Linear Measurements Research Articles

Cardiovascular magnetic resonance insights into anomalies of the mitral valve apparatus in Fabry cardiomyopathy and hypertrophic cardiomyopathy.

Despite different etiopathogenesis, Fabry Disease cardiomyopathy (FDc) and sarcomeric hypertrophic cardiomyopathy (HCM) share a similar hypertrophic phenotype, including anomalies of the mitral valve apparatus (AMVA). Some of these anomalies have also been described in the pre-hypertrophic stage of both diseases. This cardiovascular magnetic resonance (CMR) study aimed to: (i) compare AMVA between FDc and HCM with a similar degree of left ventricular hypertrophy (LVH), to add new insights into differential diagnosis; (ii) assess whether AMVA represent an early and progressive alteration in FDc; (iii) propose simple and potentially reproducible measurements of AMVA. This observational, retrospective study enrolled: (i) 80 Fabry patients, divided into three groups with increasing severity of cardiac phenotype (20 patients LVH-/normal T1, 20 patients LVH-/low T1 and 40 patients LVH+), and (ii) 40 patients with HCM. All patients underwent CMR. The LVH + FDc and the HCM groups were matched for age, sex, body surface area and left ventricular (LV) mass. The following AMVA were measured on cine images: papillary muscles (PMs) hypertrophy (maximal diameter (Dmax) of anterolateral (Al) and posteromedial (Pm) PM), apical displacement, anteriorization of Al PM and anterior mitral valve leaflet (AMVL) elongation. Reference values for defining AMVA were derived from a matched healthy control group (n = 40). Both HCM and FDc LVH + patients showed PMs hypertrophy, with a greater degree in the FDc LVH + group [Dmax Al PM 16 ± 3.4 vs. 15 ± 3.1 mm, p 0.017; Dmax Pm PM 14 ± 4.0 vs.12 mm (10.0-14.0), p 0.039] As compared to controls, both HCM and FDc LVH + patients showed PMs apical displacement (HCM 83% vs. healthy volunteers 8%, p < 0.001; FDc LVH + 65% vs. healthy volunteers 8%, p < 0.001), with a greater prevalence in HCM. Anteriorization of Al PM was only evident in HCM (15 ± 6.2 vs. healthy controls 21 ± 5.3 mm, p < 0.001). Elongation of AMVL was detected both in HCM and FDc with LVH + (HCM 29 ± 4.0 vs. healthy volunteers 24 ± 2.9 mm, p < 0.001; FDc LVH + 27 ± 4.0 vs. healthy volunteers 24 ± 2.9 mm, p < 0.001) without significant differences between the two phenocopies. The prevalence of myocardial crypts was higher among HCM patients than in FDc LVH + patients (75% vs. 48%, p 0.012). we report greater PMs hypertrophy in FDc and a higher prevalence of PMs positional alterations (anterior and apical displacement) and myocardial crypts in HCM. All these AMVA became more pronounced with the progression of the FDc phenotype. We suggest the systematic inclusion of the analysis of AMVA by simple linear measurements on cine images in the CMR assessment of hypertrophic cardiomyopathies, to help in the differential diagnosis between HCM and FDc and to facilitate early detection of cardiac involvement in FDc.

Effect of slow breathing exercise on heart rate variability: A non linear analysis in female major depressive disorder patients

Background: Major depressive disorder (MDD) is a mental health problem, associated with cardiac autonomic dysfunction. Cardiac autonomic function (CANF) can be assessed by non linear analysis of heart rate variability (HRV), a simple non-invasive software based analytical method. Yoga based slow breathing exercise (SBE) has role to improve autonomic dysfunction in some disease condition. Objective: To observe the effect of SBE on non linear measures of HRV in newly diagnosed female MDD patients. Methods: The quasi-experimental study was conducted in 2023 on sixty (60) newly diagnosed female MDD patients of 20-40 years aged, collected from the Department of Psychiatry, Bangabandhu Sheikh Mujib Medical University (BSMMU). Among them 30 were assigned with SBE and remaining 30 patients without SBE were followed up after 90 days. Both patient groups received conventional treatment during this period. Thirty apparently healthy female subjects with similar age &amp; BMI were included as control for comparison and they did not perform breathing exercise. Data were taken at baseline and after 90 days in all the subjects. CANF was assessed by analysing non linear (poincare plot) of HRV by using ECG based data acquisition device, Power lab 8/35. Data were expressed as mean±SD. For statistical analysis, ANOVA followed by post hoc Bonferroni test and paired sample “t” test were used. Results: At baseline pulse rate and BP were significantly lower in both group of MDD patients compared to control. The pre-intervention values of standard deviation of short term RR interval variability (SD1), standard deviation of long term RR interval variability (SD2) and ratio of short term and long term RR interval variability (SD1/SD2) were found significantly (p&lt; 0.001) lower in MDD patients compared to healthy control. Following 90 days of SBE, significant (p&lt; 0.001, p&lt; 0.05) rise of these poincare plot parameters was noted in MDD patients whereas no significant changes of these parameters were observed in patients without SBE after 90 days of follow-up. Moreover, the pulse BP almost reached control level though the non linear parameters were still below control level after 3 months of SBE.. Conclusion: Autonomic dysfunction occured in MDD patients SBE can improve cardiac autonomic dysfunction and sympathovagal balance in female MDD patients. J Bangladesh Soc Physiol 2023;18(2): 45-52

