Alopecia Research Articles

A Comprehensive Review of "Herbal Hair Oil: A Natural Remedy for Hair Loss and Scalp Health"

Hair loss is a common condition affecting individuals of all ages and genders, often resulting in psychological distress and reduced quality of life. Herbal hair oils have emerged as a promising alternative to synthetic treatments due to their natural composition, minimal side effects, and holistic benefits. This study explores the formulation and efficacy of herbal hair oil enriched with traditional medicinal plants known for their hair-nourishing properties. Key ingredients, such as Bhringraj (Eclipta alba), Amla (Phyllanthus emblica), Neem (Azadirachta indica), and Coconut Oil (Cocos nucifera), are known to promote hair growth, reduce scalp inflammation, and strengthen hair follicles. The oil's mechanism of action involves nourishing the scalp, improving blood circulation, and providing antimicrobial effects to combat dandruff and other scalp infections. Preliminary clinical trials and user feedback suggest that regular application of the herbal oil significantly reduces hair fall, enhances hair density, and improves overall scalp health. This study highlights the potential of herbal hair oils as a safe and effective solution for managing hair loss, with further research warranted to optimize formulations and validate long-term outcomes.

A prospective study in the treatment of androgenic alopecia using combination of procapil, capixyl, redensyl

Background: Androgenic alopecia is characterized by its diffuse loss and the miniaturization of the hair. The study aimed to assess the safety and efficacy of procapil, redensyl, capixyl, bicapil, and anagain in topical hair growth serum in androgenic alopecia. Methods: A prospective study was conducted on 110 healthy subjects aged 18-60 with androgenic alopecia in the Department of Dermatology, Tundla, Etmadhpur. Each subject applied 1 ml of serum on a dry scalp and was followed up on the 4th, 8th, 12th, and 16th week. Mean, median, and standard deviation were calculated. A repeated measure of the ANOVA test followed by post-hoc pairwise comparison using the Bonferroni test was applied. JAMOVI® (Sydney, Australia) software, was used for the statistical analysis. Results: Seventy subjects completed the four follow-ups. Post hoc pair-wise comparison showed that each pair differed significantly, and an increased mean score was observed between the initial and follow-up assessments for the mean Anagen:Telogen (A:T) ratio and mean hair diameter [76.84 μm vs 77.77μm, 76.84μm vs 80.03 μm, 76.84 μm vs 82.33 μm; p<0.05]. A significant difference was found in hair density between baseline and 16th week [76.84 vs 84.60; p=0.002]. No adverse effects were observed. Conclusion: This study's results suggest that after 120 days of treatment with hair serum, it is safe and effective, improving the A:T ratio, hair density, and hair thickness and hence reducing hair fall.

Use of phototechnologies in the treatment of diffuse alopecia

Today, diffuse alopecia is considered a multifactorial dermatosis, in the development of which an important role is played by a genetic determinant with a polygenic inheritance system with a determining effect of provoking factors, through the action of which a predisposition to hair loss is realized. The purpose of this study is the scientific substantiation and development of a combined method including fractional laser therapy, transvenous blood irradiation and minoxidil for the treatment of patients with diffuse telogen effluvium. Based on the data obtained, it can be concluded that the greatest impact on the indicators of the microcirculation efficiency index is exerted by combined therapy with an erbium laser, transcutaneous laser blood irradiation and external use of minoxidil. In second place is an erbium laser and external use of minoxidil, in 3rd place is transcutaneous laser blood irradiation and external use of minoxidil, in 4th place is external use of minoxidil.

