Local Conversion Research Articles

Biomass-based high-efficiency solar-driven interface evaporator based on natural pomelo peel with multi-curvature gradient structure

Interfacial solar-driven steam generation (ISSG) applied to desalination is considered as a promising technology to solve freshwater crisis. However, challenges remain in the high cost of raw materials, complex manufacturing and the inability to scale. In this paper, a novel interfacial solar-driven evaporator based on ultra-black carbon black-coated pomelo peel (UB-PP) is proposed for high-efficiency desalination, the synergistic effect of natural PP with unique structural properties and the surface high absorption rate photothermal material endows the UB-PP evaporator with high evaporation efficiency, in which the unique multi-curvature gradient and interconnected porous structure is the key to achieving superior solar water evaporation. Under the local high photothermal conversion heat on the surface, the ubiquitous structure provides timely self-water supply, fast water transport, water activation and multi-channel steam release, resulting in the UB-PP evaporator with excellent water evaporation rate of 1.81 kg·m−2·h−1 under 1 sun. Benefiting from the "Turning waste into treasure" strategy and simple preparation method, the overall material cost is as low as $2.7 m−2, enabling the practical large-scale application of UB-PP in desalination and providing a cost-effective management strategy for biowaste.

Abstract A073: Human prostate-on-chip models to define stromal and epithelial interactions in normal and cancerous prostate

Abstract Background: The secretion of morphogenic factors from the stroma, whose production is dependent on stromal androgen receptor (AR) action, is crucial for maintaining glandular structure and homeostatic function of the prostate gland. However, the precise nature of the factors involved, their regulation, and how they impact homeostasis in the human prostate is not clear. We hypothesize that loss of stromal AR function as seen in prostate cancer progression and during androgen-deprivation therapy likely contribute to tumor progression through disruption of this homeostasis. It is important to understand these interactions in the human context to better aid in improving patient outcomes. Approach: Microfluidic-based technology was used to develop the first human Prostate-on-Chip (PoC) where human prostate fibroblasts are co-cultured with human prostate basal epithelial cells under flow. Addition of androgen to the stromal cells is sufficient to induce luminal cell differentiation on top of the neighboring basal cells – recapitulating the cellular architecture of the human gland. To study prostate cancer in this context, we replaced the normal epithelial cells with tumor cells to interrogate the tumor-stromal interactions; thus, generating a human Prostate Cancer-on-Chip model (PCoC). Cytokine arrays and RT-qPCR was used to identify androgen-induced stromal morphogens and tumor cytokines involved in tumor/stromal interactions. Molecular biology approaches were used to identify the mechanisms involved. Results: Within the PCoC model, tumor cells invaded into the stroma and conversely stromal cells invaded into the tumors. This was accompanied by localized CAF conversion of the stroma. Invasion of tumor cells into the stroma could be blocked with an integrin-α6 binding peptide. Strikingly, the level of AR expression in the stroma was also reduced, recapitulating the loss of stromal AR expression seen in patients. A cytokine array identified TNFα and TGFβ as tumor secreted factors responsible for suppressing stromal AR protein and mRNA expression. TNFα suppressed stromal AR expression in the absence of CAF conversion via NF-κB binding to the AR promoter. On the other hand, p38-MAPK signaling suppressed AR expression independent of TNFα. FGF10 and Wnt16, but not KGF, were identified as androgen-induced stromal secreted morphogens. Loss of stromal AR expression, led to suppression of FGF10 and Wnt16, but not KGF expression. Thus, stromal AR inhibition by tumor secreted TNFα or p38-MAPK signaling suppresses the stromal morphogens required to maintain normal prostate homeostasis. Conclusions: We have developed the first human Prostate-on-Chip and Prostate Cancer-on-Chip models which recapitulate the biology of both the normal human prostate as well as prostate cancer stromal interactions. These models can be used to address a range of clinical problems in cancer development, drug response, and biomarker identification in the context of the tumor microenvironment. This model can easily be adapted for personalized medicine approaches. Citation Format: Shekha K. Tahsin, Linan Jiang, Neha Sane, Kailie Szewczyk, Hunain Khawaja, Yitshak Zohar, Cindy K. Miranti. Human prostate-on-chip models to define stromal and epithelial interactions in normal and cancerous prostate [abstract]. In: Proceedings of the AACR Special Conference: Advances in Prostate Cancer Research; 2023 Mar 15-18; Denver, Colorado. Philadelphia (PA): AACR; Cancer Res 2023;83(11 Suppl):Abstract nr A073.