Enhancing Sex Estimation Accuracy with Cranial Angle Measurements and Machine Learning.

The development of current sexing methods largely depends on the use of adequate sources of data and adjustable classification techniques. Most sex estimation methods have been based on linear measurements, while the angles have been largely ignored, potentially leading to the loss of valuable information for sex discrimination. This study aims to evaluate the usefulness of cranial angles for sex estimation and to differentiate the most dimorphic ones by training machine learning algorithms. Computed tomography images of 154 males and 180 females were used to derive data of 36 cranial angles. The classification models were created by support vector machines, naïve Bayes, logistic regression, and the rule-induction algorithm CN2. A series of cranial angle subsets was arranged by an attribute selection scheme. The algorithms achieved the highest accuracy on subsets of cranial angles, most of which correspond to well-known features for sex discrimination. Angles characterizing the lower forehead and upper midface were included in the best-performing models of all algorithms. The accuracy results showed the considerable classification potential of the cranial angles. The study demonstrates the value of the cranial angles as sex indicators and the possibility to enhance the sex estimation accuracy by using them.

Linear measurements of the mandible on panoramic radiograph for sex estimation in populations in Yogyakarta, Indonesia

BackgroundIdentification is one of the main aspects of forensics. Sex estimation is an essential part of identification because it can simplify the whole process. Mandible is the largest, strongest, and sexually dimorphic bone and is part of the orofacial structure, which has the second highest level of dimorphism after the pelvic bone. Sex estimation using the mandible can be performed by conducting various linear measurements on a panoramic radiograph, including right minimum ramus width (RMiRW), left minimum ramus width (LMiRW), right projective height of ramus (RPHR), left projective height of ramus (LPHR), right maximum ramus width (RMxRW), left maximum ramus width (LMxRW), right coronoid height (RCH), left coronoid height (LCH), symphysis height (SH), right mandibular corpus height (RMCH), and left mandibular corpus height (LMCH). This study aimed to analyze how linear measurements in panoramic radiographs differ between men and women and to estimate sex by utilizing these parameters.ResultsIn this study, 195 panoramic radiographs from 95 men and 100 women aged 20–40 years obtained from our dental hospital were used as a training data. Meanwhile, 61 panoramic radiographs from 29 men and 32 women outside the training data with same characteristics were used as the testing data. The linear measurements of the mandible using panoramic radiographs were taken with EzDent-i Vatech software. Independent t-test showed significant difference (p < 0.05) in some linear measurements of the mandible between adult men and women. These significantly different linear measurements were then subjected to discriminant function analysis to produce sex estimation equations. The equation accuracy percentage ranged between 63.6 and 94.4% for the training sample and 59.5% and 85% for the testing sample.ConclusionThe linear measurements of the mandible using diagnostically acceptable panoramic radiographs taken from a patient with standardized head positioning can serve as an alternative method for sex estimation. The accuracy of discriminant analysis for sex estimation varies depending on the parameter used in the estimation.

Post-mechanotherapy differences in postural control in patients with Achilles tendinopathy - A randomized controlled trial

