Although CrNb coated zirconium alloy materials are considered as ATF candidates with excellent oxidation resistance and mechanical properties, the irradiation response behavior under harsh and complex service conditions is still unrevealed. Here, we report the evolution of the microstructure of pure Cr and CrNb coatings with different Nb contents under simultaneous irradiation with Cr+-He+-H2+ triple ion beams at 633 K by using an advanced in-situ transmission electron microscope (TEM). The results show that CrNb coatings with high Nb content have better irradiation stability. Under high-temperature irradiation conditions, irradiation-induced oxidation and grain growth or crystallization are observed for both Cr-8 Nb with a nanocrystalline structure and Cr-18 Nb coatings with an almost amorphous structure, whereas Cr-37 Nb coatings maintains relatively intact in the amorphous phase after irradiation at a dose of 10 dpa. Based on the in-situ tracking of the microstructural evolution, it is revealed that the mechanism of irradiation-accelerated oxidation and crystallization of coatings originates from displacement cascades enhancing local atomic diffusion and rearrangement.