Eco-friendly functional cellulose paper as a fire alarming via wireless warning transmission for indoor fireproofing

Herein, a strategy for fabricating wallpaper-based smart fire-warning systems to monitor and mitigate indoor fires is proposed. The fire-warning system, based on eco-friendly cellulose paper (CP), is produced via a simple dip-coating technique and provides flexibility, rapid low-temperature warning, and novel local and remote wireless signal conversion capability. Specifically, this fire-warning system can balance flexibility and flame retardancy, reducing the negative impact on the mechanical properties after adding flame retardants. Furthermore, the proposed fire-warning system meets the critical requirement of a fast low-temperature warning, showing warning messages within 2 s under 250 ºC, decreasing the response temperature below the combustion temperature of common materials (＞300 ºC). Moreover, the luminosity and temperature data collected can be sent to local and remote computers by wireless conversion. This work gives insight into the new generation of low-temperature smart fire-warning systems, including the contribution of wireless warning signal transmission to achieve smart and efficient fire detection.

Online chemical characterization of atmospheric fine secondary aerosols and organic nitrates in summer Nanjing, China

The mechanisms leading to secondary aerosol pollution in the Yangtze Delta region (such as Nanjing) are still poorly constrained. Here we conducted a field campaign to elucidate the chemical characteristics of fine aerosols, with a focus on variations and formation mechanisms of secondary components in summer Nanjing. The average PM1 mass concentration was 18.88 μg m−3 and was dominated by the secondary species (78%). Secondary inorganic species accounted for 30% of PM1 mass and high PM1 loading was closely relevant with nitrate rather than sulfate. Nitrate was mainly produced from nighttime heterogeneous/aqueous process (production rate of 0.38 g/g H2O) and its variation was driven by thermodynamic equilibrium. On the other hand, sulfate was governed by daytime photochemical production (production rate of 0.013 g/g Ox)(Ox=NO2 + O3) while contribution of aqueous process was minor. Positive matrix factorization identified and quantified a traffic-related hydrocarbon OA (HOA), a cooking OA (COA), and four SOA factors including a local secondary OA (LSOA), a less oxygenated OA (LO-OOA), a moderately oxygenated OA (MD-OOA), and a more-oxidized oxygenated OA (MO-OOA). LSOA was likely from local photochemical conversion of HOA and COA; LO-OOA was semi-volatile thus evaporation/diffusion would offset its weak photochemical production. MO-OOA was very clearly linked with photochemistry, based on its afternoon enhancement and tight positive correlations with Ox (0.029 g/g Ox, occupying ∼60% of photochemical SOA production) and sulfate. MD-OOA was a minor contributor of SOA (∼6%) but it was clearly from aqueous process given the strong positive correlation with aerosol liquid water content (ALWC) and nitrate. Both nitrate and MD-OOA concentrations increased against pH while those of sulfate and MO-OOA decreased. We further investigated the organic nitrate (ON) characteristics, and found that ON was a very minor component of OA in summer Nanjing (0.08–0.14 μg m−3, 0.6–1.1% of OA) and it was predominantly associated with aqueous process. Overall, this work reveals in details formation processes of different secondary species, and therefore is insightful for future air pollution modelling and efficient control in similar regions.

Compound‐specific stable isotopes resolve sources and fate of polyunsaturated fatty acids in biota of headwater streams

