List Task Research Articles

A - 123 Word List Task Outperforms Cognitive Screener in Neurocognitive Disorder Detection

Abstract Objective The California Verbal Learning Test II (CVLT II) demonstrated utility in characterizing neurocognitive disorders (Webber et al., 2018). The Mini-Mental State Examination (MMSE) is considered the most widely used assessment tool in screening for possible neurocognitive disorders (Tsoi et al., 2015). The purpose of this study was to establish which cognitive assessment tool, MMSE or CVLT II, better-identified individuals at risk for neurocognitive impairment. Method Older adults (n = 113; age 60–90, M = 73.53, SD = 7.16) from the general community received a comprehensive neuropsychological evaluation. We performed ROC curve analysis using SPSS to assess the predictive performance of two test variables, MMSE (M = 26.37; SD = 3.68) and CVLT LDFR (M = −0.14; SD = 1.45), in predicting whether the participant has a neurocognitive disorder. Results ROC curve analysis demonstrated that both variables, MMSE and CVLT LDFR, significantly predicted the presence of a neurocognitive disorder, with AUC values of 0.84 and 0.89, respectively. The variable CVLT LDFR shows a higher AUC value, indicating slightly better discriminatory power to the variable MMSE. Conclusions CVLT II’s long-delay free recall trial directly assesses verbal memory retention and recall. Memory impairment, particularly delayed recall deficits, is a hallmark feature of many neurocognitive disorders. This specificity aligns with the involvement of the hippocampus, a brain region crucial for memory consolidation, which is often dysfunctional in neurocognitive disorders. Therefore, a test targeting this aspect of memory function may offer greater sensitivity and specificity in detecting neurocognitive impairments compared to more general cognitive screening tools like the MMSE.

2 Vigilant Coping Moderates the Relationship between Discrimination and Memory among Black and Latinx Adults

Objective:In the U.S, Black and Latinx individuals disproportionately experience daily acts of discrimination. To counteract the psychological distress, many individuals develop coping mechanisms, like vigilant coping, where behaviors are modified to attempt to prevent discriminatory experiences. Researchers have investigated how coping mechanisms moderate the relationship between discrimination and psychological stress, but not their role in the relationship between discrimination and cognitive function. Prior research has shown a link between discrimination and poor episodic memory. The current study examined vigilant coping as a potential moderator in the relationship between discrimination and memory among Black and Latinx people.Participants and Methods:We partnered with 1317 non-Latinx Black (n= 291) and Latinx (n= 1026) individuals who participated in the Offspring Study of Racial and Ethnic Disparities in Alzheimer's Disease. Participants were assessed in English or Spanish, according to their preference. Experiences of discrimination were measured on two scales: Major (civil rights violations) and Everyday (daily hassles), and were coded according to yearly chronicity. Vigilance was measured among people with at least one reported experience of discrimination on either scale, using a 5-item survey which was dichotomized as low and high vigilant coping. The Selective Reminding Test, a 12-item word list task with 6 learning trials and a delayed recall trial, yielded scores for total immediate recall and delayed memory. Linear regression models were used to assess if vigilance moderated the relationship between discrimination and memory, with years of education and age as covariates.Results:Participants ranged in age from 27 to 91, with a mean age of 56.5 (SD=11.0) years, a mean education of 12.7 (SD=3.7) years, and were 67% women. High vigilant coping was associated with more experiences of major (b = 1.7, 95% CI = 0.9,2.5) and everyday (b = 90.3, 95% CI=66.2,114.3) discrimination. Memory was not associated with reported everyday discrimination, but lower delayed recall was observed among people who reported more experiences of major discrimination (b= -0.04, 95% CI = -0.07,-0.01). This relationship was moderated by vigilance, such that among people with low vigilant coping, major experiences of discrimination predicted lower memory (b= -0.06, 95% CI = -0.12,-0.01), but the association between discrimination and memory was weakened among people with high use of vigilant coping (b= -0.02, 95% CI = -0.05,0.01).Conclusions:This study builds on Black researchers' work that laid the foundations for examination of stress and coping in marginalized populations. Future studies on discrimination and cognitive health should consider coping mechanisms as key aspects of pathways linking structural racism and inequalities to cognitive health among Black and Latinx individuals.

