The use of graded-index (GRIN) lenses in infrared imaging systems is an effective way to reduce system volume. Chalcogenide glass has been considered an ideal matrix material to produce infrared GRIN lenes because of its excellent rheological property and large refractive index (RI) tunability. Herein, an axial GRIN Ge-As-Se-Te chalcogenide glass with large RI contrast (Δn) was designed and prepared. The GRIN glass was obtained by hot-pressing 11 stacked glass disks with gradually changing RIs and thermally treating them. The glass compositions of the disks were designed according to (1-x) (Ge20As20Se20Te40)-xGe12As22Se66, where x = 0–1. It was found that these glasses had similar glass transition temperatures of 194∼199 °C, and excellent anti-crystallization performance. The RI (at 10 μm) of the glass dropped approximately linearly from 3.050 to 2.566 as x increased from 0 to 1. More than 1.2 mm diffusion depth was observed on hot-pressed two-layer glass preforms after only 24-h heat treatment. A GRIN glass with a thickness of ∼4.3 mm and linear RI profile was achieved by treating a hot-pressed eleven-layer glass preform for 24 h. The obtained GRIN glass showed good transmittance in the 3–12 μm wavelength range. These results indicate good prospects of the GRIN Ge-As-Se-Te glass for infrared imaging.