3d yield criterion is calibrated by inverse identification procedures and applied to predict the localized necking and fracture for DP590 sheets under biaxial tensions.

Enhancing grain refinement and mechanical properties of AA1100/MgAZ31/AA1100 composites by using different roll bonding techniques

This paper examines the microstructure and mechanical properties of AA1100/Mg AZ31/AA1100 composites processed by conventional accumulative roll bonding (ARB) and cross accumulative roll bonding (CARB) methods. Based on the results, with an increase in deformation strain, Mg layers gradually lose their continuity in the form of localized necking and fragmentation. However, changing the strain path and pre-annealing the initial sheets could retard and homogenize the plastic instabilities. According to the results of electron back-scattering diffraction (EBSD), applying severe plastic deformation led to refined-grain structures with equiaxed grains. The finer grains were obtained in composites processed by the CARB method following the pre-annealing treatment. Employing this procedure also intensified the basal-type texture and circled its shape. The strong basal texture and grain refinement led to the highest Mg alloy and Al hardness values of 99 and 64 HV, respectively. Furthermore, changing the strain path and pre-annealing treatment increased the elongation by 46% in the seventh pass compared to ARBed samples. Also, this procedure increased the ultimate strength from 375 to 391 MPa and gave rise to yield strength from 164 to 176 MPa.

Histological predictors of outcome for cutaneous squamous cell carcinoma in renal transplant patients: A case-control study

BackgroundCutaneous squamous cell carcinoma (cSCC) is a significant cause of morbidity for immunosuppressed patients such as organ transplant recipients, however histological parameters which predict the likelihood of tumor progression are typically based on general population studies in which immunosuppressed patients represent only a small fraction of cases. ObjectivesTo determine the histological parameters which have independent prognostic value for cSCC arising in renal transplant recipients. MethodsCase-control study incorporating a retrospective blinded histological review of 70 archived specimens of cSCC diagnosed in renal transplant recipients, comprising 10 cases where the tumor had progressed and 60 controls. ResultsProgression was significantly associated with head and neck location, size, depth, poor histological grade, perineural invasion (including small calibre perineural invasion), lymphovascular invasion and a desmoplastic growth pattern. LimitationsThe retrospective nature and the low number of cases compared to controls. ConclusionIn immunosuppressed patients both small calibre perineural invasion and a desmoplastic growth pattern may also have prognostic significance in addition to other histological parameters already recognised in formal staging schemes.

Integral thermo-mechanical performance analysis of helium-cooled T-tube divertor

To verify the mechanical properties of the helium-cooled T-tube divertor, based on the thermal hydraulic optimization of the T-tube divertor, a preliminary analysis was conducted through a combination of elastic and elasto-plastic analysis.The results show that for the M-type damage mode, the T-tube divertor exhibits a small-scale plastic yielding phenomenon, but this has no effect on the overall divertor. The T-tube divertor has local necking deformation but does not fail due to immediate local fracture, and the T-tube divertor has no creep rupture. For the C-type damage mode, the plastic strain of the T-tube divertor is not accumulated under cyclic loading, but in the fatigue analysis, the life of the divertor does not meet the design standards and further optimization is needed.The conclusion shows that the optimized helium-cooled T-tube divertor has good thermo-mechanical properties, and the safety of the helium-cooled T-tube divertor unit can be guaranteed.

HPV-associated head and neck cancer is characterized by distinct profiles of CD8+ T cells and myeloid-derived suppressor cells

Patients with HPV−-localized head and neck cancer (HNC) show inferior outcomes after surgery and radiochemotherapy compared to HPV-associated cancers. The underlying mechanisms remain elusive, but differences in immune status and immune activity may be implicated. In this study, we analyzed immune profiles of CD8+ T cells and myeloid-derived suppressor cells (MDSC) in HPV+ versus HPV− disease.The overall frequency of CD8+ T cells was reduced in HNC versus healthy donors but substantially increased after curative therapy (surgery and/or radiochemotherapy). In HPV+ patients, this increase was associated with significant induction of peripheral blood CD8+/CD45RA−/CD62L− effector memory cells. The frequency of HPV-antigen-specific CD8+ cells was low even in patients with virally associated tumors and dropped to background levels after curative therapy. Pre-therapeutic counts of circulating monocytic MDSC, but not PMN-MDSC, were increased in patients with HPV− disease. This increase was accompanied by reduced fractions of terminally differentiated CD8+ effector cells. HPV− tumors showed reduced infiltrates of CD8+ and CD45RO+ immune cells compared with HPV+ tumors. Importantly, frequencies of tumor tissue-infiltrating PMN-MDSC were increased, while percentages of Granzyme B+ and Ki-67+ CD8 T cells were reduced in patients with HPV− disease.We report differences in frequencies and relative ratios of MDSC and effector T cells in HPV− HNC compared with more immunogenic HPV-associated disease. Our data provide new insight into the immunological profiles of these two tumor entities and may be utilized for more tailored immunotherapeutic approaches in the future.

