Due to uncertainty of single-method interpretation we applied 2-D integrated lithospheric modelling along three CELEBRATION 2000 profiles CEL01, CEL04 and CEL05. Modelling of the lithospheric thermal structure is based on the joint interpretation of gravity, geoid, topography and surface heat flow data with temperature-dependent density. The models for each profile were constrained by seismic modelling results of the large-scale international project CELEBRATION 2000. The results indicate large variations of the lithosphere thickness from the old and cold East European Craton (~200 km) and the Trans European suture zone via the Western Carpathian orogeny to the young and hot Pannonian Basin (~90 km). Important differences in the lithospheric thickness were also found along-strike of the Western Carpathian orogeny and the Trans-European Suture Zone. The western part of the Western Carpathians is characterized by weak thickening of the lithosphere (only about 145 km), while their eastern segment presents strong lithospheric thickening (~190 km). The Małopolska unit in southern Poland has a lithospheric thickness of about 130 km. Thickest lithosphere (220 km) is observed around the junction of the Carpathian Foredeep and the East-European Craton. The crustal thickness follows generally the course of the lithosphere-asthenosphere boundary. The results suggest different geodynamic evolution of the collision of the ALCAPA microplate with the European platform on the one hand and the East-European Craton on the other hand. It is suggested that the tectonic evolution of this very complex area consisting of different tectonic units has changed in time and space.