Linear Growth Research Articles

Impact of single and two successive droplets on a liquid pool

The interaction between droplets and a liquid pool is a widely observed fluid phenomenon with significant relevance to various industrial applications. This study numerically investigates the impact of both a single droplet and two successive droplets on a liquid pool with a fixed thickness. Particular emphasis was focused on the evolution of cavity depth and width during the deformation process. For single droplet impacts, the cavity depth exhibits linear growth with time in the early stage, consistent with predictions based on energy balance. This growth is independent of the Weber number (We) within the explored range of 96<We<345. Similarly, the cavity width shows weak dependence on the Weber number during early development, deviating and reaching a maximum width at later times. The maximum cavity width follows a power-law relationship with the Weber number, with a 0.5 exponent. In the case of successive droplet impacts with small initial separation, cavity depth also evolves linearly with time in the early stage but over an extended period. This prolonged growth is attributed to droplet merging, resulting in an effectively larger merged droplet. However, for successive droplets with large separation, the two linear growth stages exhibit intermittent interruptions due to the second impact occurring at a later time. The variation in cavity width due to different initial spacings between two successive droplets still exhibits similarity until a larger spacing causes a change in the rate of cavity width development.

Multiplexed immunohistochemical evaluation of small bowel inflammatory and epithelial parameters in environmental enteric dysfunction

BackgroundEnvironmental enteric dysfunction (EED) is characterized by reduced absorptive capacity and barrier function of the small intestine, leading to poor ponderal and linear childhood growth. ObjectivesTo further define gene expression patterns that are associated with EED to uncover new pathophysiology of this disorder. MethodsDuodenal biopsies from cohorts of children with EED from Bangladesh, Pakistan and Zambia were analyzed by immunohistochemistry (IHC) to interrogate gene products that distinguished differentiation and various biochemical pathways in immune and epithelial cells, some identified by prior bulk RNA sequence analyses. Immunohistochemical staining was digitally quantified from scanned images and compared to cohorts of North American children with celiac disease (gluten-sensitive enteropathy) or with no known enteric disease and no pathologic abnormality (NPA) detected in their clinical biopsies. ResultsAfter multivariable statistical analysis, we identified statistically significant (P < 0.05, 2-tailed t-test) elevated signals representing cluster of differentiation 45 (80%; 95% confidence interval [CI]: 24%, 127%), lipocalin 2 (659%; 95% CI: 198%, 1838%), and regenerating family 1 beta (221%; 95% CI: 47%, 600%) and lower signals corresponding to granzyme B (−74%; 95% CI: −82%, −62%), and sucrase isomaltase (−58%; 95% CI: −75%, −29%) in EED biopsies compared with NPA biopsies. Computerized algorithms also detected statistically significant elevation in intraepithelial lymphocytes (49%; 95% CI: 9%, 105%) and proliferation of leukocytes (267%; 95% CI: 92%, 601%) in EED biopsies compared with NPA biopsies. ConclusionsOur results support a model of chronic epithelial stress that decreases epithelial differentiation and absorptive function. The close association of several IHC parameters with manual histologic scoring suggests that automated digital quantification of IHC panels complements traditional histomorphologic assessment in EED.

Solvent‐free crystallization for fractionation of virgin coconut oil: Effect of process conditions on kinetics and crystal properties