Abstract Organisms at the base of stream food webs are typically poor in long‐chain polyunsaturated fatty acids (LC‐PUFA), especially in docosahexaenoic acid (DHA), whereas consumers at higher trophic levels are often rich in LC‐PUFA. For example, fish tissues, especially the brain, are DHA‐rich. This obvious mismatch between consumer LC‐PUFA and their basal dietary supply may result from selective retention and/or endogenous conversion of dietary precursors to LC‐PUFA. To determine which is more likely, we investigated compound‐specific carbon stable isotopes in PUFA (δ13CPUFA) of potential basal resources (stream epilithon, leaf litter) and consumers (invertebrates, European bullhead, and two salmonid species and their brain, eye, liver, and muscle tissues). We predicted that consumer‐PUFA, depleted in 13C values relative to their dietary sources, would indicate internal de novo PUFA synthesis. Alternatively, higher consumer‐δ13CPUFA values would imply selective retention of aquatic (epilithon and conditioned leaves) rather than terrestrial resources or internal production, irrespective of trophic levels. Invertebrate grazers and predators resembled δ13C values of essential fatty acids (δ13CEFA) of benthic algae, while shredder‐δ13CEFA values reflected those of conditioned rather than fresh leaves. Lower eye‐δ13CEFA values of salmonids than in livers indicated high retention of dietary PUFA sources (invertebrates and epilithon). Stable isotope values of eicosapentaenoic acid suggest that all consumers retained algal EPA, while insectivorous fish produced DHA in their liver. There is no further evidence from carbon stable isotopes for local PUFA conversion within neural tissues. Our study demonstrates that δ13CPUFA can be used to track sources of these highly functional molecules in aquatic consumers and highlights the importance of algal derived‐PUFA for these consumers in oligotrophic headwater streams.

Influence of fiber hollowness on the local thermo-electro-elastic field in a thermoelectric composite

The fiber geometry is one of the important parameters in the effective conversion performance and local strength of thermoelectric composites. In this study, the plane problem of a hollow fiber embedded within a non-linear thermoelectric medium in the presence of a uniform remote in-plane electric current and a uniform remote energy flux is investigated based on the complex variable method. Closed-form expressions for all the potential functions characterizing the thermoelectric field and the associated thermal stress field in both the matrix and fiber are obtained by solving the corresponding boundary value problem. Numerical examples are presented to illustrate the effect of hollowness ratio of the fiber on the local energy conversion efficiency and interfacial thermal stress concentration. It is found that a higher conversion efficiency and a lower amount of thermal stress concentration around a hollow fiber than that around a solid fiber could be achieved simultaneously by appropriate selection of the hollowness ratio of the fiber. The results can be directly used for performance optimization and reliability evaluation in design of thermoelectric composites in engineering.

Strong oxygen-content dependence of the magnetic excitations in antiferromagnetic NiO nanoparticles: A Raman probe

Nanostructured antiferromagnetic (AFM) NiO has attracted much attention from both the fundamental and applied perspectives. Understanding the two-magnon (2 M) is of great significance in NiO applications such as spin valves and next-generation magnetic random access memories (MRAM). We investigated the phonon modes and antiferromagnetically ordered states of NiO nanoparticles prepared by empirically controlled measurements. An intensity enhancement of the 2 M mode was observed by Raman spectroscopy as the NiO nanoparticles were vacuum annealed at 650 ℃. The increased 2 M peak intensity in NiO nanoparticles is explained by the local symmetry conversions from NiO5 to NiO6 configurations due to the oxygen redistribution during the vacuum annealing. The change of the splitting of anisotropic transverse optical (TO) phonon with different oxygen contents was also revealed by the Raman spectroscopy. We have shown that the changes in the oxygen environment underlie both the change in the 2 M intensity and the splitting of TO phonon in the NiO nanoparticles. Our work offers an efficient avenue to strengthen the AFM ordering and emphasizes the effect of vacuum annealing of the NiO nanoparticles, opening the interesting possibility of individual parameter control in practical applications.

Local structure and conversion chemistry of high-entropy oxides as Li-ion anodes

Local structure and conversion chemistry of high-entropy oxides as Li-ion anodes

Spatial position recognition method of semi-transparent and flexible workpieces: A machine vision based on red light assisted

In the automatic sorting process, overlapping translucent and flexible workpieces on the conveyor belt, blurring the imaging edge features of translucent and flexible workpieces is a challenge to locate the upper and lower workpieces spatially, we propose a method for locating translucent and flexible workpieces spatially under the overlapping environment in conjunction with the most common automatic sorting of translucent and flexible workpieces such as infusion tube drip buckets. Firstly, we propose a rectangular surface light source based on 650 nm band and monocular CCD for imaging translucent workpieces such as infusion tube drip buckets and optimize the imaging parameters. Secondly, we study a feature matching recognition algorithm for flexible workpieces that are prone to deformation, construct a mapping relationship between the position of overlapping layers and imaging quality of translucent and flexible workpieces such as infusion tube drip buckets based on clarity and information entropy, and establish The mapping relationship between the position of the overlapping layers and the imaging quality of translucent and flexible workpieces such as infusion tube drip buckets is constructed based on clarity and information entropy, and a local spatial coordinate conversion model is established. Finally, the spatial positioning coordinates of overlapping and non-overlapping translucent and flexible workpieces in the local coordinate system are identified, and the results show that the imaging method and theory can be effectively applied to the identification of overlapping and spatial positioning coordinates in the automatic sorting of translucent workpieces such as infusion tube drip buckets.