Congenital alopecia with multiple nodules over face in an infant

Congenital alopecia with multiple nodules over face in an infant

Mexican Mint (Coleus amboinicus) Emulgel: Natural Solution for Antidandruff Hair Care

Today, the world is developing more and more in all sectors at a faster pace. But with all these developments, people are more prone to falling ill due to factors such as pollution, unhealthy lifestyles, busy work schedules, etc. Nowadays, even children suffer from the issue of dandruff and scalp infections which in later teenage years leads to unhealthy scalp and hair fall problems. Dandruff is a common scalp condition that affects individuals of all ages. It not only causes discomfort but also undermines hair health and aesthetics. Although scalp disorders are not among those that cause severe physical illness or morbidity yet are of great social concern. Scalp and hair conditions have more of a psychological impact on societies. Even minor changes in hair like graying of hair, affects the self-confidence and self-esteem of an individual. There are many types of medications and formulations to treat hair dandruff issues, one of which includes a novel drug delivery system such as “Emulgel” in the form of a mask. The anti-dandruff hair mask offers multiple benefits, including reduction in scalp inflammation and effective management of hair dandruff problems. Furthermore, it rejuvenates the scalp and nourishes hair follicles due to its natural vitamins and nutrient content. Keywords: Dandruff, Pityriasis capitis, Seborrheic dermatitis, Mexican mint, Herbal hair mask, Hair mask

Dermal Filler-Induced Alopecia: A Case Report and Literature Review.

Dermal filler-induced alopecia is a rare yet significant complication of aesthetic procedures primarily associated with vascular occlusion and subsequent tissue ischemia. Hyaluronic acid (HA) fillers, though widely used for facial rejuvenation, can lead to adverse outcomes such as skin necrosis and hair loss, particularly in high-risk areas like the temples and glabella. This case report aims to highlight the clinical presentation, diagnostic approach, and multidisciplinary management of filler-induced alopecia, contributing to the existing literature with a comprehensive review of previously reported cases. A 21-year-old female presented with localized skin necrosis and alopecia four days after receiving 7 mL of HA filler injections in the temples, tear trough, and eyebrow glabella regions. Trichoscopy revealed follicular dropout and white dots, consistent with ischemic hair loss. Treatment included hyaluronidase injections (1500 units), intralesional corticosteroids, topical minoxidil, and CO2 laser therapy. Over 1 year of follow-up, the patient achieved complete hair regrowth and resolution of facial scarring. Only 16 cases of filler-induced alopecia have been documented, predominantly involving HA fillers. This case underscores the importance of early recognition and intervention with hyaluronidase to mitigate ischemic damage. The multidisciplinary management approach employed here demonstrates the potential for full cosmetic recovery. Filler-induced alopecia, though rare, necessitates heightened awareness among dermatologists and aesthetic practitioners. Adhering to recommended injection techniques and dosages, alongside the judicious use of ultrasound guidance, can minimize risks and improve patient safety.

Golgotha in the novel "The Master and Margarita": semantic symbol suggestion

The study aims to perform a semantic-semiotic analysis of the symbol "Golgotha" in M. A. Bulgakov’s novel "The Master and Margarita" in the light of the theory of suggestion. The symbol "Golgotha" consists of a signifier, i. e. the perceptual image of Golgotha, and a signified, namely three biblical symbolic meanings: ‘head’ (Adam’s in the Bible), ‘punishment’, and ‘absolution’. By suggestion in a literary text, we will mean the energy of semantic attraction between the signifier and the signified of a symbol. This is the impact of the writer’s persuasion on the reader (E. V. Shelestyuk) which is feasible since some linguistic units are polysemantic and include semantic overtones in the lexical meaning within a micro- or macro-context (B. A. Larin, G. O. Vinokur). The main research method employed is the superimposition of suggestion in the literary text under consideration on the semantic-semiotic structure of the "Golgotha" symbol. The study identifies three symbolic models implemented in the text with the aid of linguistic units. The main semantic tension arises between the perceptual image of Bald Mountain and the bald (balding) characters of the novel, as well as those characters whose heads also experienced something. Such suggestion is based on the foregrounding of the inner form of the word Golgotha (‘a bald skull’) and implements the symbolic model ‘Golgotha → Head’. The signifier of this model is expressed not only by the toponym Bald Mountain, the words bald (Russian lysyy, lys), bald spot (Russian lysina), bald-headed (Russian oblysevshii), balding (Russian lyseyushchii), baldpate (Russian pleshivyi), thinning (Russian zhidkii), skull (Russian cherep), head (Russian golova), but also by the names of the novel characters, i. e. the bearers of this feature. The second and third suggestion lines implement the symbolic models ‘Golgotha → Punishment, death’ and ‘Golgotha → Absolution’. Many characters in the book are punished to a greater or lesser extent, and most of them are forgiven. The signified "punishment" is represented by a thematic group of words and phrases whose lexical meaning includes the seme of punishment or death. The Bald Mountain features are symbolically transferred to the rocky platform of Pilate’s eternal imprisonment, Stravinsky’s clinic, and Woland’s globe. The signified "forgiveness" is expressed by the words forgive (Russian prostit’), forgiven (Russian proshchennyi), and mercy (Russian miloserdie).

