Gastric cancer patients with metastasis limited to a single liver lobe were subjected to pathological study, retrospectively. The primary gastric lesion had been resected in all 16 cases, whereas the liver metastasis were resected in 8 cases. The measured cell proliferation index using Ki-67 antibody kit was not significant between primary and metastatic lesions. However, the vascular endothelial growth factor was significantly lower in liver metastatic lesions (p<0.01). Postoperative surviving period was significantly prolonged in the resected liver metastasis group over the nonresected group (p<0.05). When multiple liver metastasis were confirmed in a single lobe, micrometastasis were proven pathologically in all cases (2/2). The above findings suggest the usefulness of liver resection in gastric cancer patients with liver metastasis that is limited to a single lobe, and the necessity of systematic liver excision in multiple liver metastasis cases.