Lipemia Retinalis Research Articles

The Retina in Type 5 Hyperlipoproteinemia

Of two patients with type 5 hyperlipoproteinemia, one exhibited lipemia retinalis with multiple retinal hemorrhages and intraretinal lipid extravasations. Postmortem examination showed hemorrhages in the inner retinal layers and lipid deposits largely in the outer plexiform layer. Lipid within the walls of the retinal vessels was demonstrated by light and electron microscopy. The second patient exhibited visual loss due to progressive obstruction of retinal vessels with white material presumed to be lipid. Findings were confined to one eye.

Eruptive Xanthoma in a Patient with Type V Hyperlipoproteinemia

A case of type V hyperlipoproteinemia manifested by eruptive xanthoma and lipemia retinalis is described. The patient also had an accelerated ESR, leukocytosis and hyperhidrosis. His karyotype was found to be XXY, which is typical of Klinefelter’s syndrome. The possible relationship between type V hyperlipoproteinemia and Klinefelter’s syndrome is discussed.

A Case of Xanthomatosis and Hyperlipoproteinemia Type V Propably Induced by Overdosage of Insulin

A woman, aged 46 years, with a hyperlipoproteinemia phenotype V, an unusual type of xanthomatosis, as well as lipemia retinalis, diabetes mellitus, and nephropathia, is discussed. The withdrawal of 64 IU insulin and the institution of a hypocaloric diabetes diet resulted in the disappearance of the skin lesions and a regression of the eye lesion. During this treatment the total lipid-level became almost normal (6,965 mg% before treatment and 947 mg% after 10 weeks). The chylomicrons disappeared but the VLDL content remained relatively and absolutely elevated, as in type IV hyperlipoproteinemia.

Lipaemia of the limbal vessels.

A rise in the plasma triglycerides above a certain level imparts a milky opalescence to the plasma. This is termed lipaemia. Like other lipids the triglycerides are transported in the bloodstream within lipid-protein complexes, the plasma lipoproteins. Triglyceride of dietary origin is carried in the large lipoprotein particles called chylomicrons, while that synthesized within the body is carried in the pre-beta lipoprotein fraction of the plasma. An excess of either of these fractions is able to produce lipaemia (Rifkind, I970). Lactescence of the plasma in a specimen of withdrawn blood is sufficient to diagnose hypertriglyceridaemia and indicates the need for a full lipid analysis of the blood. However, hypertriglyceridaemia may also be diagnosed by clinical examination of the fundus oculi from the presence of lipaemia retinalis (Duke-Elder and Dobree, I967). In this situation the retinal arteries and veins become indistinguishable, assume a milky, pinkish colour, and lose their light reflex. When the lipaemia is of severe degree the fundus colour may lighten also; this is due to lipaemia of the choroidal vessels. A sufficiently raised triglyceride blood level, whatever its cause, may produce lipaemia, which has thus been seen with primary hyperlipoproteinaemia of Types I, III, IV, and V (Fredrickson, Levy, and Lees, I967), and in their secondary phenotypes (Vinger and Sachs, I970). The observation of lipaemia retinalis may therefore be the first indication of a significant disorder of lipoprotein metabolism. The present paper describes a new ocular sign of lipaemia observed in the vessels of the globe and limbus.

Lipemia retinalis: Microcirculatory changes and lipid studies in a family

A 13-year-old girl with diabetic acidosis had lipemia retinalis and massive hyperchylomicronemia ( 19.5 Gm. 100 ml. total lipids) corrected by insulin administration. Fat uptake by embryonic cells in tissue culture using the patient's lipemic serum was very marked and was maximal after heparin administration. Red-cell aggregation could be induced in the retinal vessels at the height of her hypertriglyceridemia while conjunctival red-cell aggregation persisted at lower levels of hyperlipemia. Whole-blood viscosity was actually subnormal during the stage of lipemia. With clearing of the hyperchylomicronemia a pre-β band appeared in the lipoprotein electrophoretic pattern of the plasma, which persisted when blood lipid levels returned to normal. The patient's father, mother and brother had pre-β bands despite normal blood lipid and insulin levels and normal glucose tolerance. The pre-β band disappeared on heparin administration. This pattern may represent a prototype of carbohydrate-induced lipemia.

