Linear Model Analysis Research Articles

A short-term comparison of surgical results between an ab-externo microshunt and trabeculectomy with a main focus on postoperative corneal astigmatism.

To compare surgical results between ab-externo microshunt surgery and trabeculectomy, focusing on postoperative corneal astigmatism. Retrospective study. Subjects were patients with glaucoma who underwent either standalone ab-externo microshunt surgery or trabeculectomy. Data on ophthalmic examinations obtained preoperatively and 1, 3, and 5 months postoperatively were analyzed. To assess corneal astigmatism, two separate data sets measured by anterior segment optical coherence tomography and autorefractometer were evaluated. Multivariate linear mixed model analyses were conducted to identify factors associated with the astigmatism changes. Sixty eyes were examined: 13 eyes underwent microshunt surgery, and 47 eyes underwent trabeculectomy. The total corneal astigmatism measurements by anterior segment optical coherence tomography (AS-OCT) were: -1.15 ± 0.85 D and -1.17 ± 0.81 D for the microshunt and trabeculectomy groups, respectively, preoperatively. At five months postoperatively they were -0.92 ± 0.47 D and -1.61 ± 0.83 D, respectively (P = 0.807 for the microshunt group and P = 0.005 for the trabeculectomy group: Wilcoxon signed-rank test). AS-OCT also indicated similar results for posterior corneal astigmatism. Autorefractometry also found the total corneal astigmatism was significantly changed only in the trabeculectomy group. The linear mixed model analysis revealed that trabeculectomy (P = 0.001), older age (P = 0.004), and longer postoperative period (P = 0.015) were correlated with greater astigmatism changes. The intraocular pressures significantly decreased following both surgical treatments. Standalone ab-externo microshunt surgery has less effect on corneal astigmatism during a 5month period than trabeculectomy. Both surgical procedures significantly reduced intraocular pressure.

A comparison of fMRI presurgical mapping techniques with intraoperative brain mapping-based validation

Abstract Resting-state functional MRI (rsfMRI) could enable preoperative risk assessment and intraoperative guidance for patients who cannot undergo task-based fMRI (tbfMRI). To ascertain rsfMRI’s applicability, we investigated differences in accuracy between tbfMRI with a voxel size of 1.8 x 1.8 x 3.2 mm³ and rsfMRI acquired with single-echo (sTE) with a voxel size of 2 x 2 x 2.2 mm³ and multiecho (mTE) with a voxel size of 3 x 3 x 3 mm³ using intraoperative mapping with direct electrical stimulations (DES) as the ground truth. Functional sensory-motor mapping results of hands and feet were spatially compared relative to positive (pDES, functional effect) and negative (nDES, no functional effect) coordinates in 16 preoperative patients. A general linear model analysis was used for tbfMRI, and seed-based analysis (SBA) for rsfMRI. Minimum Euclidean distances between fMRI and DES were calculated and compared between fMRI methods. Receiver-operating characteristic (ROC) curves were used to compare accuracy and determine distance cutoffs for fMRI agreement with DES, and binary agreement rates were compared at different cutoffs. Two-part mixed-effects linear models were used to compare fMRI methods while accounting for unequal intersubject DES repetition. Only minor differences were found between fMRI methods in unthresholded distances (mean differences ~2 mm). ROCs and binary agreement measures showed comparable accuracy for tbfMRI and sTE-rsfMRI at 2 mm, but mildly worse for sTE-rsfMRI at 3 mm and mTE-rsfMRI. However, differences in relative accuracy between sTE-rsfMRI and mTE-rsfMRI were minor when the same distance cutoff was applied to all methods. This was also reflected in comparing binary agreement rates and confirmed by the two-part linear models, which showed no significant differences between fMRI methods and a significant effect of DES response. A similar accuracy for SBA rsfMRI functional sensory-motor mapping compared with tbfMRI for the hands and feet indicates that rsfMRI may be suitable for presurgical mapping. The differences in relative accuracy between sTE-rsfMRI and mTE-rsfMRI warrant further investigation in a larger sample.

