Pyogenic Granuloma Research Articles

Surgical Removal of Recurred Pyogenic Granuloma Using Diode Laser in a Pediatric Patient: A Case Report

Surgical Removal of Recurred Pyogenic Granuloma Using Diode Laser in a Pediatric Patient: A Case Report

Rare presentation of pyogenic granuloma: a case report

The pyogenic granuloma (PG) Also called lobular capillary hemangioma, is a prevalent tumorlike growth and vascular hyperplasia of the skin and mucous membranes. The condition arises in reaction to a chronic, recurring tissue injury that stimulates an exuberant or excessive tissue repair response. It can manifest at any age. The most common site is gingiva, extra gingival occurrence of PG is rare, although have been reported. Management of PG Depends on the area, size of lesion and patient preferences. However, the conservative surgical excision usually the curative treatment of PG. Alternative treatment modalities that have been employed include laser therapy, corticosteroid injections, cryosurgery, and sclerotherapy. In the case report has described an extra gingival PG which occurred on the lower lip in a 19-year-old female patient. The clinical and histopathological assessments confirmed the diagnosis of PG.

Hidradenoma Papilliferum Mimicking Pyogenic Granuloma

Hidradenoma papilliferum is a rare, benign apocrine tumour that occurs almost exclusively in the anogenital region of middle aged women. Here, we present a case of a 28-year-old married female presenting with asymptomatic, erythematous nodule over left labia majora mimicking pyogenic granuloma. A surgical excision was done and histopathological examination revealed the diagnosis of hidradenoma papilliferum.

Oral pyogenic granuloma with calcification

Rationale: Pyogenic granuloma (PG) is a commonly observed reactive soft-tissue lesion, often arising due to prolonged mild irritation or hormonal fluctuations in the oral cavity. Clinically, PG presents as a lesion with a smooth or lobulated appearance, which can be either sessile or pedunculated, and typically exhibits an hemorrhagic tendency. Very few cases of calcification in a PG have been reported in the past as these rarely exhibit ossification when viewed under a microscope. Patient Concerns: The following report is a case of a PG, that presented as a growth with occasional pain in the right upper back region of a 54 year old female. The patient reported no other concerns. Diagnosis: A provisional diagnosis of PG was given following thorough clinical and radiographic investigations. This was confirmed by a histopathological examination following an excisional biopsy. Intervention: The patient was treated with surgical excision as a part of the excisional biopsy of the lesion. Follow-up for the patient was done after 6 months, and there were no signs or indications of recurrence. Outcomes: The histopathological examination revealed regions of calcification, which are uncommon in PG, in addition to the characteristic hallmarks of proliferating endothelial cells, blood vessels, and inflammatory cells.

Cutaneous Vascular Anomalies: A Cross-Sectional Study in a Tertiary Care Hospital

Background: Vascular anomalies are a group of disorders that are divided into two categories: tumors and malformations. Given the vast diversity of clinical presentations with overlapping signs and symptoms, diagnosis can be difficult. Objective: We conducted a cross-sectional study to evaluate the common cutaneous vascular anomalies encountered in our outpatient department. Materials and Methods: A total of 28 patients suspected to be having cutaneous vascular anomalies were screened and subjected to biopsy. The diagnosis was based on clinicopathological correlation. Results: In our study, pyogenic granuloma was the most common vascular anomaly seen in 25% of patients; majority of these patients gave a history of trauma and spontaneous bleeding. It was followed by angiokeratoma (17.8%), infantile hemangioma, port-wine stain, and verrucous hemangioma which was seen in 10.7% of patients. Other common vascular anomalies included are glomus tumor and tufted angioma. Conclusion: Vascular anomalies comprise a spectrum of diseases, diagnosis of which is often challenging. Accurate diagnosis is critical to generate a management plan for the patient. Our study highlights the varied clinical spectrum of vascular tumors that we come across in clinical practice and it will increase familiarity of the various clinical presentations, thereby enabling clinicians to better identify and manage these challenging entities.

Wet table salt and its saturated hypertonic solution for treating retinoic acid resistant plane viral warts on face.

Plane viral warts on the face can be difficult to treat at times. Various treatment approaches for facial viral warts have had variable degrees of effectiveness. In contrast, the majority of existing treatments are more costly, painful, and difficult to manage. In approximately 15.6% of instances, retinoic acid (0.05%) is also ineffective. It is very difficult to cure warts on the face at a young age. In pyogenic granuloma, table salt (NaCl) is useful as a sclerosing agent, and its hypertonic solution (15%) is effective in prolabial mucoceles. The aim of treating viral warts is to necrose infected cells and sclerose or thrombose their feeding capillaries at the wart's base.