Glycogen storage disease: type I.

To the Editor .—I read with interest Dr. Richard Fine's article inThe Journal(Amer J Dis Child115:238-331 [March] 1968). I would like to make some comments with regard to the author's statement: Retinal changes have not been previously described in patients with GSD Type I. Newer mentioned Von Gierke's disease among conditions in which lipemia retinalis occurs. To quote from his book 1 : Lipemia retinalis occurs most commonly in diabetic acidosis, usually in growth onset diabetes. It may occur also in essential familial hyperlipidemia, secondary hyperlipidemias of the nephrotic syndrome, pancreatitis, Von Gierke's disease, or other conditions with increased triglyceride concentration of the blood. Dr. Fine and his associates described: Multiple bilateral symmetrical, yellowish, nonelevated discrete paramacular lesions in the occular fundi of their cases and found them most striking in patients with the highest serum triglyceride levels. These changes are not consistent with the classical description of

HYPERLIPEMIA FOLLOWING SULFONYLUREA THERAPY IN YOUNG DIABETICS.

PATIENTS with untreated diabetes mellitus often demonstrate some elevations of plasma lipids. The increased blood concentrations of free fatty acids (FFA), triglycerides, cholesterol, and phospholipids usually return to normal with treatment which improves glucose utilization. This report describes the occurrence of severe hyperlipemia associated with lipemia retinalis and xanthomatosis in certain diabetic patients treated with sulfonylurea compounds. In each instance, the control of the patient's hyperglycemia by the sulfonylurea was inadequate. These observations emphasize the importance of adequate follow-up of carbohydrate metabolism in patients treated with oral hypoglycemic agents. <h3>Methods</h3> Venous blood was drawn while the patient was in the fasting state unless otherwise noted. Blood glucose was determined by the method of Somogyi,¹total lipids by the method of Folch,²FFA by the method of Dole,³cholesterol by the method of Abell,⁴and phospholipids by the method of Sperry.⁵Patients were hospitalized during the

Essential hyperlipemia.