White Matter Microstructural Changes Using Ultra-Strong Diffusion Gradient MRI in Adult-Onset Idiopathic Focal Cervical Dystonia.

Adult-onset idiopathic focal cervical dystonia (AOIFCD) involves abnormal posturing of the cervical musculature and, in some individuals, an associated head tremor. Existing neuroimaging studies have implicated key motor networks. However, measures used to date lack specificity toward underlying pathophysiologic differences. We aim to assess white matter motor pathways for localized, microstructural differences, which may aid in understanding underlying mechanisms. Individuals diagnosed with AOIFCD and an age- and sex-matched control group were prospectively recruited through the Welsh Movement Disorders Research Network. All participants underwent in-depth clinical phenotyping and MRI (structural and diffusion sequences) using ultra-strong diffusion gradients. Tractography (whole-tract median values) and tractometry (along tract profiling) were performed for key white matter motor pathways assessing diffusion kurtosis imaging (DKI), neurite orientation dispersion and density imaging (NODDI), and standard model parameters. Groups were compared using linear model analysis with Bonferroni multiple comparison correction. Fifty participants with AOIFCD and 30 healthy control participants were recruited, with 46 with AOIFCD and 30 healthy controls included for analysis (33 without head tremor, 13 with head tremor). Significant differences were observed in the anterior thalamic radiations (lower mid-tract fractional anisotropy [estimate = -0.046, p = 3.07 × 10-3], radial kurtosis [estimate = -0.165, p = 1.42 × 10-4], f-intra-axonal signal fraction [estimate = -0.044, p = 2.78 × 10-3], p2 orientation coherence [estimate = -0.043, p = 1.64 × 10-3], higher Orientation Dispersion Index [ODI, estimate = 0.023, p = 2.22 × 10-3]) and thalamopremotor tracts (higher mid-tract mean kurtosis [estimate = 0.064, p = 7.56 × 10-4], lower Neurite Density Index [estimate = 0.062, p = 2.1 × 10-3], higher distal tract ODI [estimate = 0.062, p = 3.1 × 10-3], lower f [estimate = -0.1, p = 2.3 × 10-3], and striatopremotor tracts [proximal lower f: estimate = -0.075, p = 1.06 × 10-3]). These measures correlated with clinical measures: dystonia duration (right thalamopremotor distal ODI: r = -0.9, p = 1.29 × 10-14), psychiatric symptoms (obsessive compulsive symptoms: left anterior thalamic radiation p2 r = 0.92, p = 2.797 × 10-11), sleep quality (Sleep Disorders Questionnaire Score: left anterior thalamic radiation ODI: r = -0.84, p = 4.84 × 10-11), pain (left anterior thalamic radiation ODI: r = -0.89, p = 1.4 × 10-13), and cognitive functioning (paired associated learning task p2, r = 0.94, p = 6.68 × 10-20). Overall, localized microstructural differences were identified within tracts linking the prefrontal and premotor cortices with thalamic and basal ganglia regions, suggesting pathophysiologic processes involve microstructural aberrances of motor system modulatory pathways, particularly involving intra-axonal and fiber orientation dispersion measures.

The Influence of Three-Dimensional Building Morphology on PM2.5 Concentrations in the Yangtze River Delta

