Compilation Of Literature Research Articles

Community gardens: contribution to food safety and social inclusion

Sustainability in large-scale food production is one of humanity's greatest contemporary challenges. Today’s society is totally dependent on agricultural fields. In face of the increasing environmental and food crisis in the world, it is necessary to improve ways of promote sustainable agriculture. Conventional agriculture has proved to be predatory to the environment and maleficent to human health due to the intensive use of agrochemicals, and also inefficient to supply with quality and safety the whole urban population. Therefore, urban agroecology has become a tendency. The study presented here investigated a community garden of the West Zone of São Paulo City, organically grown in the Previdência Municipal Park, which is an intensely urbanized area. Observations were carried out in loco, plus interviews with the responsible for the community garden, and compilation of relevant literature, focusing on the importance of horticulture, practical difficulties in the community involved in the project, benefits to society, and the role in urban sustainability. Horticulturists’ social aspects, involvement of the regulars, and adopted cultivation techniques were also investigated. The challenges of urban agriculture projects reported in the literature were identified, so as to define the best cultivation strategies to be adopted in the community garden. The main results pointed to benefits to food and nutrition safety, interpersonal involvement, and environmental education; the main challenges consist of social leaderships, technical-scientific knowledge regarding productivity of organic cultivars, and planning aiming the continuity of the projects. Relevant benefits can be obtained from the implementation of urban garden projects, contemplating some of the Objectives of Sustainable Development that are related not only to sustainable agriculture, but also to the sustainability of cities and communities. KEYWORDS: Urban Agriculture. Food Safety. Urban Parks. Sustainability.

<strong>Verbenaceae in Espírito Santo, Brazil: richness, patterns of geographic distribution and conservation</strong>

Verbenaceae is represented in Brazil by 15 genera and ca. 290 species, with most of its richness in the Cerrado and Atlantic Forest domains. The state of Espírito Santo has an area of 46,184.1 km2, wholly embedded in the Atlantic Forest. Nonetheless, due to the intense environmental degradation in the state, only 10.5% of its original vegetation remains. The present study is part of the “Flora do estado do Espírito Santo” project and aims to provide a taxonomic treatment to Verbenaceae in the state, as well as to analyze its distribution patterns, together with preliminary conservation assessments for each species. It is based on morphological analysis of herbaria collections, field expeditions, and literature compilation. Distribution maps were made for each species, while the preliminary conservation assessments followed the criteria proposed by the IUCN. Verbenaceae is represented in the state of Espírito Santo by 31 species arranged in 11 genera: Aloysia (2 spp.), Bouchea (1 sp.). Casselia (1 sp.), Citharexylum (1 sp.), Glandularia (1 sp.), Lantana (10 spp.), Lippia (4 spp.), Petrea (1 sp.), Priva (2 spp.), Stachytarpheta (6 spp.) and Verbena (2 spp.). Eight species occurring in Espírito Santo are threatened with extinction. Three new records are verified, including species of the genus Lantana. The dense rainforest, which covers most of the state’s territory, presents the most significant number of species (20 spp.), followed by pioneer vegetations (12 spp.), seasonal semideciduous forests (11 spp.), inselbergs (8 spp.), and ecological refuges (2 spp.). The main richness centers for Verbenaceae in the state of Espírito Santo are the municipalities of Linhares, Santa Teresa, Vitória, Vila Velha, and Guarapari in this order. In contrast, the family is noticeably little represented in the northern region of the state, as well as near its borders, where the forest remnants are highly fragmented and scattered. The current results contribute to the taxonomic and biogeographic knowledge of Verbenaceae, to the creation of conservation strategies for threatened species in the State of sspírito Santo, and reinforce the need of fieldwork in several areas of the state.

