Irrational spatial configuration of campuses has contributed to changes in local microclimates, thus reducing human thermal comfort, particularly in severely cold regions of China. This paper sets out to establish correlation equations between campus spatial morphology indicators and Physiologically Equivalent Temperature (PET). Based on measured data from two campus sites, Geographic Information Systems (GIS) were utilized to analyze the characteristics of microclimate distribution and highly sensitive morphological parameters were screened. Regression analysis was conducted to determine the correlation between spatial morphology indicators and PET. During winter, open spaces were most correlated with Sky View Factor (SVF), with each 0.1 increase in SVF resulting in a 0.7 °C rise in PET. Enclosed spaces exhibited strong correlations with the Closure Ratio of Enclosure (Ce) and Surface Wall Area (SW), where every 10% increase in Ce led to a 0.46 °C increase in PET and every additional 1000 m2 of SW caused a 1 °C rise in PET. We finally quantified the impact of changes in spatial morphology indicators on human thermal comfort, with the aim to integrate campus planning with climatic design and improve the outdoor thermal environment of campuses.