AbstractThis research was aimed to conduct solvent‐free crystallization and fractionation of virgin coconut oil (VCO). This study investigated the effect of surface contact area‐to‐volume ratio and mixing conditions on crystal characteristics. Commercially available VCO samples, extracted by different methods, were analyzed for fatty acid and triacylglycerol composition using GC–MS and UPLC–ELSD. VCO extracted through enzyme and chilling–thawing cycles exhibited higher medium chain fatty acids and medium chain triacylglycerols, which was selected for crystallization studies. Isothermal crystallization of VCO at 21°C assessed the effect of scale of crystallizer tube on cooling rate using Newton's law of cooling equation. The smaller tube (20 mm diameter) with a higher surface contact area‐to‐volume ratio produced 4.1‐fold faster cooling and a higher crystallization yield (44%) compared to the 80 mm diameter tube when no agitation was applied. Whereas mixing with a magnetic stirrer produced a large number of nuclei, generating intense crystallization heat, and rendering the crystals inseparable from liquid fraction. The process of VCO crystallization was also studied for kinetics and crystal growth mechanism using the Avrami model employing angled rotation of sample tube during non‐isothermal crystallization. Angled rotary mixing produced stable crystals and significantly increased the crystallization rate (t1/2 = 26.86 min) with polyhedral or spherulitic crystal growth (n = 3.25) compared to non‐mixing condition (t1/2 = 161.87 min) with restricted linear growth (n = 1.64). DSC analysis of VCO and its fractions obtained after crystallization using the 20 mm tube with angled rotary mixing indicated shifts in their thermogram peaks, suggesting differences in triacylglycerol compositions.Practical applicationsVirgin coconut oil (VCO) is well recognized for its health‐beneficial properties, yet its application is limited due to its complex triglyceride composition. The solvent‐free crystallization method facilitates VCO fractionation into phases with different melting points without hazardous solvents. The efficacy of this process is highly dependent on temperature, cooling rate, and agitation, which affects crystal morphology and growth kinetics. This study addresses these challenges in the scarcely investigated area of VCO crystallization. The resulting fractions can be customized for specific applications based on their altered functional properties in producing baking and confectionery coatings, salad dressings, and so on. The olein fraction obtained in this study can be utilized in nutraceutical formulations targeting digestive and cognitive health, as it is reported to be rich in medium chain triglycerides. This research optimizes process conditions, suggesting an efficient method for dry‐fractionating VCO, which is significantly associated with the food and pharmaceutical industries.

Efficacy and safety of growth hormone therapy in children with systemic lupus erythematosus: A systematic review

Introduction Childhood-onset systemic lupus erythematosus (cSLE) is a chronic autoimmune disease with long-term consequences, including growth failure and short stature. Growth hormone (GH) therapy is a potential treatment for short stature in cSLE. Objective The aim of the study was to evaluate the current evidence on the efficacy and safety of GH therapy in cSLE. Methods A systematic review was conducted through PubMed, Cochrane, and Web of Science databases to identify relevant publications from January 1988 to October 2023. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist. Articles focusing on GH therapy in cSLE were included after an initial screening of their titles and abstracts. The articles were extracted and analyzed by two independent reviewers, with a third reviewer addressing any discrepancies that arose to reach an agreement. Results Among the 6364 screened citations, only two case reports fulfilled the inclusion criteria. Both were for males with cSLE who had short stature due to the disease and corticosteroids. Both case reports demonstrated improved linear growth; however, GH therapy was discounted because of a lupus flare concurrent with GH use, with one case necessitating treatment escalation to control disease activity. Conclusion GH therapy has shown favorable effects on growth in cSLE; however, it may increase the risk of disease flare. Limited evidence precludes a definitive conclusion, highlighting the need for further studies to fill the knowledge gap on the safety and efficacy of GH therapy in cSLE patients.

Impact of Spent Mushroom Substrate Combined with Hydroponic Leafy Vegetable Roots on Pleurotus citrinopileatus Productivity and Fruit Bodies Biological Properties.

