Limited Mouth Opening Research Articles

Infratemporal Fossa Metastasis of Non-Small-Cell Lung Adenocarcinoma: A Case Report and Literature Review.

Neoplasms in the infratemporal fossa (ITF) are rare and insidious lesions that cause various symptoms due to involvement of the temporomandibular joint (TMJ), paranasal sinuses, and orbit. Here, we report a case of metastatic non-small cell lung adenocarcinoma in the ITF. The patient presented with facial pain and limited mouth opening, which did not respond to treatment for TMJ disorder, and a neoplasm was discovered in the ITF through medical imaging. With an open biopsy, the diagnosis was finalized. This report suggested that the physician should consider lesions in the ITF when facial pain and limited mouth opening failed local treatment, and distant metastasis of malignant tumor should be alerted. We also reviewed the literature regarding metastatic cancer to the ITF.

Condylar Osteochondroma: A Rare Case Report.

Osteochondroma (OC) is an uncommon reason for the mandibular condyle to grow excessively. Usually unilateral, it can impact the entire mandible, the condyle and ramus, or just the condyle. It is a bony projection covered in cartilage that protrudes from the damaged bone's exterior. Condylar OC are more prevalent as a result of endochondral ossification-related development. The most notable characteristic is the gradual asymmetry of the face over time. Clinical symptoms of the patient include pain, asymmetry, malocclusion, partial or total hearing loss, trismus, and hypomobility of the TMJ. We report a case of 40-year-old male patient complaining of reduced mouth opening since last 10 years. Clinical examination revealed gross facial asymmetry, hard swelling over right TMJ, jaw deviation towards left side, restricted mouth opening of 3mm and deranged occlusion. An irregular radiopaque mass was seen over the right condylar region in OPG. A large, hyperdense mass that obliterated the sigmoid notch and extended medially to the right condyle was visible on CT scans. Using a pre-auricular Alkayat-Bramley technique, the mass was surgically removed. Occlusal corrections and jaw physiotherapy were then administered. On follow up, deviation was corrected and adequate mouth opening was achieved.

A challenging dental treatment of a patient with spinal muscular atrophy

After a fall from his wheelchair, a 23-year-old wheelchair-dependent patient with spinal muscular atrophy type 1 was initially seen by an emergency dentist, who repositioned and splinted the luxated teeth number 31 and 32. For stabilization, the patient was subsequently referred to a centre for special dental care. In the past, few treatments had been carried out on the patient. A jaw defect and very limited mouth opening compromised dental treatment. In addition, due to the muscle disease, the patient had respiratory and breathing problems, for which he used respiratory equipment. This case describes the importance of a multidisciplinary team in the treatment of patients with spinal muscular atrophy, and the options for performing minimally invasive dental treatment, where the priority is a painless dentition.

Application of an ultrasonic bone knife combined with a dental electric motor in the extraction of mandibular middle and low impacted teeth

ObjectiveTo investigate the clinical application of an ultrasonic bone knife (UBK) combined with a dental electric motor (DEM) in the extraction of mandibular middle and low impacted teeth.MethodsFrom January 2022 to May 2023,200 patients with wisdom teeth were randomly divided into three groups: experimental group A (UBK combined with DEM), experimental group B (UBK combined with high-speed turbine mobile phone (HSTMP)), and the control group (bone chisel split crown (BCSC)). The operation time, psychological state during operation, pain, swelling, limitation of mouth opening and other complications on the first, second and third days after operation were recorded.ResultsThe operation time of experimental group A (EAG) (12.95 ± 2.12) minutes was shorter than that of experimental group B (EBG) (17.06 ± 2.25) minutes and the control group (CG) (23.43 ± 2.18) minutes, and the difference was statistically significant (P < 0.05). The psychological state of the EAG was significantly lower than that of the EBG and CG (P < 0.05). The postoperative pain, swelling, limitation of mouth opening and complications in the EAG were significantly lower than those in the EBG and CG (P < 0.05).ConclusionUBK combined with DEM in the extraction of mandibular middle and low obstructed teeth has good results, good prognosis, high safety, short operation time, better psychological status of patients, low postoperative pain, swelling, mouth opening restriction and complication rate, and is currently the preferred extraction method.

