Local Regulation Research Articles

Detailed phenotyping of Tbr1-2A-CreER knock-in mice demonstrates significant impacts on TBR1 protein levels and axon development.

Cre recombinase knock-in mouse lines have served as invaluable genetic tools for understanding key developmental processes altered in autism. However, insertion of exogenous DNA into the genome can have unintended effects on local gene regulation or protein function that must be carefully considered. Here, we analyze a recently generated Tbr1-2A-CreER knock-in mouse line, where a 2A-CreER cassette was inserted in-frame before the stop codon of the transcription factor gene Tbr1. Heterozygous TBR1 mutations in humans and mice are known to cause autism or autism-like behavioral phenotypes accompanied by structural brain malformations, most frequently a reduction of the anterior commissure (AC). Thus, it is critical for modified versions of Tbr1 to exhibit true wild-type-like activity. We evaluated the Tbr1-2A-CreER allele for its potential impact on Tbr1 function and complementation to Tbr1 loss-of-function alleles. In mice with one copy of the Tbr1-2A-CreER allele, we identified reduction of TBR1 protein in early postnatal cortex along with thinning of the AC, suggesting hypersensitivity of this structure to TBR1 dosage. Comparing Tbr1-2A-CreER and Tbr1-null mice to Tbr1-null complementation crosses showed reductions of TBR1 dosage ranging from 20% to 100%. Using six combinatorial genotypes, we found that moderate to severe TBR1 reductions (≥44%) were associated with cortical layer 5 expansion, while only the complete absence of TBR1 was associated with reeler-like "inverted" cortical layering. In total, these results strongly support the conclusion that Tbr1-2A-CreER is a hypomorphic allele. We advise caution when interpreting experiments using this allele, considering the sensitivity of various corticogenic processes to TBR1 dosage and the association of heterozygous TBR1 mutations with complex neurodevelopmental disorders.

Analysis of Local Governance and Legal Protection of Students' Information Security in the Context of Sustainable Development of Digital Education

Local governments are dealing with student information more and more frequently, resulting in the risk of student information being leaked, so it is necessary to introduce relevant policies, laws and regulations to standardize information collection activities and improve the level of social information governance. Therefore, this study proposes three hypotheses: on the one hand, whether the information policy issued by the local government can guide students' information collection activities, and on the other hand, whether the introduction of local laws and regulations can provide protection for students' information security; Finally, whether public participation can provide supervision for student information collection and governance, and create a good public management environment. The results show that local information laws and regulations can regulate the behavior of students' information collection and clarify the purpose and direction of students' information collection. At the same time, laws and regulations such as privacy protection and local codes of conduct can improve the security of student information and ensure the legal collection of information. The active participation of the public is conducive to the public information collection environment and ensures the overall security of student information. Therefore, local government policies, laws, and regulations can provide assurance and support for students' information security and promote the sustainable development of digital education.

Acclimatation of Microbial Biomass to Effluents From a Swine Slaughterhouse in Batch Reactors

Objective: To evaluate the acclimatization of microbial biomass in sequential reactors to optimize the treatment of wastewater from pig slaughterhouses. Theoretical framework: The meat industry generates highly contaminated wastewater. Biological treatments, such as aerobic and anaerobic systems, are more efficient and sustainable than physicochemical ones. Materials and methods: Industrial effluents were collected in a pig slaughterhouse and then characterized. The microbial biomass was collected from the same slaughterhouse and was subjected to an acclimatization process in a sequential batch reactor. Results and discussion: The results showed that the wastewater from the pig slaughterhouse had high levels of BOD, COD and suspended solids, exceeding the limits established by local regulations. During the acclimatization process, the microbial biomass demonstrated a gradual improvement in its COD removal capacity, reaching efficiencies greater than 70%. The positive correlation observed between volumetric organic load and organic matter removal efficiency indicates that acclimated biomass has a greater capacity to treat effluents with high levels of organic load. Research implications: Biomass acclimatization is essential to improve the efficiency of biological treatment in slaughterhouse effluents, reducing its environmental impact and the need for costly treatments. Value/originality: This study proposes a more sustainable and efficient solution for the treatment of slaughterhouse wastewater, highlighting the importance of biomass acclimatization.

