To evaluate the effect of cervical margin relocation (CMR) for crowns designed using CAD/CAM technology and fabricated from lithium disilicate (e.max, CAD) before and after aging; and to compare the fracture forces and failure type of the tested crowns. Mesio-occluso-distal(MOD) cavities 1 mm above the cementoenamel junction(CEJ) were prepared on 40 maxillary first premolars. The teeth were divided into four groups. In group A, all cervical margins (CM) were located 1 mm above the CEJ. However, in both mesial and distal proximal boxes of groups B, C, and D, in addition to the MOD cavities, the CMs were extended 2 mm on both sides below the CEJ apically to simulate the CMR technique. In group B, the mesial and distal proximal boxes were filled with flowable composite, while for group C and group D, specimens were filled with composite resin fillings. To simulate the CMR technique, the cavities were filled with composite layers of 3 mm in two increments. Using the CAD/CAM system, 40 standard crowns were prepared on premolars, then cemented using a dual-curing adhesive cement. Assessments of the marginal integrity of interfaces of the proximal boxes of the cemented crowned teeth were recorded. Statistical differences between groups were analyzed using the ANOVA and Bonferroni's posthoc test. The first null hypothesis was accepted since no statistically significant differences were found in marginal integrity before and after aging (p>0.05), while the second was partially rejected since different fractured force values were recorded and a significant difference was detected between group D and group B. The third hypothesis was rejected because the catastrophic fracture rate was the highest among the four groups. The implementation of CMR before and after aging had a good effect on the marginal integrity of CM relocation. The CMR technique with resin luting cement of lithium disilicate crowns is effective and recommended for the restoration in deep proximal boxes of premolars or posterior teeth. CAD/CAM-generated e. max all-ceramic crowns with composite as the CMR enable the reconstruction of severely destroyed teeth irrespective of the position of the cavity margins.
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