Pyogenic Granuloma of the Gingiva

Pyogenic granuloma is a benign vascular lesion that usually occurs in response to various stimuli caused by chronic irritation, trauma and hormonal factors. These lesions generally occur on the gingiva but can also occur on the lips, tongue and buccal mucosa. A 22 year old female patient came with complaints of a lump on the gingiva between teeth 35 and 36 and felt uncomfortable. I have had complaints since 7 months ago after a filling was made on the left back molar tooth, then 1 day later a lump appeared. Complaints are not accompanied by pain. The treatment plan in this case is to carry out information education communication, scaling, gingivectomy and a histopathological examination to confirm the diagnosis and carry out control and evaluation. Pyogenic granuloma is a benign, non-neoplastic lesion. The clinical picture of this lesion is generally a mass with a soft consistency, painless, and dark red to reddish purple in colour which usually appears as a solitary lesion with a diameter of 5-10 mm and is very fragile, so it bleeds easily due to minor trauma. Management of this lesion can be done with a surgical procedure to completely remove the lesion and then carry out an anatomical histopathological examination to confirm the diagnosis of this lesion. This lesion has no signs of malignancy

Botriomycoma on arteriovenous malformation

Botriomycoma and Arteriovenous Malformation (AVM) are two different entities. The botriomycoma or also called Pyogenic Granuloma (GP) is a vascular tumor benign of the skin and mucous membranes, often post-traumatic, whereas AVM is a high flow vascular malformation. The occurrence of GP on AVM is extremely rare. We report an original clinical image of this association. This is a 12 year old patient, without any notable pathological history, who consults for a fleshy nodule bleeding post traumatic injury to the forehead (Figure 1A). Clinical examination reveals a warm underlying mass and pulsatile which dates back to the age of 7 years. The diagnosis is suggested clinically and by Doppler ultrasound, and confirmed intraoperatively (Figure 1B) and after histological study of the specimen excision. The diagnosis was made after elimination of other causes: Isolated GP, GP on fistula arteriovenous and others.

Pyogenic granuloma of gingiva –A case report

Reactive hyperplasia of connective tissue caused by local irritants is known as pyogenic granuloma. It is a tumor-like development of the oral cavity that is thought to be neoplastic in nature. It is typically found around the skin or anterior teeth. Numerous stressors, such as intense injury, low-grade local discomfort, hormone fluctuations, or certain drugs, are commonly the cause of it. Histologically, the surface epithelium may show foci of ulcerations, hyperkeratosis, or even intact. It sits on top of a thick mass of connective tissue with a high concentration of fully grown collagen. The most often impacted area is the gingiva, which is followed by the lips, tongue, and buccal mucosa. In general, pyogenic granuloma does not develop when the base and its contributing variables are removed.

Pyogenic Granuloma Gravidarum of the Nasal Cavity Causing Recurrent Epistaxis. A Case Report and Review of the Literature

Pyogenic Granuloma Gravidarum of the Nasal Cavity Causing Recurrent Epistaxis. A Case Report and Review of the Literature

Nasal Lobular Capillary Hemangioma During Pregnancy: A Systematic Review.

Objective: To perform a systematic review of published cases of nasal lobular capillary hemangioma (LCH) during pregnancy. Data Source: PubMed, Embase, Scopus, Web of Science, and LILACS. Review Methods: We searched electronic databases from inception to June 30, 2022. Case report and case series that reported clinical data on nasal LCH during pregnancy were included. Categorical variables were expressed as proportions and numerical variables as mean ± standard deviation or median (interquartile range). Results: Twenty-three studies (20 case reports and 3 case series) involving 29 patients were included. The mean age was 30.5 ± 5.3 years. A total of 62% cases were diagnosed in the third trimester of pregnancy. The most frequent (62%) location of LCH was the nasal septum. All cases presented with epistaxis. A total of 48% cases were treated by surgical excision after delivery and the recurrence was 11%. Conclusion: Our review shows that nasal LCH during pregnancy usually manifests in the third trimester. This lesion can be treated by surgical excision with a relatively low risk of recurrence.

Oral Pyogenic Granuloma at Different Spots: A Series of Case Reports

ABSTRACT Pyogenic granuloma is an inflammatory non-neoplastic lesion of the oral cavity. Chronic, mild, local irritation, trauma, hormonal variables, and certain medications are typical causes of pyogenic granulomas. Women have a higher prevalence than men. The risk is greatest in the second to fifth decades of life. Clinically, the lesion appears smooth, with soft to firm consistency and nontender with a pedunculated or sessile base. Various modalities have been proposed for the treatment of lesion, which include the conventional approach, the use of laser, cryotherapy, and electrocauterization. This case series discusses three cases of pyogenic granuloma in female patients at different locations in the oral cavity. The lesion was subsequently treated with electrosurgery and surgical convention methods. No recurrence of the lesion has been seen in either of the cases.

