Lipid Profile In Postmenopausal Women Research Articles

Effects of resveratrol on the lipid profile of post-menopause women: Systematic review and meta-analysis.

Postmenopausal women experience an increase in cardiovascular, sexual, and emotional changes that can significantly impact their quality of life. Although phytoestrogens offer therapeutic benefits, our understanding of resveratrol's effects remains limited. This study aims to evaluate the effects of using resveratrol on the lipid profile of postmenopausal women. We conducted a systematic review using search terms like "postmenopausal" and "resveratrol" and their synonyms. Two reviewers handled study selection and data extraction. Randomized clinical trials assessing resveratrol in post-menopausal women were included. The meta-analysis on total cholesterol levels found no significant difference between groups, Standardized Mean Difference (SMD) -0.09 (95% Confidence Interval (CI) -0.39 to 0.22, p=0.59; I2=0%, 2 studies, low-quality evidence). No significant differences were found in high-density lipoprotein (HDL) levels, SMD 0.00 (95% CI -0.31 to 0.31, p=1; I2=0%, 2 studies, low-quality evidence), Low-Density Lipoprotein (LCD) levels, SMD -0.10 (95% CI -0.40 to 0.21, p=0.54; I2=0%, 2 studies, low-quality evidence), and triglyceride levels, SMD -0.12 (95% CI -0.18 to 0.43, p=0.43; I2=0%, 2 studies, low-quality evidence). This review concludes there's limited evidence for recommendations; further studies with higher doses, longer supplementation durations, and exploration of outcomes are needed to clarify therapeutic potential.

Olive Leaf Extract Supplementation Improves Postmenopausal Symptoms: A Randomized, Double-Blind, Placebo-Controlled Parallel Study on Postmenopausal Women.

Menopause negatively impacts women's health. Objectives: The aim of this study was to investigate whether an olive leaf extract (OLE) improves postmenopausal symptoms, body composition, handgrip strength and blood lipid profile in postmenopausal women. In a randomized, double-blinded parallel study design, 60 healthy postmenopausal women aged 47-70 years received either OLE (250 mg/day) or placebo supplementation for 12 weeks. Postmenopausal symptoms were assessed with the Menopause-Specific Quality of Life Questionnaire (MENQoL), the Hot Flash Interference scale (HFI), and body composition and bone mineral density (BMD) with a DXA scan; the lipid profile was measured in the blood serum. After six and twelve weeks of OLE supplementation, the overall MENQoL score significantly improved (estimated mean difference [95% CI]: -0.2 [-0.4-0.2], p = 0.027) compared to the placebo. A significant improvement (+0.017 [0.003, 0.030], p = 0.019) was recorded in the BMD in the right arm in the OLE group compared to the placebo. The intervention did not affect other body composition outcomes. TG concentrations and the TG/HDL-C ratio were significantly decreased (-0.1 [-0.2, 0.0], p = 0.010; -0.1 [-0.2, -0.0], p = 0.029, respectively) in the OLE group compared to the placebo. Twelve weeks of daily OLE supplementation improved postmenopausal symptoms. Further studies are needed to elucidate the mechanisms underlying the observed effects.

Estimation of Some Antioxidant Factors in Postmenopausal Iraqi Women with Hypertension

Postmenopausal women with hypertension may be linked with cardiovascular risk factors like visceral obesity. Changes in antioxidant levels and lipid profile are considered risk factors concerning heart disease that arises during postmenopausal. Ninety Iraqi women aged between 53-70 years, sixty women with postmenopausal hypertension, and thirty healthy postmenopausal women were selected as control for this study. Blood samples were taken to measure some antioxidants through enzyme-linked immune sorbent assay (ELISA) and lipid profile by enzymatic technique. Results showed that the mean of catalase levels was significantly lower in patients (257.62±6.99) compared towith the control group (499.30±13.08). Glutathione results were significantly lower in patients (10.99±0.26) compared with the healthy control (39.32±2.03). Cholesterol levels were significantly higher in patients (236.09±1.91), while lower levels were observed in the control group (172.67±4.92). Triglyceride levels were significantly higher both in patients (182.10±2.68) and the healthy group (145.92±5.85). HDL levels were significantly lower in patients (29.91±0.37) compared with the control group (43.02±1.38). VLDL levels were significantly higher in patients (36.49±0.54) compared with the control (29.16±1.17). LDL levels were significantly higher in patients (169.74±2.20) than in the control group (1 00.48±5.41). It can be concluded from the results that antioxidant levels decreased in postmenopausal women than in the control group. Elevation in lipid profile of postmenopausal women was observed compared with the control group.