An extended M-K model under surface traction with adjustable gradient distribution

The forming limit of sheets usually corresponds to the strain accumulation before localized necking and is closely related to the loading state. In the viscous pressure forming (VPF) method, the surface traction generated by the force-transmitting medium with high-viscosity fluid-flow characteristics on the sheet exhibits the obvious gradient distribution near the necking region. However, existing necking instability theories have not factored in the surface traction gradient distribution (STGD) and can't accurately explain the inherent mechanism of the VPF method with this loading state to improve the forming limit. To deal with the issue, STGD-related ‘stress balance’ equations are established and an extended M-K model with STGD response under 3D stress state (STGD-3D-MK model) is proposed, based on the analysis of the adjustable STGD generated in the VPF method during the necking development. The proposed model is used to explore the influence and mechanism of the STGD on the forming limit, as well as to provide suggestions on how to achieve the full positive effect of tangential surface traction. This research demonstrates that the forming limit is sensitive to the STGD, which affects the ability of surface traction to improve the forming limit. The STGD changes the stress path of the groove, affecting the development of necking. In addition, the critical STGD that can increase the limit strain is also provided and its magnitude is related to the strain path. Finally, the VPF-based experimental results are provided to support the effectiveness of the analysis of the STGD-3D-MK model. This work provides a new perspective on the loading method to improve the forming limit.

Nasal obstruction in a 14 year old girl caused by a huge middle turbinate mucocele appearing radiologically as an inverted papilloma

Introduction: We present a case of a fourteen year old girl who presented with a large intra-nasal mass to the ENT team at a district general hospital in the UK. Presentation of case: The girl presented predominantly with nasal obstruction and some symptoms of allergic rhinitis. Imaging revealed a large lesion abutting the skull base and causing bony remodelling with marked septal deviation. Based both on CT and MRI imaging, the reporting (non-head and neck) radiologist suggested inverted papilloma as a differential diagnosis. Intra-operative exploration in fact revealed a very large left middle turbinate mucocele extending to the left frontal sinus. The mass was excised endoscopically without complications. Discussion: Although concha bullosa of the middle turbinate of the nose are common, development of a mucocele within them is far less common and for such a mucocele to develop to this size in a child is extremely rare. The egg shell lining of the lesion can be a tell-tale sign of their aetiology when taken alongside other radiological factors. This case highlights challenges in radiological diagnosis of intra-nasal masses in children, which can lead to delays and increased anxiety. Conclusion: When assessing nasal masses in children it is important to keep a wide differential due to the challenges of diagnosis. A close conversation should be had with local head and neck radiologists and, of course, where there is a unilateral nasal mass tissue sampling is essential and may be taken as part of a full excision where clinically indicated.

A Retrospective Multicenter Italian Analysis of Epidemiological, Clinical and Histopathological Features in a Sample of Patients with Acinic Cell Carcinoma of the Parotid Gland.

The acinic cell carcinoma (AciCC) of the parotid gland is a rare tumor with an indolent behavior; however, a subgroup of this tumor presents an aggressive behavior with a tendency to recur. The aim of this multicenter study was to identify and stratify those patients with AciCC at high risk of tumor recurrence. A retrospective study was carried out involving 77 patients treated with surgery between January 2000 and September 2022, in different Italian referral centers. Data about tumor characteristics and its recurrence were collected. The histological specimens and slides were independently reviewed by a senior pathologist coordinator (L.C.) and the institution's local head and neck pathologist. The patients' age average was 53.6 years, with a female prevalence in the group. The mean follow-up was 67.4 months (1-258, SD 59.39). The five-year overall survival (OS) was 83.2%. The 5-year disease-free survival (DFS) was 60% (95% CI 58.2-61.7). A high incidence of necrosis, extraglandular spread, lymphovascular invasion (LVI), atypical mitosis, and cellular pleomorphism was observed in the high-risk tumors compared to the low-risk ones. AciCC generally had an indolent behavior, optimal OS, DFS with few cervical node metastases, and rare distant relapses. This multicenter retrospective case series provides evidence of the need for clinical-epidemiological-histological stratification for patients at risk of poor outcomes. Our results suggest that the correct definition of high-risk AciCC should include tumor size, the presence of necrosis, extraglandular spread, LVI, atypical mitosis, and cellular pleomorphism.