Single-Sample Networks Reveal Intra-Cytoband Co-Expression Hotspots in Breast Cancer Subtypes

Breast cancer is a heterogeneous disease comprising various subtypes with distinct molecular characteristics, clinical outcomes, and therapeutic responses. This heterogeneity evidences significant challenges for diagnosis, prognosis, and treatment. Traditional genomic co-expression network analyses often overlook individual-specific interactions critical for personalized medicine. In this study, we employed single-sample gene co-expression network analysis to investigate the structural and functional genomic alterations across breast cancer subtypes (Luminal A, Luminal B, Her2-enriched, and Basal-like) and compared them with normal breast tissue. We utilized RNA-Seq gene expression data to infer gene co-expression networks. The LIONESS algorithm allowed us to construct individual networks for each patient, capturing unique co-expression patterns. We focused on the top 10,000 gene interactions to ensure consistency and robustness in our analysis. Network metrics were calculated to characterize the topological properties of both aggregated and single-sample networks. Our findings reveal significant fragmentation in the co-expression networks of breast cancer subtypes, marked by a change from interchromosomal (TRANS) to intrachromosomal (CIS) interactions. This transition indicates disrupted long-range genomic communication, leading to localized genomic regulation and increased genomic instability. Single-sample analyses confirmed that these patterns are consistent at the individual level, highlighting the molecular heterogeneity of breast cancer. Despite these pronounced alterations, the proportion of CIS interactions did not significantly correlate with patient survival outcomes across subtypes, suggesting limited prognostic value. Furthermore, we identified high-degree genes and critical cytobands specific to each subtype, providing insights into subtype-specific regulatory networks and potential therapeutic targets. These genes play pivotal roles in oncogenic processes and may represent important keys for targeted interventions. The application of single-sample co-expression network analysis proves to be a powerful tool for uncovering individual-specific genomic interactions.

Performance Evaluation and Optimization of Flux-Regulated Axial-Radial Eddy Current Coupling

Abstract This paper proposes a novel axial-radial permanent magnet eddy-current coupling equipped with a mechanical magnetic adjuster. The innovative design integrates mechanical flux weakening technology with an enhanced magnetic method rooted in axial-radial hybrid flux topology. Concise analytical models for air-gap field and torque are developed, leveraging the magnetic equivalent circuit method and Faraday’s law. These models are subsequently validated using the 3D finite-element method. The results indicate that this device boasts an exceptionally broad torque adjustment range, reaching approximately 93% at a given slip. Furthermore, it exhibits a substantial optimal working area, spanning from 20% to 80% of the mechanical magnetic adjuster's movable distance. To comprehensively analyze the impact of structural parameters on overall performance, three novel metrics are defined. The analysis reveals that the pole pairs of the radial magnetic circuit (RMC) have the most significant influence on the device's comprehensive performance. In the end, a multi-objective optimization method to maximize the global torque regulation capabilities, local torque regulation abilities, and maximum torque potential is developed to enhance the overall performance of this innovative magnetic coupling design.

Neoliberalism and managerial governance in the Swedish pre-school sector

ABSTRACT Tax-funded private provision of welfare services in Sweden is among the most extensive in Europe. This paper focuses on a contradictory example of how discrepancies between neoliberal ideals and practice are embedded in the governance of Swedish preschool. Over time, national and local regulations in Sweden have become increasingly comprehensive and moved toward managerial systems. Using Alain Enthoven’s model of managed competition, and drawing on documents and interviews, this paper focuses on two right-wing, urban municipalities with a very high share of preschools operated by private actors, and their organization of local preschool quasi-markets in terms of so-called sponsors concerning five functions: establishing rules of equity, approving all participating private pre-schools, managing the enrollment process, creating price-elastic demand, and managing risk-selection. The findings show how instead of limiting bureaucratic power, municipal managers have been empowered to plan and optimize the organization of the preschool sector in ways discordant with neoliberal ideas.

Nuclear–Cytoplasmic Shuttling of the Usher Syndrome 1G Protein SANS Differs from Its Paralog ANKS4B