Spectral Budget of Rotational and Divergent Kinetic Energy in Global Analyses

Abstract To study the multiscale interactions between rotational and divergent components of atmospheric motion, a new formulation of spectral budget of rotational kinetic energy (RKE) and divergent kinetic energy (DKE) based on the primitive equations in the pressure coordinate is derived, with four main characteristics: 1) horizontal kinetic energy (HKE) spectral transfer is exactly divided into spectral transfer of RKE and DKE, 2) the exact spectral conversion term between DKE and RKE is constructed, 3) the Coriolis term is considered, and 4) both the baroclinic conversion from available potential energy (APE) and the vertical flux of HKE act only on DKE. With this new formulation, outputs from ERA5 global reanalysis are investigated. At planetary scales, HKE spectral transfer, mainly attributed to β effect, is dominated by downscale DKE transfer. At synoptic scales, it is dominated by an upscale transfer of RKE energized by conversion of DKE mainly due to the Coriolis effect. The ultimate source of DKE in the upper troposphere is conversion of APE, while in the stratosphere it is the vertical flux. At mesoscales, the spectral transfers of RKE and DKE are both downscale, and conversion from RKE to DKE exists at sub-800-km scales in the upper troposphere, which is mainly attributed to the contribution from relative vorticity. At different heights, the intersection scales of RKE and DKE spectra are affected by the scales of positive peaks of the local spectral conversion from DKE to RKE around total wavenumber 10. Significance Statement The purpose of this study is to explore more physical insights on the dynamics underlying the atmospheric energy spectra from the perspective of rotational and divergent components of motion. We derive a new formulation of the spectral rotational and divergent kinetic energy budget in the pressure coordinate for the global atmosphere, with application to ERA5 global reanalysis. Our results reveal the differences of spectral energy budget between rotational and divergent motions at different heights and scales. This new formulation provides a good tool for revealing the multiscale cascade and interaction between atmospheric rotational and divergent motions. Future work should investigate these dynamical processes with higher-resolution simulations and datasets.

Efficient Energy Conversion through Vortex Arrays in the Turbulent Magnetosheath

Turbulence is often enhanced when transmitted through a collisionless plasma shock. We investigate how the enhanced turbulent energy in the Earth's magnetosheath effectively dissipates via vortex arrays. This research topic is of great importance as it relates to particle energization at astrophysical shocks across the universe. Wave modes and intermittent coherent structures are the key candidate mechanisms for energy conversion in turbulent plasmas. Here, by comparing in-situ measurements in the Earth's magnetosheath with a theoretical model, we find the existence of vortex arrays at the transition between the downstream regions of the Earth's bow shock. Vortex arrays consist of quasi-orthogonal kinetic waves and exhibit both high volumetric filling factors and strong local energy conversion, thereby showing a greater dissipative energization than traditional waves and coherent structures. Therefore, we propose that vortex arrays are a promising mechanism for efficient energy conversion in the sheath regions downstream of astrophysical shocks.

Capability Approach and Inclusion: Developing a Context Sensitive Design for Biobased Value Chains

Biomass such as crops and agricultural waste is increasingly used as the primary resource for products like bioplastics and biofuels. Incorporating the needs, knowledge, skills and values of biomass producers in the design of global value chains – the steps involved in creating any finished product from design to delivery – can contribute to sustainability, reliability and fairness. However, how to involve biomass producers, especially if they are resource poor, remains a challenge. To make sure that inclusion in global biobased value chains is both fair and effective, the capabilities of relevant actors need to be taken into account, especially of those producing biomass. Access to resources determines to what extent a specific actor can participate in a global value chain. Therefore, differences in capabilities should be a central consideration when new (biobased) value chains are designed. Using the capability approach as an ethical framework to realize inclusion, we discern three complementary strategies for setting up inclusive value chains. Firstly, designing for local conversion factors second, providing adaptive design for new capabilities, and third, investing in local conversion factors. Applying these strategies can lead to context-sensitive design of biorefineries that allow for true inclusion of local stakeholders. We support these claims with reference to case-studies of sugarcane production in Jamaica, modified tobacco in South Africa and the non-edible parts of corn (stover) in the US.