The rapid urbanization of urban areas in China has brought about great variation in the layout of cities and serious air pollution. Recently, the focus has been directed toward understanding the role of urban morphology in the generation and spread of atmospheric pollution, particularly in PM2.5 emissions. However, there have been limited investigations into the impact of three-dimensional (3D) features on changes in PM2.5 concentrations. By analyzing a wealth of data on building structures based on a mixed linear model and variance partition analysis in the Yangtze River Delta throughout 2018, this study sought to examine the associations between PM2.5 concentrations and urban building form, and further compared the contributions of two-dimensional (2D) and 3D building features. The findings revealed that both 2D and 3D building forms played an important role in PM2.5 concentrations. Notably, the greater contribution of 3D building forms on PM2.5 concentrations was observed, especially during the summer, where they accounted for 20% compared to 7% for 2D forms. In particular, the building height range emerged as a crucial local factor affecting PM2.5 concentrations, contributing up to 12%. Moreover, taller buildings with more variability in height were found to aid in the dispersion of pollution. These results underscore the substantial contribution of 3D building morphology to PM2.5 pollution, contrasting with previous studies. Furthermore, compact buildings were linked to lower pollution levels, and an urban landscape characterized by polycentric urban structures and lower fragmentation was deemed more favorable for sustainable urban development. This study is significant in investigating the contribution of 3D morphology to PM2.5 and its importance for pollution dispersion mechanisms. It suggests the adoption of a polycentric urban form with a broader range of building heights in urban planning for local governments in the Yangtze River Delta.

Intra- and interindividual variability in fasted gastric content volume.

Gastric fluid plays a key role in food digestion and drug dissolution, therefore, the amount of gastric fluid present in a fasted state may influence subsequent digestion and drug delivery. We aimed to describe intra- and interindividual variation in fasted gastric content volume (FGCV) and to determine the association with age, sex, and body size characteristics. Data from 24 MRI studies measuring FGCV in healthy, mostly young individuals after an overnight fast were pooled. The analysis included 366 participants who had up to 6 repeated measurements, with a total of 870 measurements. Linear mixed model analysis was performed to calculate intra- and interindividual variability and to assess the effects of age, sex, weight, height, weight*height as a proxy for body size, and body mass index (BMI). FGCV ranged from 0 to 156 mL, with a mean (± SD) value of 33 ± 25 mL. The overall coefficient of variation within the study population was 75.6%, interindividual SD was 15 mL, and the intraindividual SD was 19 mL. Age, weight, height, weight*height, and BMI had no effect on FGCV. Women had lower volumes compared to men (MD: -6 mL), when corrected for the aforementioned factors. FGCV is highly variable, with higher intraindividual compared to interindividual variability, indicating that FGCV is subject to day-to-day and within-day variation and is not a stable personal characteristic. This highlights the importance of considering FGCV when studying digestion and drug dissolution. Exact implications remain to be studied.

Genome‐wide association analysis of resistance to anthracnose in the Middle American Diversity Panel of common bean (Phaseolus vulgaris L.)

AbstractAnthracnose (ANTH) caused by Colletotrichum lindemuthianum is a major disease of common bean (Phaseolus vulgaris L.). The genetic basis of ANTH resistance in the Middle American Diversity Panel (MDP) is unknown. The objectives of this study were to identify (1) Middle American accessions resistant to races 7, 19, 51, 63, 167, and 1085 of C. lindemuthianum and (ii) genomic regions and positional candidate genes associated with resistance to these races. The MDP composed of 240 Middle American accessions was evaluated for resistance to races 7, 19, 51, 63, 167, and 1085. The MDP was genotyped with 211,763 single nucleotide polymorphisms (SNPs), and mixed linear model analysis was conducted to identify genomic regions associated with resistance to the six races. Seven accessions were highly resistant to all six races, and these can be used as sources of resistance to improve specific market classes in the Middle American gene pool. The genomic region (385,894 bp) on chromosome Pv04 was significantly associated with resistance to race 167. Genomic regions on Pv02 (41,570,325 bp), Pv07 (24,122,343 bp), and Pv11 (51,707,917 bp) were significantly associated with resistance to race 19. Disease resistance (R) genes with the nucleotide binding‐APAF resistance protein and CED‐4 domain were identified as positional candidate genes on Pv04 and Pv11. There were no SNPs significantly associated with resistance to races 7, 51, 63, and 1085. Pyramiding the identified genomic regions on Pv04, Pv07, and Pv11 could provide durable ANTH resistance in Middle American varieties for races 19 and 167.