BackgroundNeuromuscular deficits affecting functional ability can occur in patients with Achilles tendinopathy during difficult balance activities. This study aimed to assess postural control in patients with Achilles tendinopathy after shockwave and sonotherapy, using advanced analytical methods, including rambling-trembling signal decomposition and sample entropy. Research questionWhat are the differences in postural control between patients with Achilles tendinopathy after shockwave therapy, ultrasound therapy, and placebo ultrasound? MethodsThirty-nine patients were included in the study, and randomly assigned to 3 groups, i.e., shockwave therapy, ultrasound therapy and placebo ultrasound. Postural sway was assessed during quiet standing with eyes open and closed, with two force platforms, one for the affected and the other for the non-affected limb, at baseline and at weeks 1 and 6 after treatment. Rambling-trembling trajectories and sample entropy were calculated for the antero-posterior and medio-lateral directions. ResultsThe parameters of trembling trajectory in both directions were significantly smaller for the affected compared to non-affected limb. The ultrasound group had significantly larger rambling-trembling trajectories in the antero-posterior and medio-lateral sway directions than the shockwave therapy group. Also, all patients had more difficulty controlling their postural sway while standing with eyes closed compared to eyes open. Sample entropy was not significantly affected by the therapy type, timepoint and limb condition. SignificanceAs opposed to sample entropy, rambling-trembling decomposition can complement or replace traditional linear measures of COP time series in functional assessment of the Achilles tendon.

Linear measurements, body proportions, and biomechanical insights: morphological analysis of arabian horses in São Paulo, Brazil

Este estudo, conduzido com meticuloso rigor científico, avaliou medições lineares, proporções corporais e índices corporais em cavalos Árabes para uma melhor compreensão de sua morfologia, aptidão e biomecânica. A amostra foi composta por 168 cavalos Árabes puros adultos (76 machos e 92 fêmeas) alojados em uma fazenda de cavalos no estado brasileiro de São Paulo. Vinte e seis medições lineares foram realizadas usando uma fita métrica, a partir das quais os índices morfométricos foram calculados. Os dados foram meticulosamente analisados utilizando análise de variância e o teste de Tukey, com o nível de significância fixado em 5%. Os resultados deste estudo, respaldados por uma robusta análise estatística, revelaram que os cavalos Árabes são animais geométricos, ligeiramente alongados (ectomorfos), cavalos de trabalho leve e podem suportar cargas equivalentes a 25% de seu peso corporal. O comprimento dorsolombar, da garupa e da coxa mais longos do que as medições lineares dos membros anteriores sugerem uma desproporção corporal. Resultados semelhantes foram relatados em outras raças de cavalos atléticas, como o Quarto de Milha e o Cavalo de Esporte Brasileiro, uma vez que o exercício físico requer mais propulsão do que a equitação de lazer. Os índices dactilo- torácico e de habilidade colocam os cavalos Árabes na categoria de cavalos de trabalho leve, apoiando esta hipótese. Algumas medições e índices diferiram entre os gêneros, com os machos superando as fêmeas na maioria dos casos, exceto no comprimento corporal. As medições lineares se mostraram ferramentas essenciais para a avaliação do movimento e da conformação. Os cavalos Árabes desta amostra não atenderam aos padrões de conforto para equitação, mas foram considerados ter um bom potencial atlético com base em medições lineares e proporções.

Influence of Head Circumference on the Accuracy of Facial Scanning: An In vitro Study

ObjectivesThis study aimed to investigate the impact of head circumference on the accuracy of three-dimensional (3D) facial scans, focusing on trueness and precision across three mannequin heads of different sizes. Material and methodsThree 3D-printed mannequin heads with circumferences of 30, 50, and 65 cm were used. Ten facial landmarks were identified to measure seven interlandmark distances and two angles. Direct anthropometric measurement, serving as the reference value, was taken using a digital vernier calliper for linear distance, and angle was calculated using the law of cosines. Each head was scanned six times using two systems: a dual-structured light facial scanner (iTom) and a stereophotogrammetry system (3dMD). Digital measurements were analysed using Meshlab and Blender for distances and angles, respectively. Trueness values were determined by comparing measurements to reference measurements, while precision values were derived from the variability among the six scans. Statistical analysis was performed using the Kruskal–Wallis test due to nonhomogeneous variances, followed by Bonferroni correction for pairwise group comparisons. ResultsFor each scanning system, overall deviations in trueness and precision significantly increased with head circumference. Five of the seven distances and one angle showed significant compromises in trueness with larger head circumferences. Most measurements exhibited significant precision decreasing due to head circumference changes, except for N-Pn and Pn-Sn. Additionally, 3dMD displayed higher overall trueness compared to iTom, with five out of seven linear measurements and one angular measurement showing better results. ConclusionHead circumference significantly affects both trueness and precision of 3D facial scans for both technologies, suggesting that facial imaging should be used with caution for larger faces. Selecting an appropriate scanning system, such as 3dMD, can help mitigate the negative effects of scanning larger objects.

