Lipid Profile In Adults Research Articles

A study of correlation between iron deficiency anaemia and serum lipid profile in Indian adults in BRIMS, Bidar

Background: Both iron deficiency anemia and dyslipidaemia are widely prevalent public health problems, especially in the Indian population. Some link has been suggested between the two potentially morbid conditions but a sufficient Indian study could not be found in this regard. Methods: This study was planned to find the changes in serum lipid profile in adult Indian patients with iron deficiency anemia and the effect of oral iron therapy on them. 100 iron deficiency anemia and 70 age and sex matched healthy controls, in the age group 18-35 years were investigated for any possible changes in serum lipid profile i.e., triglycerides, total cholesterol, high density lipoprotein cholesterol, very low density lipoprotein cholesterol. The patients were followed up after 3 months of oral iron therapy. Results: The results are shown as mean± standard deviation. Triglycerides and very low density lipoprotein cholesterol levels were found to be significantly (P <0.001) elevated in the iron deficiency anemia group (151.87 ± 48.06 mg/dl and 30.40 ± 9.71 mg/dl) as compared to controls (109.99 ± 30.81 mg/dl and 21.96 ± 6.69 mg/dl), whereas level of low density lipoprotein cholesterol were found to be significantly (P = 0.02) lower in patients (90.96 ± 41.55 mg/dl) as compared to controls (105.24 ± 26.45 mg/dl). However, after treatment (in 43 patients) there was significant (P <0.001) reduction in the levels of triglycerides and very low density lipoprotein cholesterol (111.56 ± 26.87 mg/dl and 22.30 ± 5.36 mg/dl) when compared to their pretreatment level (154.70 ± 53.89 mg/dl and 30.93 ± 10.84 mg/dl), whereas low density lipoprotein cholesterol levels did not show any significant change. Conclusion: These findings indicate that iron deficiency anemia in Indian adults is attended by abnormal serum lipid profile, which responds significantly to iron therapy.

PReS-FINAL-2290: Is an abnormal lipid profile at diagnosis related to increased disease activity in JSLE patients

Lipid profile has been studied in Systemic Lupus Erythematous (SLE) due to the significant morbidity and mortality associated with premature coronary heart disease. Variations in lipid profile in adults with SLE are associated with overall disease activity, with Triglyceride (TG) levels associated with renal flare. Examination of lipid profile in juvenile-onset SLE (JSLE) showed a statistically significant drop in TG in transition from a state of active disease to inactive disease & TG levels to be significantly correlated with proteinuria at diagnosis.

The association between childhood trauma and lipid levels in an adult low-income, minority population

BackgroundThe objective of this study is to investigate the association between childhood trauma and lipid profiles in adults from a highly traumatized population at-risk for cardiovascular disease. MethodWe recruited 452 participants, primarily African-American and of low socioeconomic status, from general medical clinics in a large urban hospital. We performed direct comparisons, univariate analysis of variance and regression analyses together and separated by sex, examining the associations of child abuse, body mass index, lipid lowering drug use, blood pressure, age, and substance use to HDL levels and HDL/LDL ratios. ResultsA history of moderate to severe levels of childhood trauma and abuse was associated with a significant decrease in HDL levels (P≤.01) and HDL/LDL ratios (P≤.001) relative to males with low levels of abuse. This relationship held when the status of lipid-lowering drugs was considered. When controlling for age, substance abuse, tobacco use, and adult trauma, the effects of childhood trauma remained significant. We found a significant child abuse by sex interaction on HDL/LDL ratios [F(1,369)=13.0, P≤.0005] consistent with a differential effect of trauma on dyslipidemia in male but not female subjects. ConclusionsOur data suggest that childhood trauma exposure, obtained with self-report measures, may contribute to increased risk of cardiovascular disease by way of stress-mediated alterations of lipid concentration and composition in male, but not female, subjects.

