Linked Inhibitor Of Apoptosis Protein Research Articles

Significance and expression of X chromosome linked inhibitor of apoptosis protein, B-cell lymphoma-2 and Survivin in thymoma

Objective To explore significance and expression of X chromosome linked inhibitor of apoptosis protein (XIAP), B-cell lymphoma-2 (bcl-2) and survivin in thymoma. Methods The expressions of XIAP, bcl-2 and Survivin in 19 cases of thymic hyperplasia, 45 cases of thymoma and 13 cases of thymic adenocarcinoma were detected by immunohistochemical method, and the relationship between the expression of XIAP, bcl-2 and Survivin and age, sex, histological type, clinical stage, ymph node metastasis and myasthenia gravis was analyzed. Results The positive rate of XIAP in normal thymic tissue (2/19), thymoma (26/45) and thymic adenocarcinoma (10/13) increased in turn, and the difference was statistically significant (P<0.05). The positive rates of bcl-2 in normal thymic tissue (2/19), thymoma (29/45) and thymic adenocarcinoma (11/13) increased in turn (P<0.05). The positive rates of Survivin in normal thymic tissue (1/19), thymoma (23/45) and thymic adenocarcinoma (11/13) increased in turn (P<0.05). The positive rates of XIAP, bcl-2 and Survivin in thymoma tissues were correlated with histological type, clinical stage, ymph node metastasis, and was not correlated with age, sex and myasthenia gravis. The expressions of XIAP was correlated wih the expression of bcl-2 (r=0.568, P<0.01), the expression of XIAP was correlated with the expression of the expression of Survivin (r=0.671, P<0.01), the expression of bcl-2 was correlated with Survivin in thymoma tissues (r=0.529, P<0.01). Conclusion XIAP, bcl-2 and Survivin were highly expressed in thymoma tissues, which could be used as predictors of the occurrence and malignancy of thymoma. Key words: X chromosome linked inhibitor of apoptosis protein; B-cell lymphoma-2; Survivin; Thymoma

Significance and expression of X chromosome linked inhibitor of apoptosis protein、CD44v6 and matrix metalloproteinase-2 in gastric cancer

Objective To explore significance and expression of X chromosome linked inhibitor of apoptosis protein (XIAP), CD44v6 and matrix metalloproteinase-2 (MMP-2) in gastric cancer. Methods The expression of XIAP, CD44v6 and MMP-2 in 82 cases of gastric cancer and adjacent normal tissues was detected by immunohistochemical method The relationship between XIAP, CD44v6 and MMP-2 and age, sex, tumor size and histological grade, clinical stage, lymph node metastasis was analyzed. Statisticalanalysis of data using the statistical product and service solutions 17.0 software. Results The positive rate of XIAP in gastric cancer (54/82, 65.85%) was higher than that in adjacent normal tissues (16/82, 19.51%) (χ2=32.083, P<0.01). The positive rate of CD44v6 in gastric cancer (72/82, 87.80%) was higher than that in adjacent normal tissues (18/82, 21.95%) (χ2=71.805, P<0.01). The positive rate of MMP-2 in gastric cancer (61/82, 74.39%) was higher than that in adjacent normal tissues (13/82, 15.85%) (χ2=56.735, P<0.01). The positive expression rate of XIAP, CD44v6 and MMP-2 in gastric cancer was related to clinical stage and lymph node metastasis (P<0.05), was not related to age, sex, tumor size and histological grade. The expression of XIAP was positively correlated with the expression of CD44v6 (r=0.652, P<0.05), the expression XIAP was positively correlated with the expression of MMP-2 (r=0.613, P<0.05), the expression CD44v6 was positively correlated with the expression of MMP-2 (r=0.729, P<0.05). Conclusion XIAP, CD44v6 and MMP-2 were highly expressed in gastric cancer tissues and were closely related to the occurrence, development and metastasis of breast cancer. Key words: Gastric cancer; X chromosome linked inhibitor of apoptosis protein; CD44v6; Matrix metalloproteinase-2; Expression; Significance