Medium-pH above 6.4 is a common cause of micronutrient deficiency for container-grown plants, and technologies are required to correct an excessively high medium-pH. The objective was to quantify the dose response from application of several acidic materials that have been recommended for lowering medium-pH in soilless media. A 70% peat/30% perlite (by volume) medium was mixed with a preplant nutrient charge, a wetting agent and 1.5, 1.8, 2.1, or 2.4 kg·m-3 of a dolomitic hydrated lime resulting in four starting pH levels ranging from 6.4 to 7.6. Aluminum sulfate (17% Al) at 1.8-28.8 g·L-1, flowable elemental sulfur (52% S) at 3.55-56.8 mL·L-1, ferrous sulfate (20.8% Fe) at 1.8-28.8 g·L-1, Seplex-L organic acid at 0.32-5.12 mL·L-1, sulfuric acid (93%) at 0.08-2.56 mL·L-1, 21.1N-3.1P-5.8K water-soluble fertilizer at 50-400 mg·L-1 N (potential acidity 780 g CaCO3 equivalents/kg), and a deionized water control were applied at 60 mL per 126-cm3 container with minimal leaching as a single drench (except repeat sulfuric acid applications at 0.08 or 0.16 mL·L-1 and 21.1N-3.1P-5.8K treatments that were applied about every 3 days). Medium-pH and electrical conductivity (EC) were tested over 28 days using the saturated medium extract method using deionized water as the extractant. One day after application, aluminum sulfate, ferrous sulfate, and sulfuric acid lowered pH by up to 3 pH units at the highest concentrations and medium-pH remained fairly stable for the following 27 days. Flowable sulfur lowered pH gradually over the course of the experiment by up to 3.3 pH units, with no difference across the wide range in concentrations. Organic acid had minimal impact on medium-pH, and 21.1N-3.1P-5.8K did not lower medium-pH despite the fact that all nitrogen was supplied in the ammonium and urea form. At recommended concentrations, chemicals tested raised medium-EC, but not above acceptable levels for plant growth. The highest rates of aluminum and ferrous sulfates, and sulfuric acid, however, increased medium-EC by 2.0 dS·m-1 on day 1. Medium-pH-responses to acid-reaction chemicals would be expected to vary in commercial practices depending on additional factors such as lime type and incorporation rate, water alkalinity, media components, and plant interactions.