Orofacial fascial space abscess disguised as temporomandibular disorder: a report of 3 cases and literature review

Fascial space abscess is a condition in which infections spread into fascial spaces. It is a severe and life-threatening disease unless treated at an early stage. Due to the similarity of clinical symptoms, fascial space abscesses in the orofacial area are often disguised as other diseases, such as temporomandibular disorder (TMD). In this case series, we report three cases of fascial space abscesses disguised as TMD. In all cases, patients complained of severely limited mouth opening and pain in the temporomandibular joint (TMJ) and masseter muscles, which led clinicians to diagnose them with TMD. After two patients showed facial swelling and the third complained of dyspnea, clinicians realized the possibility of an orofacial fascial space abscess. On further evaluation, all patients showed increased C-reactive protein in blood tests, and the location of the fascial space abscess was confirmed by enhanced computed tomography images. Moreover, all patients had suspicious sources of odontogenic infections in panoramic images, periapical abscess on maxillary molars and periodontal disease on maxillary and mandibular molars, which were not appropriately evaluated at the first visit. This case series emphasizes the need for clinicians to realize the possibility of orofacial fascial space abscesses based on: clinical symptoms of severely limited mouth opening (< 15 mm) with pain in the facial area, including TMJ or masseter muscle, and possible sources of infection such as odontogenic infection, other infectious lesions, trauma, or invasive treatments. These clinical insights will enable the early detection of fascial space abscesses.

Аналіз комп’ютерних томограм після лікування дисфункції скронево- нижньощелепного суглоба

The aim. To define the dimensions of upper joint space during TMJ disc displacement, associated with limited mouth opening by analyzing computer tomography images. Materials and methods. 79 patients were clinically examined by means of an anamnesis collection, isometric tests, palpation of TMJ and masticatory muscles, detection of occlusal supra contacts in habitual and dynamic occlusion. For all the examined patients with permanently limited mouth opening up to 35 mm between incisors a TMJ computer tomography (CT) in habitual occlusion was performed before and after gnathological treatment. Computer tomogram images are represented by sagittal plane where dimensions of upper joint space were measured. The distance between the upper and lower central incisors was measured in millimetres at the largest mouth opening position during clinical examination. Results. For 48 (60, 7%) examined patients chewing food wearing a gnathological splint was considered as an optional recommendation and was aimed at maintaining the therapeutic effect achieved during the first three months of treatment, and for 31 (39,2%) patients consuming food in a gnathological splint was a necessity for achieving physiological measurements of mouth opening, within 43-53 mm between the incisors. Conclusions. During the comparison of TMJ computer tomogram images in the closed jaws position on both sides before and after treatment of TMJ disc displacement, which is accompanied by limited mouth opening, it was found out that the maximum admissible asymmetry in articular condyle position after gnathological treatment, measured along the upper joint space was 2,8 ± 0,31 mm and was found in 11,3% of examined patients. Key words: TMJ (Temporomandibular joint), limited mouth opening, computer tomography (CT).

Comparative Evaluation of Conventional Nasolabial Flap with and without Fishtail Modification in Patients with Oral Submucous Fibrosis: A Research Protocol

Introduction: Oral Submucous Fibrosis (OSMF) is a longterm condition characterised by the gradual buildup of fibrous tissue in the oral cavity, often extending to the throat and upper oesophagus. The primary symptoms include progressive limitation in mouth opening due to the formation of stiff fibrous bands in the oral mucosa, accompanied by muscle atrophy. However, the most concerning aspect of this restriction, known as trismus, is its hindrance to effective cancer monitoring. Surgical approaches typically aim to release these fibrotic bands, while medical interventions focus on managing inflammation and preventing further fibrosis. Need of the Study: A modification of the nasolabial flap has been suggested for the reconstruction of intraoral defects following ablative surgery for OSMF. The study will assess its merits in comparison to the conventional nasolabial flap. Aim: To evaluate and compare the aesthetic and functional outcomes of the rima oris between the Conventional Nasolabial Flap and the Nasolabial Flap with Fishtail Modification in patients undergoing surgical intervention for OSMF. Materials and Methods: A prospective, double-blinded, randomised controlled trial will be conducted in the Department of Oral and Maxillofacial Surgery at Acharya Vinoba Bhave Rural Hospital, associated with Jawaharlal Nehru Medical College, Wardha, Maharashtra, India, from November 2023 to November 2024. Patients older than 18 years of age diagnosed with OSMF, without any superimposing cancerous lesions, will be included in the study. They will be divided into two groups: Group A will be treated with bilateral fibrotomy, coronoidotomy and reconstruction with the conventional nasolabial flap, while Group B will undergo the same surgical intervention, except that the reconstruction will be performed using the fishtail modification of the nasolabial flap. The parameters that will be compared include interincisal mouth opening, intercommissural width, dehiscence and flap necrosis. The analysis will be conducted using the Chi-square test and Fisher’s-exact test for categorical data and the independent t-test for continuous data that follow a normal distribution. These statistical tests will help evaluate the association between different demographic, clinical and etiological factors and the outcomes under consideration. A p-value of &lt;0.05 will be considered statistically significant.