Impact of Multicomponent Training Frequency on Health and Fitness Parameters in Postmenopausal Women: A Comparative Study.

Menopause induces physiological changes in women, including increased risks of obesity, cardiovascular diseases, and muscle loss, which can be mitigated by physical exercise. This study aimed to evaluate the effects of a 12-week multicomponent exercise programme, performed 2 or 3 days per week, on health and fitness parameters in postmenopausal women. Eighty-three postmenopausal women (aged 50-65 years) were randomly assigned to three groups: control group (CG, n = 27), 2 days/week exercise group (EG2, n = 28), and 3 days/week exercise group (EG3, n = 28). The intervention included strength, balance, aerobic, and flexibility exercises. Anthropometric measurements (body weight, BMI, waist-to-hip ratio, lean body mass, body fat percentage), lipid profile, and isometric strength were assessed pre- and post-intervention. Data were analysed using a repeated-measures ANOVA, with p < 0.05 considered significant. Significant reductions in body weight, BMI, and waist-to-hip ratio were observed in EG2 and EG3 compared to CG. Lean body mass increased significantly in both EG2 (p < 0.001, ES = 1.37) and EG3 (p < 0.001, ES = 1.50). EG3 showed a greater reduction in body fat percentage than EG2 (p = 0.049). Strength and balance improved significantly in both experimental groups compared to CG, with no significant differences between EG2 and EG3. EG3 also showed superior improvements in lipid profile compared to EG2 and CG. A multicomponent exercise programme, particularly with higher frequency (3 days per week), improves body composition, strength, balance, and lipid profile in postmenopausal women.

Effects of Long-term Resistance Training and Synbiotic on Arterial Stiffness and Lipid Profile in Postmenopausal Women with Type 2 Diabetes

Effects of Long-term Resistance Training and Synbiotic on Arterial Stiffness and Lipid Profile in Postmenopausal Women with Type 2 Diabetes

Effect of radiofrequency on postmenopausal adipose tissue: A randomized control trial

Aim. To determine the effect of radiofrequency on anthropometric measurements and lipid profile in postmenopausal women. Material and methods. Sixty postmenopausal women diagnosed as having abdominal adiposity and abnormal lipid profiles were incorporated into this study. Participants were assigned at random into two equal groups. Group A adhered to a Mediterranean diet and engaged in aerobic exercise for 12 weeks (n = 30), whereas group B followed a Mediterranean diet and participated in both aerobic exercise and radiofrequency treatments for the same 12-week period (n = 30). Both groups had their anthropometric measurements, encompassing weight, body mass index (BMI), and waist circumference, along with lipid profile components involving total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL), and triglycerides (TG), assessed before and after the 12-week program duration. Results. Significant improvements (p &lt; 0.05) were noted in all outcome measures within both groups. Upon post-treatment comparison, both groups exhibited statistically significant reductions in all anthropometric measurements, LDL and TG (p &lt; 0.05), while there was a statistically significant increase in HDL (p &lt; 0.05) favoring group B. Nevertheless, there were no significant differences between groups for TC and VLDL (p &gt; 0.05) after treatment. Conclusion. Radiofrequency has positive effect on anthropometric measurements and lipid profile in postmenopausal women.

Comprehensive Analysis of the Correlation between Estrogen Levels, Homocysteine, and Lipid Profiles in Postmenopausal Women with Coronary Heart Disease

