Local Imbalance Research Articles

Local bone metabolism balance regulation via double-adhesive hydrogel for fixing orthopedic implants

The effective osteointegration of orthopedic implants is a key factor for the success of orthopedic surgery. However, local metabolic imbalance around implants under osteoporosis condition could jeopardize the fixation effect. Inspired by the bone structure and the composition around implants under osteoporosis condition, alendronate (A) was grafted onto methacryloyl hyaluronic acid (H) by activating the carboxyl group of methacryloyl hyaluronic acid to be bonded to inorganic calcium phosphate on trabecular bone, which is then integrated with aminated bioactive glass (AB) modified by oxidized dextran (O) for further adhesion to organic collagen on the trabecular bone. The hybrid hydrogel could be solidified on cancellous bone in situ under UV irradiation and exhibits dual adhesion to organic collagen and inorganic apatite, promoting osteointegration of orthopedic implants, resulting in firm stabilization of the implants in cancellous bone areas. In vitro, the hydrogel was evidenced to promote osteogenic differentiation of embryonic mouse osteoblast precursor cells (MC3T3-E1) as well as inhibit the receptor activator of nuclear factor-κ B ligand (RANKL)-induced osteoclast differentiation of macrophages, leading to the upregulation of osteogenic-related gene and protein expression. In a rat osteoporosis model, the bone-implant contact (BIC) of the hybrid hydrogel group increased by 2.77, which is directly linked to improved mechanical stability of the orthopedic implants. Overall, this organic-inorganic, dual-adhesive hydrogel could be a promising candidate for enhancing the stability of orthopedic implants under osteoporotic conditions.

Short-Range Migration of A-Site Cations Inhibit Photoinduced Phase Segregation in FAxMAyCs1–x–yPbI3–zBrz Single Crystals

Mixed halide perovskites, particularly for mixed iodine (I) and bromine (Br), are promising semiconductor materials for multi-junction solar cells due to their band gap modulations; however numerous research studies have shown that halides undergo ion migration under light excitation, resulting in undesired phase segregation, which severely affects the device long-term stability. In high-Br-content (40%) mixed halide perovskites, I-rich and Br-rich regions simultaneously come into being under illuminations, whereas in a low Br content (<10%), the photoinduced phase segregation process is still unclear until now. On the other hand, the severity of phase segregation relies on defect density, especially prone to occur at grain boundaries in thin films. Here, we investigated the regulation of the phase segregation process by A-site cations in FAxMAyCs1–x–yPbI3–zBrz single crystals (SCs) under illuminations that evade disturbance of grain boundaries. It reveals that the introduction of MA, Cs, and Br into FAxMAyCs1–x–yPbI3–zBrz SCs leads to crystal lattice distortion, which confins the long-range migration of ions, and only the short-range migration at a local range occurs under illuminations. This short-range migration further affects the directional polarization of MA and brings lattice relaxation, which is helpful for eliminating local stress imbalance and shallow level traps, ultimately enhancing the stability under illumination.

Decentralization of Government Functions, a European Principle of the Albanian Modernization Process: A libertarian approach to territorial issues

Abstract Albania, for 30 years, has entered the phase of transition from a society organized into a one-party central governing regime to a democratic society of a free market economy. But the pace of moving in this direction and modernizing the country is not the expected one, because the centralized proclamations of the political elite and expertise have not allowed liberal approaches to enter Albanian legislation and governing practices. This has been the case in particular in the sector of territorial planning, where central governments have aimed and managed to not allow the actual decentralization of the governing function of drafting and adopting local territorial planning instruments. This has resulted in a shortage of local instruments, in general, but even when managed to ensure they are presented far beyond the needs, problems and objective local imbalances. This is because their distance mapping from the actual municipality for which they were designed failed to recognize the specifics and characteristics of each of them. The result has been evident; in both cases, planning has been inexistent to drive sustainable, smart and inclusive urban development processes. In this paper we aim to build another approach for future development in Albania, a country which aims at integration into the European Union. This path should be development based on previously adopted territorial planning instruments, drawn up in democratic and parliamentary processes as a local political activity. Central government must understand and accept the new and different role than the one it played 30 years ago in territorial development issues, and that the process of drafting and adopting local territorial planning instruments should be a function of local government itself.

Microvascular angina (Cardiac Syndrome X) from a historical overview, epidemiology, pathophysiology to treatment recommendations - a minireview.