Complex application of high-intensity phototechnologies in the treatment of diffuse alopecia

The purpose of the study. The issues of treatment of patients with diffuse alopecia are being actively investigated at the present time. Promising in this regard are laser technologies, including in combination with drugs, which determined the relevance of this study. The aim of the study was to scientifically substantiate and develop a combined method including fractional laser therapy, intravenous blood irradiation and minoxidil for the treatment of patients with diffuse telogenetic alopecia. Materials and methods. To study the effectiveness of laser technologies, 4 treatment regimens were analyzed. A total of 177 patients with an established diagnosis of diffuse telogenetic alopecia were under observation. To study the effectiveness and safety of the developed combined method, as well as its components, a visual hair loss scale (VSHVV) was used in the study. Results. The best result in patients with mild severity was obtained in the combination therapy group, where the dynamics was 36.9 %. While in the group using erbium and neodymium lasers, the dynamics was 25 %, in the group where percutaneous laser irradiation of blood was used –21.1 %, in the control group — 19.3 %. The best result in patients with severe severity was obtained in the combination therapy group, where the dynamics was 70.8 %. While in the group using erbium and neodymium lasers, the dynamics was 60.8 %, in the group using percutaneous laser irradiation of blood –57.7 %, in the control group 55.7 %. Conclusion. Thus, the developed method of combined therapy of patients with mild and severe diffuse alopecia is highly effective and can be recommended for use in a wide clinical practice.

Using high-intensity phototechnology as a method of treating mild to severe diffuse alopecia

Purpose of the study. Publications on the use of laser technologies are isolated and additional studies on representative samples and with an assessment of the stability of the effects of laser therapy are needed to confirm their effectiveness. The aim of the study was the scientific substantiation and development of a combined method including fractional laser therapy, intravenous blood irradiation and minoxidil for the treatment of patients with diffuse telogen effluvium. Material and methods: To study the effectiveness of laser technologies, 4 treatment regimens were analyzed. A total of 177 patients with an established diagnosis of diffuse telogen effluvium were observed. The work used the DIQOL index (dermatological index of quality of life), which is a universal tool for assessing quality of life indicators in various skin diseases. Results: The data obtained show that the relief of clinical symptoms in diffuse alopecia improves the psycho-emotional state and increases the quality of life of patients, which is confirmed by the improvement in the dynamics of the DIQOL index in all study groups: in the group using erbium and neodymium lasers, the dynamics were 27.2 % / 41.2 %, in the group where transcutaneous laser irradiation of blood was used — 20 % / 29.4 %, in the control group 9.1 % / 23.5 %. The best result was obtained in the combination therapy group, where the dynamics were 45.4 % and 52.9 %, with a mild and severe degree, respectively.