Objective: To investigate the correlation between estrogen levels, blood homocysteine, and blood lipids in postmenopausal female patients with coronary heart disease. Methods: This study selected 50 postmenopausal female patients with coronary heart disease from Northeast Normal University Hospital (observation group). The data collection period extended from June 2021 to June 2023. Simultaneously, 50 healthy patients with no history of coronary heart disease were selected during the same period as the control group. Physical examinations were conducted for all participants. Estrogen levels, blood homocysteine, and blood lipid levels were tested in both groups. Results: Compared to the control group, the observation group exhibited higher levels of follicle-stimulating hormone (FSH), total cholesterol (TC), and homocysteine (Hcy), and lower levels of high-density lipoprotein cholesterol (HDL-C; P &lt; 0.05). Pearson correlation analysis revealed a negative correlation between estradiol (E2) levels and changes in Hcy, TC, and low density lipoprotein cholesterol (LDL-C) levels (P &lt; 0.01). Multivariate analysis indicated that E2 serves as a protective factor against coronary heart disease in postmenopausal women. Decreased E2 levels, LDL-C, and Hcy were identified as independent risk factors for coronary heart disease in women (P &lt; 0.05). Conclusion: A declining trend in estrogen levels among postmenopausal women has implications for their blood lipid levels and is closely associated with the development of chronic complications of menopause.

Lipid profile of postmenopausal women

Objectives: The main objectives of the research are to examine the incidence of hyperlipoproteinemia in postmenopausal women and to determine the differences in lipid profile considering age, duration of menopause and body mass index in postmenopausal women. Respondents and methods: The research is structured as cross-sectional with historical data. The research used data collected during regular check-ups in primary health care clinics in Osijek Health Center from November 2021 to March 2022. Collected data: demographic data, information on the duration of menopause, body mass, body height, body mass index, values of total, LDL, HDL cholesterol and triglycerides, and data on associated diseases. Results: 98 postmenopausal women were included in the research, of which over 50% had elevated total and LDL cholesterol values, and 39.8% had elevated triglyceride values. Subjects aged 45 to 65 years and subjects with a duration of menopause of 10 or more years had significantly higher values of total and LDL cholesterol while no difference was observed in the lipid profile with regard to the body mass index. Using the SCORE2 table, it was estimated that 65% of the subjects had a very high cardiovascular risk, and only 6% of the subjects achieved the target values of LDL cholesterol in accordance with the cardiovascular risk. Conclusion: There is a very high incidence of hyperlipoproteinemia in postmenopausal women, and the age and duration of menopause have an impact on the poorer achievement of the target values of the lipid profile, while the body mass index showed no impact. Given the high prevalence of subjects with a very high cardiovascular risk (SCORE 2 tables), intensive interventions are needed at all levels of health care, especially at the primary level of health care, which include non-pharmacological and pharmacological methods of treating hyperlipoproteinemia.

Effect of fsh on lipid profile in postmenopausal women

The World Health Organization (WHO) and Stages of Reproductive Aging Workshop (STRAW) define menopause as a permanent endpoint of the menstrual cycle for one year that occurs naturally or by induction of surgical procedure, chemotherapy or radiation .The etiology of menopause is classified into physiological and non-physiological. Pathophysiology of menopause includes the decline of ovary function in menopause, response to a loss of ovarian feedback mechanism, and the decline of the hypothalamus and pituitary function. Endocrine changes in menopause lead to alteration of gonadotropin secretion cycle patterns, changes in steroid and peptide hormones through monophasic patterns to increase gonadotropin, and decreased estrogen .Aim: This study aims to investigate the effect of FSH on lipid profile in postmenopausal women. Study design: A cross-section observational study. Method: The study is a cross-sectional study done on 90 women. These women aged more than 50 years had cessation of menstrual cycle for over a year. The blood samples were taken from 90 postmenopausal women, and interviews were conducted using a questionnaire. FSH measure, by ElectroChemiLuminescence (ECL) technology for immunoassay analysis done by Cobas e411 device. Lipid profile measure, by manual techniques done by use of spectrophotometer device. Result: We observed increase in Follicle-stimulating hormone (FSH) during postmenopause has a positive significant correlation with body mass index (BMI) (r 0.350, p 0.001), total cholesterol (TC) (r 0.397, p 0.001) and Low-density lipoprotein (LDL) ( r 0.421, p 0.001) FSH also correlated positively but insignificant correlation with triglyceride (TG) (r 0.175, p 0.098) and very low-density lipoproteins (VLDL) ( r 0.055, p 0.604). FHS has a negative significant correlation with Estradiol ( r -0.509, p 0.001) and Vit.D( r-0.220, p 0.037) as well as FSH correlated negative but insignificant with age ( r -0.142, p 0.183) and High-density lipoprotein (HDL) (r -0.048, p 0.656). Conclusion: The current study showed a significant positive correlation of FSH with TC and LDL, an insignificant positive correlation with TG, and an insignificant negative correlation with HDL. Keywords: Postmenopause, FSH, Lituenizing Hormone, HDL