Unlocking wind power potential: The pivotal role of R&D investment in boosting wind power enterprise performance

Boosting the core competitiveness and operational efficiency of enterprises while minimizing costs through strategic R&D investments is crucial for the advancement of wind power companies. This paper examines data from listed wind power enterprises from 2015 to 2023 and develops a detailed multiple linear regression model for comprehensive analysis. Goldwind Science & Technology Co., Ltd. is used as a case study. The paper explores the impact of R&D investment on wind power enterprise performance through empirical and case analyses, revealing several key insights. First, both R&D intensity and per capita R&D investment positively affect wind power enterprise performance, with R&D intensity having a more substantial impact. Second, the case study of Goldwind demonstrates a clear positive correlation between R&D intensity, per capita R&D investment, and corporate performance. Third, the impact mechanism analysis shows that increased R&D investment enhances Goldwind's technological advancements, leading to new products that meet market demand and improve enterprise performance. Based on these findings, the paper proposes policy recommendations, including increasing R&D investment and recruiting more scientific researchers.

An initial assessment of an opinion leader-informed intervention to improve concussion-related outcomes among middle school parents: a randomized controlled trial

Introduction There is a need for evidence-based prevention programming that can reduce head impacts and increase reporting and disclosure of concussion. This study assessed an intervention to decrease concussion risk and improve concussion management through improving concussion-related knowledge, attitudes, intentions, and self-efficacy among parents in the middle school (MS) sport setting. Patients and methods This randomized controlled trial (NCT04841473) examined parents of MS-aged children. Participants were randomized into one of two study arms: (1) CDC, which completed an education training module that compiled concussion education from the Centers for Disease Control and Prevention (CDC); and (2) TRAIN + CDC, which completed the CDC training module and an additional TRAIN educational module that provided strategies (originating from the Popular Opinion Leader framework) on communicating such information with one’s personal peer networks and children. Validated measures of concussion-related knowledge, attitudes, intentions, and self-efficacy were collected before completing the training modules and one week following completion. Linear mixed model analyses examined differences in outcomes between study arms. Results Overall, 103 parents completed the training modules and had valid pre- and post-intervention data (TRAIN + CDC n = 49; CDC n = 54). Analyses found that the study arms did not differ in the change scores from pre- to post-intervention across concussion-related outcomes. However, scores from pre- to post-intervention improved across both study arms for knowledge metrics, such as ‘Concussions are less likely to happen when athletes play by the rules of the sport’ (p < 0.001), and self-efficacy metrics, such as feeling confident in one’s knowledge and recognition of concussion symptoms (p < 0.001 and p = 0.001, respectively). Conclusions Although study arms did not differ in change scores from pre- to post-intervention, beneficial increases were nonetheless found across both knowledge and self-efficacy. Additional research is needed to further examine the beneficial manners in which concussion education can be best delivered and the most effective.

Using design of experiment via the linear model of analysis of variance to predict the thermal conductivity of Al2O3/ethylene glycol-water hybrid nanofluid

In this paper, the thermal conductivity (knf) of the Al2O3/Ethylene Glycol -Water nanofluid is measured. MATLAB software is used to fit a nonlinear function, and the analysis of variance (ANOVA) is implemented to determine the effect of temperature and volume fraction of nanoparticles (φ) on extracting the residuals and knf. In the experimental part, various combinations of temperatures (from 30 to 60 °C) and volume fractions (fromφ = 0.15 up to 1.3%) are examined, and then the obtained data are analyzed using MINITAB software. The results show that the knf is highly dependent on φ and less dependent on temperature. By changing the φ from 0.15 to 1.3%, the thermal conductivity increases around 40%. In contrast, increasing the temperature from 30 to 60 °C will increase the knf by almost 10%. Also, the results show that the thermal conductivity slope is lower at φ < 0.75%, and this rate increases drastically for higher volume fractions. The obtained results, especially the fitting function, are useful for designing and optimizing systems using nanofluids as a working fluid in heat exchangers or energy systems.