Radiological Study of Synovial Chondromatosis of the Temporomandibular Joint

Abstract Temporomandibular joint disorders (TMDs) are usually accompanied by changes in the bone structure of the TMJ brought on by degenerative processes. Osteophytes, erosion, flattening, subchondral sclerosis, pseudocysts, TMJ remodeling, articular cartilage abrasion, bone degradation, and synovial inflammation are among the characteristics of degenerative joint disease. Synovial chondromatosis (SC) is one of the degenerative joint conditions, which is defined by the growth of cartilaginous nodules, which are typically loose in the joint space of the synovial membrane. Its appearance in the TMJ, however, is more uncommon than in other large joints such as the knee and hip and is accompanied by preauricular pain, swelling, and restricted mouth opening. However, we recently encountered cases of degenerative joint disorder, i.e., of SC of TMJ, which showed the typical histopathological findings along with the typical imaging findings on Panoramic radiography (PAN) TMJ and cone-beam computed tomography images.

Comparison of McCoy, Macintosh, and Truview laryngoscope for bougie-aided naso-tracheal intubation: A randomized controlled study.

Video laryngoscopes are commonly used along with Macintosh and McCoy laryngoscopes for Nasotracheal intubation (NTI). The purpose of this study was to evaluate the performance of McCoy, Macintosh, and Truview laryngoscopes during bougie-aided NTI with respect to intubation time, success rate, and hemodynamic changes during the procedure. Forty-five American Society of Anesthesiologists (ASA) I-II adult patients, with Mallampati grade 1-4, requiring NTI, were enrolled after taking written informed consent. ASA III/IV, restricted mouth opening, and body mass index >30 were excluded from the study. Patients were randomly allocated to intubate with one of the three laryngoscopes (McCoy, Macintosh, and Truview) and the anesthesiologists were well experienced with all of them. The primary outcome was intubation time and secondary outcomes included first attempt success rate, external laryngeal manipulation, Cormack-Lehane (CL) grade, and hemodynamic responses. The intubation time of McCoy, Macintosh, and Truview, was 86.87 ± 15.92, 82.87 ± 16.46, and 79.93 ± 14.53 (mean ± standard deviation) seconds, respectively, which is comparable with Truview being the shortest. CL grade 1 was obtained more in the Truview group (53.3%) compared to the other two groups, while CL grade 3 was obtained in 20% each in McCoy and Macintosh groups. McCoy, Macintosh, and Truview laryngoscopes were comparable in performance during bougie-aided NTI, with Truview having the shortest intubation time and better visualization.

A New Technique for Arthroscopic Discectomy of the Temporomandibular Joint Disc Perforation: A Technical Note

Disc perforation represents the result of the degenerative process in joint structures that may lead to pain, joint noise, restricted mouth opening, osteoarthritis, and even dentofacial anomalies. Even though discectomy has proven benefits, with promising outcomes reported, it is mainly described using an open approach. While some arthroscopic techniques have been published, they are limited to managing perforation, edge widening, and inflammation treatment and do not describe complete disc removal. We describe a novel step-by-step arthroscopic discectomy technique (ADT) utilizing two operative cannulas that completely remove non-functional cartilaginous tissue.