Characteristics of Barotropic Energy Conversion in Rapid Intensifying and Decaying Tropical Cyclones Over the Western North Pacific

AbstractThe prediction of the tropical cyclone (TC) intensity remains a difficult issue. This study analyzes local instantaneous barotropic kinetic energy conversion in the lower troposphere in rapid intensifying (RI) and rapid decaying (RD) TCs over the western North Pacific (WNP) during June through November from 1979 to 2017. The kinetic energy conversion to the synoptic eddies is separated for climatological mean, interannual and intraseasonal flows. It is found that the intraseasonal cyclonic flows display a northwest‐southeast orientation in the RI TCs, but a circular feature in the RD TCs. Intraseasonal and climatological mean zonal flows contribute together to the positive kinetic energy conversion in the northwest quadrant of the RI TCs. Intraseasonal meridional flows induce positive (negative) kinetic energy conversion in the northeast (south) part of the RD TCs. The kinetic energy conversion associated with interannual flows is small for both the RI and RD TCs.

Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models

BackgroundRoughly half of all diffuse large B-cell lymphomas (DLBCLs) are infiltrated by large numbers of regulatory T-cells (Tregs). Although the presence of ‘effector’ Tregs in particular is associated with an...

Quantitative nanoscale temperature mapping across the multi-quantum well of a light-emitting diode in operation using vacuum null-point scanning thermal microscopy to evaluate local energy conversion efficiency.

Electrical energy that is not converted into light in light emitting diodes (LEDs) is locally dissipated as heat in the active layers. Therefore, by measuring the temperature distribution with nanoscale resolution across the multi-quantum well (MQW) of an LED in operation, the effect of nanostructures inside the LED on the local energy conversion efficiency can be observed. In this study, we first demonstrated that vacuum null-point scanning thermal microscopy (VNP SThM) could be used to quantitatively map the two-dimensional temperature distribution across the MQW of an LED in operation with a sufficient signal-to-noise ratio. Subsequently, by increasing the injection current in four steps, we quantitatively mapped the temperature distribution across the MQW at each step and observed the shift in the temperature peak across the active layers due to the increase in injection current. The measurements of the temperature distribution around the MQW indicate that as the injection current increased, the overall temperature around the MQW increased significantly, and the temperature peak position shifted. These results show that the main cause of the dissipation of electrical energy into thermal energy inside an LED changes as the injection current increases, and the nanostructures inside an LED affect the dissipation of electrical energy into thermal energy. The high thermal sensitivity, nanoscale resolution, and convenience of VNP SThM may enable the direct observation of the effect of the nanostructures inside various types of nanophotonic devices on local energy conversion even under intense localized radiation.

Infrared sensitive mixed phase of V7O16 and V2O5 thin-films.

We report an infrared (IR) sensitive mixed phase of V7O16 and V2O5 thin films, grown by cathodic vacuum arc-deposition on glass substrates at relatively low temperatures. We have found that the mixed phase of V7O16 and V2O5 can be stabilized by post-annealing of amorphous VxOy between 300-400 °C, which gets fully converted into V2O5 after annealing at higher temperatures ∼450 °C. The local conversion from VxOy to V2O5 has also been demonstrated by applying different laser powers in Raman spectroscopy measurements. The optical transmission of these films increases as the content of V2O5 increases but the electrical conductivity and the optical bandgap decrease. These results are explained by the role of defects (oxygen vacancies) through the photoluminescence (PL) and time-resolved photoluminescence (TRPL) measurements. The IR sensitivity of the mixed phase is explained by the plasmonic absorption by the V7O16 degenerate semiconductor.

