Significance and expression of X chromosome linked inhibitor of apoptosis protein、CD44v6 and matrix metalloproteinase-2 in gastric cancer

Abstract

Objective To explore significance and expression of X chromosome linked inhibitor of apoptosis protein (XIAP), CD44v6 and matrix metalloproteinase-2 (MMP-2) in gastric cancer. Methods The expression of XIAP, CD44v6 and MMP-2 in 82 cases of gastric cancer and adjacent normal tissues was detected by immunohistochemical method The relationship between XIAP, CD44v6 and MMP-2 and age, sex, tumor size and histological grade, clinical stage, lymph node metastasis was analyzed. Statisticalanalysis of data using the statistical product and service solutions 17.0 software. Results The positive rate of XIAP in gastric cancer (54/82, 65.85%) was higher than that in adjacent normal tissues (16/82, 19.51%) (χ2=32.083, P<0.01). The positive rate of CD44v6 in gastric cancer (72/82, 87.80%) was higher than that in adjacent normal tissues (18/82, 21.95%) (χ2=71.805, P<0.01). The positive rate of MMP-2 in gastric cancer (61/82, 74.39%) was higher than that in adjacent normal tissues (13/82, 15.85%) (χ2=56.735, P<0.01). The positive expression rate of XIAP, CD44v6 and MMP-2 in gastric cancer was related to clinical stage and lymph node metastasis (P<0.05), was not related to age, sex, tumor size and histological grade. The expression of XIAP was positively correlated with the expression of CD44v6 (r=0.652, P<0.05), the expression XIAP was positively correlated with the expression of MMP-2 (r=0.613, P<0.05), the expression CD44v6 was positively correlated with the expression of MMP-2 (r=0.729, P<0.05). Conclusion XIAP, CD44v6 and MMP-2 were highly expressed in gastric cancer tissues and were closely related to the occurrence, development and metastasis of breast cancer. Key words: Gastric cancer; X chromosome linked inhibitor of apoptosis protein; CD44v6; Matrix metalloproteinase-2; Expression; Significance