Temporal changes in concentrations of lipids and apolipoprotein B among adults with diagnosed and undiagnosed diabetes, prediabetes, and normoglycemia: findings from the National Health and Nutrition Examination Survey 1988--1991 to 2005--2008

BackgroundDiabetes is characterized by profound lipid abnormalities. The objective of this study was to examine changes in concentrations of lipids and apolipoprotein B among participants stratified by glycemic status (diabetes, undiagnosed diabetes, prediabetes, and normoglycemia) in the United States from 1988–1991 to 2005–2008.MethodsWe used data from 3202 participants aged ≥20 years from the National Health and Nutrition Examination Survey (NHANES) III (1988–1991) and 3949 participants aged ≥20 years from NHANES 2005–2008.ResultsAmong participants of all four groups, unadjusted and adjusted mean concentrations of total cholesterol, low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B, but not triglycerides, decreased significantly. Among participants with prediabetes and normoglycemia, unadjusted and adjusted mean concentrations of high-density lipoprotein cholesterol increased significantly. Adjusted mean log-transformed concentrations of triglycerides decreased in adults with undiagnosed diabetes and prediabetes. During 2005–2008, unadjusted concentrations of apolipoprotein B ≥80 mg/dl were observed in 72.8% of participants with diagnosed diabetes, 87.9% of participants with undiagnosed diabetes, 86.6% of participants with prediabetes, and 77.2% of participants with normoglycemia. The unadjusted use of cholesterol-lowering medications rose rapidly, especially among participants with diabetes (from ~1% to ~49%, P <0.001). The use of fenofibrate, gemfibrozil, and niacin rose significantly only among adults with diagnosed diabetes (from ~2% to ~8%, P = 0.011).ConclusionLipid profiles of adults with diabetes improved during the approximately 16-year study period. Nevertheless, large percentages of adults continue to have elevated concentrations of apolipoprotein B.

Changes in dietary protein intake differentially affect glucose tolerance and lipid profile in adults with impaired versus normal glucose tolerance

The effects of changes in total protein intake (PRO) on oral glucose tolerance (GT) and lipid‐lipoprotein profile (LLP) were studied in 136 overweight/obese 35–65y, free feeding adults who consumed supplements with 400 kcal/d and 0, 20, 40 or 60 g/d whey protein and exercised 3d/week for 9 months. Retrospectively, subjects were divided into impaired GT (baseline 2‐h glucose &gt; 140 mg/dL) and normal GT groups. Insulin sensitivity was assessed by the Homeostatic Model Assessment (HOMA: 405/(glucosef (mg/dL) • insulinf (U/L)). A multiple regression model assessed the moderating effects of impaired GT on the impact of change in PRO on the GT, HOMA and LLP parameters (adjusted for weight change and gender). A change in PRO was positively associated with changes in HOMA, fasting triacylglycerol (p&lt;0.05) and fasting insulin (p=0.060) in the GT impaired group only (group by PRO, p &lt; 0.05, &lt; 0.05 and 0.061). Change in PRO was not associated with changes in glucose and insulin responses to a 75‐g oral glucose tolerance challenge, or changes in total cholesterol and HDL. In summary, while most research has focused on the effects of total protein intake on health‐related outcomes, these results indicate that the change in protein intake is also important to consider when helping overweight/obese adults with impaired glucose tolerance improve their health.Support: US Whey Protein Res Consort; NIH T32AG025671 and UL1 RR025761

Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials

The effect of green tea beverage and green tea extract on lipid changes is controversial. We aimed to identify and quantify the effect of green tea and its extract on total cholesterol (TC), LDL cholesterol, and HDL cholesterol. We performed a comprehensive literature search to identify relevant trials of green tea beverages and extracts on lipid profiles in adults. Weighted mean differences were calculated for net changes in lipid concentrations by using fixed-effects or random-effects models. Study quality was assessed by using the Jadad score, and a meta-analysis was conducted. Fourteen eligible randomized controlled trials with 1136 subjects were enrolled in our current meta-analysis. Green tea consumption significantly lowered the TC concentration by 7.20 mg/dL (95% CI: -8.19, -6.21 mg/dL; P < 0.001) and significantly lowered the LDL-cholesterol concentration by 2.19 mg/dL (95% CI: -3.16, -1.21 mg/dL; P < 0.001). The mean change in blood HDL-cholesterol concentration was not significant. Subgroup and sensitivity analyses showed that these changes were not influenced by the type of intervention, treatment dose of green tea catechins, study duration, individual health status, or quality of the study. Overall, no significant heterogeneity was detected for TC, LDL cholesterol, and HDL cholesterol; and results were reported on the basis of fixed-effects models. The analysis of eligible studies showed that the administration of green tea beverages or extracts resulted in significant reductions in serum TC and LDL-cholesterol concentrations, but no effect on HDL cholesterol was observed.