Evaluation and management of benign tumors of the eye and eyelid

Benign tumors of the eye and eyelid are common in children and adults, and they rarely undergo malignant transformation. Their workup and management have evolved over the years with increasing advancements in surgical and laser therapies. This contribution focuses on describing the following benign eye and eyelid tumors and their diagnostic and treatment approaches: congenital and acquired melanocytic nevi; nevus of Ota (Hori nevus); conjunctival papilloma; seborrheic keratosis; epidermoid cyst; dermoid cyst; milium; xanthelasma; hemangioma (cherry angioma and pyogenic granuloma); neurofibroma; neurilemmoma (schwannoma); and fibroepithelial polyp. Surgical removal is the primary treatment approach for many of these benign tumors. With advancements in laser technologies, there are now several laser types that can be used in the treatment of these benign eye and eyelid tumors. Other treatment modalities include cryosurgery, electrosurgery, and topical or intralesional medications. We hope this review will provide a reference to dermatologists and ophthalmologists in their approach to evaluation and management of benign eye and eyelid tumors.

Oral Manifestations in Pregnant Women: A Systematic Review

Background: The period of pregnancy is characterized by a multitude of diverse changes that exert a notable impact on the oral cavity of women. During this gestational phase, patients necessitate tailored oral care and specific recommendations to preempt and address potential oral diseases. This systematic review aimed to perform a detailed analysis of the research studies that focused on the oral manifestations observed in pregnant women. Methods: A meticulous search was conducted in the databases Medline, Scopus, and Scielo by employing the following search terms: ((pregnant OR pregnancy)) AND ((“oral manifestation*”) OR (“oral health”)). Articles that were published between 2013 and 2023 and written in English or Spanish and studies that scrutinized oral manifestations in pregnant women and included a diagnosis conducted by a qualified dentist were selected; we excluded articles published before 2013, articles that could not be accessed in full text, studies whose patients were not pregnant women at the time of the study, studies where patients were selected because they had a specific disease, studies where the clinical examination was not performed by a dentist, and articles written in languages other than English or Spanish. Subsequently, the risk of bias in the chosen articles was assessed in accordance with the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) scale. Results: A total of 20 studies were included in the analysis, following the exclusion and inclusion criteria. These studies were categorized as cross-sectional, cohort, longitudinal, or case–control. Various oral manifestations in pregnant women were examined, with five studies comparing these manifestations with those observed in nonpregnant women. Conclusions: The most prevalent oral manifestations associated with pregnancy encompass dental caries, periodontitis, gingivitis, pyogenic granuloma, and candidiasis. Nonetheless, less common lesions may also emerge during the course of pregnancy.

Uncommon Presentation of Pyogenic Granuloma in the Small Intestine: A Rare Case Report

Uncommon Presentation of Pyogenic Granuloma in the Small Intestine: A Rare Case Report

Phenomena of Intussusceptive Angiogenesis and Intussusceptive Lymphangiogenesis in Blood and Lymphatic Vessel Tumors.

Intussusceptive angiogenesis (IA) and intussusceptive lymphangiogenesis (IL) play a key role in the growth and morphogenesis of vessels. However, there are very few studies in this regard in vessel tumors (VTs). Our objective is to assess the presence, characteristics, and possible mechanisms of the formation of intussusceptive structures in a broad spectrum of VTs. For this purpose, examples of benign and malignant blood and lymphatic VTs were studied via conventional procedures, semithin sections, and immunochemistry and immunofluorescence microscopy. The results demonstrated intussusceptive structures (pillars, meshes, and folds) in benign (lobular capillary hemangioma or pyogenic granuloma, intravascular papillary endothelial hyperplasia or Masson tumor, sinusoidal hemangioma, cavernous hemangioma, glomeruloid hemangioma, angiolipoma, and lymphangiomas), low-grade malignancy (retiform hemangioendothelioma and Dabska tumor), and malignant (angiosarcoma and Kaposi sarcoma) VTs. Intussusceptive structures showed an endothelial cover and a core formed of connective tissue components and presented findings suggesting an origin through vessel loops, endothelialized thrombus, interendothelial bridges, and/or splitting and fusion, and conditioned VT morphology. In conclusion, the findings support the participation of IA and IL, in association with sprouting angiogenesis, in VTs, and therefore in their growth and morphogenesis, which is of pathophysiological interest and lays the groundwork for in-depth molecular studies with therapeutic purposes.