The Potential Applications of Moringa oleifera Leaves in Functional Herbal Beverages: A Review of its Nutritional, Medicinal, and Toxicity Profiles

: In recent times, Moringa oleifera Lam. has become one of the most sought after therapeutic cure-all plants in tropical and subtropical zones, including Jamaica. Anecdotally, the most popular choice of Moringa consumption locally is in the form of functional herbal beverages, such as teas and juices, prepared from the leaves of the plant. However, there is little or no scientific evidence to validate the efficacy and or safety of such beverages. : An extensive search of scientific literature published over the last decade (2010-2020) related to the nutritional, medicinal, and toxicological profiles of Moringa oleifera was, therefore conducted with special emphasis on literature related to the dried leaves and aqueous leaf extracts thereof. Google Scholar, Science Direct, and PubMed databases were the main search tools employed. Articles that referred to varieties of Moringa, other than oleifera, were excluded from the searches, as were articles that referred to subject matters outside of nutrition, medicinal properties, and toxicity. All peer-reviewed journal articles, and other online articles, which referred to the subject matters of interest were critically read and included in the review. : This review is a compilation of evidence-based literature, indicating the outstanding nutritive value, high therapeutic potential, and the relatively non-toxic properties of the dried leaves and aqueous leaf extracts of Moringa oleifera. Prospects for their application in the development of safe and efficacious functional herbal beverages are indicated.

Learning to read while reading to learn: Marcius Willson’s basal readers, science education, and object teaching, 1860–1890

ABSTRACT The essay discusses innovations in reading education by the schoolbook author Marcius Willson (1813-1905) through an examination of two popular series of basal readers he produced during and after the American Civil War. His School and Family Series (Harper & Brothers, 1860-) generated acrimonious debate about science education, literacy, and object pedagogy in the primary grades. His successor Popular Series (Lippincott, 1881-) went beyond compilation of classic literature in a basal reader by creating a fictitious community populated with a diverse cast of characters and storyboard of incidents that could draw young readers out of the classroom and into a broader world of nature and commerce. Both series competed effectively against rivals in national and regional markets and foreshadowed modern concepts of reading education based on the idea of “learning to read while reading to learn.” The essay also affirms the centrality of individual authorship and scholarship as the textbook market industrialized.

The Role of Education Support in Enhancement of Entrepreneurial Intentions Amongst Undergraduates in Malaysia

Entrepreneurship has long been a topic of interest for many researchers. The economy being volatile has impeded job opportunities for many, particularly amongst youths. In Malaysia specifically, where unemployment has been increasing over the years, measures have been taken by the government to promote entrepreneurship to youth and undergraduates to make them more entrepreneurially inclined. Despite the numerous incentives and programs by the government to encourage youth to be entrepreneurial inclined, the unemployment rate is still high in many countries, particularly Malaysia. This research aims to offer a systematic literature review on the growing role of education support in promoting entrepreneurial intention amongst undergraduates in Malaysia. This research will highlight the increasing importance of education in fostering entrepreneurial intentions amongst undergraduates in Malaysia over the last five years. Through the compilation of past literature and research, this study aims to contribute to entrepreneurship research by discussing the impact of education support as well as highlighting ongoing discussions on education support in nurturing undergraduate entrepreneurial intention.

Gall midges (Insecta, Diptera, Cecidomyiidae) associated with Clusiaceae in Brazil: richness and distribution.

A literature compilation was done to gather information about Cecidomyiidae galls on Clusiaceae in Brazil. Botanical names were verified in the site "Flora do Brasil" as well as data on plant distribution and origin. Two herbaria were visited in order to examine galled specimens of Clusiaceae and retrieve new locality records. Thirteen gall morphotypes have been recorded on three genera (Clusia, Garcinia, and Tovomita) and eight species. Clusia showed the greatest number of galled species. Tovomita brevistaminea is the super host species. Only three gallers, Parazalepidota clusiae, Clusiamyia granulosa and C. nitida, were identified at species level, which highlights how the taxonomy of the gall midges is still poorly known. The examination of galled exsiccates resulted in the expansion of their distribution area. The low gall richness as well as the low number of galled plants on Clusiaceae can be related to the presence of resinous sticky sap and waxy cuticle. The known occurrence of gallers associated with Clusiaceae is restricted to the Atlantic Forest as their host plants. The gallers distribution is less wide than that of the host plants, indicating that their geographic limits can be further extended.

No Butts on the Beach: Aquatic Toxicity of Cigarette Butt Leachate Chemicals.