Lipid profile of postmenopausal women

Searchable abstracts of presentations at key conferences in endocrinology ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Relationship between years since menopause and lipid variation in postmenopausal women: A cross-sectional study

Lipid alteration in postmenopausal women is commonly due to hormonal changes. This study aimed to explore the association between the years since menopause and lipid profiles in postmenopausal women. In this cross-sectional study, a total of 1033 postmenopausal women were recruited from the Women's Hospital of Zhejiang University in China between 2015 and 2022. Each participant was interviewed using questionnaires regarding sociodemographic and reproductive data. Anthropometric measurements, lipid profiles, and reproductive hormone levels were assessed. Participants were divided into 3 groups based on the length of time since menopause: 2, 2 to 5.9, and 6 years. Differences in lipid profiles and reproductive hormones among the groups were compared. Logistic and linear regression analyses were used to examine the relationship between years after menopause and lipid profile. High-density lipoprotein cholesterol (HDL-C) and luteinizing hormone levels were significantly lower in postmenopausal women with time since menopause of ≥6 years than those <2 years (P < .05), whereas low-density lipoprotein cholesterol levels were significantly higher (P < .05). A longer time after menopause was independently associated with lower HDL-C levels (β, -0.059, standard error, 0.023, P = .01) after adjustment for age, body mass index, and other confounders. Compared to women who had menopause for <2 years, those who were postmenopausal for >6 years had lower HDL-C levels after adjustment for age, body mass index, and other covariates (β, -0.123, 95% confidence interval, [-0.221, -0.014], P = .014). Longer time since menopause was associated with an atherogenic lipid profile with appreciably low levels of HDL-C subfraction. Future multicenter studies are necessary to examine postmenopausal population and determine how differences in lipids influence the risk of cardiovascular disease in this group.

The effects of phytosterol and phytostanol supplementation on the lipid profile in postmenopausal women: A systematic review and meta-analysis of randomized controlled trials.

Various studies have proven that phytosterols and phytostanols (PS) are lipid-lowering agents. These compounds play a role in regulating high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC), and triglyceride (TG) metabolism. Although various drugs are available and are currently used to treat dyslipidemia, the management of lipid abnormalities during the postmenopausal period remains a challenge. Thus, scientists are trying to develop new strategies to reduce serum lipids concentrations using natural products. However, the impact of PS administration on serum lipids in postmenopausal women remains unclear. Hence, the purpose of this study was to assess the effect of PS supplementation on the lipid profile in postmenopausal women based on a systematic review of the literature and a meta-analysis of randomized controlled trials. PubMed/Medline, Scopus, Embase, and Web of Science were searched to identify suitable papers published until January 18, 2022. We combined the effect sizes with the DerSimonian and Laird method using a random effects model. PS supplementation resulted in a significant decrease in TC (weighted mean difference [WMD]: -16.73 mg/dl) and LDL-C (WMD: -10.06 mg/dl) levels. No effect of PS supplementation on TG (WMD: -1.14 mg/dl) or HDL-C (WMD: -0.29 mg/dl) concentrations was detected. In the stratified analysis, there was a notable reduction in TC and LDL-C levels when the PS dose was ≥2 g/day (TC: -22.22 mg/dl and LDL-C: -10.14 mg/dl) and when PS were administered to participants with a body mass index ≥25 kg/m2 (TC: -20.22 mg/dl and LDL-C: -14.85 mg/dl). PS administration can decrease TC and LDL-C, particularly if the dose of administration is ≥2 g/day and if the participants are overweight or obese. Further high-quality studies are needed to firmly establish the clinical efficacy of PS usage in postmenopausal females.

Association of follicle stimulating hormone and serum lipid profiles in postmenopausal women.