Effects of Transcutaneous Electrical Nerve Stimulation, Laser Therapy, and Ultrasound in Managing Temporomandibular Disorders: A Randomised Clinical Study

Introduction: Temporomandibular Joint Disorders (TMDs) are considered multifactorial, and several treatment approaches have been proposed for their effective management. The use of non invasive treatment modalities is recommended, which includes Transcutaneous Electric Nerve Stimulation (TENS), Low-Level Laser Therapy (LLLT), acupuncture, ultrasound, and manual therapies. Aim: To evaluate the effectiveness of TENS, LLLT, and ultrasound therapy in patients suffering from TMDs. Materials and Methods: This prospective, randomised clinical trial was conducted on thirty patients (11 males, 19 females) clinically diagnosed with TMD associated with Temporomandibular Joint (TMJ) pain, clicking joint sound, pain in the muscles of mastication, and limited mouth opening. Patients were sequentially randomised into three groups to be treated with TENS, laser beam, and ultrasound therapies, respectively. The Visual Analog Scale (VAS) Score and painfree mouth opening were recorded before, during, and after treatment. Data were analysed using Statistical Package for Social Sciences(SPSS) version 16.0 statistical software. Statistical tests such as the paired sample t-test, Analysis of Variance (ANOVA), and post-hoc Tukey test were performed. Results: There was a significant reduction in the VAS score in the TENS group (3.15), LLLT group (5.75), and ultrasound group (5.50) post-treatment (p&lt;0.001). In addition, improvements in Mean Mouth Opening (MMO) levels were observed with TENS (7.80 mm), LLLT (9.09 mm), and ultrasound therapy (7.15 mm). These differences were found to be statistically significant (p&lt;0.05). The laser and ultrasound groups fared better than the TENS group in the reduction of VAS scores (p&lt;0.05), and there was no significant difference in MMO among the three therapies. Conclusion: Reductions in VAS scores and improvements in mouth opening were noticed in all three groups post-treatment. The laser and ultrasound therapies were more effective in reducing pain compared to TENS therapy. Comparing pretreatment and mid-treatment values, laser beam therapy proved to be more effective in reducing pain scores compared to TENS and ultrasound therapy.

Prevalence Of Different Stages Of Oral Submucous Fibrosis In India: A Cross Sectional Study

Background: Oral Submucous Fibrosis (OSMF) is a persistent and gradually developing disorder that impacts the mouth and occasionally the throat. It is marked by an inflammatory response just beneath the epithelium and alterations in the fibroelastic components of the lamina propria. These changes result in stiffness of the oral mucosa, limited mouth opening (trismus), and challenges with eating. OSMF is distinguished by its significantly elevated potential to progress into malignancy, compared to other oral lesions with a risk of malignancy, predominantly affecting those of Indian and Southeast Asian descent. The global prevalence rate stands at 2.28% - 8.62%, with a notable gender disparity in occurrence and a malignant transformation rate of 4.2%. Aim: The objective of this research is to evaluate the prevalence and distribution by gender of OSMF stages within a private dental institution, with a particular emphasis on examining the relationship between the frequency of the disease and the occurrence of its stages. Materials and Methods: Over a period of 32 months, a cross-sectional analysis was carried out in the outpatient section of the Department of Oral Medicine and Radiology. After receiving approval from the ethics committee, 337 individuals diagnosed with OSMF were selected for inclusion in the study, with information categorized according to gender and age. Results: The study found a significant male predominance (94%) among the patients, with a mean age of 31-50 years. Stage 2 OSMF was more prevalent among both genders, followed by stage 3 and 1, indicating a specific pattern of disease progression. Discussion: Consistent with previous studies, our research confirmed a male predominance in OSMF occurrence. The age and stage distribution aligns partially with existing literature, suggesting a predominant affliction of individuals in their mid-life. Contrary to Anuna Liala Mathew et al.'s findings, our study observed a higher prevalence of stage 2 OSMF, underscoring potential variations in disease progression or detection practices. Conclusion: OSMF presents a significant public health challenge due to its high malignant transformation potential and association with arecanut and tobacco use. This study highlights the urgent need for public education on the adverse effects of these substances and calls for enhanced awareness and management strategies for OSMF, particularly considering its prevalence and severity among males in the studied population.

Evaluation of Efficacy of Tulsi-Turmeric Oil Pulling in Oral Submucous Fibrosis (Vata Pitta Dominant Tridosaja Sarvasara Mukharoga): A Narrative Review