33 Title: Examining memory performances in a sample of cognitively healthy illiterate older adult population in India

Objective:Despite the rise in literacy, 773 million of the global population is estimated to be illiterate. The rate of illiteracy is even higher among women and older adults (OA). Literacy has been well documented to impact cognitive skills, and most neuropsychological tests developed are for individuals with higher education. Moreover, there is sparse research on cognitive process and performance of illiterate individuals across cognitive domains.Per a 2011 census, the illiteracy rate in the Indian older adult population was as high as 56%, and within this group, women and older adults in rural regions were especially vulnerable. Thus, it is important to understand cognitive performance of illiterate Indian older adult population, especially when they are being assessed for neurodegenerative disorders.Participants and Methods:This study used subset of data from Harmonized Longitudinal Aging Study of India, Diagnostic Assessment of Dementia (LASI DAD), which was developed by the Gateway to Global Aging Data. A sample of cognitive healthy OA (n = 715) was selected based on Hindi Mental Status Exam score of >19 and a Clinical Dementia Rating Scale of 0 (literate = 419, illiterate = 296). Given the heterogeneity of the population, adapted cognitive instruments were used. This study compared memory performances, using word list and constructional praxis with delayed recall tasks, of OA based on their literacy status (illiterate vs. literate).Results:Literate cognitive healthy OA (M = 15.27, SD = 3.9) learned more words over three trials than illiterate OA (M = 12.17, SD = 3.7) on a world list task, a statistically significant difference (M = 3.1, 95% CI [2.5, 3.6], t (713) = 10.62, p<0.05. Literate OA (M = 8.7, SD = 2.2) had higher scores on task of copy of simple geometrical figures than illiterate OA (M = 5.3, SD = 2.8), a statistically significant difference (M = 3.3, 95% CI [2.9, 3.7], t (713) = 7.1, p<0.05. Literate OA (M = 4.5, SD = 1.8) also recalled more words than illiterate OA (M = 3.6, SD = 2.1) after a delay. Recall of geometric figures after a delay was higher for literate OA (M = 5, SD = 2.9) as well compared to illiterate OA (M = 2.4, SD = 2.5).Conclusions:Conclusion: In a sample of cognitively healthy Indian older adults, literate OA consistently performed better than illiterate OA on both verbal and nonverbal memory measures. This is consistent with past literature which shows that illiterate individuals take longer to learn verbal information and have lower recall. Additionally, use of geometric figure may be complicated for these individuals. These are important considerations when assessing an OA for memory problems with low or no education. Next steps would be to look at differences across other cognitive domains and also examining if cognitive differences exist in illiterate OA based on gender.

Is seeing believing?

Abstract This study compares the effects of visual and oral corrective feedback (CF) on L2 pronunciation development. While many studies have investigated the effects of oral CF for various types of L2 learner productions (Li, 2010; Mackey & Goo, 2007), research in visual biofeedback is still developing (Antolík et al., 2019; Gick, et al., 2008). In this study, 21 Japanese learners of English were divided into two groups: an oral CF group and a visual (ultrasound) CF group where participants received either oral or visual feedback on task-essential pronunciations of English /l/ and /r/ after induced communication breakdowns in task-based interactions. Development, determined by accuracy ratings of /l/ and /r/ productions and comprehensibly ratings of phrases from reading passages by naïve raters, was examined pre and post participation in task-based interactions. Introspective reports in the form of stimulated recall interviews assessed learners’ noticing of visual and oral CF and provided qualitative evaluations of the utility of ultrasound imaging for improving pronunciation. Findings uncovered gains for the group who received biofeedback using ultrasound on a story reading task, but not a word list task, when compared with learners who only received oral CF. The training was positively received by participants with those in the ultrasound group finding use of the ultrasound motivating and useful for their production of /r/ and /l/.

App-based assessment of memory functions in patients after transfemoral aortic valve replacement.

