Liquid-filled Lungs Research Articles

Vertical gradients of pleural and transpulmonary pressure with liquid-filled lungs

In supine dogs with saline-filled lungs the vertical gradient of pleural surface pressure (VGPpI) was not significantly different from −1 cm H 2O/cm and that of transpulmonary pressure (VGPtp) was not significantly different from zero. Hence the hydrostatic gradient of the liquid was entirely taken up by the chest wall, the ribs being rigid in the direction of gravity and the diaphragm facing an equal hydrostatic gradient on both sides. In head-up dogs VGPpI was −0.8 cm H 2O/cm when the level of the liquid in the filling system was 19.5 cm below the lung top and −0.5 cm H 2O/cm when this level corresponded to the top. The hydrostatic gradient of the liquid was not entirely taken up by the rib cage because of its uneven regional compliance and VGPtp was reversed with respect to that of the air-filled lung. With fluorocarbon (specific gravity 1.75) filled lungs in the supine posture VGPpI was about −1.28 cm H 2O/cm and VGPtp was reversed. In the head-up posture VGPpI was about −1.2 cm H 2O/cm and VGPpt was reversed.

Maximum expiratory flow and estimated CO 2 elimination in liquid-ventilated dogs' lungs.

ArticleMaximum expiratory flow and estimated CO 2 elimination in liquid-ventilated dogs' lungs.W H Schoenfisch, and J A KylstraW H Schoenfisch, and J A KylstraPublished Online:01 Jul 1973https://doi.org/10.1152/jappl.1973.35.1.117MoreSectionsPDF (1002 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformation Cited ByLiquid Ventilation in the Management of Preterm Infants28 August 2021 | Current Stem Cell Reports, Vol. 7, No. 3Liquid VentilationA Regulator for Pressure-Controlled Total-Liquid VentilationIEEE Transactions on Biomedical Engineering, Vol. 57, No. 9Effects of Respiratory Rate and Tidal Volume on Gas Exchange in Total Liquid VentilationASAIO Journal, Vol. 55, No. 4Expiratory Flow Limitation during Gravitational Drainage of Perfluorocarbons from Liquid-Filled LungsASAIO Journal, Vol. 51, No. 6Flow Limitation in Liquid-Filled Lungs: Effects of Liquid Properties6 February 2005 | Journal of Biomechanical Engineering, Vol. 127, No. 4A prototype of a liquid ventilator using a novel hollow-fiber oxygenator in a rabbit modelCritical Care Medicine, Vol. 32, No. 10Total Liquid Ventilation: Dynamic Airway Pressure and the Development of Expiratory Flow LimitationASAIO Journal, Vol. 50, No. 5Liquid VentilationAssessment of the development of choked flow during total liquid ventilationCritical Care Medicine, Vol. 32, No. 1Effect of ventilatory variables on gas exchange and hemodynamics during total liquid ventilation in a rat modelCritical Care Medicine, Vol. 31, No. 7Perfluorocarbon Enhanced Gas ExchangeAmerican Journal of Respiratory and Critical Care Medicine, Vol. 164, No. 1Development and application of a double-piston configured, total-liquid ventilatory support deviceCritical Care Medicine, Vol. 28, No. 5Liquid-assisted ventilation: An alternative respiratory modalityPediatric Pulmonology, Vol. 26, No. 1Physiologic, Biochemical, and Histologic Correlates Associated with Tidal Liquid VentilationPediatric Research, Vol. 43, No. 1Comparison of perfluorochemical fluids used for liquid ventilation: Effect of endotracheal tube flow resistancePediatric Pulmonology, Vol. 23, No. 6Shunt and ventilation-perfusion distribution during partial liquid ventilation in healthy pigletsElisabeth A. Mates, Jacob Hildebrandt, J. Craig Jackson, Peter Tarczy-Hornoch, and Michael P. Hlastala1 March 1997 | Journal of Applied Physiology, Vol. 82, No. 3Gas Exchange during Gas and Liquid Ventilation1 November 1996 | Journal of Intensive Care Medicine, Vol. 11, No. 6Liquid ventilation: An alternative ventilation strategy for management of neonatal respiratory distressEuropean Journal of Pediatrics, Vol. 155, No. S2Improvement of Gas Exchange, Pulmonary Function, and Lung Injury With Partial Liquid VentilationChest, Vol. 108, No. 2Diving physiology and pathophysiologyClinical Physiology, Vol. 14, No. 6Liquid ventilationPediatric Pulmonology, Vol. 14, No. 2Pathophysiology of CoughClinics in Chest Medicine, Vol. 8, No. 2Man in the Ocean Environment: Physiological Factors More from this issue > Volume 35Issue 1July 1973Pages 117-21 https://doi.org/10.1152/jappl.1973.35.1.117PubMed4716145History Published online 1 July 1973 Published in print 1 July 1973 Metrics

HEMODYNAMIC RESPONSE OF THE PULMONARY CIRCULATION TO BRONCHOPULMONARY LAVAGE IN MAN

ROGERS, R. M.; SZIDON, J. P.; SHELBURNE, J.; NEIGH, J. L.; SHUMAN, J. F.; TANTUM, K. R. Author Information

Hemodynamic response of the pulmonary circulation to bronchopulmonary lavage in man.