Toxic pollutants leaching from littered cigarette butts (CB) raise environmental impact concerns. The US Food and Drug Administration (FDA) is required to assess the environmental impacts of its tobacco regulatory actions per the US National Environmental Policy Act (NEPA). We determined the chemical constituents in CB leachate through analyses of 109 field-collected CB and literature compilation and characterized their ecotoxicity to aquatic organisms. One-third of the 98 identified CB leachate chemicals were very toxic and 10% were toxic to aquatic organisms due to acute and chronic toxicity. Polycyclic aromatic hydrocarbons, metals, phthalates, nicotine and volatile organic compounds were the most hazardous CB leachate chemicals for aquatic organisms. Of the 98 CB leachate chemicals, 25 are included in FDA's list of harmful or potentially harmful constituents in tobacco products and tobacco smoke. Our study quantifies CB leachate constituents, characterizes their ecological hazard and identifies chemicals of concern. Thus, it aids in evaluating the environmental impacts of tobacco products per NEPA requirements. These results provide important information for strategies to prevent and reduce CB litter (eg, awareness programs, litter laws enforcement), thereby reducing environmental hazards from CB toxicants.

Revisão do parecer BRASPEN de terapia nutricional em pacientes hospitalizados com COVID-19

Introduction: After a year since the start of the COVID-19 pandemic, nutritional therapy has been shown to be a fundamental part of the integral care of critical patients. This BRASPEN technical report revises and updates the previous report on how to deal with COVID-19 and proposes suggestions to guide multidisciplinary nutritional therapy teams (MNTTs) in Brazil. Methods: The text reflects a compilation of the current literature updates on nutritional therapy for COVID-19 patients. Results: The combat against the COVID-19 pandemic currently has turned into a great challenge worldwide and nutritional therapy is an essential part of the critically ill patients’ integral care. The document tackles the patients’ evaluation, choosing the best formula, discusses the necessity calculation, the use of nutritional therapy for pronated patients in both ECMO and rehabilitation. Conclusion: It is emphasized that COVID-19 patients in EMTN treatment must receive nutritional therapy and the attention they need.

Differences between fixed day shift workers and rotating shift workers in gastrointestinal problems: a systematic review and meta-analysis.

This study comprised a review and compilation of literature to gain an in-depth understanding of the impact of rotating shift work on gastrointestinal health. PubMed, CINAHL, and the Cochrane Library were searched for studies published between January 1, 1985, and June 30, 2020. Fixed day shifts were defined as work shifts that began between 7:00 and 9:00 in the morning. Shifts beginning at any other time were classified as rotating shifts. A meta-analysis was performed using Comprehensive Meta-Analysis Software (CMA) version 3. In the end, 16 studies were included in the meta-analysis. An odds ratio (OR) of 1.56 (95% confidence interval (CI): 1.24–1.95), indicating that gastrointestinal problems are more common in rotating shift workers than in fixed day shift workers. Four gastrointestinal problems, namely, irritable bowel syndrome, constipation, indigestion, and peptic ulcers, were then analyzed separately. Significant differences between rotating shift workers and fixed day shift workers were found only for indigestion and peptic ulcers. For indigestion, the OR was 1.72 (95% CI: 1.28–2.30). For peptic ulcers, the OR was 1.66 (95% CI: 1.19–2.30). Thus, research indicates that rotating shift work may increase the risk of gastrointestinal problems, particularly indigestion and peptic ulcers.

Dynamically Tagged Groups of Very Metal-poor Halo Stars from the HK and Hamburg/ESO Surveys

Abstract We analyze the dynamical properties of ∼1500 very metal-poor (VMP; [Fe/H] ≲ −2.0) halo stars, based primarily on medium-resolution spectroscopic data from the HK and Hamburg/ESO surveys. These data, collected over the past 30 yr, are supplemented by a number of calibration stars and other small samples, along with astrometric information from Gaia DR2. We apply a clustering algorithm to the 4D energy-action space of the sample, and identify a set of 38 dynamically tagged groups (DTGs), containing between 5 and 30 member stars. Many of these DTGs can be associated with previously known prominent substructures such as Gaia-Sausage/Enceladus (GSE), Sequoia, Helmi Stream (HStr), and Thamnos. Others are associated with previously identified smaller dynamical groups of stars and streams. We identify 10 new DTGs as well, many of which have strongly retrograde orbits. We also investigate possible connections between our DTGs and ∼300 individual r-process-enhanced (RPE) stars from a recent literature compilation. We find that several of these objects have similar dynamical properties to GSE (5), the HStr (4), Sequoia (1), and Rg5 (1), indicating that their progenitors might have been important sources of RPE stars in the Galaxy. Additionally, a number of our newly identified DTGs are shown to be associated with at least two RPE stars each (DTG-2: 3, DTG-7: 2; DTG-27: 2). Taken as a whole, these results are consistent with ultra-faint and/or dwarf spheroidal galaxies as birth environments in which r-process nucleosynthesis took place, and then were disrupted by the Milky Way.