Effects of solidification on flow dynamics: A novel comprehension of defects formation in laser penetration welding

The laser penetration welding for medium-thickness plates struggles with unstable molten pool behavior and a limited processing window, often leading to welding defects including spatters, depressions, and especially humps. In this study, forming processes of the defects were observed by using a high-speed camera, and forming mechanism of the defects were then analyzed in detail by simultaneously considering the influences of force and solidification. It was clear that the mass loss caused by spattering during the heating phase contributed to the depression, which was consistent with the existing knowledge. However, the formation mechanism of humps concluded in this study was different to the present understanding. Apart from the influences of force, the effects of solidification on molten pools and humps were analyzed. Under the specific conditions, middle part of molten pool solidified rapidly, causing localized necking, and disrupting the circular flow of the molten metal. As a result, molten metal once flowed downward due to the gravity and temperature can no longer refill to the upper part again, leading to the accumulation of molten metal at lower part and ultimately the formation of humps. These findings offered a fresh perspective on the formation of hump, provided valuable guidance for enhancing the quality and efficiency of thick-plate laser welding.

What are the “dispersive shear bands” on the surfaces of layered heterostructured materials?

Hetero-deformation-induced (HDI) strengthening mechanism has been well investigated in heterostructured materials including layered/gradient materials prepared by surface attrition or other processing techniques. While the roles played by the geometrically necessary dislocations (GNDs) and the forward/back stresses on the grain scale have been a focus in nearly all these studies, some latest works reveal the peculiar formation of “dispersive shear bands” or strain localizations on the surfaces of layered/gradient materials. Feature sizes of these “shear bands” are commensurate with the macroscopic sample size, but not on the microstructural length scales, thus excluding the HDI strengthening as the primary mechanism. In this work, using a sandwich structure as an illustrative example, we demonstrate that the origin of these shear bands be localized necking with intermediate wavelengths and inclined orientations, which are critically dictated by the hardening behavior of the constituent layers, the geometric parameters, and the initial morphological perturbations. The layered structure under tension may not neck with an infinite wavelength (i.e., the Considère mode), but neck at intermediate wavelengths which actually correspond to a much larger uniform ductility than the commonly observed Considère necking mode. The arrangements of these shear bands can be further classified as I, X, and W types. Findings in this work not only resolve the origin of recent unusual experimental observations, but also suggest an alternative way of understanding and improving the ductility in heterostructured materials.

Towards ultra-high strength dual-phase steel with excellent damage tolerance: The effect of martensite volume fraction

Ultra-high strength (> 1 GPa) dual-phase (DP) steels have been extensively investigated in literature. Yet, the damage tolerance of these DP steels remains mostly unexplored, whereas this parameter is crucial for the sheet formability and anti-crushing performance. In this work, a medium-Mn DP steel was proposed in order to develop strong but damage-resistant DP steel by refining the microstructure. Ultra-fine grained (< 1 µm) DP steels were obtained by a simple cold rolling and intercritical annealing process. The developed DP steel can achieve an outstanding ultimate tensile strength (UTS) of over 1470 MPa with appreciable elongation to failure (EtF) of over 9 % when the martensite volume fraction (Vm) is 55 %. Higher Vm results in higher strength. However, the fracture strain, which is connected with damage tolerance, decreases significantly with increasing Vm, and it is even much lower than that of a full-martensite steel. Furthermore, the necking behaviour transfers from diffuse plus localized necking to diffuse necking with increasing Vm. The sufficient ferrite content in the proposed DP1470 steel enables void growth after nucleation, consequently leading to the occurrence of localized necking and higher fracture strain. Thus, a moderate Vm ranging from 45 % to 65 % is suggested for the development of a 1470 MPa grade DP steel with excellent damage tolerance.

Analysis of the Temperature Evolution at Necking during Tensile Deformation of H240LA Steel Sheets

The study of localized necking based on strain analysis using Digital Image Correlation (DIC) is the most widely used technique in sheet metal forming to study the FLD (Forming Limit Diagram). However, due to the heat generated by plastic deformation during the forming operations, another way is to analyze the temperature field of the specimen during the test by using Digital Infrared Thermography (DIT). A series of Nakazima tensile tests of high-strength low-alloy steel were tested using DIC and DIT synchronized systems. In this study, a thermomechanical numerical model was developed in ABAQUS/Standard in order to study the energy balance between the different effects of heat generation by plastic deformation, and transient conductive and convective heat transfers through the sample and to the environment. Analysis of the predicted energy balance during the tests allowed to understand the temperature evolution observed both at the beginning and at the development of the unstable necking until fracture. The numerical results are consistent with the analysis obtained from experimental temperature field, making feasible the use of DIT systems to study new necking detection criteria.