Case Reports1 December 1958ESSENTIAL HYPERLIPEMIAB. C. PAYNE, M.D., A. M. WALDRON, M.D., F.A.C.P.B. C. PAYNE, M.D.Search for more papers by this author, A. M. WALDRON, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-49-6-1420 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptEssential hyperlipemia is a disease of rather recent recognition. Described first by Holt et al. in 1939,11 it was repeatedly reported in pediatric literature as a relatively benign condition. Almost 10 years later, reports from Scandinavia and America indicated a high incidence of coronary heart disease at a relatively early age in adults. An excellent descriptive analysis of the condition was published by Joyner13 in 1953. More recent reports only emphasize the frequency of associated coronary atherosclerosis (10 of 17 case reports).15, 17The condition has definite familial tendencies, and no racial predilection can be anticipated on the basis...Bibliography1. AhrensKunkel EHHG: The stabilization of serum lipid emulsions by serum phospholipids, J. Exper. Med. 90: 409, 1949. CrossrefMedlineGoogle Scholar2. BloomfieldShenson AB: The syndrome of idiopathic hyperlipemia with crises of violent abdominal pain, Stanford M. Bull. 5: 185, 1947. MedlineGoogle Scholar3. BernsteinWilliamsHummelShepherdErickson SSHHFCMLBN: Metabolic observations on a child with essential hyperlipemia, J. Pediat. 14: 570, 1939. CrossrefGoogle Scholar4. ChapmanKinney FT: Hyperlipemia, Am. J. Dis. Child. 62: 1014, 1941. CrossrefGoogle Scholar5. FrankLevitt LL: Idiopathic hyperlipemia with secondary xanthomatosis, Arch. Dermat. and Syph. 64: 434, 1951. CrossrefGoogle Scholar6. Fulton JK: Essential hyperlipemia, acute gout, peripheral neuritis and myocardial disease in a Negro male, Arch. Int. Med. 89: 303 (Feb.) 1952. CrossrefGoogle Scholar7. GoodmanShumanGoodman MHS: Idiopathic hyperlipemia with secondary xanthomatosis, hepatosplenomegaly and lipemia retinalis, J. Pediat. 61: 596, 1940. CrossrefGoogle Scholar8. GrossmanHitz EEJB: Lipemia retinalis associated with essential hyperlipemia, Arch. Ophth. 40: 570, 1948. CrossrefGoogle Scholar9. Harslof E: Idiopathic familial hyperlipemia attended with hepatosplenomegaly, Acta med. Scandinav. 130: 140, 1948. CrossrefMedlineGoogle Scholar10. Hetzel PS: Idiopathic hyperlipemia with report of two cases, occurring in one family, M. J. Australia 2: 396 (Sept.) 1951. CrossrefMedlineGoogle Scholar11. HoltAylwardTimbres LEFXHG: Idiopathic familial lipemia, Bull. Johns Hopkins Hosp. 64: 279, 1939. Google Scholar12. Hopgood WC: Idiopathic hyperlipemia, New England J. Med. 238: 429, 1948. CrossrefMedlineGoogle Scholar13. Joyner CR: Essential hyperlipemia, Ann. Int. Med. 38: 759, 1953. LinkGoogle Scholar14. KoszalkaLevin MFJL: Idiopathic hyperlipemia, Ann. Int. Med. 33: 473, 1950. LinkGoogle Scholar15. LeverWaddell WW(a) : Idiopathic hyperlipemia and primary hypercholesteremic xanthomatosis. VII. Effects of intravenously administered fat on the serum lipids, J. Invest. Dermat. 25: 233 (Oct.) 1955. (b) Lever, W. F., Smith, P. A., and Hurley, N. A.: Idiopathic hyperlipemic and primary hypercholesteremic xanthomatosis. I. Clinical data and analysis of the plasma lipids, J. Invest. Dermat. 22: 33 (Jan.) 1954. (c) Lever, W. F., Smith, P. A., and Hurley, N. A.: Idiopathic hyperlipemia and primary hypercholesteremic xanthomatosis. III. Effects of intravenously administered heparin on the plasma proteins and lipids, J. Invest. Dermat. 22: 71, 1954. CrossrefMedlineGoogle Scholar16. Levy B: Idiopathic lipemia, J. Pediat. 29: 367, 1946. CrossrefMedlineGoogle Scholar17. MalmrosSwahnTruedsson HBE: Essential hyperlipaemia, Acta med. Scandinav. 149: 91, 1954. CrossrefMedlineGoogle Scholar18. MovittGerstlSherwoodEpstein ERBFCC: Essential hyperlipemia, Arch. Int. Med. 87: 79, 1951. CrossrefGoogle Scholar19. Thannhauser SJ(a) : Lipoidoses, 1950, Oxford University Press, New York. (b) Thannhauser, S. J., and Stanley, M.: Serum fat curves following oral administration of I131 labeled neutral fat to normal subjects and those with idiopathic hyperlipemia, Tr. A. Am. Physicians 62: 245, 1949. Google Scholar20. Wilkinson CF: Personal communication. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Ann Arbor, Michigan*Received for publication April 29, 1957.Requests for reprints should be addressed to B. C. Payne, M.D., St. Joseph Mercy Hospital, Ann Arbor, Michigan. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 December 1958Volume 49, Issue 6Page: 1420-1426KeywordsAtherosclerosisCoronary heart diseaseFatsHyperlipidemiaIngestionLactoseStable coronary artery disease Issue Published: 1 December 1958 PDF downloadLoading ...