The fauna of caves and other subter-ranean habitats of North Carolina, USA

Over 1,500 caves have been documented in North Carolina, however, cave fauna in the Blue Ridge Mountains and Piedmont regions of North Carolina have been overlooked historically compared to the cave-rich karst terrains in the Appalachian Valley and Ridge and Interior Low Plateau to the west. Here, we provide the first comprehensive faunal list of caves and other subterranean habitats in the state based on over 40 years of periodic surveys and compilation of literature, biodiversity databases, and museum records. We report 475 occurrences from 127 caves, springs, and wells in 29 counties, representing 5 phyla, 17 classes, 43 orders, 90 families, 124 genera, and at least 164 species. Vertebrate fauna comprised 32 species, including 4 fishes, 9 salamanders, 1 lizard, 4 snakes, 2 birds, and 12 mammals (8 bats). Diverse invertebrate groups included spiders (11 families and 18 genera), springtails (7 families and 9 genera), segmented worms (3 families and 8 genera), and snails (6 families and 9 genera). At least 25 taxa are troglobites/stygobites (cave obligates), including 5 species of cave flatworms, 5 cave springtails, and 5 cave amphipods. Most troglobitic/stygobitic fauna documented in this study are endemic to North Carolina. Counties with the greatest cave biodiversity include Rutherford, McDowell, Swain, Henderson, Polk, and Avery counties. Over 20 species documented are of conservation concern, including 14 troglobites and 3 federally-listed bats. Although not as diverse as adjacent states, caves and other subterranean habitats in North Carolina support a diverse community of invertebrates and vertebrates. Our review serves as a base line for future cave biological surveys in the state and highlights the importance of subterranean habitats for North Carolina biodiversity.

Slow Tourism – The Fashion for Slowness or a Conscious Choice?

Abstract Research background: The fast pace of life of contemporary people living in developed countries results in a search for peace and relaxation, which is reflected in new forms of tourism. One of them is slow tourism, which is at an early stage of development. A new type of tourist is emerging – one who is conscious, responsible, critical, respectful of nature, open to learning about the customs, culture and religion of local populations. Purpose: This paper analyses the changes that take place in tourism from a socio-economic perspective, characterized by withdrawing from mass tourism and a shift towards individual tourism, with particular emphasis on slow tourism. Research methodology: The paper is based on a compilation of the current literature of the subject, reports and analysis of Polish websites devoted to slow travel. It is a synthesis of economic and social aspects of slow tourism development, including the motives for taking up slow tourism by tourists and the offer of slow travel in Poland. Results: The analysis of the literature reveals a large diversity in the definition of slow tourism. A lively discussion is going on regarding the meaning of the new trend, its importance and future. In Poland, slow tourism is becoming increasingly popular, as evidenced by, among others: an increase in the number of offers for slow tourists. Novelty: This analysis contributes to deepening the knowledge on new trends in tourism – slow tourism. These considerations contribute to the author’s further research on the development of this phenomenon.

Marine-derived fungi as a source of bioactive indole alkaloids with diversified structures.

Marine-derived fungi are well known as rich sources of bioactive natural products. Growing evidences indicated that indole alkaloids, isolated from a variety of marine-derived fungi, have attracted considerable attention for their diverse, challenging structural complexity and promising bioactivities, and therefore, indole alkaloids have potential to be pharmaceutical lead compounds. Systemic compilation of the relevant literature. In this review, we demonstrated a comprehensive overview of 431 new indole alkaloids from 21 genera of marine-derived fungi with an emphasis on their structures and bioactivities, covering literatures published during 1982-2019.