Agricultural activities produce large quantities of organic byproducts and waste rich in lignocellulosic materials, which are not sufficiently utilized. In this study, alternative agricultural waste products, namely, spent mushroom substrate (SMS) from the cultivation of edible Pleurotus ostreatus mushrooms and the roots of leafy vegetables from hydroponic cultivation (HRL), were evaluated for their potential to be used as substrates for the cultivation of Pleurotus citrinopileatus and their effects on the quality, the nutritional value, the chemical properties (lipid, protein, carbohydrate, ash, fatty acid and carbohydrate composition) and the bioactive content (total phenolic compounds and antioxidant activity) of produced mushrooms. SMS and HRL (in different ratios with and without additives) and wheat straw with additives (WS-control) were used. During incubation, the linear growth rate of the mycelium (Kr, mm/day) was measured and used for screening. Mushroom cultivation took place in bags, where several characteristics were examined: earliness (duration between the day of substrate inoculation and the day of first harvest) and biological efficiency (B.E. %, the ratio of the weight of fresh mushrooms produced per dry weight of the substrate × 100). Furthermore, this study aimed to investigate the effect of the protein extract (PE) and carbohydrate extract (CE) of P. citrinopileatus after in vitro digestion (fraction less than 3kDa: PE-DP-3; digestate fraction: CE-D, respectively) on the expression of antioxidant-related genes in the THP-1 cell line. The results showed that mushrooms grown on SMS 50%-HRL 40% had the fastest growth (6.1 mm/d) and the highest protein and lipid contents (34.7% d.w.; 5.1% d.w.). The highest B.E. (73.5%), total carbohydrate (65.7%) and total phenolic compound (60.2 mg GAE/g d.w.) values were recorded on the control substrate. Antioxidant activity was observed in all extracts; the total flavonoid content was low in the samples, and the maximum total triterpene value was detected in SMS 80%-HRL 20% (9.8 mg UA/g d.w.). In all mushrooms, linoleic acid (C18:2) was the main fatty acid (above 60%), and fructose was the dominant individual saccharide. In the investigation of the regulation pathway, NFE2L2 gene expression was upregulated only in the SMS 60%-HRL 40% intervention during incubation with CE-D samples. Additionally, the transcription levels of antioxidant-related genes, SOD1, CAT, HMOX1 and GSR, were increased in the SMS 60-30% intervention. Compared to WS, the alternative substrates are observed to trigger a pathway concerning CE that may resist oxidative stress. This study supports the utilization of agricultural byproducts through sustainable and environmentally friendly practices while simultaneously producing high-value-added products such as mushrooms. Therefore, alternative substrates, particularly those containing HRL, could serve as natural sources of antioxidant potential.

Should a single growth standard be used to judge the nutritional status of children under age 5 years globally? No

Universal growth standards for under-five children, given the worldwide variation in healthy growth and several determinants of anthropometry, are imprecise measures of nutritional status, particularly when used cross-sectionally. In constructing the global-use WHO growth standard, linear growth differences between contributing sites and pooled mean were >0.2 SD in 37% of observations. Systematic reviews confirm even greater variability, notably amplified for weight-for-age and head-circumference-for-age metrics. Unsurprisingly, developed nations had higher, and LMICs lower, growth dimensions. Contextual growth references predict neonatal morbidities, pathological short stature, macrocephaly, cardiometabolic risk factors, and adult noncommunicable diseases better than the WHO standards. Child body composition also varies contextually, with greater adiposity despite comparable weights in South Asian populations. Thus, contextual references, though not the perfect solution, are better suited for everyday practice and nutrition policy. Growth standards should only be used as a screening for clinical judgments aided by precise biomarkers.

A PDE with drift of negative Besov index and linear growth solutions

A PDE with drift of negative Besov index and linear growth solutions

Fe4N soft magnetic composite with ultra-low eddy current loss and excess loss above megahertz

In this study, Fe4N particles were synthesized from pure iron by gas nitridation and then fabricated into soft magnetic composite through silica-polyurethane insulation combined with warm compaction. The composite exhibits excellent soft magnetic properties in the several-megahertz frequency range. The complex permeability spectra of Fe4N composite show a remarkable frequency stability, with the real part remaining nearly constant below 100 MHz. The resonance frequencies of domain wall motion mechanism and spin rotation mechanism are up to 481 MHz and 2.24 GHz, respectively, which are ten times higher than those of Fe composite. Due to the effective suppression of both eddy current loss and excess loss, the total core loss decreases to 725.6 kw/m3 at 3000 kHz and 10 mT, exhibiting almost a linear growth with frequency. These outstanding properties are mainly due to the relatively large magnetocrystalline anisotropy and high resistivity of Fe4N particles. In addition, Fe4N composite also exhibits an excellent DC bias performance, maintaining over 98 % permeability under a superimposed magnetic field of 100 Oe. This study presents an effective solution for suppressing eddy current and excess losses at high frequencies, offering potential for the application of power inductors in high-frequency scenarios.