Lipemia Retinalis

Lipemia retinalis is a visible ophthalmic manifestation of a profound disturbance in lipid metabolism. It occurs most frequently in association with diabetes concomitant with acidosis of a more or less severe degree. Only an ophthalmologist who has been lucky enough to see the fundus of a patient with lipemia retinalis can appreciate Heyl's 1 astonishment when, in 1880, he described its remarkable appearance for the first time. The case of a 28-month-old boy presented here shares with that of Koch and Strong 48 the distinction of being the youngest diabetic with lipemia retinalis reported to date. Case History A white boy, aged 28 months, was admitted to the Montreal Children's Hospital on Oct. 9, 1956. He had been well until three weeks prior to admission, when easy fatiguability and refusal to play were noted. A week later it was realized that his appetite, previously exceptionally good, had diminished, although he

Serum lipids in lipemia retinalis: report of a case.

Excerpt Lipemia retinalis and xanthoma diabeticorum are occasionally seen in patients with diabetes mellitus and are thought to be due to abnormalities in the serum lipid fractions. Since the first...

Idiopathic lipemia retinalis.

LIPEMIA retinalis is that condition found ophthalmoscopically in a patient with hyperlipemia in whom the blood lipids have become sufficiently increased to alter the appearance of the retinal blood column, the arteries and veins appearing as broad creamcolored ribbons against a milky background. Hyperlipemia occurs as the result of an abnormal increase in the neutral fats, the serum developing a milky appearance when the neutral fat content reaches about 500 mg. per 100 cc. Lipemia retinalis, however, does not appear until the neutral fat content is much higher. According to Thannhauser, 1 the amount of lipid substance in the serum is dependent upon the following factors: (1) the absorption of fat from the intestine; (2) the migration of fat from fat depots to the organs of fat disintegration; (3) the deposition of fat in subcutaneous and other fat-storing tissue; (4) the speed of fat disintegration in the organs, that is,

Persistent hyperlipemia and hepatosplenomegaly in a patient with controlled diabetes mellitus.