Transfemoral aortic valve replacement (TAVR) is the standard treatment for elderly patients with aortic valve stenosis. Although safe and well-established, there is a risk of intraprocedural hemodynamic instability and silent cerebral embolism, which can lead to a decline in neurocognitive function and dementia. In clinical practice, comprehensive cognitive testing is difficult to perform. AI-assisted digital applications may help to optimize diagnosis and monitoring. Neurocognitive function was assessed by validated psychometric tests using "∆elta -App", which uses artificial intelligence and computational linguistic methods for extraction and analysis. Memory function was assessed using the 'Consortium to Establish a Registry for Alzheimer's Disease' (CERAD) word list and digit span task (DST) before TAVR and before hospital discharge. The study is registered in the German Register of Clinical Trials (https://drks.de/search/de/trial/DRKS00020813). From October 2020 until March 2022, 141 patients were enrolled at University Hospital Heart Centre Brandenburg. Mean age was 81 ± 6 years, 42.6% were women. Time between the pre- and post-interventional test was on average 6 ± 3 days. Memory function before TAVR was found to be below average in relation to age and educational level. The pre-post TAVR comparison showed significant improvements in the wordlist repeat, P < 0.001 and wordlist recall test of CERAD, P < 0.001. There were no changes in the digital span test. Despite impaired preoperative memory function before TAVR, no global negative effect on memory function after TVAR was detected. The improvements shown in the word list test should be interpreted as usual learning effects in this task.

A comparison of basic color terms in Mandarin and Spanish

AbstractBasic perceptual abilities are universal, and most people can distinguish between millions of distinct shades. However, languages differ in the set of basic color terms (BCTs) they have. Despite numerous prior studies, the exact number of BCTs in Mandarin (Sino‐Tibetan) and Spanish (Indo‐European) is still debated. In Mandarin, this number varies from 6 to 11, whereas in Spanish there are about 11 or 12 BCTs. Additionally, differences between these two languages can be expected with regard to the differing usage of BCTs in reference to color, as well as the naming strategies used for specifying references. To clarify this, we recruited a group of Mainland Mandarin speakers and a group of Castilian Spanish speakers and assessed them in two related tasks: the list task, in which participants were asked to write down as many color names as they could recall; and the color‐naming task, in which they were asked to name color chips from the Munsell color chart that were presented randomly. Our results suggest that Mandarin has nine BCTs, while Spanish has 12 BCTs. Furthermore, we found that Mandarin speakers use more modified terms and compounds to achieve precise color reference, whereas Spanish speakers rely more on monomorphemic non‐basic terms. Finally, we observed that Mandarin speakers use some colors (gray, blue, and purple) less consistently; although, the color space is partitioned similarly by these two languages. Our results reinforce the view that there are universal constraints on color naming that are compatible with subtle cross‐cultural differences in how colors are used.

Paid and hypothetical time preferences are the same: lab, field and online evidence

The use of real decision-making incentives remains under debate after decades of economic experiments. In time preferences experiments involving future payments, real incentives are particularly problematic due to between-options differences in transaction costs, among other issues. What if hypothetical payments provide accurate data which, moreover, avoid transaction cost problems? In this paper, we test whether the use of hypothetical or one-out-of-ten-participants probabilistic—versus real—payments affects the elicitation of short-term and long-term discounting in a standard multiple price list task. We analyze data from a lab experiment in Spain and well-powered field and online experiments in Nigeria and the UK, respectively (N = 2,038). Our results indicate that the preferences elicited using the three payment methods are mostly the same: we can reject that either hypothetical or one-out-of-ten payments change any of the four preference measures considered by more than 0.18 SD with respect to real payments.