Pyogenic granuloma as rare post-operative complication following pterygium surgery: a case report

Pyogenic granuloma as rare post-operative complication following pterygium surgery: a case report

Pyogenic Granuloma or HaemangiomaA Diagnostic Dilemma in a 13-year-old Female

Pyogenic granulomas and haemangiomas are well-known benign lesions of the oral cavity. Although pyogenic granulomas are known to have a gingival preference, while capillary haemangiomas are more commonly found on the lips, cheeks, tongue, and palate. There are several lesions in the oral cavity that resemble haemangiomas microscopically. Pyogenic granuloma is one of these lesions, characterised by the proliferation of endothelial cells, and is often indistinguishable from true haemangiomas microscopically. The clinical diagnosis of such a rare phenomenon can be quite difficult, as they can sometimes resemble more serious lesions, such as malignancies. Hereby, the authors present a case report of capillary haemangioma in the maxillary left posterior region of the jaw in a 13-year-old female, which was clinically diagnosed as pyogenic granuloma. The patient presented with a painless swelling, and no significant findings were observed on radiographic examination. The present case report aimed to resolve the dilemma in the diagnosis of vascular tumours and malformations, and to assess their histological, biological behaviour, and clinical presentation.

The Correlation between VEGF and CD34 Protein Marker and Pyogenic Granuloma.

A typical non-neoplastic connective tissue proliferations called a pyogenic granuloma. A vascular adhesion molecule used to assess angiogenesis is the CD34 marker. The primary memberof a family of growth factors, VEGF helps in generating and maintaining the lymphatic and blood circulation systems. The aim of the study was to know the correlation between VEGF and CD34 protein marker and pyogenic granuloma. Thirty-one formalin fixed paraffin embedded (FFPE) blocks were taken from female pyogenic granuloma patients ranging in age from 29 to 70. The IHC was used to identify VEGF and CD34 expression in the cytoplasm of the cells. Seventeenout of 31 patients had VEGF positive expression. Twenty-sixout of 31 had CD34 positive expression and 5 with no expression (negative expression). Brown-stained cytoplasm showed high VEGF and CD34 expression, whereas blue stained cytoplasm showed no VEGF and CD34 expression in these cells. The results suggest the role of suchbiomarkers in the oral pyogenic granuloma pathogenesis, and it appears that CD34 and VEGF are valuable biomarkers in evaluating vascular and inflammatory diseases like pyogenic granuloma.

The clinical characteristics and outcomes of the patients with pyogenic granuloma: A retrospective study of 144 patients

Aim: Pyogenic granuloma (PG), also known as lobular capillary hemangioma, is a benign, reactive vascular tumor. We aimed to evaluate the demographic and clinical characteristics, treatments received, and outcomes of patients followed up at our clinic with PG. Materials and Methods: We retrospectively evaluated all patients followed up at our clinic with PG in the last 4 years. Results: A total of 144 patients were included in our study. 73 (51%) of the patients were female and 71 (49%) were male. The mean age of the patients was 31.3±8.3 years. When we examined the PG locations in our patients, we observed that it was most commonly found in the arm/hand area (40%), on the face (29%), foot/leg area (19%), and on the trunk (8.3%). The highest number of lesions were respectively in the hand, foot nail edge, and lip locations. Out of the patients where the lesion side was specified, 63 had the lesion on the left while 20 had it on the right (p=0.001). 51% of our patients underwent excisional surgery. Other treatments applied to our patients, in order, were cryotherapy (15.3%), electrocauterization (8.3%), cauterization with silver nitrate, cryotherapy+electrocauterization, topical antibiotic and cryotherapy+timolol drop. When evaluating the outcomes of the patients, we learned from the notes dropped into the system at later controls that 73% had recovered. The remaining patients were lost to follow-up. When comparing the features of patients who were treated with non-excisional methods to those who underwent excision, we observed that there was a higher rate of patients younger than 12 years (p=0.023), a higher incidence of foot nail edge (p=0.016) and lip location (p=0.048), and a higher frequency of pregnancy in this group. Conclusion: PG is a vascular tumor of importance due to its potential for bleeding and ulceration and its chronic course if left untreated. Since there are malignant lesions in its differential diagnosis, we believe that surgical excision is a more appropriate treatment option when feasible. We think that the data we have obtained needs to be supported by more comprehensive, broader, and prospective studies.