Linear polarization study of open clusters in the anticenter direction: Signature of the spiral arms

Aims. Our objective is to investigate the distribution of dust and associated large-scale structures of the Galaxy using optical linear polarization measurements of various open clusters located at different distances in the Galactic anticenter direction. Methods. We present R-band linear polarization observations of stars toward five open clusters: Kronberger 1, Berkeley 69, Berkeley 71, Berkeley 19, and King 8 in the anticenter direction. The polarization observations were carried out using the ARIES (Aryabhatta Research Institute of Observational Sciences) IMaging POLarimeter mounted on the 104 cm Sampurnanand telescope of ARIES, Nainital, making it the first study to target the polarization observations toward distant clusters (~6 kpc). We combined the observed polarization data with the distance information from the Gaia space telescope to infer the dust distribution along the line of sight. Results. The variation in the degree of polarization and extinction with distance reveals multiple dust layers in each cluster direction. In addition, common foreground-dust layers detected toward different cluster directions highlight global features such as spiral arms. Our results show that the dust clouds at 2 kpc toward Berkeley 69 and Berkeley 71 coincide with the Perseus arm, while the dust layer at ~4 kpc toward the distant clusters Berkeley 19 and King 8 indicates the presence of the Outer arm. The large-scale dust distribution obtained by combining our polarization results with previous polarization studies of nearby open clusters suggests that the anticenter direction is characterized by a low-extinction homogeneous dust distribution with a somewhat uniform orientation of the plane-of-sky component of the magnetic field along the line of sight. Conclusions. Our study demonstrates that polarization is useful as a tool for studying the large-scale dust distribution and structural features where kinematic distance methods are inadequate and cannot provide accurate distances to the dust clouds. The global dust distribution in the anticenter direction shows signatures of the intervening spiral arms.

Feasibility of Immediate, Early and Delayed Implant Placement for Single Tooth Replacement in the Premaxilla: A Retrospective Cone-Beam Computed Tomography Study of 100 Cases.

To assess the feasibility of immediate (IIP), early (EIP) and delayed implant placement (DIP) for single tooth replacement in the premaxilla on the basis of the complete indication area of each approach in routine practice. Data from 100 patients (59 women, 41 men, all Caucasians) aged between 19 and 81 years old (mean age 51.71) who had been consecutively treated with a single implant in the premaxilla (13-23) in one private periodontal practice were retrospectively collected. Demographic data, diagnostic information and linear measurements were extracted from patient files and CBCTs. The feasibility of IIP, EIP and DIP was assessed for all cases by both authors, based on the following criteria: availability of apical bone, position of the tooth in relation to the morphology of the alveolar process, buccal bone morphology and presence of midfacial recession. The reasons for not being able to perform an approach, and the viable alternatives for each approach were secondary outcomes. DIP was considered to have been preceded by alveolar ridge preservation (ARP). Ninety-two patients could be treated by means of IIP, EIP or DIP. In eight patients none of these approaches were possible as they required bone augmentation prior to implant placement. Fifty-two patients (95% CI: 42%-62%) could by treated with IIP, 58 (95% CI: 48%-67%) with EIP and 88 (95% CI: 80%-93%) with DIP. The feasibility proportions of IIP and EIP were significantly lower than the one of DIP (p < 0.001). All patients who could be treated with IIP could also be treated with EIP or DIP. Lack of apical bone for implant anchorage was the main reason for not being able to perform IIP and EIP. Complete loss of the buccal bone wall and the need for bone augmentation prior to implant placement were the reasons for not being able to perform DIP. From the results of this retrospective CBCT analysis, DIP is nearly always possible in contrast to IIP and EIP. Therefore, and since it is much easier than IIP and EIP, inexperienced clinicians should mainly focus on ARP and DIP in clinical practice deferring IIP and EIP until more surgical skills have been acquired.

Selection and genetic parameters of sheep of the Aginskaya breed of the Zugalay type

The results of the study of selectable traits, exterior-constitutional features of medium wool sheep of the Aginskaya breed of the Zugalay type are presented. The data of correlation-regression, variance analysis are given, according to the results of which paired and multifactor regression models have been designed. Body weight (6.4–12.6%), down length (19.3–19.7%) and awn length (13.1–16.9%) and cannon bone girth (9.1%) are characterized by the greatest variability in the studied sheep. In terms of physique indices, rams are distinguished by longer legs, better breast development, stronger bones, ewe lambs are distinguished by a more stretched, bunched and massive body with a better developed hind part. Correlation analysis of the breeding traits with external body parts indicates that live weight and wool clip in rams has a closer correlation with linear measurements in comparison with ewe lambs. In both males and females, live weight was more strongly correlated with the width in the dippers, wool clip – with the width at hips in rams, in ewe lambs the relationship was weak or practically absent. Linear regression coefficients indicate that live weight and wool clip gain in rams are predicted by an increase per unit in hip width (4.37 abs. gain; r = 0.824; p &lt; 0.001 and 0.13 abs. gain; r = 0.792; p &lt; 0.001). The coefficient of determination showed that in rams the changes in live weight and wool clip by 67.9 and 62.8% were explained by the width at hips, the influence of other factors – 32.1 and 37.2%, respectively. In multifactor regression models, 90.3 and 78.0% of changes in body weight and wool clip in rams are explained by the influence of a complex of linear measurements, in ewe lambs – by 25.7 and 17.5%, respectively, the remaining share is attributed to the influence of other factors, respectively.