Impact of Nutrition Supplementation on linear growth among 12–18 months children of Belagavi city: A randomized control trial

BackgroundAdequate nutrition is one of the most important factors influencing growth & immunity. Bovine colostrum (BC) is the first milk produced after birth of a calf and is a rich natural source of macronutrients, micronutrients, immunoglobulins, growth factors and peptides with anti-microbial activity. ObjectiveThe current study was conducted to test the hypothesis whether BC supplementation would lead to an increase in linear growth of children of age 12–18 months. The secondary objectives were 1) To measure biomedical parameters among 12–18 months children in the 2 groups, i.e., BC and control group. 2) To assess the acceptability and tolerability of BC among children. Materials & methodsA double blinded randomized control trial was conducted among children in the age group of 12–18 months. A total of 78 participants were included and were randomly divided into experiment and control groups. Anthropometric measurements and biochemical parameters were measured before and after intervention. The acceptability and tolerability of BC was assessed through a questionnaire filled by the mothers of study participant. ResultsThere was a significant difference observed in Body mass index (BMI), Chest circumference and Mid upper arm circumference in the BC group but there was not any significant difference found in biochemical parameters. Mothers of study participant reported high acceptability and no side effects of the intervention. ConclusionSupplementation of BC in children's diet lead to improved anthropometric outcomes in children of Belagavi city and was acceptable by them.

The roles of growing up milk on growth and anemia prevention in children under 5 years of age

Background: Adequate nutrition during the early years of life is necessary for good growth, development, and long-term health outcomes. The first 1000 days of life are a critical time for nutrition. Aims: This literature review aimed to evaluate the role of growing up milk on growth, stunting, and anemia prevention of under-five children. Methodology: This study used a literature review approach, searching three databases: PubMed, Google Scholar, and Cochrane. The inclusion criteria in this literature review were 1) randomized clinical trials, systematic review, and meta-analysis, 2) studies conducted over the last 10 years, 3) available in full text, 4) written in Indonesian or English, and 5) Research studies conducted in humans. Result: We identified 3 publications, that matched the inclusion criteria and research aims, including 2 original articles from Lovell AL, et al and Cervo MCM, et al, and 1 meta-analysis by Brooker PG et al. Fortified milk (GUM) consumption significantly had a positive impact on nutritional status, especially growth and hemoglobin status (anemia). Conclusion: Fortified milk (GUM) consumption is a solution to macro-micronutrient adequacy in under five children. More efforts are needed to conduct studies in Indonesia on GUM and address specific nutrients that may promote linear growth, reverse stunting and anemia in children.

General Mean-Field BDSDEs with Continuous and Stochastic Linear Growth Coefficients

General Mean-Field BDSDEs with Continuous and Stochastic Linear Growth Coefficients

Nutrition, Other Environmental Influences, and Genetics in the Determination of Human Stature.

Linear growth during three distinct stages of life determines attained stature in adulthood: namely, in utero, early postnatal life, and puberty and the adolescent period. Individual host factors, genetics, and the environment, including nutrition, influence attained human stature. Each period of physical growth has its specific biological and environmental considerations. Recent epidemiologic investigations reveal a strong influence of prenatal factors on linear size at birth that in turn influence the postnatal growth trajectory. Although average population height changes have been documented in high-income regions, stature as a complex human trait is not well understood or easily modified. This review summarizes the biology of linear growth and its major drivers including nutrition from a life-course perspective, the genetics of programmed growth patterns or height, and gene-environment interactions that determine human stature in toto over the life span. Implications for public health interventions and knowledge gaps are discussed.