Knowledge, attitudes, and practices of healthcare professionals regarding dengue fever in high-risk regions of southeastern Iran

BackgroundDengue fever (DF) is one of the most prevalent arboviral infections worldwide. In Iran, the dengue-positive serological cases as well as the presence of the dengue vector Aedes aegypti have raised health concerns, highlighting the need to enhance the dengue surveillance system. This study aims to assess the knowledge, attitudes, and practices (KAP) of healthcare professionals (HCPs) regarding dengue fever in a large and high-risk region of southeastern Iran.MethodsA total of 492 HCPs were recruited using a multi-stage sampling method from May 2022 to July 2023. Data were collected using a self-administered questionnaire. Data analysis was done using independent t-tests, one-way analysis of variance (ANOVA), one-factor and multi-factor general linear models, and simple and multiple regression models.ResultsAbout two-thirds (71%) of the participants did not receive any training on DF. A small percentage of participants were familiar with ovitrap (32.6%) and only 21.7% knew that destroying larval breeding sites could not eliminate the dengue vector. The knowledge of disease symptoms among HCPs was found to be lower in border areas compared to non-border areas (P = 0.018). However, the practice situation in HCPs working in border areas was better than in non-borders (P = 0.003). According to the multiple regression model, the most influential factors associated with knowledge, attitude, and practice were the type of healthcare facility and passing the DF training course. Additionally, education level, work experience, and gender were identified as other factors associated with it, respectively. Significant correlations were found between knowledge and practice (P < 0.001), indicating that higher knowledge led to better practice. Similarly, a positive attitude was significantly linked to better practice (P < 0.001).ConclusionRegular, targeted, and continuous training courses are necessary to improve the knowledge level of HCPs, particularly those with lower education levels working in low-level health centers. Utilizing comprehensive dengue KAP studies to evaluate the status and impact of health education programs and identify gaps between knowledge and practice should be a research priority.

A multivariate analysis on characteristics of hand and wrist tumours: a multiethnic study.

Hand tumours are frequently encountered in clinical practice. However, large-scale epidemiological data of soft tissue tumours in the hand are infrequently published. Epidemiological data provide diagnostic cues to guide the workup and management of hand tumours. Assessing significant independent demographic factors and tumour characteristics associated with hand tumours is essential in health care. A retrospective review of patients who underwent excision of hand tumours in Singapore General Hospital between 2004 and 2015 was conducted. The data collected included age, gender, ethnicity, histological diagnosis, malignancy and location of tumour. Generalised linear latent and mixed models (GLLAMM) analyses were performed. A total of 4476 tumours were identified from 4226 patients with a mean age of 51.3 (range 8-101) years and male to female ratio of 1 to 1.15. Most patients were Chinese (75%), followed by Malay (9%), Indian (8%) and others (8%). The most common hand tumours excised were ganglions (43%) (majority in the wrist), followed by giant cell tumours (9%) (commonly in the digits). Most soft tissue tumours were benign (97%), with only 3% of malignant cases. The GLLAMM analyses revealed further potential factors on the status of malignancy, tumour origin and tumour location. Most soft tissue tumours in the hand and wrist are benign. This can guide workup and counselling of patients before the operation. While malignant tumours are uncommon, they have the potential for significant morbidity and mortality if not appropriately evaluated or treated. The application of GLLAMM analyses showed that age, ethnicity and gender were significant predictors of malignancy.

Steamed hay and alfalfa pellets for the management of severe equine asthma.