The USH1G protein SANS is a small multifunctional scaffold protein. It is involved in several different cellular processes, such as intracellular transport, in the cytoplasm, or splicing of pre-mRNA, in the cell nucleus. Here, we aimed to gain insight into the regulation of the subcellular localization and the nuclear–cytoplasmic shuttling of SANS and its paralog ANKS4B, not yet reported in the nucleus. We identified karyopherins mediating the nuclear import and export by screening the nuclear interactome of SANS. Sequence analyses predicted in silico evolutionarily conserved nuclear localization sequences (NLSs) and nuclear export sequences (NESs) in SANS, but only NESs in ANKS4B, which are suitable for karyopherin binding. Quantifying the nuclear–cytoplasmic localization of wild-type SANS and NLS/NES mutants, we experimentally confirmed in silico predicted NLS and NES functioning in the nuclear–cytoplasmic shuttling in situ in cells. The comparison of SANS and its paralog ANKS4B revealed substantial differences in the interaction with the nuclear splicing protein PRPF31 and in their nuclear localization. Finally, our results on pathogenic USH1G/SANS mutants suggest that the loss of NLSs and NESs and thereby the ability to control nuclear–cytoplasmic shuttling is disease-relevant.

Growth of a Tessellation: Geometric rules for the Development of Stingray Skeletal Patterns.

The skeletons of sharks and rays, fashioned from cartilage, and armored by a veneer of mineralized tiles (tesserae) present a mathematical challenge: How can the continuous covering be maintained as the skeleton expands? This study, using microCT and custom visual data analyses of growing stingray skeletons, systematically examines tessellation patterns and morphologies of the many thousand interacting tesserae covering the hyomandibula (a skeletal element critical to feeding), over a two-fold developmental change in hyomandibula length. The number of tesserae remains surprisingly constant, even as the hyomandibula expands isometrically, with all hyomandibulae displaying self-similar distributions of tesserae shapes/sizes. Although the distribution of tesserae geometries largely agrees with the rules for polyhedra tiling of complex surfaces-dominated by hexagons and a minor fraction of pentagons and heptagons, but very few other polygons-the agreement with Euler's classic mathematical laws is not perfect. Contrary to the assumed uniform growth rate (which is shown would create geometric incompatibilities), larger tesserae grow faster to accommodate skeletal expansion. It is hypothesized that this local regulation of global system complexity is driven by tension (from cartilaginous core expansion) in the fibers connecting tesserae, with strain-responsive cells orchestrating local mineral apposition.

Flying Free? Risk and Regulation in Recreational Flying Trapeze

ABSTRACT Legal and regulatory theory has been fascinated by the relationship between law and other forms of regulation in a differentiated society. While some scholars have pointed out the benefits of local regulation, especially when managing the risks of modern society, others have seen regulation in Foucauldian terms as discipline, the dark underside of liberal society. Law, in a Foucauldian approach, is usually understood as another form of constraint. There have, however, been recent suggestions that an enabling law could contain possibilities for openness and agency – much like Foucault’s concept of ‘technologies of the self’. At the same time, sociologists have used the technologies of the self to describe voluntary risk-taking, or ‘edgework’, as a form of escape from the disciplinary society. In this article, I examine these possibilities by investigating the operation of law and regulatory techniques in flying trapeze. Recreational flying trapeze is the kind of risky activity that was facilitated by the enabling law of the 2002 tort reforms. Recreational flyers, who are usually women, appear to experience a moment of freedom. Yet flyers are subject to local regulations and their own practice of self-regulation. As such, this activity provides a practical opportunity for examining the intersection of law, regulation, and the technologies of the self, and considering what they mean for the possibilities and limitations of freedom.

Integration of flexible corporate demographic policy tools into the personnel management system

Amid staff shortages and rising labour costs, many Russian enterprises are looking for non-material methods to man age personnel. Organizational, labour and socio-psychological aspects of employee incentives are closely linked to the corporate demographic policy tools. The article aims to analyse the demand for flexible working arrangements for employees with family responsibilities, as well as to determine the opportunities for integrating flexible organizational and labour tools of corporate de mographic policy into the personnel management system. Flexibilization theory in the context of corporate demographic policy constitutes the methodological basis of the study. The standard methods of structured personal interviews, frequency analysis with equality of proportions hypothesis test using a chi-square statistic, and comparison of mean values based on the Kruskal Wallis test were applied. The empirical evidence includes collective agreements and local regulations of the largest employers in the Russian Federation, as well as results of a sociological survey conducted in June–September, 2023 (the analyzed sample cov ered 2,804 respondents). The study statistically proves that employees working flexible hours are more satisfied with their job and life compared to those with rigid schedules. It also shows that flexible working arrangements are in demand among employees with parental commitments. The paper presents a model and an algorithm for integrating flexible organizational and labour tools of corporate demographic policy into the personnel management system. We develop a list of HR metrics and identify potential positive implications of this integration through strengthening the HR brand, increasing employee loyalty and engagement, and reducing staff turnover.