A combination of Green Tea and Melatonin Consumption Improve Plasma Lipid Profiles in Adults

Cardiovascular diseases (CVDs) are the major cause of morbidity and mortality in the world. The green tea prepared with leaves of Camellia sinensis is particularly rich in antioxidants, which seems to have a crucial role in atherogenesis. Melatonin also participates in many physiological functions and exhibit antioxidant activity.The aim of our investigation was to evaluate the effects of green tea drinking and melatonin on the lipid profile in 36 subjects. The lipid profile included the measurement of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglycerides (TGs), apolipoprotein A-I, apolipoprotein B, and lipoprotein (a). The measurements were performed at the beginning of the study, and after 3 weeks of drinking 1 L of water, and after 4 weeks of drinking 1 L of green tea daily plus 3mg/day melatonin at night. Tea was prepared every day at the same conditions of temperature, time of infusion, and concentration. After drinking green tea plus melatonin a significant beneficial improvement in the lipid profile of subjects was observed. Our data suggest that drinking green tea plus melatonin have beneficial effects protecting against the risk for cardiovascular disease by improving blood lipid levels.

Improvements in glycaemic control and cholesterol concentrations associated with the Quality and Outcomes Framework: a regional 2‐year audit of diabetes care in the UK

To determine whether there have been changes in glycaemic control and lipids in a cohort of people with repeated glycated haemoglobin (HbA(1c)) measurements since the implementation of the Quality and Outcomes Framework (QOF) for diabetes care. Retrospective retrieval of computer-held biochemical measurements of glycaemic control (HbA(1c)) and lipid profiles in adults in Hampshire, UK between 2006 and 2008. Routine data on age, sex, HbA(1c) and plasma lipids were available on an NHS database on 8997 adults with data available for HbA(1c) in both 2006 and 2008. In 2006, 39.7% of adults had glycaemic control within the QOF threshold (HbA(1c) < 7.5%); by 2008, this proportion had risen to 52.1% (P < 0.001). In 2006, 11.8% of subjects had poor glycaemic control (HbA(1c) > 10.0%); by 2008, this proportion had decreased to 10.1% (P < 0.001). The proportion of subjects achieving HbA(1c) and cholesterol targets (both HbA(1c) < 7.5% and total cholesterol < or = 5.0 mmol/l) was 30.2% in 2006; in 2008, this proportion had increased to 43.7% (P < 0.001). Individuals with poorer glycaemic control (HbA(1c) > 10.0%) were younger and had higher cholesterol concentrations than people with good (HbA(1c) < 7.5%) or moderate (HbA(1c) 7.5-10.0%) glycaemic control (P value for trend, both P < 0.001). Since the introduction of performance indicators for primary care and the incorporation of pay for performance in 2004, there has been marked improvement in the management of hyperglycaemia and hypercholesterolaemia among people with diabetes with data available in 2006 and 2008. It remains to be seen whether the new HbA(1c) audit target (HbA(1c) < 7.0%) introduced in 2009 will result in a further improvement in glycaemic control.

Improvements in glycaemic control and cholesterol concentrations associated with the Quality and Outcomes Framework: a regional 2 year audit of diabetes care in the UK

