Fatigue behavior of superelastic NiTi alloys under variable amplitude loading is experimentally studied and two energy-based fatigue models were used to analyze the fatigue behavior. Cyclic tests were conducted in strain-controlled condition. Load sequence effects are studied by performing fatigue testing under load paths consisting of two steps of constant amplitude loading. Both low-high (LH) and high-low (HL) load paths were considered in experimentations. Variable amplitude load paths were also generated at a constant strain rate using random values, which resulted in reversals of different strain amplitudes and mean strains. Analysis of the fatigue results was carried out using two energy-based fatigue models that have been shown to appropriately account for the effects of mean strain and stress. The energy-based total-fatigue-toughness parameter, ∑Wt, together with the Rainflow cycle counting method provided satisfactory fatigue life predictions for this alloy. Based on this combination of the fatigue parameter and cycle counting technique, the predicted fatigue lives fall within prediction bands of 2.5 for all the different variable amplitude loading paths.