The phonetic realization of the plain uvular /q/ in a variety of South Bolivian Quechua

This paper presents an acoustic description of the production of the plain uvular /q/ in the speech of eight speakers of South Bolivian Quechua. While this sound patterns phonologically as a stop, its primary realization is as a voiced continuant. Variation is documented with respect to segmental and prosodic position. Segmentally, a voiced continuant is the most common realization intervocalically and after a rhotic, while a voiceless continuant is comparatively more frequent after a voiceless sibilant, and voiced stops are most common after a nasal. In post-pausal position, voiced continuant productions are still attested and are particularly common for certain speakers, suggesting that this sound category has been reanalyzed as a continuant. For other speakers, voiceless stop productions are common or preferred in post-pausal position, reflecting a standard prosodically conditioned lenition pattern. Interestingly, voiced stops also show increased frequency in post-pausal position. The production of the plain uvular is analyzed in spontaneous speech collected in an interview format, as well as in scripted speech from a word list task. A second analysis compares the realization of /q/ to the other three stops /p t k/ in the language in spontaneous speech, and finds significantly more continuant productions for /q/.

Rosyjskie słownictwo barw u kobiet i mężczyzn (badania wstępne)

The aim of the paper is to present the results of a study of psychological salience of colour terms for women and men who are native speakers of Russian. In our study, we employed the elicitation list task which is a five-minute psychological test designed to determine which and to what degree colour terms are psychologically important to language users. There were 26 Russian speakers – 13 women and 13 men – who participated in the test. The test results provide us with adequate material to be used to analyze both quantitative and qualitative differences between the female and male colour lexicons, and additionally, to estimate the scope of these differences. The study confirms the observations made by other researchers, as well as the popular opinion that women have a richer selection of colour words at their disposal and that they actually know many more metonymic colour terms than men.

Smooth and Hard or Beautiful and Elegant? Experts’ Conceptual Structure of the Aesthetics of Materials

The present study’s aim was to examine whether interindividual differences in levels of expertise influence the aesthetic processing of materials. In particular, we elucidated experts’ conceptual structure of the aesthetics of different materials using a free list task and compared it to recent non-expert data. To this end, we asked 401 architects, designers, and interior designers to list adjectives that could be used to describe the aesthetics of materials. The experts listed a large number of sensorial as well as aesthetically evaluative terms. As measured in a supplementary study, a slight majority of the listed terms had a neutral valence, followed by a large proportion of positive terms. The term beautiful, frequently the preeminent term in aesthetics, was by no means one of the most relevant terms in both studies. The results suggest that the conceptual structure of the aesthetics of materials is multifaceted and expressive, and, to some extent, influenced by expertise. Furthermore, the findings indicate that concepts underlying materials aesthetics differ from other domains.

Remembering Molly: Immediate and delayed false memory formation after acute MDMA exposure

The entactogen 3,4-Methylenedioxymethamphetamine (MDMA) is increasingly being recognized for its therapeutic potential but is also widespread in nightlife settings where it may co-occur with crime. Since previous research detected impaired verbal memory during acute MDMA intoxication, understanding the drug's ramifications in an applied legal context becomes crucial. We conducted a double-blind, placebo-controlled trial to examine acute and delayed effects of MDMA (75 mg) on false memory in 60 healthy volunteers with a history of MDMA use, using three well-established false memory methods: a basic, associative word list (Deese/Roediger-McDermott (DRM)) paradigm and two applied misinformation tasks using a virtual reality crime. Memory was tested immediately (encoding and retrieval under drug influence) and 1 week later (retrieval when sober). Small MDMA-induced impairments of true memory in the word list task were detected at both time points. MDMA increased false memory for related but non-critical lures during the immediate test, and decreased false memory for critical lures after a delay. Episodic memory assessed in the misinformation tasks was not consistently affected. Findings indicate a complex memory profile but no heightened vulnerability to external suggestion in response to MDMA intoxication. Recommendations for future applied legal psychological research include adding measures of recall on top of recognition, using study designs that separate the different memory phases, and potentially testing higher doses. Further research on false memories and suggestibility using imagination procedures can also be relevant for the clinical context.

