* Abbreviation: USPSTF — : US Preventive Services Task Force In their article, “Breastfeeding in Infancy and Lipid Profile in Adolescence,” Hui et al1 report that exclusive breastfeeding in early infancy may promote a healthier lipid profile in adolescence. In the original study, 8327 infants and families were recruited to prospectively study the impact of secondhand smoke. The sample represented 88% of all births in Hong Kong. Multiple factors were assessed at birth and early in life. At 17.5 years of age, 3261 participants agreed to a biobank clinical follow-up including anthropometric and lipid measurements. Key findings from this longitudinal follow-up included lower total cholesterol and low-density lipoprotein cholesterol for those who had been exclusively breastfed as infants compared with those who were formula fed. Similar results were not seen for those with mixed breast and formula feeding. Per Hui et al,1 the associations between exclusive breastfeeding and lower cholesterols were independent of BMI. This study has several strengths. The original population … Address correspondence to Alex H. Krist, MD, MPH, Department of Family Medicine and Population Health, Virginia Commonwealth University, One Capital Square, Room 631, 830 E. Main St, Richmond, VA 23219. E-mail: ahkrist{at}vcu.edu