Diabet. Med. 27, 354–359 (2010) Abstract Aims To determine whether there have been changes in glycaemic control and lipids in a cohort of people with repeated glycated haemoglobin (HbA1c) measurements since the implementation of the Quality and Outcomes Framework (QOF) for diabetes care. Methods Retrospective retrieval of computer-held biochemical measurements of glycaemic control (HbA1c) and lipid profiles in adults in Hampshire, UK between 2006 and 2008. Routine data on age, sex, HbA1c and plasma lipids were available on an NHS database on 8997 adults with data available for HbA1c in both 2006 and 2008. Results In 2006, 39.7% of adults had glycaemic control within the QOF threshold (HbA1c < 7.5%); by 2008, this proportion had risen to 52.1% (P < 0.001). In 2006, 11.8% of subjects had poor glycaemic control (HbA1c > 10.0%); by 2008, this proportion had decreased to 10.1% (P < 0.001). The proportion of subjects achieving HbA1c and cholesterol targets (both HbA1c < 7.5% and total cholesterol ≤ 5.0 mmol/l) was 30.2% in 2006; in 2008, this proportion had increased to 43.7% (P < 0.001). Individuals with poorer glycaemic control (HbA1c > 10.0%) were younger and had higher cholesterol concentrations than people with good (HbA1c < 7.5%) or moderate (HbA1c 7.5–10.0%) glycaemic control (P value for trend, both P < 0.001). Conclusion Since the introduction of performance indicators for primary care and the incorporation of pay for performance in 2004, there has been marked improvement in the management of hyperglycaemia and hypercholesterolaemia among people with diabetes with data available in 2006 and 2008. It remains to be seen whether the new HbA1c audit target (HbA1c < 7.0%) introduced in 2009 will result in a further improvement in glycaemic control.

Association between breast-feeding and anthropometry and CVD risk factor status in adolescence and young adulthood: the Young Hearts Project, Northern Ireland

To examine the association between breast-feeding and blood pressure, anthropometry and plasma lipid profile in both adolescence and young adulthood. Longitudinal study of biological and behavioural risk factors for CVD. The Young Hearts Project, Northern Ireland. Schoolchildren aged 12 years and 15 years who participated in a cross-sectional study of lifestyle and health, and who were followed up as young adults aged 20-25 years. There was no significant difference in height, weight, BMI, skinfold thickness measurements, blood pressure or plasma lipid profile in adolescents who had been breast-fed compared with those who had not been breast-fed. However, by the time these adolescents had reached adulthood, those who had been breast-fed were significantly taller than those who had not been breast-fed (standing height, P = 0.013; leg length, P = 0.035). Specifically, the breast-fed group was on average taller by 1.7 cm (95 % CI 0.4, 3.0 cm) and had longer legs by 1.0 cm (95 % CI 0.1, 1.9 cm). There was no significant difference in other anthropometric measures, blood pressure or plasma lipid profile in adults who had been breast-fed compared with those who had not been breast-fed. Compared with those who had not been breast-fed, individuals who had been breast-fed were taller in adulthood. Given the known association of increased adult height with improved life expectancy, the results from the present study support a beneficial effect of breast-feeding.

Poster 195: Body Mass Index and Lipid Profiles in Adults with Cerebral Palsy: An Assessment of their Interaction with Gross Motor Function Classification

PM&RVolume 1, Issue 9S p. S189-S189 Poster Presentation Poster 195: Body Mass Index and Lipid Profiles in Adults with Cerebral Palsy: An Assessment of their Interaction with Gross Motor Function Classification Christina M. Marciniak MD, Christina M. Marciniak MD Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorDiane Dudas-Sheehan Nursing Doctorate, Diane Dudas-Sheehan Nursing Doctorate Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorSteven Glocke Nursing Doctorate, Steven Glocke Nursing Doctorate Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorBenjamin Grover BS, Benjamin Grover BS Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorDaniel R. Lueders BS, Daniel R. Lueders BS Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorPatrick Semik BA, Patrick Semik BA Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorSantiago D. Toledo MD, Santiago D. Toledo MD Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this author Christina M. Marciniak MD, Christina M. Marciniak MD Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorDiane Dudas-Sheehan Nursing Doctorate, Diane Dudas-Sheehan Nursing Doctorate Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorSteven Glocke Nursing Doctorate, Steven Glocke Nursing Doctorate Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorBenjamin Grover BS, Benjamin Grover BS Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorDaniel R. Lueders BS, Daniel R. Lueders BS Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorPatrick Semik BA, Patrick Semik BA Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this authorSantiago D. Toledo MD, Santiago D. Toledo MD Northwestern University/Rehabilitation Institute of Chicago, Chicago, ILSearch for more papers by this author First published: 25 September 2009 https://doi.org/10.1016/j.pmrj.2009.08.216Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article. Volume1, Issue9SSeptember 2009Pages S189-S189 RelatedInformation