On the critical role of martensite hardening behavior in the paradox of local and global ductility in dual-phase steels

The ductility of sheet metal is typically limited by either localized necking or by damage and fracture. A recent ductility classification refers to these failure modes respectively as “global” and “local” formability. The forming limit curve (FLC) and the uniaxial tensile test assess global formability, whereas the fracture forming limit (FFL), the true thickness fracture strain, hole expansion ratios (HER), etc. are indicators of local formability. Experimental hole expansion data in the literature for different dual-phase (DP) steel grades of similar strength and composition presents a paradox: grades which are found to be ductile in a tensile test and/or FLC show a low ductility in hole expansion, whereas other grades with a low ductility in conventional tests perform surprisingly well at cut edges. In this work, an in-depth systematic statistical analysis of idealized artificial two-phase microstructures is carried out to unravel the underlying mechanisms of the observed paradoxical trends. This is done by scaling the hardness of martensite and its volume fraction to generate virtual DP steels of the same strength but different strain hardening and mechanical phase contrast (hardness difference). The proposed micromechanical model adequately reproduces the experimentally observed trends. The results show that in DP steels, a higher global (necking-driven) ductility is obtained upon delaying martensite plasticity by increasing the mechanical contrast of the two phases. Consequently, the stress–strain distributions becomes more heterogeneous, resulting in a lower fracture limit of one of the phases or interfaces in shear loading, thereby, reducing the local ductility. Global ductility is improved by higher mechanical phase contrast and lower martensite volume fraction, whereas local ductility is improved by low phase contrast and higher martensite volume fraction. The hardening behavior of martensite is the key to avoiding the above trade-off between local and global ductility. It is shown that if the strain hardening capacity of martensite in the later stages of deformation (in high strains) can be increased, this would result in removing the observed paradoxical trends of local and global ductility in DP steels.

Superiority of BNCT Treatment Planning Metrics Achieved Using Novel vs. Reference (BPA-F) Pharmaceuticals in Head and Neck Locations

Several novel boron delivery compounds currently under investigation by our group have demonstrated formulation, biodistribution, and dose response benefits in small animal models [1]. In this study we analyze the potential clinical impact of these compounds for boron neutron capture therapy (BNCT) in human patients. Pharmacokinetic models were used to estimate the tumor and normal tissue boron concentrations after continuous infusion of the novel compounds and BPA-F. Patient model segmentation, material assignment, and alignment of one or more treatment beams were exported from a commercial treatment planning system (TPS) to a novel dose calculation tool. This information was used to generate a voxelized model that incorporated the source, beam shaping assembly, collimator, and patient materials so that the full albedo effect was included in each dose calculation. Physical dose from 10B(n,α), 14N(n,p), 1H(n,n') interactions plus gamma rays from 1H(n,γ) and other reactions within the patient and treatment equipment were calculated by Monte Carlo transport of particles originating in a pre-generated phase space at the cover surface. RBE and CBE weighting factors are applied to combine these four physical dose volumes into an equivalent dose volume, and these five dose volumes were passed back to the TPS for evaluation. Tumor dose was increased by up to 2.6x for the novel compounds while normal tissue doses were constant or slightly reduced in comparison to BPA-F plans. Alternatively, for identical tumor dose the normal tissue doses and treatment time were reduced by up to 2.6x. In addition, in some cases it was possible to generate a single beam treatment plan using the new compounds that delivered higher tumor dose and lower normal tissues doses than a multiple beam plan using BPA-F. This study demonstrates both dosimetric and practical benefits of the new compounds in comparison to BPA-F, including the potential to deliver treatment using fewer beam directions and correspondingly easier treatment setups and higher patient throughput. The potential of these compounds to extend the range of clinical indications for BNCT is also discussed. These results motivate upcoming experimental testing of the key assumptions involved in their calculation.

Modeling and tests on the damage and fracture behaviors of non-irradiated zirconium alloys with different hydrogen concentrations at RT and 350°C

Zirconium alloys are widely used as the materials of nuclear cladding tubes or some other structural components. The chemical reaction of zirconium with coolant water leads to hydrogen pickup during reactor exposure, degrading the mechanical properties of zirconium alloy tubes. In this study, the load-displacement curves and fracture morphologies of ring-typed un-irradiated zirconium alloy specimens with various hydrogen contents are obtained at RT and 350 °C by circumferential tensile tests. An efficient modeling strategy for the damage and fracture behaviors of hydrided zirconium alloy specimens is proposed and numerically implemented, reproducing the local necking, damage initiation and evolution, crack propagation and ultimate fracture of the specimens. The predictions of load-displacement curves for different hydrided specimens agree well with the experimental data, and the fracture morphologies are also captured. The combinations of experimental tests and numerical simulation herein successfully identify the mechanical constitutive models of hydrided zirconium alloy materials, well describing their hydrogen-concentration related characteristics of strain hardening, softening and collapsing rupture. In the considered mean hydrogen concentrations less than 800 ppm, the hydride-induced hardening and embrittlement are predicted to appear dominantly at room temperature (RT); these effects are negligible at 350 °C, resulting from the greatly improved ductility of hydrides and zirconium alloy matrix at high temperatures. This work lays a foundation for simulation of the failure behaviors of hydrided zirconium alloy tubes.