A condition called Oral Submucous Fibrosis (OSMF) primarily affects the Indian subcontinent. It is characterised by abnormal collagen deposition and fibrosis of submucosal tissue that progresses over time. Chewing betel nut is the most prevalent behaviour among Oral Submucous Fibrosis (OSMF) patients, with a 6.3% prevalence rate. Symptoms include ulceration, burning sensation, xerostomia, and limited mouth opening. According to the Brihatrayi (three main classical books), OSMF is associated with sarvasaramukharoga, or disorders of the oral cavity. Tobacco, lime, chilies, betel nuts, and other substances act as irritants and can damage the oral mucosa. Treatment methods include Gandusha (oil pulling), Pittashamaka, yoga, Nasya (nasal drops), Pratisarana (rubbing), etc. The present review was conducted to assess and evaluate the potential efficacy of Tulsi-turmeric oil pulling as a complementary or alternative therapy in managing OSMF

The necessity and reasons for referrals to endodontists among general dentists in Mashhad: A cross-sectional study

Introduction: This study aimed to identify the necessity and reasons for patient referral to endodontists among general dentists in Mashhad, Iran, in 2021. Materials and Methods: This research employed a descriptive cross-sectional study design. Two hundred general dentists participated in the survey, answering a questionnaire with confirmed reliability and validity. The questions focused on their reasoning for deciding to perform or not perform root canal treatment, their rationale for referring or not referring patients to endodontists, and the factors influencing these decisions. Data were analyzed using the SPSS-19 software, using Chi-square and Mann–Whitney tests (α = 0.05). Results: Of the respondents, 68% performed root canal therapy routinely, while 8.5% reported never performing root treatment. Men were more likely to perform root canal therapy than women (P &lt; 0.001). Among the dentists who performed root canal therapy, 76.5% considered endodontic referrals necessary, and the number of referrals was higher among female dentists than male dentists (P &lt; 0.001). Overall, the main reasons for referral to endodontists include noncooperation of the patient, open apex, and mouth opening limitations. Fear of losing the patient and the high costs of specialized treatment were the reasons for nonreferral to endodontists. Conclusion: There is a need to eliminate the barriers to endodontic referral among general dentists in Mashhad. Economic issues played a substantial role in dentists’ unwillingness to perform root canal therapy and endodontic referral. The study provides insights into the reasons for referral, which can guide the development of strategies to improve endodontic care and patient outcomes.

Therapeutic Potential of Centella asiatica Linn in Oral Submucous Fibrosis: A Short Communication

Oral Submucous Fibrosis (OSMF) is a chronic progressive disease characterised by fibrosis of the oral mucosa, leading to restricted mouth opening and difficulties in speech and swallowing. Modern science has explored a variety of surgical and medicinal therapy approaches, but the outcomes are often unsatisfactory due to recurrence, side effects, and, at times, a worsening of the condition due to fibrosis. Adjuvant therapies, especially antifibrotic herbs, are urgently needed for better treatment outcomes in OSMF. Centella asiatica Linn, also known as Indian pennywort or Asiatic pennywort, has shown potential therapeutic benefits in the treatment of OSMF. This short communication summarises studies indicating that Centella asiatica Linn has the potential to act as an antifibrotic agent, as it downregulated most fibrotic markers in both in-vivo and in-vitro set-up.

Challenging Airway Management in a 5-year-old Male Child with Sublingual Lymphovascular Malformation

ABSTRACT We report a 5-year-old male child with a large lymphovascular malformation of the tongue presenting with signs of airway obstruction scheduled for bleomycin sclerotherapy and tracheostomy. Anesthetic concerns include limited mouth opening, airway obstruction, poor visualization, bleeding, and distorted anatomy, thereby rendering mask ventilation, laryngoscopy, intubation, and possible invasive airway access difficult. While awake airway management options are ideal for difficult airways in general, these techniques may be inapplicable to pediatric patients. Management options are further constrained in resource-limited clinical settings where critical equipment may be unavailable. By conducting a thorough preoperative evaluation and by adopting a multidisciplinary approach to case planning, preparation, and management, a strategy was developed, enabling successful airway management. The use of this approach may facilitate the successful anesthetic management of a difficult pediatric airway in austere clinical environments.

Therapeutic challenges in temporomandibular disorders.