Scope of Ayurvedic Nasal Instillation Therapy (Nasya Karma) in Cosmetology: A Review

Cosmetics has become an important & influential part of human’s daily life in today’s world due to one’s tendency for self-care & regard as it boost their confidence and self-esteem. The increase in daily use of these various cosmetics has also garnered a lot of increased demand in pharmaceutical industry; resulting into various harmful & chemical drug practices for monetary gain also leading to lots of side effects of such cosmetics on human skin. The beauty ailments that commonly affect people are hair fall, greying of hairs, dandruff, acne, melasma, minor skin and oral disorders. These problems are not only difficult to treat but also requires a lot of expenses too. Ayurveda has mentioned various methods to tackle these problems as Ayurvedic scholars has put heavy weightage on importance of beauty; external as well as internal in both male and female and has described treatments for these ailments in ancient texts such as Nasya Karma [Ayurvedic Nasal Instillation Therapy]. Nasya is one of famous Panchakarma procedure used for management of above mention cosmetic ailments. It is a procedure in which herbal drug [oil/decoction/extract/powder] is instilled through nasal route and is highly appreciated for its therapeutic value in diseases related to Urdhava-Jatrugata [above clavicle region]. In this article, we have discussed various types and probable action of Nasya Karma [Ayurvedic Nasal Instillation Therapy] in these disorders and how this single Ayurvedic procedure can be a one stop solution for multiple beauty ailment and can be helpful in reaching the goal of enhancement of beauty with assurance of safety and prevention from any harmful effect.

Prevalence and Determinants of Hair Fall, Hair Loss and Premature Graying in Young Adults: A Cross-Sectional Study

Prevalence and Determinants of Hair Fall, Hair Loss and Premature Graying in Young Adults: A Cross-Sectional Study

Consumer survey to evaluate the effects of Mintop serum in the management of hair fall

Background: Hair fall, or alopecia, is a common concern influenced by various factors, necessitating diverse treatment. Methods: This single-group, non-comparative study enrolled 165 participants aged 18-55 years with hair fall complaints. Participants applied Mintop serum twice daily for 90 days. Assessments included hair pull tests, 1-minute comb tests, consumer questionnaires, and dermatologist evaluations at baseline, 1 month, and 3 months. Results: Of the 161 participants who completed the study, significant reductions in hair fall were observed after 1 month (p<0.001) and 3 months (p<0.001) of product use. Participants reported high satisfaction with the serum’s effectiveness in reducing hair fall (100% agreement) and stimulating new hair growth (99.4% after 1 month, 100% after 3 months). Objective measures such as the hair pull test and 1-minute comb test demonstrated substantial decreases in hair shedding across the study period. No adverse events were reported. Conclusions: Mintop Pro+ hair regrowth serum showed promising efficacy in reducing hair fall and improving hair density, strength, and overall hair health. The serum was well-tolerated without adverse effects, suggesting its potential as a safe and effective non-surgical option for managing hair loss.

Filling the Gaps: Vitamin D Status in Diffuse Hair Fall Among Pakistanis.

Hair loss can happen for various reasons, including emotional stress, physical strain, certain medical issues, and nutritional gaps. When it comes to nutrition, a lack of vitamin D3 could be linked to diffuse hair loss. The aim was to look for the frequency of vitamin D3 deficiency with diffuse hair fall, especially in the Pakistani population. A total of 120 patients of both sexes and all ages presenting to the Dermatology Clinic with complaints of non-scarring alopecia and loss of over 100 strands of hair within a 24-hour period (counted by patient) of any duration and positive hair pull test were advised to take serum vitamin D3. Tests and results were then analyzed by SPSS statistical software package (version 19.0 for Windows). The mean age of participants enrolled in the study was 28.56 ± 11.62 years. The majority of the patients, i.e., 77 (63.64%), were ≤30 years of age. Among the 120 patients, 17 were males and 103 were females. Mean serum vitamin D3 levels were 17.33 ± 5.43 ng/ml. 95 (79.17%) patients were found to be vitamin D3 deficient, with 37 patients having female pattern hair loss, seven patients with male pattern hair loss, seven patients with diffuse alopecia areata, and 44 patients with telogen effluvium. This study concluded that there is considerable frequency of vitamin D3 deficiency in individuals with diffuse hair fall. Therefore, we recommend that there should be early recognition and treatment of this condition in these particular patients in order to reduce hair fall.