Identification of Kelvin-Helmholtz generated vortices in magnetised fluids

The Kelvin-Helmholtz Instability (KHI), arising from velocity shear across the magnetopause, plays a significant role in the viscous-like transfer of mass, momentum, and energy from the shocked solar wind into the magnetosphere. While the KHI leads to growth of surface waves and vortices, suitable detection methods for these applicable to magnetohydrodynamics (MHD) are currently lacking. A novel method is derived based on the well-established λ-family of hydrodynamic vortex identification techniques, which define a vortex as a local minimum in an adapted pressure field. The J×B Lorentz force is incorporated into this method by using an effective total pressure in MHD, including both magnetic pressure and a pressure-like part of the magnetic tension derived from a Helmholtz decomposition. The λMHD method is shown to comprise of four physical effects: vortical momentum, density gradients, fluid compressibility, and the rotational part of the magnetic tension. A local three-dimensional MHD simulation representative of near-flank magnetopause conditions (plasma β’s 0.5–5 and convective Mach numbers Mf∼0.4) under northward interplanetary magnetic field (IMF) is used to validate λMHD. Analysis shows it correlates well with hydrodynamic vortex definitions, though the level of correlation decreases with vortex evolution. Overall, vortical momentum dominates λMHD at all times. During the linear growth phase, density gradients act to oppose vortex formation. By the highly nonlinear stage, the formation of small-scale structures leads to a rising importance of the magnetic tension. Compressibility was found to be insignificant throughout. Finally, a demonstration of this method adapted to tetrahedral spacecraft observations is performed.

Fully invertible hyperbolic neural networks for segmenting large-scale surface and sub-surface data

The large spatial/temporal/frequency scale of geoscience and remote-sensing datasets causes memory issues when using convolutional neural networks for (sub-) surface data segmentation. Recently developed fully reversible or fully invertible networks can mostly avoid memory limitations by recomputing the states during the backward pass through the network. This results in a low and fixed memory requirement for storing network states, as opposed to the typical linear memory growth with network depth. This work focuses on a fully invertible network based on the telegraph equation. While reversibility saves the major amount of memory used in deep networks by the data, the convolutional kernels can take up most memory if fully invertible networks contain multiple invertible pooling/coarsening layers. We address the explosion of the number of convolutional kernels by combining fully invertible networks with layers that contain the convolutional kernels in a compressed form directly. A second challenge is that invertible networks output a tensor the same size as its input. This property prevents the straightforward application of invertible networks to applications that map between different input–output dimensions, need to map to outputs with more channels than present in the input data, or desire outputs that decrease/increase the resolution compared to the input data. However, we show that by employing invertible networks in a non-standard fashion, we can still use them for these tasks. Examples in hyperspectral land-use classification, airborne geophysical surveying, and seismic imaging illustrate that we can input large data volumes in one chunk and do not need to work on small patches, use dimensionality reduction, or employ methods that classify a patch to a single central pixel.

A Web-Based Thai School Lunch Program Promotes Children's Heights: A Cross-Sectional Study in Rural Schools.

Nutrition has an impact on development and linear growth. However, a few studies examine the connections between children's age-standardized height and their nutritional status and diet quality. This study aimed to find a relationship between dietary consumption and height for age among school students under a web-based Thai school lunch program. Anthropometric data and nutrient consumption were obtained from 24-hour records. Nutrient consumption was calculated using Inmucal. The parent and custodian's data were from the electronic health records. Children's heights were not correlated with parents' heights (P<0.720). Moreover, children with low height-for-age Z-score (HAZ) had significantly lower intakes of minerals (iron, magnesium, and selenium) and vitamins (B6, B12, C, and E). On the other hand, magnesium, selenium, vitamin B12, and vitamin E intakes of the children with normal HAZ were higher than their custodians. The Thai school lunch program effectively maintains the normal HAZ of children. Nutritional education in the community is recommended.

Nonnegative Ricci curvature and minimal graphs with linear growth

Nonnegative Ricci curvature and minimal graphs with linear growth

Characterization of δ-PuGa (1 at%. Ga) Oxidation Under Dry Oxygen Atmosphere Exposure

The oxidation of δ-stabilized plutonium alloy was studied under dry oxygen exposures for temperatures varying from 100 up to 300 °C and oxygen partial pressures varying from 10–4 up to 500 mbar. The coupling of X-ray diffraction, Raman spectroscopy and FIB-SEM has allowed to show that the oxide scale is composed of an outer layer of PuO2 and an inner mixed layer of α + β-Pu2O3 platelets propagating into a metallic zone corresponding to the stable phase of unalloyed Pu. Furthermore, the analysis of Pu oxidation kinetics has displayed first a parabolic growth governed by the diffusion of interstitial oxygen. This step consists of the thickening of the Pu2O3 layer with a decrease in α-Pu2O3 ratio in favor of β-Pu2O3. Then, a second step occurs consisting of a linear growth of the PuO2-layer with the formation of thick nodules which tend to cover the whole oxide surface. Based on the results of this work, a general oxidation mechanism for δ-Pu alloy is provided.