Microvascular angina (MVA) is a condition characterized by the presence of angina-like chest pain, a positive response to exercise stress tests, and no significant stenosis of coronary arteries in coronary angiography, with absence of any other specific cardiac diseases. The etiology of this syndrome is still not known and it is probably multifactorial. Coronary microvascular dysfunction is proposed as the main pathophysiological mechanism in the development of MVA. Altered somatic and visceral pain perception and autonomic imbalance, in addition to myocardial ischemia, has been observed in subjects with MVA, involving dynamic variations in the vasomotor tone of coronary microcirculation with consequent transient ischemic episodes. Other theories suggest that MVA may be a result of a chronic inflammatory state in the body that can negatively influence the endothelium or a local imbalance of factors regulating its function. This article presents the latest information about the epidemiology, diagnostics, etiopathogenesis, prognosis, and treatment of patients with MVA.

Structural and biomechanical properties and trace elements composition of the corneoscleral eye shell in normal tension glaucoma

The results of comparative studies of the structural and biomechanical features of the corneoscleral eye shell in various clinical forms of glaucoma are presented. The article discusses how the systemic and local imbalance of trace elements that regulate collagen biosynthesis, the formation of cross-links in the connective tissue structures of the sclera, and the hydrodynamics of the intraocular fluid, affect the intraocular pressure level, and thereby the character of the development of glaucomatous lesions in normal tension glaucoma. Modern literature is shown to indicate the prospects for further research in this direction.

Multi-label sampling based on local label imbalance

Class imbalance is an inherent characteristic of multi-label data that hinders most multi-label learning methods. One efficient and flexible strategy to deal with this problem is to employ sampling techniques before training a multi-label learning model. Although existing multi-label sampling approaches alleviate the global imbalance of multi-label datasets, it is actually the imbalance level within the local neighbourhood of minority class examples that plays a key role in performance degradation. To address this issue, we propose a novel measure to assess the local label imbalance of multi-label datasets, as well as two multi-label sampling approaches, namely Multi-Label Synthetic Oversampling based on Local label imbalance (MLSOL) and Multi-Label Undersampling based on Local label imbalance (MLUL). By considering all informative labels, MLSOL creates more diverse and better labeled synthetic instances for difficult examples, while MLUL eliminates instances that are harmful to their local region. Experimental results on 13 multi-label datasets demonstrate the effectiveness of the proposed measure and sampling approaches for a variety of evaluation metrics, particularly in the case of an ensemble of classifiers trained on repeated samples of the original data.

Drug-target interaction prediction via an ensemble of weighted nearest neighbors with interaction recovery

Predicting drug-target interactions (DTI) via reliable computational methods is an effective and efficient way to mitigate the enormous costs and time of the drug discovery process. Structure-based drug similarities and sequence-based target protein similarities are the commonly used information for DTI prediction. Among numerous computational methods, neighborhood-based chemogenomic approaches that leverage drug and target similarities to perform predictions directly are simple but promising ones. However, existing similarity-based methods need to be re-trained to predict interactions for any new drugs or targets and cannot directly perform predictions for both new drugs, new targets, and new drug-target pairs. Furthermore, a large amount of missing (undetected) interactions in current DTI datasets hinders most DTI prediction methods. To address these issues, we propose a new method denoted as Weighted k-Nearest Neighbor with Interaction Recovery (WkNNIR). Not only can WkNNIR estimate interactions of any new drugs and/or new targets without any need of re-training, but it can also recover missing interactions (false negatives). In addition, WkNNIR exploits local imbalance to promote the influence of more reliable similarities on the interaction recovery and prediction processes. We also propose a series of ensemble methods that employ diverse sampling strategies and could be coupled with WkNNIR as well as any other DTI prediction method to improve performance. Experimental results over five benchmark datasets demonstrate the effectiveness of our approaches in predicting drug-target interactions. Lastly, we confirm the practical prediction ability of proposed methods to discover reliable interactions that were not reported in the original benchmark datasets.