The aim of the study was to observe the association between follicle stimulating hormone (FSH) levels and serum lipid profiles in postmenopausal women. A total of 411 healthy postmenopausal women with a mean age of 55 years (range 45–65 years) were enrolled in this study. Data on age, time of last menstrual period, past medical history, use of medications, and smoking status were collected, and body weight, height, and blood pressure were measured. Blood samples were collected to measure the serum concentrations of FSH, luteinizing hormone (LH), estradiol (E2), glucose, total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) using routine methods. FSH levels were negatively associated with LDL-C, even after adjustment for age, LH, E2, BMI, systolic blood pressure (SBP), and diastolic blood pressure (DBP) (OR = 0.185, 95% CI = 0.051‐0.669). Although FSH may also be negatively associated with dyslipidemia (P = .06 for trend) and hypercholesterolemia (P = .079 for trend), but no statistical significance was found after adjusting for confounding factors, particularly BMI. All relevant data are within the paper and its Supporting Information files. The results indicated that lower FSH levels might increase the odds of dyslipidemia, especially the risk of LDL-C elevation, which is an important factor that increases the risk of CVD in postmenopausal women.

STUDY OF FASTING PLASMA GLUCOSE AND LIPID PROFILE IN POSTMENOPAUSAL WOMEN

Objectives: The study was designed to determine fasting plasma glucose (FPG) and lipid profiles in postmenopausal women. Methods: 200 postmenopausal women were enrolled for the study and were compared to 100 normal healthy women of the same age from the Outdoor Patient Department of LN Medical College and research center of Bhopal city. Those fulfilling inclusion and exclusion criteria were enrolled for the study and the blood samples were analyzed for lipid profile and FPG. Results: Significant higher concentrations of total cholesterol (p&lt;0.001), triglyceride (p&lt;0.001), low-density lipoprotein (LDL) (p&lt;0.001), very LDLs (p&lt;0.001), and FPG (p&lt;0.001) were demonstrated in postmenopausal women when compared with normal healthy women. A significantly lower concentration of high-density lipoprotein (p&lt;0.001) was demonstrated in postmenopausal women when compared with normal healthy women. Conclusion: Menopausal transition and the related changes in the hormonal milieu (e.g., decreased systemic estradiol (E2) levels) are linked with adverse changes in several indicators of metabolic health. For instance, during the menopausal transition elevated blood glucose levels and adverse changes in serum lipids have been reported.

Role of Phytoestrogen-Rich Bioactive Substances (Linum usitatissimum L., Glycine max L., Trifolium pratense L.) in Cardiovascular Disease Prevention in Postmenopausal Women: A Systematic Review and Meta-Analysis.

The aim of this report was to determine the impact of flaxseed, soy and red clover, and their bioactive substances on the lipid profile in postmenopausal women in cardiovascular diseases prevention. We used the following databases: MEDLINE (PubMed), EMBASE and the Cochrane Library. Meta-analysis indicates that the intake of flaxseed by postmenopausal women is associated with a statistically significant reduction in total cholesterol (TC) levels (weighted-mean difference (WMD) = −0.26; 95% confidence interval (95% CI): −0.38 to −0.13; p = 0.0001), low-density lipoprotein cholesterol (LDL-C) levels (WMD = −0.19; 95% CI: −0.30 to −0.08; p = 0.0006), and high-density lipoprotein cholesterol (HDL-C) levels (WMD = −0.06; 95% CI: −0.11 to −0.01; p = 0.0150). The effect of soy protein on the lipid profile showed a significant decrease in TC levels: WMD = −0.15; 95% CI: −0.25–0.05; p = 0.0048, LDL-C levels: WMD = −0.15; 95% CI: −0.25–0.05; p = 0.0067, as well as a significant increase in HDL-C levels: WMD = 0.05; 95% CI: 0.02–0.08; p = 0.0034. Changes in the lipid profile showed a significant reduction in TC levels after the use of red clover (WMD = −0.11; 95% CI: −0.18–−0.04; p = 0.0017) and a significant increase in HDL-C levels (WMD = 0.04; 95% CI: 0.01 to 0.07; p = 0.0165). This meta-analysis provides evidence that consuming flaxseed, soy and red clover can have a beneficial effect on lipids in postmenopausal women and suggest a favorable effect in preventing cardiovascular diseases.