Sliding Crack Model for Nonlinearity and Hysteresis in the Triaxial Stress‐Strain Curve of Rock, and Application to Antigorite Deformation

AbstractUnder triaxial deviatoric loading at stresses below failure, rocks generally exhibit nonlinearity and hysteresis in the stress‐strain curve. In 1965, Walsh first explained this behavior in terms of frictional sliding along the faces of closed microcracks. The hypothesis is that crack sliding is the dominant mode of rock inelasticity at moderate compressive stresses for certain rock types. Here we extend the model of David et al. (2012, https://doi.org/10.1016/j.ijrmms.2012.02.001) to include (i) the effect of the confining stress; (ii) multiple load‐unload cycles; (iii) calculation of the dissipated strain energy upon unload‐reload; (iv) either frictional or cohesive behavior; and (v) either aligned or randomly oriented cracks. Closed‐form expressions are obtained for the effective Young's modulus during loading, unloading, and reloading, as functions of the mineral's Young's modulus, the crack density, the crack friction coefficient and cohesion for the frictional and cohesive sliding models, respectively, and the crack orientation in the case of aligned cracks. The dissipated energy per cycle is quadratic and linear in stress for the frictional and cohesive models, respectively. Both models provide a good fit to a cyclic loading data set on polycrystalline antigorite, based on a compilation of literature and newly acquired data, at various pressures and temperatures. At high pressure, with increasing temperature, the model results reveal a decrease in friction coefficient and a transition from a frictionally to a cohesively controlled behavior. New measurements of fracture toughness and tensile strength provide quantitative support that inelastic behavior in antigorite is predominantly caused by shear crack sliding and propagation without dilatancy.

Contrasting physiological traits of shade tolerance in Pinus and Podocarpaceae native to a tropical Vietnamese forest: insight from an aberrant flat-leaved pine.

The absence of pines from tropical forests is a puzzling biogeographical oddity potentially explained by traits of shade intolerance. Pinus krempfii (Lecomte), a flat-leaved pine endemic to the Central Highlands of Vietnam, provides a notable exception as it seems to compete successfully with shade-tolerant tropical species. Here, we test the hypothesis that successful conifer performance at the juvenile stage depends on physiological traits of shade tolerance by comparing the physiological characteristics of P. krempfii to coexisting species from two taxa: the genus Pinus, and a relatively abundant and shade-tolerant conifer family found in pantropical forests, the Podocarpaceae. We examined leaf photosynthetic, respiratory and biochemical traits. Additionally, we compiled attainable maximum photosynthesis, maximum RuBP carboxylation (Vcmax) and maximum electron transport (Jmax) values for Pinus and Podocarpaceae species from the literature. In our literature compilation, P. krempfii was intermediate between Pinus and Podocarpaceae in its maximum photosynthesis and its Vcmax. Pinus exhibited a higher Vcmax than Podocarpaceae, resulting in a less steep slope in the linear relationship between Jmax and Vcmax. These results suggest that Pinus may be more shade intolerant than Podocarpaceae, with P. krempfii falling between the two taxa. However, in contrast, Vietnamese conifers' leaf mass per areas and biochemical traits did not highlight the same intermediate nature of P. krempfii. Furthermore, regardless of leaf morphology or family assignation, all species demonstrated a common and extremely high carbon gain efficiency. Overall, our findings highlight the importance of shade-tolerant photosynthetic traits for conifer survival in tropical forests. However, they also demonstrate a diversity of shade tolerance strategies, all of which lead to the persistence of Vietnamese juvenile conifers in low-light tropical understories.

A critical literature survey and prospects on tampering and anomaly detection in image data

Concernings related to image security have increased in the last years. One of the main reasons relies on the replacement of conventional photography to digital images, once the development of new technologies for image processing, as much as it has helped in the evolution of many new techniques in forensic studies, it also provided tools for image tampering. In this context, many companies and researchers devoted many efforts towards methods for detecting such tampered images, mostly aided by autonomous intelligent systems. Therefore, this work focuses on introducing a rigorous survey contemplating the state-of-the-art literature on computer-aided tampered image detection using machine learning techniques, as well as evolutionary computation, neural networks, fuzzy logic, Bayesian reasoning, among others. Besides, it also contemplates anomaly detection methods in the context of images due to the intrinsic relation between anomalies and tampering. Moreover, it aims at recent and in-depth researches relevant to the context of image tampering detection, performing a survey over more than 100 works related to the subject, spanning across different themes related to image tampering detection. Finally, a critical analysis is performed over this comprehensive compilation of literature, yielding some research opportunities and discussing some challenges in an attempt to align future efforts of the community with the niches and gaps remarked in this exciting field.