Fatigue and cognitive impairment in post-COVID syndrome: possible treatment approaches

Post-COVID syndrome can develop in all patients who have had COVID-19, regardless of the disease severity. Clinical manifestations postCOVID syndrome vary greatly, but the most common symptoms include fatigue, anxiety and depression disorders (ADDs), and cognitive impairment (CI).Objective: to evaluate the efficacy and safety of Cholytilin (choline alfoscerate) and the combined drug MexiB 6 in patients with post-COVID syndrome and fatigue, ADDs, and CI.Patients and methods. The study included 100 patients aged 22 to 71 years who have had COVID-19 5.4 months ago. Inclusion criterion: cognitive complaints, fatigue, and emotional disturbances. The evaluation included neurological exam, Montreal Cognitive Assessment Scale (MoCA), Frontal Assessment Battery (FAB), 10-words list task, Multidimensional Fatigue Inventory (MFI-20), Hospital Anxiety and Depression Scale (HADS). Study participants were divided into two groups. Patients who had ADDs (anxiety/depression level according to HADS ≥8 points; n=50) were prescribed with MexiB 6 (1 tablet three times per day). Patients with CI (mean MoCA score ≤25 points; n=50) were prescribed with Cholytilin (2 capsules (800 mg) in the morning and 1 capsule (400 mg) at lunchtime). The follow-up period was 60 days.Results and discussion. According to MoCA scores, a decrease in cognition was observed in 58% of participants, while 28% did not notice CI earlier. ADD fere present in 51%, and fatigue — in 100% of patients. We observed a significant reduction in fatigue severity (from 62.42±7.18 to 52.32±16.36 points; p&lt;0.05) in patients prescribed with MexiB 6. The majority of patients noted a significant increase in physical activity, decreased fatigue, improvement of attention and physical well-being, and increased workplace efficiency. We also found a significant decrease in ADDs severity: ADDs either regressed completely (in 42% of participants) or became subclinical (in 48%; р&lt;0.001). CI severity also reduced according to mean МоСА (from 26.60±1.31 to 27.28±1.39 points; p&lt;0.05) and FAB (from 16.98±1.06 to 17.20±0.90 points; p&lt;0.05) scores. In a subgroup of patients with mild CI treated with Cholytilin mean МоСА (from 23.50±0.99 to 26.36±1.34; р&lt;0.001) and FAB (from 16.02±0.91 to 16.96±0.99; р&lt;0.001) scores significantly increased. Complete regression of CI was observed in 74% of participants (р&lt;0.001). We also found a decrease in ADDs (р&lt;0.001) and fatigue (mean MFI-20 scores decreased from 42.28±10.73 to 35.60±8.10; р&lt;0.001) severity in all study participants.Conclusion. Patients who have had COVID-19, regardless of the disease severity, have a high prevalence of fatigue, ADDs and CI, and MexiB 6 and Cholytilin have a potential in their treatment.

Subjective organization in the episodic memory of individuals with Parkinson's disease associated with mild cognitive impairment.

Word clustering (i.e., the ability to reproduce the same word pairs in consecutive recall trials of an unrelated word list) has been extensively investigated as a proxy of subjective organization (SO) of memorandum. In healthy subjects and in groups of brain-damaged patients, the rate of SO generally predicts accuracy of word list recall. This study aimed at evaluating SO in the performance of patients with Parkinson's disease (PD) on a word list recall task in order to investigate the basic mechanisms of episodic memory impairment that are frequently observed in these patients. For this purpose, 56 PD patients, who were stratified according to the presence and quality of mild cognitive impairment (MCI), and a group of healthy controls (HCs) were administered a word list task and an extensive battery of neuropsychological tests. Results showed that recall accuracy on the word list task progressively decreased passing from HC to PD patients without cognitive impairment, to patients with single-domain dysexecutive MCI and to patients with multiple-domain dysexecutive and amnesic MCI. Conversely, only the latter PD group showed a lower SO score than that achieved by the other groups. In the overall PD group, correlational and regression analyses demonstrated that SO scores and a composite score of executive functions were not reciprocally related, but both provided an independent and significant contribution to the prediction of word list recall accuracy. These data are discussed in terms of the contribution of executive functions and hippocampal storage processes to the onset of memory impairment in PD.