The effect of vitamin D on the lipid profile as a risk factor for coronary heart disease in postmenopausal women: a meta-analysis and systematic review of randomized controlled trials

The exact effect of vitamin D administration on the lipid profile in postmenopausal women is unknown. However, as dyslipidemia is a recognized risk factor for coronary heart disease (CHD) in this population, the lipid-lowering effects of vitamin D need to be explored Thus, we conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) that evaluated the impact of vitamin D use on triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) as a risk factor for coronary heart disease (CHD) in postmenopausal women. We developed a search strategy for multiple databases (PubMed/Medline, Scopus, Embase, and Web of Science) to identify relevant RCTs whose results were published until June 1st, 2021. We combined the results using a random effects model (the DerSimonian and Laird random effects model). Lipid profile outcomes were expressed as weighted mean difference (WMD) and 95% confidence intervals (CIs) between intervention and comparator groups. Supplementation with vitamin D decreased TG (WMD: -3.55mg/dL, 95% CI: -5.34 to -1.76, P<0.001) in postmenopausal females versus controls. In the subgroup analyses, vitamin D increased TC when the treatment duration was ˂26weeks (WMD: 6.56mg/dL, 95% CI: 0.78 to 12.35, P=0.02) as compared to ≥26weeks (WMD: -2.06mg/dL, 95% CI: -5.49, 1.36, P=0.23) and in the participants with a BMI ≥30kg/m2 (WMD: 3.65mg/dL, 95% CI: 0.09, 7.22, P=0.044). Moreover, vitamin D increased HDL-C when the treatment duration was ˂26weeks (WMD: 2.67mg/dL, 95% CI: 0.66 to 4.68, P=0.009). In addition, vitamin D decreased LDL-C when the vitamin D dose was ˃400IU/day (WMD: -1.89mg/dL, 95% CI: -2.47 to -1.31, P<0.001) as compared to ≤400IU/day (WMD: 2.50mg/dL, 95% CI: -2.50, 7.52, P=0.327). Vitamin D administration on the lipid profile as a risk factor for CHD in postmenopausal women reduces TG. Its effects to lower LDL-C and increase HDL-C and TC levels are clinically negligible but should be investigated in future research. In addition, supplementation with vitamin D results in a clinically significant reduction in TG, particularly in postmenopausal females with hypertriglyceridemia at baseline.

Consumption of &lt;I&gt;Allium sativum&lt;/i&gt; (Functional Food) and Lipid Profile of Postmenopausal Women with Dyslipidemia: A Correlational Study

CVD is the leading cause of death in women around the world. Estrogen deficiency has been linked to the rapid increase in CVD in women who have undergone natural or surgical menopause. Garlic (Allium sativum) has played an important dietary as well as medicinal role in human history. The study was conducted to assess correlation of garlic consumption on lipid level among postmenopausal women with dyslipidemia. In this clinical trial 180 respondents willing to participate in intervention program, who met inclusion criteria, were divided into three groups, control (n=60), Exp-I (garlic eaters n=60) and Exp-II (non-garlic eaters n=60). Dry garlic powder was prepared using standard procedure and analyzed for its active phytonutrients. A 500 mg of dry garlic powder capsules two per day were given to the respondents for 12 weeks. Biochemical analysis for cholesterol levels were measured in the standard laboratory before and after the study. Questionnaire-cum- interview method was used to obtain relevant information. Pearson correlation and one-way analysis of variance tests were conducted to analyze the data. Mean age of the respondents was found to be (53.6 ± 0.89) years. Pretest cholesterol levels in control (211.2 ± 6.24), Exp-I (212.2 ± 6.41) and Exp-II (212.4 ± 6.74) was observed. The results indicate that all the groups exhibit negative correlation with total cholesterol, LDL, triglycerides but the values of control group are non-significant and the relationship is weak, whereas values of experimental groups (Exp-I and Exp-II) shows strong negative correlation which is significant at 1 % level. Strong positive correlation observed with HDL among experimental groups and weak positive non-significant correlation was seen with control group. It can be concluded that functional property of garlic has positive correlation in managing dyslipidemia among postmenopausal women. Significant improvement in the lipid level was observed with garlic intervention.

Vitamin D and Lipid Profiles in Postmenopausal Women: A Meta-Analysis and Systematic Review of Randomized Controlled Trials.