The dynamics of changes in linguistic complexity and writing scores in timed argumentative writing among beginning-level EFL learners

Abstract This study investigates longitudinal changes in linguistic complexity and holistic scores in EFL timed argumentative writing among beginning-level learners using Complex Dynamic Systems Theory. It also explores relationships among linguistic complexity over time and with writing scores. Over nine months, 42 Japanese EFL learners completed six timed essays. Linguistic complexity was assessed through lexical, phraseological, and syntactic features. Findings indicate linear growth in writing scores, lexical sophistication, and noun phrase (NP) complexity, alongside stable phrasal complexity and non-linear subordination. Interrelated growth patterns included connections between lexical sophistication and phrasal complexity, and phraseological complexity and subordination. Competitive dynamics were observed between lexical diversity and NP complexity, and phraseological complexity and phrasal sophistication. Linear associations emerged between writing scores and lexical sophistication or syntactic complexity, while a non-linear relationship occurred with phraseological sophistication. This study illuminates the intricate dynamics of linguistic complexity and L2 writing scores among beginning-level learners in argumentative writing.

Development of Internalizing Mental Health Symptoms from Early Childhood to Late Adolescence.

Children's mental health symptoms' development can be characterized by both continuity and discontinuity. However, existing studies ignore the potential discontinuity in children's internalizing symptoms' development. Hence, the current study examines continuous and discontinuous developmental trajectories using representative data from a sample of 2792 children (49.10% females) from the Growing Up in Australia cohort assessed seven times (ages 4, 6, 8, 10, 12, 14, 16). Longitudinal measurement invariance analyses revealed that internalizing symptoms were comparable over time. Linear, quadratic, and piecewise latent growth curve models were deployed to estimate the trajectory of internalizing symptoms from early childhood to late adolescence. The analyses showed that internalizing symptoms were characterized by a quadratic-quadratic piecewise growth curve comprising two distinct phases of upward concave growth. Internalizing scores reduced steadily between ages 4 and 8 years but exhibited a slight upward curvature between ages 8 and 10 years. By age 14 years, the trajectory remained relatively stable but spiked between age 14 and 16 years. The two phases of internalizing symptoms' development were largely unrelated. Overall, the study adds to the knowledge about the development of internalizing mental health from early childhood to late adolescence and highlights the need for additional support in late adolescence.

Approach to the child and adolescent with Adrenal Insufficiency.

The management of adrenal insufficiency is challenging, and the overall goals of treatment are to prevent life-threatening adrenal crises, to optimize linear growth, to control androgen levels without overdosing in subjects with congenital adrenal hyperplasia (CAH) and to improve quality of life in affected individuals. Standard glucocorticoid formulations fail to replicate the circadian rhythm of cortisol and control the adrenal androgen production driven by adrenocorticotropic hormone. In order to personalize and tailor glucocorticoid therapy and to improve patient outcomes, new pharmacological strategies have been developed that best mimic physiological cortisol secretion. Novel therapeutic approaches in the management of adrenal insufficiency include new ways to deliver circadian cortisol replacement as well as various adjunctive therapies to reduce androgen production and/or androgen action/effects. Preclinical studies are exploring the role of restorative cell-based therapies, and a first recombinant adeno-associated virus-based gene therapy is also being developed in humans with CAH. In this article, we present three illustrative cases of adrenal insufficiency with different underlying etiologies and times of presentation. Diagnostic and management processes are discussed with emphasis on treatment and outcomes. We have also provided the most up-to-date evidence for the tailored management of children and adolescents with adrenal insufficiency.