As a thiol-replenishing and redox-modulating agent in cells, Alpha lipoic acid ‘ALA—also known as 'thioctic acid, 1,2-dithiolane-3-pentanoic acid, 1,2dithiolane-3-valeric acid, or 6,8-thioctic acid—has attracted a lot of medicinal interest. Naturally, alpha lipoic acid is needed as a cofactor for the oxidative decarboxylation responses of the glucose digesting system to lose life. Thus, the goal of this investigation was to draw attention to how thioctic acid affects lipid profile. Critical papers were found by a deliberate search of PubMed/Medline, Scopus, Web of Science, Cochrane Library, and Embase through October 2023. The rabbits were given an oral dose of 60 mg/kg BW of thioctic acid. Rabbits were given the tried measurements daily for a period of 12 weeks. The results demonstrated that thioctic acid caused a critical (PB/0.05) decrease in the levels of glucose, "TBARS", "cholesterol", triglycerides "TG", low density lipoprotein "LDL", and very low-density lipoprotein "VLDL", while the level of high-density lipoprotein "HDL" increased in comparison to the control group.