Effect of Ultraviolet-C Light Exposure Time on the Dimensional Stability of Addition Silicone Dental Impressions: An In Vitro Study.

To compare the effect of different ultraviolet-C (UV-C) light exposure times on the dimensional stability of addition silicone dental impressions. The dimensional stability of the addition silicone dental impressions was assessed by measuring specific dimensions on dental casts that were recovered from an upper acrylic resin model of dental implants. The impressions were reproduced using a customized tray adapted in a three-point simplex dental articulator permitting only opening and closing movements. Addition silicone dental impressions were divided into five groups (N = 12) according to the UV-C light exposure time. Group A was untreated; group B received 10 minutes; group C, 20 minutes; group D, 30 minutes; and group E, 40 minutes. All the impressions were poured with type IV dental stone and the internal edges of the upper silicone retainers of impression copings were used as five reference points (E, D, C, B, and A) to determine six linear measurements between ED, CB, EA, AD, EB, and CD points using a traveling microscope of 0.001 mm accuracy. One-way analysis of variance (ANOVA) was used for the statistical analysis (p < 0.05). Expansion and contraction were noted among ED, CB, EA, and EB measurements, whereas only expansion was noted among AD and CD measurements. The ANOVA analysis showed there was no significant difference in the arithmetic means for the measurements between and within group A and the other groups (p > 0.05). The UV-C light exposure time of 10, 20, 30, and 40 minutes did not have any negative effect on the dimensional stability of the addition silicone dental impressions evaluated. In the daily routine dental practice, dental impressions need to be washed and disinfected immediately after making to prevent cross-infections. The UV-C light has been proposed as a promising method for disinfection, but only a few studies have been published about its effect on the dimensional stability of dental silicones. How to cite this article: Bravo-Cueto AG, Tinedo-López PL, Malpartida-Carrillo V. Effect of Ultraviolet-C Light Exposure Time on the Dimensional Stability of Addition Silicone Dental Impressions: An In Vitro Study. J Contemp Dent Pract 2024;25(6):507-513.

Comparative 3D Analysis of Lip Rejuvenation: Investigating Effects Before and After Soft-Tissue Filler Compared with Controls.

The aim of this study was to evaluate changes in lip metrics before and after facial rejuvenation treatment with hyaluronic acid-based fillers and to compare them with those of a control group using stereophotogrammetry (3D). This study included 63 Caucasian women divided into Group C (<30years, n=30) and Group H (>30years, n=33), which was further divided into before (HT0) and after (HT1) lip augmentation with hyaluronic acid (HA). Eleven anthropometric landmarks were identified for linear, angular, and surface area measurements. Three photos were captured in Group C, while Group H had photos taken at T0 and T1. Statistical analysis was conducted using the Shapiro-Wilk test to evaluate normality, the Kruskal-Wallis test and one-way ANOVA. Tukey's post hoc and pairwise comparison tests were performed to analyze differences between variables (P value < 0.05). There were significant differences between lip width (ChR-ChL) and philtrum width (CphR-CphL) (P<.001). The total heights of the upper (Ls-Li) and lower vermilion lips (Sto-Li) increased, and the heights of the upper (Sn-Ls) and lower (Li-Sl) cutaneous lips decreased. The angles related to the philtrum (ChR-CphR-Ls, P<.001; ChL-CphL-Ls, P<.001) and nasolabial angle (Prn-Sn-Ls) (P<.001) exhibited significant differences. The surface areas of the upper, lower, and total vermilion lip showed significant differences (P<.001). Tukey's test indicated no significant differences in surface area after lip augmentation between the HT1 and C groups. Analysis of lip morphology after a filler procedure revealed a reversal of age-related changes, with increases in vermilion lip height and surface area comparable to those of younger individuals. This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .

