We present a numerical comparison study of planar Richtmyer-Meshkov instability with the intention of exposing the role of the equation of state. Results for Richtmyer-Meshkov instability in fluids with Mie-Grüneisen equations of state derived from a linear shock-particle speed Hugoniot relationship (Jeanloz, J. Geophys. Res. 94, 5873, 1989; McQueen et al., High Velocity Impact Phenomena (1970), pp. 294–417; Menikoff and Plohr, Rev. Mod. Phys. 61(1), 75 1989) are compared to those from perfect gases under nondimensionally matched initial conditions at room temperature and pressure. The study was performed using Caltech’s Adaptive Mesh Refinement, Object-oriented C++ (AMROC) (Deiterding, Adaptive Mesh Refinement: Theory and Applications (2005), Vol. 41, pp. 361–372; Deiterding, “Parallel adaptive simulation of multi-dimensional detonation structures,” Ph.D. thesis (Brandenburgische Technische Universität Cottbus, September 2003)) framework with a low-dissipation, hybrid, center-difference, limiter patch solver (Ward and Pullin, J. Comput. Phys. 229, 2999 (2010)). Results for single and triple mode planar Richtmyer-Meshkov instability when a reflected shock wave occurs are first examined for mid-ocean ridge basalt (MORB) and molybdenum modeled by Mie-Grüneisen equations of state. The single mode case is examined for incident shock Mach numbers of 1.5 and 2.5. The planar triple mode case is studied using a single incident Mach number of 2.5 with initial corrugation wavenumbers related by k1=k2+k3. Comparison is then drawn to Richtmyer-Meshkov instability in perfect gases with matched nondimensional pressure jump across the incident shock, post-shock Atwood ratio, post-shock amplitude-to-wavelength ratio, and time nondimensionalized by Richtmyer’s linear growth time constant prediction. Differences in start-up time and growth rate oscillations are observed across equations of state. Growth rate oscillation frequency is seen to correlate directly to the oscillation frequency for the transmitted and reflected shocks. For the single mode cases, further comparison is given for vorticity distribution and corrugation centerline shortly after shock interaction. Additionally, we examine single mode Richtmyer-Meshkov instability when a reflected expansion wave is present for incident Mach numbers of 1.5 and 2.5. Comparison to perfect gas solutions in such cases yields a higher degree of similarity in start-up time and growth rate oscillations. The formation of incipient weak waves in the heavy fluid driven by waves emanating from the perturbed transmitted shock is observed when an expansion wave is reflected.