Steaming hay significantly reduces respirable particles and provides a palatable alternative to dry hay for horses with asthma, but there are few prospective studies demonstrating the clinical efficacy of steamed hay. To compare the efficacy of alfalfa pellets and steamed hay in improving lung function and inflammation of horses with severe asthma (SEA). Controlled crossover study. Ten horses with SEA were enrolled and nine completed the study. Horses were housed indoors and fed hay. Once in exacerbation, they were fed pellets and steamed hay for 4 weeks, in a crossover design. Weighted clinical scores and lung function were recorded weekly. Bronchoalveolar lavage fluid (BALF) cytology and mucus scores were recorded before and after each diet. Based on linear mixed model (LMM) analysis, weighted clinical scores significantly improved over time (p < 0.001, no diet effect or time-diet interactions). With pellets, weighted clinical scores decreased from (median (interquartile range)) 13 (5.5) to 2 (1.5), while with steamed hay, they decreased from 10 (9.5) to 6 (8.5). With pellets, lung resistance decreased significantly from a baseline of (mean (SD)) 2.62 (0.77) cmH2O/L/s to 1.17 (0.66), 0.79 (0.54), 0.70 (0.20), 0.62 (0.18) on Weeks 1-4, respectively (LMM with post hoc tests, p < 0.001). With steamed hay, the resistance decreased significantly from a baseline of 2.34 (0.93) cmH2O/L/s to 1.38 (0.49) and 1.51 (0.66) on Weeks 1 and 2, respectively (p < 0.03). Neutrophils BALF decreased significantly with both diets (pellets: 40.2 (24.4) to 20.1 (11.0) %; steamed hay 30.9 (20.2) to 25.7 (17.6) %; LMM, p = 0.006). A small number of horses in a research setting. Dust was not measured in the stalls. Clinical scores, lung function and BALF inflammation of horses with SEA improved with steamed hay and pellets, but the effect on lung function was more pronounced with pellets.

External Load Evaluation in Elite Futsal: Influence of Match Results and Game Location with IMU Technology.

The purpose of this study was to assess the external load demands in futsal, considering both home and away matches and their outcomes, in order to plan microcycles throughout the season based on the external load of each match. The external load of 10 players from a First Division team in the Spanish Futsal League was recorded throughout 15 official matches in the first half of the league championship. The players' external load was monitored using OLIVER devices. To analyse the influence of the match outcome and location on the external load, a univariate general linear model (GLM) analysis was conducted with Bonferroni post hoc. There are no differences between the variables neither comparing results nor location factors, except for accelerations of 2 to 3 m/s2 (m) per minute and the number of accelerations of 2 to 3 m/s2 per minute, reporting higher value winnings at home than away (p < 0.05). The location and results are not factors that influence on external load in futsal matches, except the number and distance performed in accelerations and distance covered at a low to medium speed. These findings are important for planning microcycles and providing the appropriate dosage to each player to achieve optimal performance in matches.

Quantifying the resistance of Australian wheat genotypes to Pratylenchus thornei based on a continuous metric from a factor analytic linear mixed model

Genetic resistance to the parasitic root-lesion nematode, Pratylenchus thornei, is one of the main management strategies cereal growers can use to minimise the impact of nematodes on winter cereal cropping. Screening of genotypes in the presence of P. thornei populations must provide reliable resistance measures that are realised under field conditions. Adoption of the latest statistical methodologies can help to better differentiate between resistant and susceptible genotypes. In this study, post-harvest P. thornei population densities were measured from a collection of 17 field experiments, with varying starting P. thornei population densities, conducted between 2011 and 2018 in locations across the northern grain growing region of eastern Australia. The experiments primarily consisted of wheat genotypes. The post-harvest P. thornei population densities were analysed across multiple environments in a linear mixed model framework, with a factor analytic structure used to model genotype by environment (G ×\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\ imes$$\\end{document} E) interaction effects exclusively for wheat genotypes. In general, genetic correlations between environments were found to be high, indicating limited G ×\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\ imes$$\\end{document} E interaction for resistance to P. thornei. Post-processing of results using the factor analytic selection tools (FAST) method provided a measure of the overall performance for each wheat genotype, as well as a stability measure reflecting the consistency of the resistance status across environments. The FAST method quantified genotype resistance on a continuous scale, better reflecting the nature of genetic resistance based on a quantitative variable such as nematode population density, and provided a statistically robust and informative means of aiding selection decisions for resistance to P. thornei.

Single neuron responses to perceptual difficulty in the mouse auditory cortex.