Case Reports1 September 1954PERSISTENT HYPERLIPEMIA AND HEPATOSPLENOMEGALY IN A PATIENT WITH CONTROLLED DIABETES MELLITUSTHOMAS A. HAYMOND, M.D., KEEHN BERRY JR., M.D.THOMAS A. HAYMOND, M.D.Search for more papers by this author, KEEHN BERRY JR., M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-41-3-609 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptHyperlipemia has been shown to occur in association with a number of disease states.1a Movitt et al.2 and Thannhauser1a, b have listed the conditions, and Thannhauser has written an excellent monograph on the lipidoses.1aOne of the disease states with which hyperlipemia is associated is diabetes mellitus.1a, b, 3, 4, 5Thannhauser states,1ahowever, that the hyperlipemia of diabetes "is controlled completely by insulin." Carfagno and Steiger,3in reviewing 63 cases of lipemia retinalis in the literature, to which they added one of their own, state that lipemia retinalis was seen in the diabetic patients only when they were in...Bibliography1. Thannhauser SJ (a) : Lipidoses, 1950, Oxford University Press, New York. (b) Thannhauser, S. J.: Serum lipids, their value in diagnosis, New England J. Med. 237: 515, 1948. Google Scholar2. MovittGerstlSherwoodEpstein ERBFCC: Essential hyperlipemia, Arch. Int. Med. 87: 78, 1951. CrossrefGoogle Scholar3. CarfagnoSteiger SCWA: The serum lipids in lipemia retinalis, Am. J. M. Sc. 221: 379, 1951. Google Scholar4. Blix G: Diabetic lipemia, Acta med. Scandinav. 64: 142, 1926. CrossrefGoogle Scholar5. WarrenRoot SF: Lipoid containing cells in the spleen in diabetics with lipemia, Am. J. Path. 2: 69, 1926. MedlineGoogle Scholar6. Lawrence RD: Lipodystrophy and hepatomegaly with diabetes, lipemia and other metabolic disturbances, Lancet 1: 724, 773, 1946. CrossrefMedlineGoogle Scholar7. ChapmanKinney FDTD: Hyperlipemia; idiopathic lipemia, Am. J. Dis. Child. 62: 1014, 1941. CrossrefGoogle Scholar8. Hopgood WC: Idiopathic hyperlipemia, New England J. Med. 238: 429, 1948. CrossrefMedlineGoogle Scholar9. KoszalkLevin MFJJ: Idiopathic hyperlipemia, Ann. Int. Med. 33: 473, 1950. LinkGoogle Scholar10. MaimonKirsnerPalmer SNJBWL: Chronic recurrent pancreatitis; a clinic study of 20 cases, Arch. Int. Med. 81: 56, 1948. CrossrefGoogle Scholar11. MentherKnight ROWA: Chronic recurrent pancreatitis, Gastroenterology 12: 24, 1949. CrossrefMedlineGoogle Scholar12. King SE: The syndrome of chronic relapsing pancreatitis, M. Clin. North America 33: 883 (May) 1949. CrossrefMedlineGoogle Scholar13. KlatskinGordon GM: Relationship between relapsing pancreatitis and essential hyperlipemia, Am. J. Med. 12: 3, 1952. CrossrefMedlineGoogle Scholar14. SteinbrockerSpitzerFriedman ONHH: The shoulder-hand syndrome in reflex dystrophy of the upper extremity, Ann. Int. Med. 29: 22, 1948. LinkGoogle Scholar15. Poulsen HM: Familial lipemia: a new form of lipoidosis showing increase in neutral fats combined with attacks of acute pancreatitis, Acta. med. Scandinav. 138: 413, 1950. CrossrefMedlineGoogle Scholar16. SchwarzWoldowDunsmore LARA: Determination of fat tolerance in patients with myocardial infarction: method utilizing serum turbidity changes following a fat meal, J. A. M. A. 149: 364 (May 24) 1952. CrossrefMedlineGoogle Scholar17. ThannhauserReinstein SJH: Fatty changes in the liver from different causes: comparative studies of lipid partition, Arch. Path. 33: 646, 1942. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Received for publication November 3, 1953. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetes mellitus und HyperlipoproteinämieDiabetes mellitus und HyperlipämiePathophysiologie der primären HypertriglyceridämienHYPERLIPEMIA ASSOCIATED WITH DIABETES MELLITUS AND PANCREATITIS: A CASE REPORT WITH AUTOPSY*CHARLES R. TOURTELLOTTE, M.D., RUSSELL D. TYLER, M.D. 1 September 1954Volume 41, Issue 3Page: 609-616KeywordsDiabetes mellitusFatsHeparinHepatosplenomegalyHyperlipidemiaInsulinLipidsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 September 1954 PDF downloadLoading ...

