The AMP‐activating protein kinase (AMPK) and its upstream kinase LKB1 are serine/threonine kinases that have been proposed to function as master regulators for a diverse array of cellular processes. In skeletal muscle, there is emerging evidence that AMPK and LKB1 regulate multiple metabolic functions, including glucose transport. Our group and others have generated mice lacking AMPK activity in skeletal muscle, as well as muscle‐specific LKB1 knockout mice. In this talk, the putative role of LKB1 and AMPK in regulating skeletal muscle metabolism will be discussed. In addition, recent data will be shown on sucrose non‐fermenting AMPK‐related kinase (SNARK), an AMPK‐related kinase that has previously been shown to be regulated by multiple cellular stresses in kidney and several tumor cell lines. This presentation will discuss our work showing that exercise and contractile activity increase SNARK activity in skeletal muscle. Data will also be presented suggesting a role for SNARK in glucose transport regulation in skeletal muscle.This research is supported by the American Physiological Society Postdoctoral Fellowship in Physiological Genomics (HJK) and NIH grants AR45670 and DK68626 (LJG).