Public Libraries and COVID-19: Perceptions and Politics in the United States

Public librarians across the United States found themselves in different political environments that challenged their ability to serve their communities, to provide the information that was needed, and to fight disinformation regarding the pandemic. Researchers at the University of Missouri examined how and what librarians communicated to the public about COVID-19. A survey was sent to a systematic sample of libraries from all states and service-area sizes, carried out from January 24 to February 7, 2022. A total of 106 responses were received, with 66 respondents having answered every question. Analysis of closed- and open-ended survey responses points to public librarians’ concerns about (a) local government officials and their decisions, (b) resistance on the part of patrons to accurate information, and (c) problems disentangling the local conversation from national media (and social media) perspectives.

Stability conditions for polarised varieties

Abstract We introduce an analogue of Bridgeland’s stability conditions for polarised varieties. Much as Bridgeland stability is modelled on slope stability of coherent sheaves, our notion of Z-stability is modelled on the notion of K-stability of polarised varieties. We then introduce an analytic counterpart to stability, through the notion of a Z-critical Kähler metric, modelled on the constant scalar curvature Kähler condition. Our main result shows that a polarised variety which is analytically K-semistable and asymptotically Z-stable admits Z-critical Kähler metrics in the large volume regime. We also prove a local converse and explain how these results can be viewed in terms of local wall crossing. A special case of our framework gives a manifold analogue of the deformed Hermitian Yang–Mills equation.

Factors of local conversion of iodothyronines correlate with indicators of hormonal, biochemical, and hematological profiles in patients with spinal canal and dural sac stenosis of the lumbar spine

In order to find out the mechanisms of pathogenesis of degenerative-dystrophic diseases of the spine, it is of particular interest to search for body parameters which are directly or indirectly interrelated with the key factors of peripheral conversion of nidus iodothyronines and constitute a system of network interactions, affecting metabolic indicators at the local and systemic level.The aim. To search for correlations of local key factors of peripheral conversion of Ligamentum flavum iodothyronines with indicators of biochemical, hematological and hormonal blood profiles of patients with stenosing processes of the spinal canal and dural sac in the lumbar spine.Materials and methods. 33 patients (15 males, 18 females) with stenosing processes of the spinal canal and dural sac in the lumbar spine were examined (mean age – 45.73 ± 1.95 years). The expression of deiodinase genes and other candidate genes was determined in Ligamentum flavum biopsies collected during surgical treatment. Biochemical, hematological and hormonal parameters were determined in peripheral blood. The resulting data array was processed in order to find correlations between the parameters of systemic and local metabolism.Results. The relationships of deiodinases with the expression of GDF5, MMP1, MMP3 and TIMP1 in Ligamentum flavum (p < 0.05) were found. Of the hormonal profile of the blood serum, the most significant indicators were thyreotropin, free triiodothyronine and thyroperoxidase antibodies. In the biochemical profile, levels of direct bilirubin, total cholesterol, HDL and LDL cholesterol and triglycerides changed along with the expression of deiodinases. Correlative relationships with the expression of deiodinases were found for the following hematological analytes of whole peripheral blood: hemoglobin, mean corpuscular hemoglobin concentration, numbers of granulocytes, lymphocytes, eosinophils, monocytes, band neutrophils, red cell distribution width and platelet crit. The data obtained indicate the involvement of peripheral conversion factors in the pathogenetic process and provide information to form a new view on the pathogenesis of degenerative-dystrophic processes in the Ligamentum flavum of patients with stenosing processes of the spinal canal and the dural sac in the lumbar spine.

Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke

The concept of the neurovascular unit emphasizes the importance of cell-cell signaling between neural, glial, and vascular compartments. In neurogenesis, for example, brain endothelial cells play a key role by supplying trophic support to neural progenitors. Here, we describe a surprising phenomenon where brain endothelial cells may release trans-differentiation signals that convert astrocytes into neural progenitor cells in male mice after stroke. After oxygen-glucose deprivation, brain endothelial cells release microvesicles containing pro-neural factor Ascl1 that enter into astrocytes to induce their trans-differentiation into neural progenitors. In mouse models of focal cerebral ischemia, Ascl1 is upregulated in endothelium prior to astrocytic conversion into neural progenitor cells. Injecting brain endothelial-derived microvesicles amplifies the process of astrocyte trans-differentiation. Endothelial-specific overexpression of Ascl1 increases the local conversion of astrocytes into neural progenitors and improves behavioral recovery. Our findings describe an unexpected vascular-regulated mechanism of neuroplasticity that may open up therapeutic opportunities for improving outcomes after stroke.