Evaluation of the Implementation Status of the Nepal Rural Road Standards (NRRS) Concerning Geometrical Parameters: A Case Study of Morang District of Nepal

Maintaining the effectiveness of the transportation system is essential to economic growth. Poor road upgrading methods in many developing nations, however, are making it impossible for traffic to flow freely. Nepal developed the Nepal Rural Road Standards (NRRS) of 2055, District Transportation Master Plan (DTMP), and Municipality Transportation Master Plan (MTMP) to regulate the construction of rural road infrastructure. These guidelines provide guidelines for rural road planning, design, building, and maintenance, among other aspects. However, each geometric design has certain features, and parameter requirements depending on the region and location to be applied. This study aims to compare the geometrical features of the rural roads that have been built with the Nepal Rural Road Standards (NRRS) 2055, second revision (2071). Using a random sampling approach, six rural roads in the Morang district were selected for the data collection. To gather geometrical data, field observations and measurements were made at random chainages. This study evaluates various geometric parameters using linear and angular field measurements. Mapping conducted via smart road software ensures road geometry compliance, including aspects such as curve radius, shoulder width, gradient, sight distance, carriageway, and additional widening. The findings demonstrate that strict adherence to established standards substantially enhances road safety. Based on the results of the field observation, the geometric elements have been built according to design specifications, except for the additional widening at shoulder width and horizontal.

Development of small, cost-efficient scintillating fiber detectors for automated synthesis of positron emission tomography radiopharmaceuticals.

Radiolabeling is critical in complex chemical reactions involving positron emission tomography (PET) radiotracer production. The process is now automated within a synthesis module to enhance efficiency and reduce radiation exposure. The key to this automation is the use of radiation detectors to monitor radioactivity transfer and ensure the progression of reactions. However, the high cost of these detectors has motivated the need for a more affordablealternative. This study aimed to develop a compact and cost-efficient detector using scintillating fibers and silicon photomultipliers (SiPMs) to track radioactivity throughout PET radiotracerproduction. Monte Carlo simulations were performed with the Geant4-based M-TAG software for four detector geometries (single fiber, single fiber with bolus, 16-fiber bundle, and spiral) to optimize the detector construction for better detection efficiency. The simulations scored the energy deposited into the scintillating fibers per simulated particle, which was used to estimate the expected voltage pulse height from the SiPM considering the total light collection efficiency. Based on the simulation results, two detector configurations (16-fiber bundle and spiral fiber) were constructed using plastic scintillating fibers, optical fibers, a 6 mm 6 mm SiPM, and commonly available electronic components. The detectors were calibrated using a Fluorine-18 ( ) source with typical activity levels used in radiotracer production. Detector performances were subsequently evaluated through linearity tests and measurement uncertainty assessments. Errors up to were considered acceptable for troubleshootingpurposes. The calibration curves showed a linear response with changing activity for both detectors. The calibrated detectors offered real-time activity measurements ranging from 0.10 to 49.41 GBq, with a 3-s refresh rate. In the activity range above 0.145 GBq, the uncertainties were less than for both the 16-fiber and spiral configurations. The spiral detector recorded a signal with a half-life of min, closely aligning with the reference half-life of . Cost-efficient plastic scintillation fiber detectors were developed to facilitate the troubleshooting of automated synthesis of PETradiotracers.

Simple biomarkers to distinguish Parkinson's disease from its mimics in clinical practice: a comprehensive review and future directions.

In the last few years, a plethora of biomarkers have been proposed for the differentiation of Parkinson's disease (PD) from its mimics. Most of them consist of complex measures, often based on expensive technology, not easily employed outside research centers. MRI measures have been widely used to differentiate between PD and other parkinsonism. However, these measurements were often performed manually on small brain areas in small patient cohorts with intra- and inter-rater variability. The aim of the current review is to provide a comprehensive and updated overview of the literature on biomarkers commonly used to differentiate PD from its mimics (including parkinsonism and tremor syndromes), focusing on parameters derived by simple qualitative or quantitative measurements that can be used in routine practice. Several electrophysiological, sonographic and MRI biomarkers have shown promising results, including the blink-reflex recovery cycle, tremor analysis, sonographic or MRI assessment of substantia nigra, and several qualitative MRI signs or simple linear measures to be directly performed on MR images. The most significant issue is that most studies have been conducted on small patient cohorts from a single center, with limited reproducibility of the findings. Future studies should be carried out on larger international cohorts of patients to ensure generalizability. Moreover, research on simple biomarkers should seek measurements to differentiate patients with different diseases but similar clinical phenotypes, distinguish subtypes of the same disease, assess disease progression, and correlate biomarkers with pathological data. An even more important goal would be to predict the disease in the preclinical phase.