Meta-analysis of the effects of flaxseed interventions on blood lipids

Background:Several clinical trials have investigated the effects of flaxseed and flaxseed-derived products (flaxseed oil or lignans) on blood lipids; however, the findings have been inconsistent. Objective:We aimed to identify and quantify the effectiveness of flaxseed and its derivatives on blood lipid profiles. Design:A comprehensive literature search was performed on the basis of English reports of randomized controlled trials of flaxseed or its derivatives on lipid profiles in adults, which were published from January 1990 to October 2008. Attempts also were made to access unpublished data. Study quality was assessed by using the Jadad score, and a meta-analysis was conducted. Results:Twenty-eight studies were included. Flaxseed interventions reduced total and LDL cholesterol by 0.10 mmol/L (95% CI: −0.20, 0.00 mmol/L) and 0.08 mmol/L (95% CI: −0.16, 0.00 mmol/L), respectively; significant reductions were observed with whole flaxseed (−0.21 and −0.16 mmol/L, respectively) and lignan (−0.28 and −0.16 mmol/L, respectively) supplements but not with flaxseed oil. The cholesterol-lowering effects were more apparent in females (particularly postmenopausal women), individuals with high initial cholesterol concentrations, and studies with higher Jadad scores. No significant changes were found in the concentrations of HDL cholesterol and triglycerides. Conclusions:Flaxseed significantly reduced circulating total and LDL-cholesterol concentrations, but the changes were dependent on the type of intervention, sex, and initial lipid profiles of the subjects. Further studies are needed to determine the efficiency of flaxseed on lipid profiles in men and premenopausal women and to explore its potential benefits on other cardiometabolic risk factors and prevention of cardiovascular disease.

Dichotomy between postprandial glucose and lipid profiles in adults with cystic fibrosis: A pilot study

Background Cystic fibrosis (CF) patients present a high incidence of glucose tolerance abnormalities. Altered insulin secretion combined with recommended high-fat intake could be associated with dysregulation of glucose and lipid metabolism. We examined postprandial glucose and lipid profiles during an oral glucose tolerance test (OGTT) and following a standardized high-fat test meal (TM). Methods Sixteen CF patients with normal glucose tolerance (NGT) or CF-related diabetes (CFRD) and 16 controls underwent a 4 h OGTT and a TM. We then measured plasma glucose, insulin, free fatty acid (FFA) and triglyceride (TG) concentrations. Results CF patients presented higher glucose excursion compared to controls after the OGTT and TM. However, in CF patients, this excursion was significantly reduced in both amplitude and length after the TM. The TM provoked a comparable increase in TG levels in both groups whereas they remained stable during the OGTT. FFAs were suppressed similarly in both groups after both challenges. Conclusion CF is associated with abnormal glucose excursion in the presence of relatively normal lipid excursion. The rapid normalization of glucose values after a mixed meal should be further explored and, if confirmed, might have significant implications for CFRD diagnostic.

Impacto da prática habitual de atividade física no perfil lipídico de adultos

The present study was designed to analyze the impact of the habitual physical activity determined by International Physical Activity Questionnaire (IPAQ) on lipid profile in representative sample of adults. A sample of 361 subjects (196 women and 165 men) aged 20-60 years old was included in the study. Plasma lipid concentrations were measured by standard procedures. The results showed that HDL-cholesterol and VLDL-cholesterol levels were not significantly different across physical activity groups in both sexes. Total cholesterol, LDL-cholesterol and triglycerides were significantly different across physical activity groups in women and men, but the pattern of variation was different between genders. The results from logistic regression analysis indicated that the odds ratios for low plasma lipid levels was significant only in subjects classified as very active compared with sedentary. In conclusion, the results suggest that increased habitual physical activity determined by IPAQ present significant impact in the plasma lipid profile in adults of both sexes, independently of the age and of the variations of the body weight.