The influence of conversational role on phonetic alignment toward voice-AI and human interlocutors

ABSTRACT Two studies investigated the influence of conversational role on phonetic imitation toward human and voice-AI interlocutors. In a Word List Task, the giver instructed the receiver on which of two lists to place a word; this dialogue task is similar to simple spoken interactions users have with voice-AI systems. In a Map Task, participants completed a fill-in-the-blank worksheet with the interlocutors, a more complex interactive task. Participants completed the task twice with both interlocutors, once as giver-of-information and once as receiver-of-information. Phonetic alignment was assessed through similarity rating, analysed using mixed effects logistic regressions. In the Word List Task, participants aligned to a greater extent toward the human interlocutor only. In the Map Task, participants as giver only aligned more toward the human interlocutor. Results indicate that phonetic alignment is mediated by the type of interlocutor and that the influence of conversational role varies across tasks and interlocutors.

How buyer-focused projective techniques can help to gain insights into consumer perceptions about different types of eggs

This study aimed to analyze the consumer perception (n = 840) about different types of eggs using Product Personality Profiling and Shopping List tasks. White egg, brown egg, organic egg, free-range egg, and eggs enriched with omega 3 and vitamins were evaluated. The consumers associated the white egg with unhealthy, sedentary, and overweight individuals in the Product Personality Profiling task and people that are not concerned with health in the Shopping List task. The brown egg was associated with a person who does physical activity and has a healthy diet in the Product Personality Profiling task. The omega 3 egg was associated with a person concerned with health in the Shopping List task, which does physical exercises and follows a healthy diet in the Product Personality Profiling task. The vitamin-enriched egg was associated with people with health disorders in the Shopping List task and following a vegetarian/vegan diet in the Product Personality Profiling task. The free-range egg was associated with a man with a rugged personality, a healthy diet, and animal welfare concern. Finally, the organic egg was associated with a person concerned with animal welfare and a vegetarian/vegan diet. Shopping list and Product Personality Profiling projective techniques proved to be useful tools for understanding consumer perceptions and beliefs about eggs, providing similar or complementary results. The Shopping List was more appropriate in eliciting egg buyers' profile, while the Product Personality Profile shows the “target buyer”.

Framing Effects in the Elicitation of Risk Aversion: An Experimental Study

The most common experimental methods to elicit risk aversion present the decision maker with a menu of lotteries and ask her to state her preferences. Lotteries are typically presented through a verbal description stating the outcomes and their likelihoods (“$100 with probability 10%”, “1 in 10 chance to win $100”), sometimes accompanied by a pictorial display (a pie chart or bar graph). Literature on risk communication suggests that alternative but equivalent numeric formats (e.g., percentages vs ratios) and pictorial displays (continuous vs discrete) may lead to a different perception of risk and aversion to it. The present experiment (N = 95) tests for such framing effects in a multiple price list task (MPL). Numeric risk information is framed either as percentages (“10%”) or as ratios (“1 out of 10”). To mirror the numeric framing, the pictorial display is framed either as a two-slice pie chart, representing likelihoods as proportions between areas, or a ten-slice pie chart, representing likelihoods as the number of units over a total. Results show that neither the numeric nor the pictorial framings significantly altered the average elicited risk aversion. This suggests that in MPLs and similar lottery-based tasks risk perception and aversion may be robust to such numeric and pictorial framings.

Cognitive task performance under (combined) conditions of a metabolic and sensory stressor

Effects of stressors on cognitive task performance have primarily been studied in isolation, and little is known about the combined effects of two or more stressors. This study examined how a metabolic stressor (skipping breakfast) and a sensory stressor (noise) affect cognitive task performance in isolation and combined. In addition to performance, we collected physiological and subjective data to get insight in the underlying mechanisms. Twenty participants came to the lab twice, once after skipping breakfast, and once after a standardized breakfast. They performed runs of the 2-back task and the International Shopping List Task, which were alternately presented with and without noise. During the 2-back task, electrocardiography (ECG), electrodermal activity (EDA), and electroencephalography (EEG) were recorded. Subjective ratings on effort and stress were also collected. No interaction effects between the two stressors on cognitive performance were found. Skipping breakfast did not cause hypoglycemia, but resulted in subjective discomfort and a lower state of arousal (as indicated by lower heart rate and EDA). These may underly the trend for more missed responses on the 2-back task after breakfast skipping. Noise appeared to generate arousal and increased attention (reflected in higher EDA and P300) in accordance with higher experienced load and stress. This is consistent with less missed 2-back responses in noise conditions. The results indicate that individuals spent extra effort to maintain task performance in the presence of noise. We propose to use a model that, besides additional effort, takes the effect of stressors on performance into account.