The Polar Radiant Energy in the Far Infrared Experiment: A New Perspective on Polar Longwave Energy Exchanges

AbstractEarth’s climate is strongly influenced by energy deficits at the poles that emit more thermal energy than they receive from the sun. Energy exchanges between the surface and atmosphere influence the local environment while heat transport from lower latitudes drives midlatitude atmospheric and oceanic circulations. In the Arctic, in particular, local energy imbalances induce strong seasonality in surface–atmosphere heat exchanges and an acute sensitivity to forced climate variations. Despite these important local and global influences, the largest contributions to the polar atmospheric and surface energy budgets have not been fully characterized. The spectral variation of far-infrared radiation that makes up 60% of polar thermal emission has never been systematically measured impeding progress toward consensus in predicted rates of Arctic warming, sea ice decline, and ice sheet melt. Enabled by recent advances in sensor miniaturization and CubeSat technology, the Polar Radiant Energy in the Far Infrared Experiment (PREFIRE) mission will document, for the first time, the spectral, spatial, and temporal variations of polar far-infrared emission. Selected under NASA’s Earth Ventures Instrument (EVI) program, PREFIRE will utilize new lightweight, low-power, ambient temperature detectors capable of measuring at wavelengths up to 50 μm to quantify Earth’s far-infrared spectrum. Estimates of spectral surface emissivity, water vapor, cloud properties, and the atmospheric greenhouse effect derived from these measurements offer the potential to advance our understanding of the factors that modulate thermal fluxes in the cold, dry conditions characteristic of the polar regions.

Derivation of a macroscopic mixture model for two-phase turbulent flows

This article addresses the issue of reduced models to describe turbulent two-phase flows in industrial applications. A spatially-averaged mixture or drift-flux model is derived theoretically from the local instantaneous Navier-Stokes description. Reynolds-averaging and space-averaging are applied successively. Between these two steps, a model reduction is achieved to account for the non-equilibrium between phases via algebraic relations. Applications of this work are not limited to porous media but also include macroscopic descriptions to model high-shear regions developing near the walls for internal flows. Thermal effects, heat transfer at the wall and phase-change are also considered and briefly discussed. The final model describes the evolution of mixture variables, including effects of both sub-filter spatial variations, turbulence, and local non-equilibrium in velocity, pressure and enthalpy. This analysis provides bridges between different approaches to model two-phase flows (local instantaneous description, two-fluid model, local drift-flux model and spatially-averaged drift-flux model). It clarifies the content of each model involved by defining them in terms of local instantaneous quantities. Turbulent fluctuations and phase intermittency are crucial mechanisms. Important effects to model also include void fraction dispersion and turbulent diffusion; then, it is necessary to model the relative velocity, including the drift velocity orthogonal to gravity induced by the complex interactions between turbulent velocity fluctuations and the interfacial momentum transfer.The final macroscopic (spatially-averaged) mixture formulation is open, in the sense that expressions to model the various terms representing the physics of the small scales are not provided; instead, the physical sense and the origin of these models are discussed. The paper is meant as a basis on which analyses on local imbalance assumptions or relative velocity closures can be assessed. CFD simulations can provide information to complement experiments in technically challenging physical conditions or on processes essential to the models yet difficult to access experimentally (such as interfacial transfers for instance). Different kinds of two-fluid models can be tested to analyse their consequences on the macroscopic spatially-averaged model. In addition, a new path to calibrate closure laws or propose new models is opened based on finer-scale descriptions. Guidelines to use fine simulations along with the open expressions to derive closure relations either for the local drift-flux or for the spatially-averaged models are presented. They concern the modelling of the local relative velocity, the spatial average of the diffusion of void fraction and of the pressure drop.

Ethnic tourism in China: tourism-related (dis)empowerment of Miao villages in Hunan province

External tourism development organizations are frequently utilized by the various levels of the Chinese government to develop tourism and boost local economies. However, this often occurs with limited community participation. We explore the role of institutional arrangements in how people within host communities are empowered and disempowered in such situations by looking into the experiences of Fenghuang Ancient Town and two Miao villages in Hunan Province, China. In-depth interviews, participant and non-participant observation, and document analysis were undertaken. Certain community members were empowered by tourism development, especially financially. However, top-down decision-making, local elite systems, cultural habits and responses to these challenges enabled power inequality. This inequality occurred between government, tourism developer and communities, and within the communities. Only through devolution of power can social impacts from tourism development be improved but, even then, local power imbalances may influence the equity of tourism-related outcomes.

