To compare production and economic performance of polyculture systems with different species combinations, a 210-day trial was carried out. In the first combination (T1), milkfish (Chanos chanos) and mudcrabs (Scylla serrata), and in the second (T2), mullets (Mugil cephalus, Liza tade and Liza parsia at 0.5:0.5:0.5 ratio) and mudcrabs were stocked keeping fish and mudcrabs at 15,000 numbers per ha, respectively, in both treatments. The finfish were fed floating pellet at 2%–3% and mudcrabs were fed fresh and farm made feed at 5%–8% body weight. Growth parameters of mudcrabs were similar in both T1 (407.64 ± 105.78 g) and T2 (418.89 ± 105.24 g), with no significant differences. Among finfish, M. cephalus attained highest final body weight, 241.55 ± 26.44 g followed by milkfish, 200.46 ± 11.82 g whereas lowest growth noticed in L. parsia (63.69 ± 6.62 g). Length–weight analysis of fish indicated negatively allometric growth (b < 3) for grey mullets, parsia and milkfish while L. tade recorded perfect cube low (b = 2.99). Male mudcrabs recorded positive allometric (b = 3.3) and female crab exhibited negative allometric growth (b = 2.68). The total productivity was 4,533 and 3,694 kg/ha with mudcrab contributes 53.69% and 60.56% to the total productivity in T1 and T2 respectively. The economic analysis indicated benefit–cost ratio (BCR) of 1.57 and 1.73 in T1 and T2 respectively with 10% and 35% insignificant increase (p > 0.05) in BCR and profit per kg, respectively, in T2 compared with T1. The study elucidates polyculture of mudcrabs with finfish can be a taken up as a profitable venture for sustainable diversification of brackishwater farming in Sundarbans.