Immediate Implantation with Autologous Mineralized Dentin Graft versus Deproteinized Bovine Bone as Space-Filling Substitute in Maxillary Anterior Zone: Retrospective Radiological and Clinical Study.

Background/Objectives: Various bone substitutes have been recommended to augment the horizontal gap following immediate implantation. The purpose of this study was to compare the effectiveness of an autogenous mineralized dentin graft or a deproteinized bovine bone in horizontal gap augmentation following immediate implant placement in the maxillary anterior region. Methods: A total of 110 patients underwent tooth extraction followed by immediate implant placement. The patients were divided into two groups. The first group received an autogenous mineralized dentin graft (the test group) while the second group received a deproteinized bovine bone (the control group) to augment the horizontal gap. Preoperative (T0), immediate postoperative (T1), and 1-year postoperative (T2) cone beam computed tomography scans were taken from all the patients. Linear measurements were recorded 1 mm (R1) and 5 mm (R2) points apical to the implant platform at both T1 and T2 time intervals. Pink Esthetic Scores and prosthetic complications were evaluated as well. Results: There were 57 patients with a mean age of 45.42 ± 9.86 (range 24-63 years) selected as the test group and 53 patients with a mean age of 40.28 ± 11.69 (range 20-63 years) as the control group. The mean reduction in the buccal bone plate at R1 was 6.39 ± 3.78% in the test group and 6.99 ± 5.01% in the control group (p > 0.05). The mean reduction in the buccal bone plate at R2 was 5.46 ± 4.98% in the test group and 6.77 ± 7.60% in the control group (p < 0.05). The PES and prosthetic-related complications were shown to be negligible between the groups (p > 0.05). Conclusions: The efficiency of using an autogenous mineralized dentin graft for horizontal gap augmentation showed similar results in comparison to using a deproteinized bovine bone in relation to buccolingual socket reduction following immediate implantation.

Facile synthesis of spherical-shaped CeC2–TiO2 nanocomposite electrocatalyst with boosted alkaline OER

Developing noble metal-free multifunctional electrocatalysts to catalyze water oxidation is vital for future renewable energy systems. Herein, through several defect modifications, the CeC2–TiO2 nanocomposite on the strength of enriched oxygen vacancies was successfully fabricated by facile hydrothermal method on SS (stainless steel) substrate, attributed to the conductive ability for fast electron transportation. A well-defined phase growth, vibrational bonding of metal atoms, morphological determination, and elemental composition for synthesized heterostructured electrocatalysts were revealed by XRD, FTIR, TEM, and EDX, respectively. XPS has complied to understand the moderate binding energies of CeC2–TiO2 for OER intermediates, which signifies the strong interactions between electronic states of Ce, C, Ti, and O atoms. With the plentiful catalytic active sites, the resultant CeC2–TiO2 entails low overpotentials of only 169 mV and 108.8 mV/dec Tafel slope to afford 10 mA cm−2 for OER in 1.0 M KOH are tested through cyclic and linear sweep voltammogram measurements, thereby exhibit promising activity in alkaline water electrolysis. EIS measurements revealed a decreased polarization resistance for the composite dominated by the small semicircle diameter, corresponding to the adsorption of intermediates. Finally, observed results strongly recommended that the CeC2–TiO2 catalyst exhibited superior OER performance due to excellent electrical chemical coupling between CeC2 and TiO2.

Holistic shape variation of the rib cage in an adult population.

Traumatic injuries to the thorax are a common occurrence, and given the disparity in outcomes, injury risk is non-uniformly distributed within the population. Rib cage geometry, in conjunction with well-established biomechanical characteristics, is thought to influence injury tolerance, but quantifiable descriptions of adult rib cage shape as a whole are lacking. Here, we develop an automated pipeline to extract whole rib cage measurements from a large population and produce distributions of these measurements to assess variability in rib cage shape. Ten measurements of whole rib cage shape were collected from 1,719 individuals aged 25-45years old including angular, linear, areal, and volumetric measures. The resulting pipeline produced measurements with a mean percent difference to manually collected measurements of 1.7% ± 1.6%, and the whole process takes 30s per scan. Each measurement followed a normal distribution with a maximum absolute skew value of 0.43 and a maximum absolute excess kurtosis value of 0.6. Significant differences were found between the sexes (p < 0.001) in all except angular measures. Multivariate regression revealed that demographic predictors explain 29%-68% of the variance in the data. The angular measurements had the three lowest R2 values and were also the only three to have little correlation with subject stature. Unlike other measures, rib cage height had a negative correlation with BMI. Stature was the dominant demographic factor in predicting rib cage height, coronal area, sagittal area, and volume. Subject weight was the dominant demographic factor for rib cage width, depth, axial area, and angular measurements. Age was minimally important in this cohort of adults from a narrow age range. Individuals of similar height and weight had average rib cage measurements near the regression predictions, but the range of values across all subjects encompassed a large portion of their respective distributions. Our findings characterize the variability in adult rib cage geometry, including the variation within narrow demographic criteria. In future work, these can be integrated into computer aided engineering workflows to assess the influence of whole rib cage shape on the biomechanics of the adult human thorax.