Effects of High-Density Mixed Planting in Artificial Grassland on Microbial Community

The construction level of artificial grassland is an important index of the development degree of grassland animal husbandry. Therefore, improving the productivity level of artificial grassland and promoting the sustainable utilization of artificial grassland have become important tasks that need to be urgently addressed. There have been numerous studies on the effects of monoculture on the soil microbial community structure in artificial grassland, but there is limited research on the effects of mixed sowing on the soil microbial community structure and the related patterns. In this study, Elymus nutans (En), Festuca sinensis (Fs), Avena sativa (As), and Poa pratensis (Pp) were used as common herbage materials in an alpine grassland pastoral area of the eastern Tibetan Plateau. Multi-density monoculture and mixed seeding were employed to establish artificial grassland communities with varying structures. By comparing the soil microbial community structure of the differently treated artificial planting grass, degraded grassland with bald spots, and natural grassland, it was confirmed that plant community diversity significantly influences the microbial community structure. The high-density planting treatment of multiple forage grasses had a more pronounced impact on the soil microbial community structure compared to that of the high-density planting treatment of a single variety of forage grass. The soil microbial community diversity index of the four mixed-planting treatments was higher than those of the other artificial grassland treatments and the natural grassland treatments, and the soil microbial community structure was most similar to that of the natural grassland. Avena sativa planting increased the abundance of Actinobacteria and Basidiomycota and decreased the number of Acidobacteria by increasing the soil pH value. The AFP (As+Fs+Pp) treatment reduced the proportion of Mortierellomycota in the soil by decreasing the content of available phosphorus. The AEFP (As+En+Fs+Pp) treatment increased the number of Proteobacteria by raising the soil total phosphorus content and reduced the abundance of Acidobacteria by lowering the soil pH value. Additionally, a machine learning method was used to evaluate the comprehensive performance of 21 artificial grassland treatments on nine soil physical and chemical properties. It was found that the AEFP mixed-planting and high-density planting treatments had the greatest improvement effect on the nine soil physical and chemical properties, which was conducive to sustainable land use.

Exosomes for Treating Hair Loss: A Review of Clinical Studies.

The regenerative properties of exosomes make them especially appealing to treat skin and hair diseases. Preclinical studies suggest that exosomes may fuel hair growth by stimulating dermal papilla cells, activating hair follicle stem cells, and promoting angiogenesis. However, very limited data are available on the safety and efficacy of exosome use in human subjects. To review the published literature on exosome use in human subjects with a focus on safety and the challenges facing clinical implementation in the treatment of androgenetic and nonscarring alopecias. A review was conducted of PubMed, EMBASE, and Cochrane databases and included 48 studies. Twenty-five studies were clinical trials, 14 case reports, 4 case series, 1 retrospective review, and 4 conference abstracts. Nine clinical studies were found relevant to alopecia. One hundred twenty-five patients received an exosome treatment for hair loss. Side effects were rare. However, in the broader field of dermatology, at least 10 serious adverse events have been reported. Although exosomes have many promising therapeutic applications, there is demand for larger well-designed clinical trials with extended follow-up periods to prove efficacy and a need for consistent manufacturing standards and regulatory oversight to ensure product safety.

Biallelic pathogenic variants in the LSS gene cause congenital alopecia-cataract syndrome.

Biallelic variants in the LSS gene have been reported in individuals affected by alopecia-intellectual disability syndrome 4, cataract 44, hypotrichosis 14, and palmoplantar keratoderma-congenital alopecia syndrome type 2. The present report described a Chinese girl with congenital alopecia universalis, cataract, esotropia, and nystagmus caused by compound heterozygous variants of c.1025T>G (p.Ile342Ser) and previously unreported c.1011G>A (p.Pro337=) in the LSS gene. Minigene assay confirmed the synonymous variant Pro337= at the edge of exon 9 could produce a novel splice site, leading to a 46-bp insertion of the 5' sequence of the intron 9, likely resulting in a frameshift effect. We consider that the clinical manifestations of this case represent a new type of LSS-related disease, namely congenital alopecia-cataract syndrome (CACS). Our data expand the phenotypic and genetic spectrum of LSS-related diseases.