XANTHOMA DIABETICORUM

Case Reports1 September 1953XANTHOMA DIABETICORUMESAR GORDON MARGOLINESAR GORDON MARGOLINSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-3-629 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIn recent years cholesterol and its esters have been singled out of the lipid constituents of the body for special consideration, largely because of their relationship to atheromatous changes and partly because of their chemical similarities to adrenal and sexual hormones. Clinicians have been impressed with the importance of the cholesterol levels in certain disease states, and the measurement of cholesterol is now a standard test in most clinical laboratories. A recent case of xanthoma diabeticorum, manifesting striking alterations in cholesterol metabolism occurring in the course of uncontrolled diabetes mellitus, is presented.CASE REPORTPresent Illness:A 21 year old...Bibliography1. AddisonGull TW: On a certain affection of the skin, vitiligoidea—(a) plana; (b) tuberosa, with remarks, Guy's Hosp. Rep. 7: 265, 1851. Cited by Thannhauser.8 Google Scholar2. McGavackShepardson THHC, cited by Buchanan, J. A., and Indelicato, J. C.: A case of xanthoma diabeticorum associated with diabetes mellitus and acromegaly, Am. J. M. Sc. 195: 50-53, 1938. CrossrefGoogle Scholar3. JoslinRootWhiteMarbleBailey EPHFPACC: The treatment of diabetes mellitus, 1946, Lea and Febiger, Philadelphia, pp. 593-595. Google Scholar4. Diamond , cited by Joslin.3 Google Scholar5. Major , cited by Sutton and Sutton.7 Google Scholar6. Beerman H: Lipid diseases as manifested in the skin, M. Clin. North America 35: 433-456, 1951. CrossrefMedlineGoogle Scholar7. SuttonSutton RLRL: Diseases of the skin, 1939, The C. V. Mosby Co., St. Louis, pp. 391-393, 866-871. Google Scholar8. Thannhauser SJ: Lipidoses, diseases of the cellular lipid metabolism, 1950, Oxford University Press, New York. Google Scholar9. CarfagnoSteiger SCWA: The serum lipids in lipemia retinalis, Am. J. M. Sc. 221: 379-383, 1951. CrossrefMedlineGoogle Scholar10. NadbathFauteux RPLZ: Diabetic lipemia retinalis, U. S. Armed Forces M. J. 3: 319-322, 1952. MedlineGoogle Scholar11. CurtisSheldonEckstein ACJMHC: Experimental reproduction of lipemia, Am. J. M. Sc. 186: 548-556, 1933. CrossrefGoogle Scholar12. ParkerCuller WRAM, cited by Curtis and Sheldon.11 Google Scholar13. Allen FM, cited by Curtis and Sheldon.11 Google Scholar14. Garb J: Lipid metabolism in relation to xanthoma diabeticorum with a recommendation for a new nomenclature, Ann. Int. Med. 19: 241-252, 1943. LinkGoogle Scholar15. Duncan GG: Diseases of metabolism, 1947, W. B. Saunders Co., Philadelphia. Google Scholar16. Spencer MC: Xanthoma diabeticorum, Arch. Dermat. and Syph. 64: 92-93, 1951. Google Scholar17. FrankLevitt LLM: Idiopathic hyperlipemia with secondary xanthomatosis, Arch. Dermat. and Syph. 64: 434-436, 1951. CrossrefGoogle Scholar18. DelevettBruger AFM: Plasma lipids in primary (xanthomatosis) and secondary hypercholesterolemia, Arch. Int. Med. 81: 859-867, 1948. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: MC Omaha, Nebraska*Received for publication March 18, 1953.From the Medical Service, 382d General Hospital, APO 54, c/o PM, San Francisco.Present address: 116 So. 50 St., Omaha. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byDiabetes and Diseases of the SkinThe diet and the development of coronary heart disease 1 September 1953Volume 39, Issue 3Page: 629-635KeywordsApolipoproteinsCholesterolClinical laboratoriesDiabetes mellitusHormonesLipidsMedical services ePublished: 1 December 2008 Issue Published: 1 September 1953 PDF downloadLoading ...

Nondiabetic lipemia retinalis; report of a case.

LIPEMIA retinalis was first described by Heyl 1 in 1880. pathognomonic quality of this phenomenon must certainly have impressed him when he wrote, The moment my eye caught the details of the fundus, I saw the remarkable appearance which I shall endeavor to describe. Duke-Elder 2 describes the condition as unmistakable. He states: change in colour of the retinal vessels is seen first in the periphery where they become hazy and slightly milky, and gradually the appearance spreads up towards the disc, the arteries and the veins in the average cases becoming flat and ribbon like and assuming a uniform appearance as if filled with milk, although in some cases a salmon-colour merging into cream is retained on or near the disc. In other cases the appearance is yellowish, but in all cases the light reflex becomes diffuse or is lost, and frequently yellowish-white stripes accompany both arteries

Essential lipemia, acute gout, peripheral neuritis, and myocardial disease in a Negro man; response to corticotropin.