Seasonal Variation of the Surface Kuroshio Intrusion into the South China Sea Evidenced by Satellite Geostrophic Streamlines

AbstractThe long-term satellite altimeter and reanalysis data show that large seasonal variations are associated with geostrophic Kuroshio intrusion, but not with the current intensity, width and axis position east of Philippine. To address this issue, we examine the seasonal variability of surface intrusion patterns by a new streamline-based method. The along-streamline analysis reveals that the seasonality of geostrophic intrusion is only attributed to the cyclonic shear part of the flow, while the anticyclonic shear part always leaps across the Luzon Strait. A possible physical mechanism is proposed to accommodate these seasonal characteristics based on globally the vorticity (torque work) balance between the basin-wide negative wind stress curl and the positive vorticity fluxes induced by the lateral wall, as well as locally loss of balance between the torques of frictional stresses and normal stresses owing to the boundary gap. Through modifying the nearshore sea surface level, the northeasterly/southeasterly monsoon increases/decreases the positive vorticity fluxes in response to global vorticity balance, and simultaneously amplifies/alleviates the local imbalance by enhancing/reducing the positive frictional stress torque within the cyclonic shear layer. Therefore, in winter when the positive torque is large enough, the Kuroshio splits and the intrusion occurs, while in summer the stress torque is so weak that the entire current keeps flowing north.

The Effect of Different Transient Trigger Methods on the Performance of Double Controlled Hydraulic System

Most of pressurized liquid pipelines are threatened by the hazards of a physical phenomenon that likely occurred in the hydraulic system when flow characteristic is rapidly changed. This change will make local energy imbalance which induced pressure wave travelling along the hydraulic system. Further, many devices are designed to control the hydraulic transients event. But, these devices still have incomplete performance because they dont be verified under different transient trigger conditions. In this paper, the performance of double controlled hydraulic system is verified by changing the transient trigger methods. Where, the double control of this system consisting of air vessel and HDPE forward configuration bypass. Moreover, four transients trigger scenarios are performed in this study and the performance of the hydraulic system for each scenario is investigated experimentally and numerically. Further, the experiments are revealed that the performance of hydraulic control system is highly affected by the way of the hydraulic transient is generated. Finally, the experimental and numerical results are well convergent by a total percentage is (92%).

Cell-free, quantitative mineralization measurements as a proxy to identify osteoinductive bone graft substitutes

Some synthetic bone graft substitutes (BGS) can trigger ectopic bone formation, which is the hallmark of osteoinduction and the most important prerequisite for the repair of large bone defects. Unfortunately, measuring or predicting BGS osteoinductive potential based on in vitro experiments is currently impossible. A recent study claimed that synthetic BGS can induce bone formation ectopically if they create a local homeostatic imbalance during their in vivo mineralization. This raised the hope that a simple cell free in vitro mineralization experiment would correlate with osteoinduction. The aim of the present study was therefore to assess the ability of a quantitative in vitro mineralization test to predict and rank the osteoinductive potential of BGS. Eight calcium phosphate BGS already tested ectopically in 9 different in vivo studies were used for that purpose. The experiment was able to identify materials that are reliably osteoinductive from those that are not, but was inaccurate in ranking the osteoinductive materials between each other. Chemical contaminants (Ca2+, Mg2+, H+, OH−, PO43−) present in some of the BGS affected the in vitro mineralization experiment results, but not in a direction that could explain the different rankings. In conclusion, this study suggests that an in vitro experiment can be used as a fast and reliable screening tool to identify osteoinductive BGS and underline the need to study ionic contaminants on calcium phosphate BGS.

New Failure Mechanism Induced by Current Limit for Superjunction MOSFET Under Single-Pulse UIS Stress

New failure mechanism induced by current limits has been investigated for the superjunction MOSFET (SJ-MOSFET) under single-pulse unclamped inductive switching (UIS) test stress. It is found that the local charge imbalance ( Q <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">n</sub> > Q <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p</sub> ) at the chip corner produces a hotspot during the UIS test. The failure of the device induced by the hotspot depends on the magnitude of the avalanche current. For a low avalanche current, the avalanche current is redistributed from the local charge imbalance region to the charge balance region due to the lattice temperature increasing, resulting in the local heating toward the full-scale heating. However, for a high avalanche current, the negative differential resistance (NDR) effect plays a dominant role in the local charge imbalance region, decreasing the dynamic breakdown voltage (BV) sharply. Therefore, the hotspot is locked at the charge imbalance region; then, the device is destroyed in a short time. Finally, an SJ-MOSFET with more p-type charges at the chip corner is produced to improve the avalanche capability relating to the current limit, also verifying the mechanism analysis.

