Lipid Peroxidation In Brain Homogenates Research Articles

Pentobarbitone stimulation of protein phosphorylation in rat brain [formula omitted

Effect of pentobarbitone on protein phosphorylation in rat brain in vitro was investigated. It was observed that at short term incubations pentobarbitone greatly enhanced incorporation of 32P into cerebral phosphoproteins which came to lower level after prolonged incubation. Dose response curve of the drug on protein phosphorylation was unconventional. The drug did not appreciably affect lipid peroxidation in brain homogenates. Effect of pentobarbitone on protein phosphorylation is not due to its inhibition of mitochondrial electron flow which would have given opposite results.

Lipid peroxidation in developing rat brain during undernutrition

The effect of undernutrition has been studied in relation to lipid peroxidation, both in vitro and in vivo, in the brain of developing rats. Lipid peroxidation in brain homogenates as well as in the mitochondrial fraction of brain was significantly higher in undernourished groups than in controls. This difference was maximal at the 12th postnatal day. Following rehabilitation for two weeks, this increased lipid peroxidation in brains of undernourished rats could no longer be observed. Determination of malonaldehyde levels in vivo did not show an appreciable difference between control and undernourished animals.