Perceptual learning leads to improvement in behavioral performance, yet how the brain supports challenging perceptual demands is unknown. We used two photon imaging in the mouse primary auditory cortex during behavior in a Go-NoGo task designed to test perceptual difficulty. Using general linear model analysis, we found a subset of neurons that increased their responses during high perceptual demands. Single neurons increased their responses to both Go and NoGo sounds when mice were engaged in the more difficult perceptual discrimination. This increased responsiveness contributes to enhanced cortical network discriminability for the learned sounds. Under passive listening conditions, the same neurons responded weaker to the more similar sound pairs of the difficult task, and the training protocol by itself induced specific suppression to the learned sounds. Our findings identify how neuronal activity in auditory cortex is modulated during high perceptual demands, which is a fundamental feature associated with perceptual improvement.

Benefits of an online group dance program for adolescents' social bonding and wellbeing.

The Covid-19 pandemic and its ensuing effects on mental health made it clearer than ever that social bonds are critical for survival, flourishing, and mental wellbeing. Experimental laboratory-based research with children and adults shows that activities involving movement alignment and joint action, such as dance, can facilitate social bonds. This study examined whether an online group dance intervention positively affects social bonding and wellbeing using a randomized control design. Participants were 58 UK adolescents aged 11-16 years (N = 52 girls, 75% White, 7% Asian/Asian British, 18% Mixed-Other), randomly assigned to an online intervention or waitlist control group. Participants in the intervention group completed an online 5-week hip-hop dance program during the Covid-19 pandemic in January to February 2021. Measures of social bonding, wellbeing, and future orientation were taken at the beginning and end of the program. Linear mixed model analyses examining group × timepoint interaction showed greater increase in social bonding (p < .0001), and wellbeing (p < .0001) in the intervention vs control group. Moreover, increases in bonding significantly predicted increases in wellbeing (p < .0001), and increases in bonding (p = .03) and wellbeing (p = .0002) significantly predicted increases in the adolescents' hope for the future. These data, collected at a time of mass social isolation, show that a 5-week-long online dance activity can help adolescents forge stronger social bonds, and improve their wellbeing and future orientation. Our findings suggest that the wellbeing and future orientation benefits of group dance may stem from having stronger social connectedness, opening up avenues for future research and interventions.

The Correlation Between the Willingness to Marry and the Household Savings Rate in China

In recent years, the decrease in household savings rate and willingness to marry is an important problem facing society in China. The traditional competitive savings theory holds that the imbalance of the male and female sex ratio is an important factor affecting the household savings rate. However, in the context of the saving rate declining year by year after 2010, it is found that the traditional competitive savings theory can not fully explain the reasons for its decline. At the same time, according to the data statistics, it is found that the trend of marriage intention in China during 2000-2021 is similar to that of the savings rate, which increases first and then decreases. Therefore, this paper established a multiple linear regression model and ridge regression model for regression analysis, and observed the size of the regression coefficient and the positive and negative effects of willingness to marry on household savings rate in China. The regression results show that for every 1% change in willingness to marry, the savings rate will change 13.526% in the same direction on average. This indicates that the decline in willingness to marry plays a positive role in explaining the decline of household savings rate.

Differential brainstem connectivity according to sex and menopausal status in healthy men and women.