Prognosis of endometrial cancer depends on intracrine ratio of sex steroids.

e17564 Background: Local imbalance of sex steroids (SS) plays a leading role in the development of gynecologic tumors. The purpose of the study was to investigate the effect of changes in SS and E6 protein levels on the course of endometrial cancer (EC). Methods: 50 patients with EC T1-2N0M0 (histologically - endometrioid adenocarcinoma, AC), aged 53.4±3.2 years, were recruited. Levels of SS and E6 protein were determined by standard ELISA systems in tumor samples. The coefficient of estrogens to the amount of testosterone and progesterone – C = (E1+E2):(T+P4) was calculated. Intact endometrium (IE) obtained in surgical treatment for uterine fibroids was used as the intact tissue. Results: AC patients demonstrated elevated estrone (E1) levels, compared to IE: by 2.2 times in 88% and by 5.9 times in 12% cases (p &lt; 0.05). Levels of estradiol (E2) were similar in AC and IE. Progesterone (P4) levels in 32 patients were 1.5 times lower than in IE, and testosterone (T) 1.5 times higher (p &lt; 0.05). P4 in 18 patients was 3 times lower than in IE, and T – 1.4 times lower in 12 women and 2.2 times lower in 6 women (p &lt; 0.05). The C coefficient increased in 32 patients by 1.3 times (p&lt; 0.05), in 12 patients by 2.7 times, in 6 patients by 8.2 times (p &lt; 0.05). E6 protein was found in tumor tissue of 18 patients with elevated C. 6 of 18 women with C = 24.54±2.4 and E6 = 420±32 ng/g of tissue developed recurrence during 6 months, and 12 patients with C = 8.15±1.2 and E6 = 28±2.1 ng/g of tissue developed recurrence in a period of 6 months to 1 year. Women with C = 4.04±0.39 without E6 oncoprotein in tumor tissue had a relapse-free period for more than 1 year. Conclusions: An analysis of C and E6 oncoprotein in tumor tissues allows identification of high-risk patients and a personalized approach to adequate treatment.

The uniform-momentum zones and internal shear layers in turbulent pipe flows at Reynolds numbers up to [formula omitted

The statistical characteristics of the internal shear layers (ISL) and the coherent structures around the ISLs in turbulent pipe flows are examined using direct numerical simulation data at four Reynolds numbers Reτ=180, 360, 500 and 1000. The ISLs are defined by the peaks on the velocity gradients with no ad hoc filter applied on the ISL selection. This is different from the previous studies where uniform momentum zones (UMZs) are identified first using a velocity histogram and then the ISL is defined as an UMZ interface. In this study, ISLs are ranked by both their strength and location. The signature behaviours of the ISL including an abrupt streamwise velocity jump and a sharp decrease in velocity fluctuation across the ISL are confirmed. Both the positive and the negative ISLs are stronger towards the wall. The local imbalance between ejections and sweeps are observed around ISLs. Near-wall ISLs have stronger ejections while ISLs in the pipe centre have stronger sweeps. The balance between ejection and sweep is achieved approximately at 0.55-0.6 of the pipe radius for the range of Reynolds numbers studied. The flow structures around an ISL have been identified via 3D conditional sampling. The average positive ISL is located between the high-speed streak above and the low-speed streak below. The low-speed streak is associated with a pair of counter-rotating streamwise vortices which result in a strong ejection around the ISL.

Equidistant distribution loss for person re-identification

Person re-identification (re-id) is a technology that matches images of a certain pedestrian among non-overlapping cameras. Recently, many approaches based on deep learning have been studied comprehensively. Most of these methods try to learn discriminative pedestrian features via elaborated network architectures and one or multi loss functions to maximize inter-class separability and intra-class compactness. However, the class imbalance characteristics from the datasets are ignored, and the discriminative information cannot be completely exploited. In this paper, we propose a novel loss function termed as Equidistant Distribution Loss (EDL) to improve the imbalance problem that exists in re-id tasks. Specifically, we first normalize the learned features in the embedding layer and the weights in the last fully connected layer, so that both the features and the weights can be projected on a hypersphere space. After that, we directly impose an equidistance constraint among the weights to guide the learned features spread uniformly in the sphere space. The proposed EDL can effectively address the local squeeze or imbalance problem caused by imbalanced samples, making full use of feature space and profiting the performance. Extensive experiments on re-id datasets, including Market-1501, DukeMTMC-reID are conducted to demonstrate the preferable performance of the proposed method.

