The amniotic band syndrome (ABS), also known as the amniotic band disruption complex or limb-body wall complex, is a common cause offetal malformations, estimated to occur in one in 1200 live births [1]. The malformations mange from mild deformities to severe anomalies that are incompatible with postnatal life. Although a wide range of malformations can occur in this syndrome, characteristic features can often suggest the diagnosis. Sonographems should be familiar with features suggestive of ABS on antenatal sonography and be able to differentiate ABS from developmental anomalies that can mimic ABS. The pathogenesis of ABS is thought to be disruption of the amnion, allowing the embryo, or fetus, to enter the chomionic cavity and contact the chomionic side of the amnion. Fetal parts may then become entrapped by the fibrous septa that traverse the chomionic space. Entanglement of fetal parts is random and the slash defects so created are nonembryologic in distribution. The fetal head, trunk, and extremities may be involved individually or in combination. If the amnion is dismupted early in gestation, during the period of embryogenesis, the fibrous septa of the chorionic cavity may interfere with normal embryologic development also, so that embryologic malformations such as a classic encephalocele or omphalocele may also be found in a fetus with ABS [2]. When the calvaria is involved in ABS, the resultant destructive lesions include encephaloceles and, with severe involvement, may resemble anencephaly. Whereas “typical” anencephaly is characterized by complete absence of the calvaria, that which occurs in ABS may demonstrate asymmetric preservation of a portion of the calvaria, generally near the skull base (Fig. 1). Classic encephaloceles occur in the midline, whereas those seen with ABS occur away from the midline. Similarly, when facial clefts occur in ABS they tend to occur in nonembryologic distributions (Fig. 2). When one of these asymmetric malformations involving the craniofacial region is observed, the sonographer should suspect ABS and search for other associated malformations. Truncal deformities seen in ABS include abdominal wall defects. Whereas extemiorization of the liver rarely occurs in isolated gastmoschisis, it commonly occurs in fetuses with ABS and an abdominal wall defect, and it therefore should lead the sonogmapher to suspect ABS when seen. The defects of the torso in ABS may be extensive and involve the chest as well as the abdominal wall (gastropleuroschisis). In this deformity extemiomization of the heart, liver, and bowel may occur (Fig. 3). In addition to wall defects and exteriomization of organs, spinal deformities commonly occur in ABS. The spine may demonstrate kyphosis, lordosis, scoliosis, and/or marked angulation deformities (Fig. 4). With severe spinal involvement, amputation of the distal spine may occur (Fig. 5). The combination of severe spinal deformity and an abdominal wall defect is diagnostic of ABS. Extremities are frequently involved in ABS, alone or in combination with the malformations previously described. Asymmetric amputations may involve one or more digits or portions of an extremity (Fig. 6). Focal constrictions caused by the amniotic bands may occur with distal lymphedema (Fig. 7). An amputation virtually diagnostic of ABS is one with