The paper provides new evidence on the relationship among per capita incomes, local expenditures and territorial economic structure in Italian inner areas. The study area comprises the municipalities belonging to three Italian regions, namely, Marche, Abruzzo and Molise. The methodology employed involves a panel multilevel regression model, in order to investigate both on territorial and time changes. The period under analysis covers 2008–2016, the years following the outbreak of the global crisis. The results highlight the importance of three public expenditure categories—Environment protection and planning, Tourism, and Cultural heritage—on the growth of per capita incomes. Regional economic structure also plays an important role, especially through the rate of employees in the industrial sector. In order to increase the effectiveness of local public policies, a re-allocation of global expenditures among its various components might be recommended. Another suggestion concerns the implementation of integrated policies oriented both to tourism and to the enhancement of territorial assets.