Green tea consumption improves plasma lipid profiles in adults

Cardiovascular disease is the major cause of mortality and morbidity in the Western world. Green tea prepared with leaves of Camellia sinensis is particularly rich in antioxidants, which seem to have a crucial role in atherogenesis. The aim of our investigation was to evaluate the effect of green tea drinking on the lipid profile in 29 Portuguese subjects. The lipid profile included the measurement of total cholesterol, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol, triacylglycerols, apolipoprotein A-I, apolipoprotein B, and lipoprotein(a). The measurements were performed at the beginning of the study, and after 3 weeks of drinking 1 L of water, and after 4 weeks of drinking 1 L of green tea daily. Tea was prepared every day at the same conditions of temperature, time of infusion, and concentration. No dilution effect was observed after water drinking. After drinking green tea, a significant beneficial improvement in the lipid profile of subjects was observed. A decrease in cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, and ratio of cholesterol/HDL-C, but an increase in HDL-C and apolipoprotein A-I, was observed in the subjects. No significant differences were observed for triacylglycerol and lipoprotein(a). Our data suggest that drinking green tea has a beneficial effect protecting against the risk for cardiovascular disease by improving blood lipid levels.

W12-P-050 The lipid profile in adults with negative or positive antibody Helicobacter pylori

W12-P-050 The lipid profile in adults with negative or positive antibody Helicobacter pylori

Carotid artery intima-media thickness and lipid profile in adults with growth hormone deficiency after long-term growth hormone replacement

To investigate the effects of growth hormone (GH) replacement on carotid artery intima-media thickness (IMT) and lipid profile, 29 adults with GH deficiency (GHD), mean age 42.5 ± 10.1 years, were studied and compared with 29 control subjects matched for sex, age, body mass index, and smoking habits. Lipid profile (total cholesterol, triglycerides, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein cholesterol, apolipoproteins A and B, and lipoprotein), serum insulin-like growth factor 1 (IGF-1) levels, and ultrasonography of the carotid arteries were performed at baseline and at 6, 12, and 24 months during GH therapy on maintenance dose. At baseline, when compared with the control group, patients presented increased carotid artery IMT ( P < .05) and triglyceride levels ( P < .001) and lower HDL concentrations ( P < .01). In a linear regression analysis, age and known mean duration of GHD were correlated with carotid artery IMT. After 24 months of GH replacement, a reduction in the mean of carotid artery IMT was observed ( P < .01). The apolipoprotein B levels decreased significantly after the first 3 months of GH treatment ( P < .001) and remained stable thereafter. Women also presented an increase in HDL cholesterol levels ( P < .01). No differences were observed in the other lipids measured. Carotid artery IMT at baseline was inversely correlated with the change in carotid artery IMT (Δ = 24 months − baseline), r = 0.63, P < .001. In conclusion, 24 months of GH replacement therapy promoted favorable effects on carotid artery IMT and lipid profile in patients with GHD. Long-term follow-up studies are required to show whether these beneficial effects will result in reduction of morbidity and mortality from vascular disease.

M.613 The lipid profile in adults and very old patients with latter thromboembolic stroke

M.613 The lipid profile in adults and very old patients with latter thromboembolic stroke

M.613 The lipid profile in adults and very old patients with latter thromboembolic stroke

M.613 The lipid profile in adults and very old patients with latter thromboembolic stroke

Plasma lipid profiles in adults after prenatal exposure to the Dutch famine

Small body size at birth has been reported to be associated with an atherogenic lipid profile in humans, and animal experiments have shown that undernutrition during pregnancy permanently alters cholesterol metabolism in the offspring. There is no direct evidence in humans that maternal malnutrition during pregnancy affects the lipid profiles of the offspring. We assessed the effects of maternal malnutrition during specific periods of gestation on plasma lipid profiles in persons aged approximately 50 y. This was a follow-up study of men and women born at term as singletons in a university hospital in Amsterdam between 1 November 1943 and 28 February 1947 around the time of a severe famine. Persons exposed to famine in early gestation had a more atherogenic lipid profile than did those who were not exposed to famine in utero. Their LDL-HDL cholesterol ratios were significantly higher (by 13.9%; 95% CI: 2.6-26.4%). Additionally, their plasma HDL-cholesterol and apolipoprotein A concentrations tended to be lower, and their plasma total cholesterol, LDL-cholesterol, and apolipoprotein B concentrations tended to be higher, although these differences were not statistically significant. The effect of famine was independent of size at birth and adult obesity. An atherogenic lipid profile might be linked to a transition from poor maternal nutrition in early gestation to adequate nutrition later on. This suggests that maternal malnutrition during early gestation may program lipid metabolism without affecting size at birth.