Abstract The experimental results of measurements of the astrophysical S-factor for dd-reaction at keV-energy range collision energies using liner plasma technique are presented. The experiments were carried out at the high current generator of the Institute of High-Current Electronics in Tomsk, Russia. The measured values of the S-factors for the deuteron collision energies 1.80, 2.06 and 227 keV are S d d = ( 114 ± 68 ) , ( 64 ± 30 ) , ( 53 ± 16 ) b ⋅ k e V , ${{S}_{dd}}=(114\pm 68),(64\pm 30),(53\pm 16)b\cdot keV,$ respectively. The corresponding cross sections for dd-reactions, described as a product of the barrier factor and measured astrophysical S-factor, are σ d d n ( E c o l = 1.80 keV ) = ( 4.3 ± 2.6 ) . $\sigma _{dd}^{n}\left( {{E}_{col}}=1.80\text{keV} \right)=(4.3\pm 2.6).$ 10 − 33 c m 2 ; σ d d n ( E c o l = 2.06 keV ) = ( 9.8 ± 4.6 ) ⋅ 10 − 33 c m 2 ; σ d d n ( E c o l = ${{10}^{-33}}~c{{m}^{2}};\sigma _{dd}^{n}\left( {{E}_{col}}=2.06\text{keV} \right)=(9.8\pm 4.6)\cdot {{10}^{-33}}~c{{m}^{\text{2}}};\sigma _{dd}^{n}\left( {{E}_{col}}= \right.$
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