ESSENTIAL lipemia is a rare disease. a recent review, Movitt, Gerstl, Sherwood, and Epstein 1 were able to find 14 previously reported cases and added 3 of their own. While the occurrence of xanthomas in the skin, lipemia retinalis, hepatomegaly, and splenomegaly was frequent in this series, the occurrence of gout or peripheral neuritis is not mentioned. These authors stated: In contrast with familial hypercholesteremic xanthomatosis, premature arteriosclerosis and atheromatosis have not been observed in idiopathic hyperlipemia of adults. Wolfson, Cohn, Levine, Rosenberg, and Hunt 2 mentioned a single case of gout associated with idiopathic lipemia and stated that, with the exception of this case, the presence of hypercholesteremia is not characteristic of gout. Because the case to be reported adds a second instance of gout in relation to essential lipemia, as well as an additional apparently related neurologic and cardiac syndrome not previously described, and because of the

Serum Lipids in a Case of Diabetic Lipemia Retinalis

Serum Lipids in a Case of Diabetic Lipemia Retinalis

Lipemia retinalis and xanthoma diabeticorum in diabetes mellitus.

Excerpt Lipemia retinalis is a rare complication of diabetes mellitus. Falls1stated in 1943 that only 61 cases of lipemia retinalis had been reported up to that time and that his case was the sixty...

SEVERE HYPERLIPEMIA ASSOCIATED WITH NONDIABETIC PREGNANCY REPORT OF A CASE

HYPERLIPEMIA associated with lipemia retinalis occurs rarely. Stearns and his associates1in a recent publication, after thorough search of the literature, reported a total of 63 cases of retinal lipemia involving diabetic patients, including their own reported case, and 6 involving nondiabetic patients. Kauffman2reported 61 cases of retinal lipemia in diabetic patients and 3 in which the condition was not associated with diabetes. Cases of lipemia retinalis in nondiabetic patients reported were as follows: Wagener3reported a case of lipemia retinalis in which the patient, who had leukemia, was receiving high doses of radium, and it was his opinion that the high fat content was due to destruction of tissue. Holt4reported the case of an 11 year old girl in whom the blood lipids rose to levels above 8,000 mg. per hundred cubic centimeters. He also noted that the girl's 5 year old brother

Diabetes Mellitus Complicated by Hypercholesterolemia, Lipemia Retinalis, and Hepatomegaly

Diabetes Mellitus Complicated by Hypercholesterolemia, Lipemia Retinalis, and Hepatomegaly: A Case Report Fred H. Mowrey, Fred H. Mowrey Search for other works by this author on: Oxford Academic Google Scholar Sidney G. White, MC, U. S. Army Sidney G. White, MC, U. S. Army Search for other works by this author on: Oxford Academic Google Scholar The Military Surgeon, Volume 105, Issue 3, September 1949, Pages 228–234, https://doi.org/10.1093/milmed/105.3.228 Published: 01 September 1949

LIPEMIA RETINALIS ASSOCIATED WITH ESSENTIAL HYPERLIPEMIA

LIPEMIA retinalis was first described by Heyl 1 in 1880. The condition is known to occur in cases of hyperlipemia when the fat in the blood is sufficiently emulsified to become visible in the retinal The hyperlipemia that is associated at times with alcoholism, phosphorus poisoning, pneumonia, peritonitis and starvation has never been known to become ophthalmoscopically visible. Duke-Elder 2 underlined the statement that diabetes is the only disease wherein the condition becomes sufficiently marked to be seen ophthalmoscopically in the retinal vessels. Duke-Elder also noted the one exception to this, the case reported by Wagener, 3 in 1922, of a 9 year old boy with leukemia who had undergone radiation treatment. Since its first description, in 1880, about 60 cases of lipemia retinalis have been reported in the literature, and it is noteworthy that all these have been of diabetic patients, usually in the younger age groups. Since