Manipulating photoluminescence properties of neodymium-doped fluorites through local structure regulation

The long upper level lifetimes are highly advantageous for laser diode pumped high energy laser systems. However, lifetimes of the rare earth neodymium ions, one of the most important active ions in 1 μm, are generally around 300 μs or less, which limits the development of laser diode pumped high energy lasers on neodymium gains. In this work, Nd:CaF2 and Nd:SrF2 were chosen and introduced with appropriate codopants to adjust the local structures, thereby modulating the coupling of active ions with the crystal fields. The transition rate was slowed down and a long lifetime nearly 600 μs was obtained. Neodymium-doped fluorites with broad emission bandwidths and high thermal conductivities are potential laser gains for generation of high repetition rate high power lasers.

Legal Certainty in the Division of Joint Property after Divorce

This study aims to analyze the legal certainty in the distribution of joint property after divorce, with an emphasis on the challenges faced in the implementation of the law in Indonesia. The division of joint property is a crucial issue in the context of divorce which often causes disputes between former spouses, where the principles of justice and equality should take precedence. In this study, a normative juridical approach is used to examine laws and regulations, legal doctrines, and court decisions related to the division of common property, with a focus on Law Number 1 of 1974 concerning Marriage and the Civil Code. The results show that despite the legal provisions governing the division of common property, its implementation is often hampered by various factors, including differences in interpretation among judges, the existence of cultural values that influence decisions, and technical obstacles in asset valuation. Variations in court decisions create legal uncertainty that not only harms one party, but also impacts the welfare of children involved in divorce. Uncertainty about the rights and obligations of each party has the potential to cause prolonged conflicts and harm all parties. As part of the analysis, the study also highlights the social and economic impact of legal uncertainty in the distribution of assets, especially for the financially weaker parties. To improve fairness and certainty in the division of common property, this study recommends the need for more detailed and uniform guidelines in court decision-making procedures, as well as harmonization between national and local regulations. Thus, it is hoped that the process of distributing joint property after divorce can be carried out in a fairer, more efficient, and transparent manner, so that the interests of all parties, especially children, can be well protected.

Exploring Strategies For Expanding The Xiaohongshu App In Malaysia And Singapore: A Study On Developing Chinese Social Media Overseas

This article discusses China's unique social media landscape, which is shaped by the country's culture, politics, and regulatory environment. Chinese social media platforms like WeChat, Weibo, and Xiaohongshu are deeply integrated and innovative, with features such as virtual red envelopes and mini-programs that significantly boost user engagement.However, expanding these platforms overseas presents challenges, such as cultural differences, regulatory environment, and competition. The article focuses on the case of Xiaohongshu (RED). It proposes strategies to improve customer loyalty and functionality in the context of e-commerce, utilizing the Unified Theory of Acceptance and Use of Technology 2 (UTAUT2) as the theoretical framework.The article highlights the importance of understanding the cultural norms and preferences of the target audience, complying with local laws and regulations, and finding ways to differentiate Chinese social media platforms from established players in the market.

Optimal Asset Allocation of Pension Funds with a Portfolio Constraint Change

We investigated the asset allocation problem of a pension fund in which the constraints on the risky investment proportion change owing to local regulations or the fund’s policy changes. We assumed that the fund manager has a utility function with respect to the funding ratio of the pension fund. A dynamic programming approach was employed and we obtained a closed-form solution to the problem. To numerically measure the effect of such changes on asset allocation, we define the concept of policy change equivalent return (PCER) as the additional expected return for the value function of the case without such changes at the same level as the value function of the case with them. In the numerical analysis, we analyzed both the effect of regime switching on market parameters and policy change on the PCER and showed the effectiveness of introducing policy changes to asset allocation.