Morphology and morphometry of the greater palatine foramen: A radio‐anatomical study using cone‐beam computed tomography

AbstractObjectiveThe aim of this study was to evaluate the morphology and morphometry of the greater palatine foramen (GPF) using cone‐beam computed tomography (CBCT).Materials and MethodsThis study included 300 CBCT images and a total of 600 GPFs were evaluated bilaterally. GPF morphology was categorised as round, antero‐posteriorly elongated (APE), or latero‐medially elongated (LME). The distance of GPF relative to the palatine suture (PS), the incisive foramen (IF), and the palatine alveolar ridge (PAR), the distance between the right GPF (GPFr) and left GPF (GPFl) and the angle formed by GPF, IF, and PS were evaluated. The GPF location was also assessed in reference to the maxillary molars.Results64.1% of total GPFs were APE in shape. Male patients presented higher GPF‐related linear and angular measurements on both sides (p &lt; 0.05). Patients aged ≥25 years had larger distances between GPFr–PS, GPFl–PS, GPFr–GPFl, and GPFl–IF (p = 0.001, p = 0.009, p &lt; 0.001, and p = 0.048, respectively; p &lt; 0.05). Patients aged ≤24 years showed a larger distance between GPFl–PAR (p = 0.011; p &lt; 0.05). The distance between GPFl–IF was larger compared to the distance between GPFr–IF, but the angle between GPFr–IF–PS was larger than the angle between GPFl–IF–PS (p = 0.043 and p = 0.004, respectively; p &lt; 0.05). 64.83% of all GPFs were located opposite the maxillary third molar.ConclusionThe shape and location of the GPF exhibit considerable variability. CBCT is a valuable diagnostic modality for assessing anatomical differences in the GPF.

ASSESSMENT OF THE ANATOMICAL STRUCTURE OF CANALIS SINUOSUS IN THE ANTERIOR MAXILLA TO AVOID SURGICAL COMPLICATIONS

Aims: The study's objective was to evaluate the canalis sinuosus (CS) anatomical structure in the front maxilla in order to prevent surgical problems in an adult Yemeni population sample acquired using cone-beam computed tomography (CBCT). Materials and Methods: A retrospective descriptive cross-sectional study was carried out to assess 226 participants' CBCT pictures. 452 sides in total were assessed. There were 140 females (61.9%) and 86 males (38.1%) among the samples. The age distribution was 18–34 years (65%) and over 35 years (35%), with a mean age of 32.13. Version 25 of the Statistical Package of the Social Sciences (SPSS) was used for all statistical analyses. Result: It was discovered that 160 right (35.4%) and 175 left (38.7%) of the 226 patients and 452 sides had CS. Among these individuals, 117 (51.8%) had unilateral CS and 109 (48.2%) had bilateral CS. The CS was 8.12 mm from the nasal cavity floor (D1), 6.99 mm from the buccal cortical bone ridge (D2), and 13.47 mm from the crest of the alveolar ridge (D3), as the mean distances were measured. Males and females had somewhat higher mean values for the linear measurements D1 and D3, but females had slightly higher mean values for the linear measurement D2. The CS had a mean diameter of 1.11 mm. Left central incisor area was the most commonly observed location of CS, and palataly was the most frequently recorded location of CS. Conclusion: Since the CS is present in 100% of adult Yemenis, it is imperative that general practitioners and maxillofacial surgeons become more knowledgeable about the position and structure of the CS. Peer Review History: Received 19 May 2024; Reviewed 12 July 2024; Accepted 23 August; Available online 15 September 2024 Academic Editor: Dr. Iman Muhammad Higazy, National Research Center, Egypt, imane.higazy@hotmail.com Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Prof. Gorkem Dulger, Duzce University, Turkey, gorkemdulger@yandex.com Dr. George Zhu, Tehran University of Medical Sciences, Tehran, Iran, sansan4240732@163.com