The effect of specimen size on microwave-induced fracturing of rocks has not been well understood. In this study, the experimental tests using open-ended microwave and numerical simulations coupling COMSOL Multiphysics and four-dimensional lattice spring model (4D-LSM) were carried out to investigate the evolution process of microwave-induced cracks, and to elucidate the mechanisms responsible for size-dependent microwave-induced fracturing. The experiments show that with the increase of the specimen dimension, the number of microwave-induced cracks is almost constant, and the total crack length first increases and then decreases, while the maximum crack width and maximum crack depth decrease gradually. A comparison of the experimental and numerical temperature characteristics as well as cracking characteristics indicates that the models established in this study are reasonable in the simulation of the rock fracturing behaviours. The numerical results show that the crack initiation time increases logarithmically with the increase of the specimen dimension. For the small-sized specimens, the microwave-induced cracks started from the outer boundary of the specimen and propagated toward to specimen center and into the depth. For the medium-sized and large-sized specimens, the microwave-induced cracks initiated near the outer boundary of the antenna aperture, and then propagated toward to the center of the specimen and the outer boundary of the specimen. The main reason for the size-dependent of fracturing behavior is that the local fracture energy will dramatically decrease when the crack is approaching the specimen boundary.