12405 A Severe Case Of Virilization Of Premenopausal Woman Secondary To A Rare Testosterone Producing Sertoli Cell Tumor

Abstract Disclosure: S. Waheed: None. N.J. Vernetti: None. S. Nakhle: None. Introduction: We present a case of a premenopausal woman with elevated testosterone who was diagnosed with an aggressive Sertoli cell tumor of the ovary. Case Description: A 49-year-old multiparous female presented to the clinic with hirsutism and markedly elevated testosterone levels. Her symptoms started a year before the presentation with diffuse alopecia, acne, and increased muscle mass. Last menstrual periods were 3 years, prior to the presentation.Denies any exposure to testosterone herself or indirectly through family. On physical exam, blood pressure 170/122 coarse features, oily skin, and muscular build. She had terminal hair loss and increased hair growth on face and arms. Laboratory data revealed testosterone levels of 9280 ng/dl (reference range premenopausal 18-55 ng/dl), free testosterone > 50 ng/dl (premenopausal0-4.2 ng/dl), LH <0.3 mIU/mL (2.4-12.6 mIU/mL), FSH <0.3 mIU/mL (3.6-12.5 mIU/mL), 17-OHP 2270 ng/dl (15-70 ng/dl), DHEA-S 71 ug/dl (<229 ug/dl), LDL 128 mg/dl, Creatinine 1.29 and hematocrit 56% (34-44.6%). CT abdomen/pelvis showed 10 cm ovarian mass. She underwent Total Abdominal Hysterectomy-Bilateral Salpingo Oophorectomy (TAH-BSO). After the surgery, her testosterone levels normalized and features of hyperandrogenism resolved. Pathology report revealed sex cord stromal tumor Not otherwise specified (NOS) with cellular atypia and possible aggressive behavior. Discussion: Androgen-producing tumors in women are rare neoplasms that can cause secondary virilizing characteristics. Of patients presenting with symptoms of hyperandrogenism, these tumors are found in ∼0.2% of cases. Androgen-producing tumors can arise from the ovary or the adrenal gland. Those arising from the ovary are rare, accounting for <5% of all ovarian tumors. Few cases of steroid cell tumors, not otherwise specified, have been reported in the literature.Testosterone elevation of more than 2 times upper normal limit increases the suspicion for cancer. In our patient, testosterone was 180 times above the normal range for women and 15 times above the normal range for men. With rapid virilization and significant elevation in testosterone, an androgen producing ovarian tumors should be considered. Presentation: 6/2/2024

Epidemiological and Trichoscopic Study of Patchy Scalp Alopecia in Children in Delta Egypt

Abstract Background Alopecia represents a distressing problem among children and has a severe psychological impact on the affected patients and their parents. Objective To investigate the clinical presentations of patchy hair loss and analysis of their prevalence and trichoscope features in children in delta Egypt. Methods The study was done on 374 patients aged from 0-18 years (231 males, 143 females) with patchy hair loss who were subjected to detailed history taking, dermatological examination as regard the patch of alopecia, scalp skin, nails, teeth, in addition to trichoscopic examination. The obtained demographic and clinical data of the included patients were tabulated and statistically analyzed. Results Mean age 7.77 years, 231 (61.8%) male patients and 143 (38.2%) female patients. Hair loss in children in this study is largely non-cicatricial causes; specifically alopecia areata, followed by infectious causes; specifically scaly tinea capitits (141 patients). The total number of patients having non-infectious alopecia was 206 patients. Alopecia areata was present in 147 patients (39.3%), toxic alopecia (post folliculitis) (12.6%), trichotillomania (2.1%), and congenital alopecia. Male preponderance in cicatricial alopecia, toxic alopecia (post folliculitis) and infectious disease groups versus female preponderance in non-cicatricial alopecia, alopecia areata, trichotillomania, patchy traction alopecia. The age groups with the largest numbers of children were those school age children aged five to ten years representing (50.5%). Alopecia presented from rural areas represents (72.5%). Trichoscope examination have confirmed the dermatologic clinical diagnosis of patchy alopecia in 368 patients. Conclusion The largest number of children presenting with patchy alopecia in Delta Egypt were those of school age children aged five to ten years, living in rural areas. Hair loss in children is largely due to alopecia areata followed by tinea capitits. Detection of specific trichoscopic features of each disease is mandatory for the accurate diagnosis and proper differentiation of -sometimes- confusing cases of hair and scalp disorders.

