The study involved 90 patients with complicated diabetic foot syndrome (DFS), who were treated in purulent-septic center with beds for diabetic foot patients — City Clinical Hospital N 3 of Zaporizhzhia during the period of 2014–2015. The average age of patients was 63.4 ± 4.7 years. According to the protocol for the management of patients with diabetes mellitus type 2, none of the experts, involved in the treatment of these patients, provide a complete integrated treatment taking into account all possible complications. Upon admission to the surgical hospital, patients from the index group, along with the elimination of purulent-necrotic complications, underwent a complete examination and received the maximum comprehensive conservative therapy in contrast with the control group received standard therapy. The difference between the two groups was significant after evaluating the long-term treatment outcomes. Complex approach to the therapy of patients with complicated DFS makes it possible to heal the wounds of the foot in 76.5 % of them versus 28.2 % of patients in the control group. Relapse of the disease, if the patient complies with all the recommendations on conservative therapy, limb immobilization, wearing orthopedic shoes and preventive measures, is reduced to 7.8 % of cases per year, which is 3 times less than when the multidisciplinary approach is not implemented.