This study aimed at evaluating the etiology and treatment challenges of temporomandibular disorders (TMDs). 160 subjects with TMDs, 38 males (23.8%) and 122 females (76.3%) were studied. A personalized coefficient was designated, which included the resolution of the main symptom, correction of secondary symptoms, patient collaboration (emotional parameter), treatment duration, and cost. The most frequent cause for consultation was muscle impairment (42.5%), or limitation of mouth opening, followed by joint impairment (23.1%). Muscle pain was noticed, particularly in the masseter (57.5%) and lateral pterygoid muscles (51.9%). Tooth pain or gingival retraction was frequently associated with tooth wear (48.1%) and dental abfraction (31.3%). Remote symptomatology was dominated by otologic symptomatology. Iatrogenic etiology was highest (69.4%), followed by untreated missing teeth (66.9%). Treatment options included muscle relaxation, occlusal balancing (equilibration), kinesitherapy, medication, and swallowing re-education. Most patients benefited from four to seven different types of therapy, which resulted in a higher cost and a longer and more uncomfortable treatment. The primary symptom was relieved in 82.3% of cases, with recurrence occurring in 15.7%. The treatment of temporomandibular joint dysfunction is time-consuming, demanding, and intricate. Most patients required four to seven different types of therapy, which increased the expense, treatment duration, and suffering.

Magnetic Sectional Denture for Microstomia Patient with Oral Submucous Fibrosis

This article presents a case report of a patient with oral sub mucous fibrosis and subsequent microstomia , that resulted in restricted mouth opening. A magnetic sectional denture was planned for the maxillary arch to overcome the problem and a conventional denture was planned for the mandibular arch. Primary impressions were made, followed by sectional maxillary special trays for border molding. The record bases for the maxillary arch was fabricated in heat cure by incorporating magnets of 3mm diameter on the anterior alveolar ridge and middle part of mid palatal raphe region, and 5 mm magnet towards the posterior most part of mid palatal raphe region. The jaw relation was carried out, followed by teeth setting and wax try in. Finally the maxillary denture was processed in two sections and denture insertion was done. Satisfactory retention was achieved and phonetics was restored.

Prevalence and Clinical Characteristics of Temporomandibular Disorders in Adults: An Epidemiological Study in the Mediterranean Region of Turkiye

The prevalence and clinical characteristics of temporomandibular disorders (TMD) in the Mediterranean region of Türkiye have not yet been thoroughly investigated. Objective: This study aimed to determine the prevalence and severity of TMD in a sample of the population in this region and to characterize the clinical findings related to TMD. Methods: Four hundred and one participants were included in this study. “Presence of TMD” in the participants was evaluated using the Fonseca Anamnestic Index. Through clinical examination, the findings in the participants were classified as limited mouth opening, deviation, temporomandibular joint (TMJ) sounds, TMJ pain, and muscle pain. Results: The prevalence of TMD was found to be 66.8%, with “Mild TMD” being the most frequent diagnosis among the participants. Clinical findings related to TMD were detected in 48.6% of the participants, and TMJ sounds were the most common clinical finding. TMD was most commonly found in participants over the age of 52, and clinical findings related to TMD were most common in participants between the ages of 25 and 38. In addition, a relationship was found between “Presence of clinical findings” and the gender and age of the participants (p &lt; 0.001 for both comparisons). Conclusion: The results show that females may be more prone to TMD than males. During clinical examinations, it should be considered that “Presence of clinical findings” may be related to gender and age.

Efficacy of Lvpao Powder on Radiation Therapy–Induced Mucositis: A Retrospective Study of 114 Patients With Head and Neck Carcinoma

PurposeTo compare the efficacy and safety of kangfuxin solution and lvpao powder on mucositis induced by radiotherapy in head and neck carcinoma patients. We retrospectively analyzed 114 patients with head and neck malignant tumors in our center. Methods and MaterialsPatients were given Kangfuxin solution to rinse the mouth or Lvpao powder sprayed on oral mucosa after the solution use. The side effect was evaluated by Common Terminology Criteria for Adverse Events, version 4.0. ResultsThe grade 3 mucositis occurred in 32.9% (23/70) and 11.4% (5/44) in Kangfuxin solution group and kangfuxin solution plus lvpao powder group respectively(P=0.009). The pain score of the Kangfuxin solution group was significantly higher than that of the Kangfuxin solution and lvpao powder group with 4.26 ± 0.81 vs 3.75 ± 1.03(P=0.007). The time of symptom relief in the combined group was significantly shorter than that in the single drug group with 3 days vs 6 days (P=0.000). The weight loss of the former groups was bigger than that of the latter group(6.67 ± 1.20kg vs 5.95 ± 0.94kg, P=0.001). There was no statistical difference in the limitations in mouth opening(P=0.164). ConclusionsLvpao powder is safe and effective as a mucosal repair drug in accelerating the recovery of patients and reducing their body weight loss.