Large eddy simulation study of a wave-induced shallow-water monopolar vortex

Detailed flow and turbulence characteristics of a long-wave-induced shallow-water monopolar vortex are investigated using a 3D large eddy simulation. The numerical model is validated with measured data where nearly 2D shallow turbulent coherent structures were generated by sending a single asymmetric wave through a harbour channel in a large 3D wave basin. Model results demonstrate that the vortex centre trajectory is sensitive to small perturbations applied via a surface tension coefficient. Instantaneous model results are averaged over three numerical runs with slightly different surface tension coefficients so that a sufficient number of realisations are obtained for ensemble-averaging. Because of shallow water depth, flow fields are dominated by a horizontally rotating current and vertically suppressed velocities resembling quasi-2D flow conditions. Bed shear stress calculated using the decay of peak azimuthal velocity is qualitatively similar to that obtained using a near-wall modelling method. Although 2D turbulent coherent structures evolve into monopolar vortices at later stages, flow is not completely axisymmetric due to secondary turbulent coherent sub-structures located in the middle of the water column and away from the core. Turbulence production and turbulence dissipation rate demonstrate a local imbalance where turbulence is mainly produced by flow shear correlated with recirculation patterns, while turbulent kinetic energy is predominantly dissipated near the no-slip bottom boundary. While the free surface elevation at the vortex core indicates an upwelling pattern consistent with laboratory experiments, model results show evidence that the recirculation pattern is influenced by a low frequency resonant mode of the wave basin.

2D‐HARECXS analysis of dopant and oxygen vacancy sites in Al‐doped yttrium titanate

AbstractA Y2Ti2O7/Al2O3 multilayer, exhibiting high thermal reflectivity and oxidation resistivity, holds potential as a functional surface coating for advanced gas turbine blades. Slight Al doping of Y2Ti2O7 has been found to significantly improve the structural stability of the multilayer, the detailed mechanism of which remains unclear. Hence, we examined the site occupancies of doped Al using high‐angular resolution electron channeling X‐ray spectroscopy with two‐dimensional rocking of the incident electron beam. A statistical linear regression analysis of a set of observed ionization channeling patterns (ICPs) of fluorescent X‐rays quantitatively confirmed that Al3+ preferentially occupied the Ti4+ site, rather than the Y3+ site, because of the large difference in the ionic radii of Al3+ and Y3+. Furthermore, the comparison of theoretical and experimental X‐ray ICPs showed that oxygen vacancies VO were introduced at the 48f site, the first‐nearest neighbor of the Ti site, which was consistent with the hypothesis that oxygen vacancies compensate for the local charge imbalance associated with preferential substitution of Al3+ for Ti4+. Our findings can aid in improving the thermal properties of environmental barrier coatings applied to advanced jet engines and also demonstrate the utility of beam‐rocking schemes for investigating dopant effects in various functional materials.

Lumbar alignment and patient-reported outcomes after single-level transforaminal lumbar interbody fusion for degenerative lumbar spondylolisthesis with and without local coronal imbalance.

The purpose of this study was to compare the preoperative radiographic features of degenerative lumbar spondylolisthesis (DLS) with and without local coronal imbalance (LCI) and to investigate the surgical outcomes of transforaminal lumbar interbody fusion (TLIF) in the treatment of DLS with LCI at the spondylolisthesis level. DLS with scoliotic disc wedging and/or lateral listhesis at the same involved segment, as well as LCI, constitutes a distinct subgroup. However, previous studies concerning surgical outcomes focused mainly on sagittal profiles. There is a paucity of valid data regarding lumbar coronal alignment and patient-reported outcomes (PROs) after surgery in DLS with LCI. The authors reviewed consecutive patients who received TLIF for L4/5 DLS between 2009 and 2018. Patients were assigned to the LCI and non-LCI groups based on preoperative radiographs. Demographics, radiographic parameters related to both sagittal and coronal alignment, and PROs were compared between the 2 groups. There were 21 patients in the LCI and 80 in the non-LCI group. Compared with the non-LCI group, the LCI group was characterized by lower preoperative lumbar lordosis on sagittal alignment (38.3° vs 43.7°, p < 0.05), higher lumbar Cobb angle on coronal alignment (12.4° vs 5.1°, p < 0.05), and worse lumbar coronal balance (18.5 mm vs 6.8 mm, p < 0.05). After surgery, lumbar alignment in the sagittal and coronal planes was significantly improved in the LCI group, whereas no significant changes occurred in the non-LCI group. Scores on the preoperative Oswestry Disability Index and the visual analog scale for back pain and leg pain scores were significantly higher in the LCI group, whereas no differences were found between the 2 groups in the postoperative evaluation (p > 0.05). DLS with LCI constitutes a distinct subgroup characterized by coronal malalignment and loss of whole lumbar lordosis, which may result in worse PROs. The TLIF procedure allows the reconstruction of the coronal and sagittal lumbar profile and achievement of satisfactory PROs.