EEG signatures of elementary composition: Disentangling genuine composition and expectancy processes

We adapted Bemis & Pylkkänen’s (2011) paradigm to study elementary composition in Spanish using electroencephalography, to determine if EEG is sensitive enough to detect a composition-related activity and analyze whether the expectancy of participants to compose contributes to this signal. We found relevant activity at the expected channels and times, and a putative composition-related activity before the second word onset. Using threshold-free cluster permutation analysis and linear models we show a task-progression effect for the composition task that is not present for the list task. In a second experiment we evaluate two-word composition incorporating all conditions in a single task. In this case, we failed to find any significant composition-related activity suggesting that the activity measured with EEG may be in part carried by expectancy processes arising from the block design of the experiment, which can be prevented by using a non-blocked design and data-driven techniques to analyze the data.

Exercise Reduces Competition between Procedural and Declarative Memory Systems.

The neural systems that govern declarative and procedural memory processing do not always operate independently. Direct evidence of competition between these two memory systems in humans is supported by studies showing that performing a declarative learning task immediately after motor skill learning can disrupt procedural memory and abolish the off-line gains in skill performance obtained during consolidation. The aim of the present study was to extend recent investigations demonstrating that the exposure to a brief bout of cardiovascular exercise can protect procedural memory by enhancing postpractice consolidation. We used an experimental paradigm designed to assess whether exercise can also protect procedural memory consolidation from interference induced with declarative learning. The implicit acquisition of a serial reaction time task (SRTT) was tested after a 6-h waked-filled period. Participants who were exposed to a non-learning vowel counting (VC) task following the practice of the SRTT exhibited successful procedural memory consolidation and significant off-line gains in skill performance. Confirming that declarative memory processes can interfere with procedural memory consolidation, off-line gains in motor skill performance were suppressed when the performance of the VC task was replaced with a word list (WL) task requiring declarative learning. Performing a bout of cardiovascular exercise after the SRTT protected the newly formed procedural memory from the interference produced by the WL task. Protection was evidenced by a return of significant off-line gains in skill performance after the waked-filled period. Exercise optimizes the utilization of neural resources reducing interference between procedural and declarative memory systems.

Hippocampal and medial prefrontal cortical volume is associated with overnight declarative memory consolidation independent of specific sleep oscillations.

The current study was designed to further clarify the influence of brain morphology, sleep oscillatory activity and age on memory consolidation. Specifically, we hypothesized, that a smaller volume of hippocampus, parahippocampal and medial prefrontal cortex negatively impacts declarative, but not procedural, memory consolidation. Explorative analyses were conducted to demonstrate whether a decrease in slow-wave activity negatively impacts declarative memory consolidation, and whether these factors mediate age effects on memory consolidation. Thirty-eight healthy participants underwent an acquisition session in the evening and a retrieval session in the morning after night-time sleep with polysomnographic monitoring. Declarative memory was assessed with the paired-associate word list task, while procedural memory was tested using the mirror-tracing task. All participants underwent high-resolution magnetic resonance imaging. Participants with smaller hippocampal, parahippocampal and medial prefrontal cortex volumes displayed a reduced overnight declarative, but not procedural memory consolidation. Mediation analyses showed significant age effects on overnight declarative memory consolidation, but no significant mediation effects of brain morphology on this association. Further mediation analyses showed that the effects of age and brain morphology on overnight declarative memory consolidation were not mediated by polysomnographic variables or sleep electroencephalogram spectral power variables. Thus, the results suggest that the association between age, specific brain area volume and overnight memory consolidation is highly relevant, but does not necessarily depend on slow-wave sleep as previously conceptualized.