Background and Aim: It is known that hyperlipidemia and low vitamin D level are risk factors associated with cardiovascular disease (CVD). However, the effect of vitamin D administration on lipid profiles in postmenopausal women remains unclear. This study aims to evaluate the effect of vitamin D on lipid profiles in postmenopausal women based on meta-analysis and systemic review. Methods: The literature search was performed in multiple databases (Scopus, PubMed/Medline, Web of Science, and Embase) from 1997 to 2021. The statistical analysis was performed using the Stata software version 14 (Stata Corp. College Station, Texas, United States). The effects of vitamin D administration of the lipid profiles, including Triacylglycerol (TG), LDL-Cholesterol (LDL-C), HDL-Cholesterol (HDL-C), and Total Cholesterol (TC) were evaluated by the Der Simonian and Laird random effects model. The weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated. Results: The level of TG changed significantly by −3.76 mg/dl (CI: −6.12 to −1.39, p = 0.004) and HDL-C by 0.48 mg/dl (CI: −0.80 to −0.15, p = 0.004) in vitamin D administration group [11 eligible trials (placebo = 505 participants, vitamin D intervention = 604 participants)] compared to the control group in the postmenopausal women. Taking into account this comparison between groups, in contrast, the level of LDL-Cholesterol (LDL-C) (WMD: 0.73 mg/dl, 95% CI: −1.88, 3.36, p = 0.583) and TC (WMD: 0.689 mg/dl, CI: −3.059 to 4.438, p = 0.719) did not change significantly. Conclusion: In conclusion, the vitamin D administration in postmenopausal women, decreased the concentrations of TG, and HDL-C, but have no effects on LDL-C and TC.

Effects of Soy Protein Containing of Isoflavones and Isoflavones Extract on Plasma Lipid Profile in Postmenopausal Women as a Potential Prevention Factor in Cardiovascular Diseases: Systematic Review and Meta-Analysis of Randomized Controlled Trials.

The aim of the report was to evaluate the impact of soy protein containing isoflavones and soy isoflavones extract on lipid profile in postmenopausal women, as compared with placebo or protein of milk, casein or isolated soy protein with or without trace isoflavone content. We used the following databases: MEDLINE (PubMed), EMBASE and the Cochrane Library. Quantitative data synthesis was performed by applying a random-effects model. Subgroup analysis and meta-regression were performed to assess the modifiers of treatment response. In total, in the analysis studies, 2305 postmenopausal women took part. Changes in the lipid profile showed statistically significant decreases of total cholesterol by −0.12 (95% CI: −0.21, −0.03) mmol/L, −4.64 (95% CI: −8.12, −1.16) mg/dL, p = 0.01 and increased HDL-cholesterol by 0.03 (95% CI: 0.00, 0.06) mmol/L, 1.15 (95% CI: 0.00, 1.93) mg/dL, p = 0.05, as well as in LDL-cholesterol −0.05 (95% CI: −0.11, 0.01) mmol/L, −1.93 (95% CI: −4.25, 0.39) mg/dL, p = 0.08 and triacylglycerols −0.07 (95% CI: −0.14, 0.00) mmol/L, −6.123 (95% CI: −12.25, 0.00) mg/dL, p = 0.06. Our results suggests that soy and its isoflavones can be effective in correction changes in lipid metabolism in postmenopausal women and may favorably influence in preventing cardiovascular events.

A cross-sectional study to assess lipid profile &amp; atherogenic index of plasma in premenopausal &amp; post menopausal women in rural Telangana

: Menopause is associated with various hormonal changes which are accountable for the dyslipidemic pattern seen in postmenopausal women. This deranged lipid profile in postmenopausal women is indicative of their susceptibility to various cardiovascular diseases.: The aim of the study is to estimate and compare serum lipid profile and Atherogenic index of plasma (AIP) among premenopausal and postmenopausal women.: A cross-sectional study was conducted at Mahavir institute of medical sciences (MIMS), Vikarabad for a period of 3 months.Fasting samples were collected from 100 healthy female volunteers of which 50 were premenopausal women and the other 50 were postmenopausal women. Lipid profile was performed on all samples and AIP was calculated.Carried out in the two groups using paired t tests. Results were expressed as mean ±SD. p value of &amp;#60; 0.05 was considered to be significant.: Total cholesterol (TC), Triglycerides (TAG), Low density lipoprotein (LDL-C) were statistically significantly increased in postmenopausal women as compared to premenopausal women. Atherogenic index plasma (AIP) was elevated in postmenopausal women’s group.Lipid profile screening should be mandatory in postmenopausal women as the hormonal disturbances make them more vulnerable to cardiovascular diseases and its associated complications.