Tithe, One-Fifth, One-Third, One-Half: Preliminary Notes On The Wider Scope of Agrarian Relations in Ottoman Bosnia in the Classic Period

Thus far, in dealing with the issue of agrarian relations in 16th-century Otto- man Bosnia the focus has been on the miri land regime, that is, on the state ownership, with a concession made for a different type like the vakıf or mülk land. Some attention was occasionally paid to phenomena such as land lease in the early phase, lump-sum paying, and gradual spread of çiftliks as an occurrence that was running against the classic regime and the like. Thereby a simple fact was overlooked, i.e., the “silent”, but necessary presence of a kind of relationship that must have coexisted with the miri regime without contradicting it. This was the very important fact rooted in the question of the volume of agrarian output, mainly the grain. From village to village the grain to people ratio was uneven: sometimes there was enough per capita, but often it was much above or much below the needs of the community as expressed by the social minimum. Here opens the possibility of taking the “surplus” in the shape of a rate higher than the tithe (or one eight) on the basis of private agreement, outside the scope of the Sacred Law. In order to present this matter in broader outline a comparison was necessary with other parts of the Empire (East Central Anatolia, Southern Syria and Palestine) where rates up to one half of the produce were in vigor according to local regulations with religious approval. The apparently diametrically opposite to each other, the two ap- proaches had still much in common “here” and “there”.

Molecular Motors in Myelination and Their Misregulation in Disease.

Molecular motors are cellular components involved in the intracellular transport of organelles and materials to ensure cell homeostasis. This is particularly relevant in neurons, where the synaptic components synthesized in the soma need to travel overlong distances to their destination. They can walk on microtubules (kinesins and dyneins) or actin filaments (myosins), themajor components of cell cytoskeleton. While kinesins mostly perform the anterograde transport of intracellular components toward the plus ends of microtubules located distally in cell processes, cytoplasmic dyneins allow the retrograde flux of intracellular cargo toward the minus ends of microtubules located at the cell soma. Axon myelination represents a major aspect of neuronal maturation and is essential for neuronal function, as it speeds up the transmission of electrical signals. Increasing evidence supports a role for molecular motors in the homeostatic control of myelination. This role includes the trafficking of myelin components along the processes of myelinating cells and local regulation of pathways that ensure axon wrapping. Dysfunctional control of the intracellular transport machinery has thereforebeen linked to several brain pathologies, including demyelinating diseases. These disordersinclude a broad spectrum of conditions characterized by pathological demyelination of axons within the nervous system, ultimately leading to axonal degeneration and neuronal death, withmultiple sclerosis representing the most prevalent and studied condition. This review highlights the involvement of molecular motors in the homeostatic control of myelination. It also discusses studies that have yielded insights into the dysfunctional activity of molecular motors in the pathophysiology of multiple sclerosis.

A Comparative Analysis of Ethnic Networks and Internationalization of Latin American Agri-SMEs: The Case of Argentina, Brazil, and Chile

This paper investigates the key drivers influencing the internationalization of agricultural small and medium-sized enterprises (agri-SMEs) in Latin America, with a particular emphasis on the role of social and ethnic networks. Focusing on Argentina, Brazil, and Chile—three of the region’s largest agricultural economies—this study examines how familial and cultural connections between descendants of European immigrants and European entrepreneurs facilitate the global expansion of agri-SMEs. Using a cross-sectional quantitative analysis, data from agri-SME managers reveal the importance of these networks in reducing market entry barriers by providing insider knowledge of foreign markets, regulatory conditions, and potential business partnerships. The findings demonstrate that ethnic networks significantly reduce market entry barriers, providing Latin American agri-SMEs access to essential insider knowledge on foreign markets and local regulations, thereby facilitating internationalization. Additionally, agri-SMEs that leverage these networks are better positioned to meet growing global demands for sustainable, traceable food products, gaining a competitive advantage in international markets. The strength and frequency of interactions within ethnic networks are positively correlated with the degree of internationalization, highlighting the importance of social capital in overcoming operational challenges. This paper contributes to the literature by highlighting the underexplored role of ethnic networks in shaping the international marketing strategies of agricultural firms and their capacity to adapt to evolving consumer behaviors. The study offers practical insights for supporting the global integration of agri-SMEs in Latin America, addressing both operational challenges and the increasing need for sustainable food production practices.