Brainstem nuclei play a critical role in both ascending monoaminergic modulation of cortical function and arousal, and in descending bulbospinal pain modulation. Even though sex-related differences in the function of both systems have been reported in animal models, a complete understanding of sex differences, as well as menopausal effects, in brainstem connectivity in humans is lacking. This study evaluated resting-state connectivity of the dorsal raphe nucleus (DRN), right and left locus coeruleus complex (LCC), and periaqueductal gray (PAG) according to sex and menopausal status in healthy individuals. In addition, relationships between systemic estrogen levels and brainstem-network connectivity were examined in a subset of participants. Resting-state fMRI was performed in 50 healthy men (age, 31.2 ± 8.0 years), 53 healthy premenopausal women (age, 24.7 ± 7.3 years; 22 in the follicular phase, 31 in the luteal phase), and 20 postmenopausal women (age, 54.6 ± 7.2 years). Permutation Analysis of Linear Models (5000 permutations) was used to evaluate differences in brainstem-network connectivity according to sex and menopausal status, controlling for age. In 10 men and 17 women (9 premenopausal; 8 postmenopausal), estrogen and estrogen metabolite levels in plasma and stool were determined by liquid chromatography-mass spectrometry/mass spectrometry. Relationships between estrogen levels and brainstem-network connectivity were evaluated by partial least squares analysis. Left LCC-executive control network (ECN) connectivity showed an overall sex difference (p = 0.02), with higher connectivity in women than in men; however, this was mainly due to differences between men and pre-menopausal women (p = 0.008). Additional sex differences were dependent on menopausal status: PAG-default mode network (DMN) connectivity was higher in postmenopausal women than in men (p = 0.04), and PAG-sensorimotor network (SMN) connectivity was higher in premenopausal women than in men (p = 0.03) and postmenopausal women (p = 0.007). Notably, higher free 2-hydroxyestrone levels in stool were associated with higher PAG-SMN and PAG-DMN connectivity in premenopausal women (p < 0.01). Healthy women show higher brainstem-network connectivity involved in cognitive control, sensorimotor function, and self-relevant processes than men, dependent on their menopausal status. Further, 2-hydroxyestrone, implicated in pain, may modulate PAG connectivity in premenopausal women. These findings may relate to differential vulnerabilities to chronic stress-sensitive disorders at different life stages.

Pengaruh Pelayanan, Promosi, Dan Motivasi Terhadap Kinerja Karyawan PT.PLN (Persero) ULP Medan Baru

This study discusses the influence of Service, Promotion, and Motivation on the performance of employees of PT PLN (PERSERO) ULP MEDAN BARU. The theory used in the study is marketing management theory. The research method used by research is a quantitative approach. The type of research is descriptive quantitative. The research population of all employees of PT PLN (PERSERO) ULP MEDAN BARU was 22 people and the sample of this study was taken with saturated sampling technique saturated sampling technique if the sample and population members are relatively small, less than 30 people, or researchers who want to make generalizations with very small errors. Another term for saturated sampling is census, where all members of the population are sampled using the slovin formula, namely 22 respondents. Data collection in this study was by means of questionnaires, interviews, documentation. The data were analyzed using multiple linear analysis models. The results showed that the X1 tcount value was 0.277 &lt; t table 2.086 with a significant 0.785&gt; 0.05, so Ha was rejected and Ho was accepted, indicating that X1 had no positive and insignificant effect on Y, X2 tcount value of 2. 102 &gt; t table 2,086 with a significant 0.050 &lt; 0.05 then Ho is rejected and Ha is accepted indicating that X2 has a positive and significant effect on Y, X3 tcount value of 4,281 &gt; t table 2,086 with a significant 0.000 &lt; 0.05 then Ho is rejected and Ha is accepted indicating that X3 has a positive and significant effect on Y.

Sight-singing in a group context: An eye-tracking study with experienced choral singers

Studies on music reading have provided insights into the cognitive processes in sight singing. However, there has been limited research on sight singing in a group setting. This study aims to assess how choral singers approach music reading as they perform previously unfamiliar choral scores together. We addressed (1) how singers’ gaze direction is distributed over staff systems, and (2) how their gaze behaviour is influenced by note density and repeated practice. Four quartets, a total of sixteen experienced singers, performed eight Baroque music excerpts three times, while the singers’ eye movements were recorded. Eye-movement measures were analysed in conjunction with the singers’ views regarding their music reading, obtained through questionnaires and group discussions. Results reveal that besides reading their own voice lines, singers typically inspected the neighbouring lines, seeking visual cues to coordinate the performance. The results of a generalised linear mixed model analysis underscore the substantial influence of note density on fixation durations on one’s own lines, but not on other voices’ lines. Practice, on the other hand, exhibited effects only on average fixation duration for one’s own lines, with no significant impact observed on other lines. The study provides evidence of coordination between an actual sight-reading process and a parallel information-gathering process that helps singers relate their parts to the overall musical structure.