AbstractWe analysed the elevated low‐relief relict landscapes in the transient Upper Satluj‐Zhada basin and the adjoining region in the tectonically active north‐western (NW) Himalaya–south‐western (SW) Tibetan orogen to understand the evolution of the regional landscape and drainage system under the influence of the Karakoram Fault‐Leo‐Pargil Horst system. This elevated low relief landscape represents the Mio‐Pliocene establishment of a new river network, which testimonies the present Sutlej River, which has been experiencing a transient surface uplift‐incision regime since (~4–1 Ma) with a local base level at the confluence of the Sutlej and Spiti River. The Miocene exhumation of the Ayilari Range and Leo‐Pargil Horst across the Karakoram fault (KF) system led to headward erosion, which abandoned the Paleo‐Sutlej‐Indus drainage system, which in turn caused drainage reversal along Qusum detachment (QD) and produced southward migration of the Paleo‐Sutlej River towards the mountain front. Our results indicate that the Upper Indus River has significantly lower χ‐ranges at higher elevations as compared with the adjacent Upper Sutlej River at lower elevations, which corresponds with a river piracy model that incorporates area gain‐loss feedback. The Upper Sutlej River in the Zhada basin is characterized by a comparable series of coplanar slope‐break knickpoints at ~4000–4500 m elevation, and their adjoining divides are in a state of disequilibrium as a consequence of the very high rapid incision across the Leo Pargil Horst, which drives the regional gradation process. The headward‐eroding Upper Indus River captured the proto‐Sutlej due to a base‐level change of >~1500 m, which significantly impacted the regional growth pattern and tectonics. The Mio‐Pliocene sedimentation pattern of the Upper Sutlej‐Zhada basin in the SW Tibet–NW Himalaya reflects this regional drainage capture, tectonic uplift and paleo‐drainage reorganization. The present finding has wider implications for the Mio‐Pliocene reorganization of drainage systems and the possible linkage of the Upper Indus River with the Paleo‐Sutlej over the Zhada basin.