Behavioural Monitoring Underlines Habituation to Repeated Stressor Stimuli in Farmed Gilthead Sea Bream (Sparus aurata) Reared at a High Stocking Density

A confinement stress test with 75% tank space reduction and behavioural monitoring through tri-axial accelerometers externally attached to the operculum was designed. This procedure was validated by demonstrating the less pronounced stress response in gilthead sea bream than in European sea bass (950–1200 g). Our study aimed to assess habituation to high stocking densities with such procedure in gilthead sea bream. Animals (420–450 g) were reared (June–August) in a flow-through system at two stocking densities (CTRL: 10–15 kg/m3; HD: 18–24 kg/m3), with natural photoperiod and temperature (21–29 °C), and oxygen levels at 5.2–4.2 (CTRL) and 4.2–3.2 ppm (HD). At the end, blood and muscle were sampled for haematology and transcriptomic analyses, and external tissue damage was assessed by image-based scoring. Four days later, fish underwent a 45 min confinement stress test over two consecutive days. HD fish showed reduced feed intake, growth rates and haematopoietic activity. Muscle transcriptome changes indicated a shift from systemic to local growth regulation and a primed muscle regeneration over protein accretion in HD animals with slight external injuries. After stress testing, HD fish exhibited a decreased recovery time in activity and respiration rates, which was shorter after a second stressor exposure, confirming habituation to high densities.

Vaccine Quality Challenges in Secretly Traded H5 and H9 Avian Influenza Vaccines in Nigeria

Avian Influenza Virus (AIV) especially the highly pathogenic subtype H5Nx causes Avian Influenza (AI) disease and it is a major threat to the poultry industry and public health worldwide. Vaccination is one of the control measures in many countries, though restricted in Nigeria. As such, some poultry farmers secretly employ imported H5 and H9 AI vaccines to vaccinate their chickens. This study investigated the antigenic quality of these imported vaccines. Four imported vaccine brands were tested using Hemagglutination (HA) test and Reverse Transcriptase Polymerase Chain Reaction (RTPCR). All four vaccine samples tested negative in the HA test, indicating a lack of detectable HA antigen titer. Similarly, RT-PCR failed to amplify the targeted region of the viral matrix gene in any of the vaccine samples against reference control. These negative results are of great concern and suggest that the imported H5 and H9 vaccines lack essential antigens that could stimulate antibodies. Thus, potentially rendering them ineffective against circulating AI subtypes. The failure in antigenic quality could be due to myriads of factors including improper storage, transport (often due to illegal import), or limitations in the original vaccine production process. Regardless of the specific cause, these findings highlight the potential risks associated with the use of unregulated vaccines. Poultry farmers who use these imported vaccines may be incurring unnecessary costs while receiving a false sense of security for their flocks. In conclusion, due to the apparent lack of efficacious antigens, we suggest a quality monitoring of imported H5 and H9 vaccines in Nigeria for compliance with local regulations on vaccine use, biosecurity measures and investigation into the root causes of the vaccine failure observed in this study.

SOME ASPECTS OF RESEARCHING THE PROBLEM RISKS IN INSTITUTIONAL MANAGEMENT TRANSFORMATIONS IN THE FIELD OF EDUCATION: US EXPERIENCE

The article is devoted to the analysis of the American accounting experience potential risks in the management of institutional transformations. Goal articles - to reveal some aspects of the US experience in taking into account risks in management institutional transformations in education. Theoretica research methods applied: study of scientific literature, analysis, systematization, comparison, specification, generalization of information. The implementation of transformations in the educational sector (of institutional transformations) is associated with the emergence of certain risks. There is set of potential risk factors with which any organization, including higher educational institutions, collides permanently or temporarily, including: threats from natural disasters such as hurricanes, fires from thunderstorms lightning, floods, etc.; failures and failures in the operation of service systems of the type interruptions and power outages, protection failure, failures equipment, etc.; malicious actions such as sabotage, terrorism, computer actions fraud; the so-called human factor, that is, errors due to negligence employees, their lack or lack of necessary knowledge and skills. Taking into account the peculiarities of educational organizations, it is suggested to divide all potential risks and the necessary institutional transformations associated with them into four main categories: strategic risks, financial, legislative, etc operating rooms Strategic risks involve long-term threats that can to influence the successful activity of a higher educational institution. Financial risks foresee the possibility of loss of material means and other assets. Legislative risks involve improper implementation of state laws and instructions, as well as local regulations when implementing institutional ones transformations Operational risks involve erroneous actions of individuals, cases of fraud in the university environment. In addition, one more is known a category of risk that is very important for educational institutions is the risk of losing reputation The reputation of the higher educational institution, its image and prestige have of great importance for the successful functioning of higher education institutions. Higher education institutions should participate in the evaluation of their propensity to risks and have a complete understanding of all the categories of risks they may face to meet The article analyzes some possible approaches to risk assessment, which are offered by American scientists. Expediency is emphasized the use of American experience in Ukraine, where they are taking place today significant institutional transformations in the field of education.