Role of polyamines in vegetable crop production: A review

Vegetables play a major role in human diet. They are enriched with various essential nutrients and therefore also called as protective food. For sustainable vegetable production and to meet the vegetable demand advancement in production techniques of vegetable crops is need of an hour. Use of polyamines as a tool for improving the vegetable production is found to be beneficial. Polyamines are the organic poly-cation compounds consisting of two or more amino groups found to improve growth and development of plants due to their effects on cell division and cell differentiation. Polyamines are also involved in various physiological processes in plants and also play major role in ion channels regulation and transportation of different molecules in cell membrane. Polyamines are associated with many fundamental processes such as DNA replication, RNA modification, synthesis of protein, modulation of enzyme activities and transcription in plants. Several studies have been conducted to study the effect of different polyamines (putrecine, spermidine, spermine etc.) on growth and development of vegetables for better outcome. Therefore, present review paper focuses on compilation of literature with respect to the effect of polyamines on growth and development of vegetables for sustainable and fruitful vegetable production.

Helping Babies Breathe: From Implementation to Impact.

* Abbreviation: HBB — : Helping Babies Breathe In this issue of Pediatrics, the article “Implementation of the Helping Babies Breathe Training Program: A Systematic Review” by Morris et al1 provides a detailed review of the body of literature that has come together since the launch of Helping Babies Breathe (HBB) one decade ago. This report explores the efficacy of the HBB training program, associated newborn outcomes, implementation strategies, and quality improvement efforts to ensure that HBB achieves its intended goal. This review compiles experience from around the globe, with articles representing a diverse range of clinical environments and cultures. In the thoughtful compilation of the available literature, it is striking that publications on HBB’s impact on skill acquisition, knowledge, and practices far outnumber those on clinical outcomes. This fact highlights the need for further study of HBB’s impact, both in terms of neonatal morbidity and mortality, in the decade to come. Although this systematic review of the literature provides insight into our experience … Address correspondence to Sara K. Berkelhamer, UBMD, Department of Pediatrics, 1001 Main St, Buffalo, NY 14203. E-mail: saraberk{at}buffalo.edu

Mental Health and COVID-19: Implications for the Future of Telehealth.

This article uses mental health trends during the COVID-19 pandemic to question how we can leverage current technologies such as telehealth to provide better mental health care. Based on this compilation of literature, an increase in suicide rates, suicidal ideation, and mental health disorders is possible as a result of the impact of COVID-19. By increasing the use of telehealth and investigating best practices for its use, the outcome is 3-fold. We can provide preventative measures after the COVID-19 pandemic subsides, more effective care to patients during future pandemics and global crises, and reduce mental health care disparities by reaching rural Americans.

PREDICTORS OF FISTULA HEALING; A STRUCTURED LITERATURE REVIEW.

Introduction: Obstetric fistula is defined as an abnormal communication between two epithelial surfaces. It is a preventable maternal morbidity that results from prolonged and obstructed labor. Often, the condition is characterized by continuous urine or stool leakage. In East Africa, the condition is common. In recent years, health workers have scaled up access to fistula repairs in an attempt to restore the dignity of affected woman. However, little is known about the number of women who gain full continence after surgery. In addition, factors that affect or promote fistula healing are scanty. The aim of this review was to describe predictors of fistula healing in these settings. 
 Methodology: Methods Structured review system to literature compilation was used. Explicit methodology was utilized to identify, select, and critically evaluate results of the studies to be included in the literature review. Authors developed a pre-defined eligibility criterion and a specific research question which guided the search process. Papers which focused on predictors of fistula healing were reviewed. The following Keywords were used in the search: Vesicovaginal Fistula (VVF), Vaginal Fistula (VF), urogenital fistula (UGF), Obstetric fistula (OF), Female Genital fistula (FGF) and Treatment outcomes. Hawkers tool was used in scoring selected papers. 
 Results: A total of 23 papers were reviewed. Few papers assessed surgical outcomes in fistula surgery especially in East Africa. Predictors of poor surgical outcomes were reported, these include: Scarring tissue, repeat repairs and large fistulas. 
 Conclusion: Factors that predict outcomes in fistula surgery are far more than those reported. There is limited evidence of mixed methods study designs in this field of surgery. As such, further inquiry is required to explore a wider range of factors and develop holistic approaches to fistula management.