Psychological Profile of Patients Presenting with Dermatological Complaints: A Cross-sectional Study

Objectives: The study evaluates the psychological profile in patients presenting to a dermatological clinic in Mumbai, India. Materials and Methods: We evaluated anxiety, depression, stress, anger, body image, and relationships in 63 outpatients presenting with dermatological complaints. We used linear regression models for multivariate analyses for coefficient and 95% confidence intervals (CIs). Results: The mean age (standard deviation [SD]) was 37.4 (14.9) years; 30 (51%) were female and 31 (49%) were male. The common diagnoses were papulosquamous conditions (24%), acne (18%), hair fall (15%), pigmentary conditions (11%), pruritus (10%), and infection (8%). The mean anxiety (SD) score was highest in pigmentary conditions (11.6 [13.9]), depression (15.0 [5.0]) and posttraumatic stress scores (16.3 [25.6]) in pigmentary conditions, social phobia scores in allergy (21.8 [17.0]), and anger scores in acne (25.4 [6.3]). The mean (SD) family scores were lowest in pruritus (8.0 4.2]), body image in infection (3.6 [0.9]), and self-image in pigmentation (6.0 [2.3]). The mean social phobia scores were higher in allergy compared with acne (12.2, 95% CI: 1.6, 22.8, P = 0.02). Body image scores were lower in pruritus (−7.7, 95% CI: −14.5, −0.9, P = 0.03). Conclusion: The psychological parameters differ in various dermatological conditions; hence, a complete profile analysis will be beneficial for designing interventions in these patients.

A New Purpose to Old Arsenal: Exploring the Safety and Efficacy of a New Regimen Comprising a Combination of Chlorhexidine Gluconate and Cetrimide for Seborrheic Dermatitis Treatment in a Randomized Placebo-Controlled Clinical Trial.

Seborrheic dermatitis is a common scalp condition affecting the quality of life of individuals across all age groups. The uninhibited proliferation of Malassezia spp. and enhanced sebaceous gland activity often leads to scalp flaking, mild erythema, and itching, thereby worsening the situation. Here, we aimed to study the efficacy of an antiseptic liquid as a pre-shampoo rinse followed by a non-anti-dandruff shampoo as a dandruff care strategy. Methods: The anti-dandruff efficacy of a chlorhexidine-cetrimide-based antiseptic liquid (ASL) as a pre-shampoo scalp rinse, followed by a regular non-anti-dandruff shampoo, was compared with a commercialZinc pyrithione (ZnPTO) based anti-dandruff shampoo following a half-head paired treatment design in a randomized, placebo-controlled, double-blind trial. The study was conducted on 50 healthy human adults of both genderswith moderate to severe dandruff. During the 12 weeks of this study, the product's safety and efficacy were evaluated based on the dermatologist's visual assessment, the subjects' self-assessment, the loose flake density score, and hair fall. ASL as a pre-shampoo scalp rinse demonstrated significant reduction (p<0.001 for n=47) in dandruff and itching after the treatment and the regression phase, performing at par with a marketed anti-dandruff shampoo. Moreover, ASL was established to be safe, non-irritant, and well-tolerated. No product-related adverse event, discomfort, or irritation symptoms were recorded, having any impact on hair sensory properties. This study demonstrates that a regimen of a chlorhexidine+cetrimide antiseptic liquid for scalp treatment followed by rinse with a regular shampoo can prove as effective as a ZnPTO-based anti-dandruff shampoo in reducing dandruff symptoms for individuals with moderate dandruff.