In the course of the experiment, the influence of new feed additives created on the basis of Gaprin and representing biomass of inactivated cell culture of non-pathogenic methane-oxidizing yeasts or bacteria on sturgeon fish productivity indicators was studied. The research was carried out in the Krasnodar Territory on sterlet fingerlings. The experiment lasted for 60 days. According to the scheme of the experiment, the 1st (control) group of fish received complete feeds without additives, i.e. containing 100.0% fish meal. In group 2 feeding, 50.0% fishmeal was replaced with 50.0% Gaprin. Group 3 diet contained 25.0% fishmeal and 75.0% Gaprin. In the feed for group 4, fish meal and Gaprin were in the ratio of 75/25%. In Group 5, fish meal was completely replaced by Gaprin, in this case the amount of additive was 10.5 kg. Sterlet fingerlings from Group 6 received feed with 10.0% Gaprin. The initial live weight in all groups was similar at 30 g. However, the inclusion of Gaprin in the diet by reducing the amount of fish meal contributed to an increase in the final live weight of sterlets in the experimental groups by 4.4–19.4% compared to the control. The exceptions were groups 5 and 6, which received 100.0 and 90.0% Gaprin instead of fishmeal. Final live weight in these groups was lower by 2.3 and 0.9%, respectively. Feed costs per 1 kg of live weight gain in the groups with partial or complete replacement of fish meal were lower relative to the 1st group (from 7.0 to 17.9%,).Inclusion of Gaprin in complete feeds contributed to the increase in profit from 553.00 to 1785.00 rubles.