During 16 bronchopulmonary lavages on nine patients, only mild hypoxemia developed. Since blood perfusing the liquid-filled lung is not exposed to alveolar gas, this suggests decreased perfusion of the lavaged lung. During four lavages, the degree of perfusion of the lavaged lung was shown to increase with the difference between the pressure in the pulmonary artery and the hydrostatic pressure of fluid filling the lavaged lung. To increase the safety of bronchopulmonary lavage, one should use high concentrations of inspired oxygen, maintain airway pressure of the lavaged lung above or as close as possible to pulmonary-artery pressure, and closely monitor arterial-blood gases.

Effect of stratified inequality of blood flow on gas exchange in liquid-filled lungs.

This investigation set out to answer two questions: (1) are the distal alveoli in the terminal lung units less well perfused than the proximal alveoli, i.e., is there stratification of blood flow; and (2) if so, does this enhance gas exchange in the presence of stratified inequality of ventilation. Excised dog lungs were ventilated with saline and perfused with blood. Following single inspirations of xenon 133 in saline and various periods of breath holding, the expired xenon concentration against volume was measured and it confirmed marked stratified inequality of ventilation under these conditions. By measuring the rate of depletion of xenon from alveoli during a period of blood flow, we showed that the alveoli which emptied at the end of expiration had 16% less blood flow than those exhaling earlier. However, by measuring the xenon concentration in pulmonary venous blood, we found that about 10% less tracer was transferred from the alveoli into the blood when the inspired xenon was stratified within the respiratory zone. Thus while stratification of blood flow was confirmed, it was shown to impair rather than enhance the efficiency of gas transfer.

Maximum expiratory flow in isolated liquid-filled lungs.

ArticleMaximum expiratory flow in isolated liquid-filled lungs.P Hamosh, and P C LuchsingerP Hamosh, and P C LuchsingerPublished Online:01 Nov 1968https://doi.org/10.1152/jappl.1968.25.5.485MoreSectionsPDF (717 KB)Download PDF ToolsExport citationAdd to favoritesGet permissionsTrack citations ShareShare onFacebookTwitterLinkedInWeChat Previous Back to Top Next Download PDF FiguresReferencesRelatedInformationCited ByAdministration of Drugs/Gene Products to the Respiratory System: A Historical Perspective of the Use of Inert Liquids10 May 2022 | Frontiers in Physiology, Vol. 13Liquid VentilationExpiratory Flow Limitation during Gravitational Drainage of Perfluorocarbons from Liquid-Filled LungsASAIO Journal, Vol. 51, No. 6Flow Limitation in Liquid-Filled Lungs: Effects of Liquid Properties6 February 2005 | Journal of Biomechanical Engineering, Vol. 127, No. 4A prototype of a liquid ventilator using a novel hollow-fiber oxygenator in a rabbit modelCritical Care Medicine, Vol. 32, No. 10Liquid VentilationAssessment of the development of choked flow during total liquid ventilationCritical Care Medicine, Vol. 32, No. 1Development and application of a double-piston configured, total-liquid ventilatory support deviceCritical Care Medicine, Vol. 28, No. 5Liquid VentilationClinics in Perinatology, Vol. 25, No. 3Atemmechanik beim AtemstoßPneumonologie Pneumonology, Vol. 149, No. 3Oscillations in Expiratory Gas Flow During Performance of Forced Vital Capacity More from this issue > Volume 25Issue 5November 1968Pages 485-8 https://doi.org/10.1152/jappl.1968.25.5.485PubMed5687352History Published online 1 November 1968 Published in print 1 November 1968 Metrics

ESTIMATION OF TISSUE ELASTICITY OF THE LUNG.

Theoretical work-volume curves for liquid-filled lungs were constructed based on an assumed geometric form and deformation of the terminal air spaces and on the characteristics of single fibers of elastic tissue. These curves were compared with those measured in rats and with one taken from the journal literature in the case of a human lung. The form of the measured curves fitted the theoretical curves. The assumptions necessary were considered in detail. In both species more elastic tissue has been found present in the lung than would be expected theoretically. The action of additional restraining elements was thought necessary at high volume. pulmonary pressure-volume curves; pulmonary work-volume curves; lung volume and elastic tissue mass; pulmonary elastic tissue; tissue elasticity; pulmonary mechanics Submitted on April 22, 1963